Adrenergic Uptake Inhibitors

Name
Adrenergic Uptake Inhibitors
Accession Number
DBCAT000439
Description

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.

Drugs
DrugDrug Description
AmphetamineA CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
ReserpineFor the treatment of hypertension
ReboxetineFor the treatment of clinical depression.
AmitriptylineA tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
ProtriptylineA tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision.
ImipramineA tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis.
NortriptylineA tricyclic antidepressant used in the treatment of depression.
AmoxapineA tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression.
MazindolA sympathomimetic used to treat obesity in combination with lifestyle modifications.
TrimipramineA tricyclic antidepressant used to treat depression.
BenzphetamineA sympathomimetic used to manage exogenous obesity short term.
MaprotilineA tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression.
DesipramineA tricyclic antidepressant used in the treatment of depression.
MidomafetamineClinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used...
TenamfetamineAn amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons...
MetamfetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity.
MilnacipranA selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder.
LevomilnacipranA selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD).
DosulepinIndicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required.
EdivoxetineEdivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant treatment....
ViloxazineIndicated for the treatment of clinical depression.
EsreboxetineEsreboxetine has been used in trials studying the treatment and basic science of Fibromyalgia.
LortalamineLortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s. This drug never made it past clinical trials, likely due to ocular toxicity in animals, but has been...
NisoxetineNisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research...
TalopramTalopram is a selective norepinephrine reuptake inhibitor (SNRI) that is structurally similar to citalopram and melitracen. It was researched in the 1960s and 1970s but never marketed.
SolriamfetolSolriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744].
TapentadolAn opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate.
Drugs & Drug Targets
DrugTargetType
AmphetamineSodium-dependent dopamine transportertarget
AmphetamineCocaine- and amphetamine-regulated transcript proteintarget
AmphetamineTrace amine-associated receptor 1target
AmphetamineCytochrome P450 2D6enzyme
AmphetamineSolute carrier family 22 member 3transporter
AmphetamineSolute carrier family 22 member 5transporter
AmphetamineSynaptic vesicular amine transportertarget
AmphetamineCytochrome P450 2A6enzyme
AmphetamineSodium-dependent noradrenaline transportertarget
AmphetamineAlpha adrenergic receptortarget
AmphetamineBeta adrenergic receptortarget
AmphetamineDopamine D2 receptortarget
AmphetamineAmine oxidase [flavin-containing] Btarget
AmphetamineSodium-dependent serotonin transportertarget
AmphetamineMonoamine oxidasetarget
Amphetaminevesicular monoamine transporter 2 (VMAT2)target
ReserpineSynaptic vesicular amine transportertarget
ReserpineP-glycoprotein 1transporter
ReserpineSolute carrier family 22 member 1transporter
ReserpineBile salt export pumptransporter
ReserpineCanalicular multispecific organic anion transporter 1transporter
ReserpineSolute carrier family 22 member 2transporter
ReserpineCytochrome P450 3A5enzyme
ReserpineChromaffin granule amine transportertarget
ReserpineBaculoviral IAP repeat-containing protein 5target
ReserpineSolute carrier organic anion transporter family member 1B1transporter
ReserpineSolute carrier organic anion transporter family member 2B1transporter
ReboxetineSodium-dependent noradrenaline transportertarget
ReboxetineCytochrome P450 3A4enzyme
ReboxetineCytochrome P450 2D6enzyme
ReboxetineP-glycoprotein 1transporter
AmitriptylineSodium-dependent serotonin transportertarget
AmitriptylineSodium-dependent noradrenaline transportertarget
AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
AmitriptylineAlpha-2A adrenergic receptortarget
AmitriptylineCytochrome P450 1A2enzyme
AmitriptylineCytochrome P450 2C19enzyme
AmitriptylineCytochrome P450 2D6enzyme
AmitriptylineSerum albumincarrier
AmitriptylineAlpha-1-acid glycoprotein 1carrier
AmitriptylineHistamine H1 receptortarget
Amitriptyline5-hydroxytryptamine receptor 2Atarget
Amitriptyline5-hydroxytryptamine receptor 1Atarget
AmitriptylineAlpha-1A adrenergic receptortarget
AmitriptylineCytochrome P450 3A4enzyme
AmitriptylineCytochrome P450 3A5enzyme
AmitriptylinePotassium voltage-gated channel subfamily A member 1target
AmitriptylineAlpha-1D adrenergic receptortarget
AmitriptylineDelta-type opioid receptortarget
AmitriptylineKappa-type opioid receptortarget
AmitriptylineHigh affinity nerve growth factor receptortarget
AmitriptylineBDNF/NT-3 growth factors receptortarget
AmitriptylineCytochrome P450 2C9enzyme
AmitriptylineCytochrome P450 2B6enzyme
AmitriptylineCytochrome P450 2C8enzyme
AmitriptylineHistamine H2 receptortarget
AmitriptylineHistamine H4 receptortarget
AmitriptylineSigma non-opioid intracellular receptor 1target
Amitriptyline5-hydroxytryptamine receptor 2Ctarget
AmitriptylineAlpha-1B adrenergic receptortarget
Amitriptyline5-hydroxytryptamine receptor 7target
Amitriptyline5-hydroxytryptamine receptor 1Dtarget
AmitriptylineMu-type opioid receptortarget
Amitriptyline5-hydroxytryptamine receptor 1Btarget
Amitriptyline5-hydroxytryptamine receptor 6target
AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
AmitriptylineUDP-glucuronosyltransferase 2B10enzyme
Amitriptyline5-hydroxytryptamine receptor 1Ctarget
AmitriptylineMuscarinic acetylcholine receptortarget
AmitriptylineHERG human cardiac K+ channeltarget
AmitriptylineP-glycoprotein 1transporter
AmitriptylineUDP-glucuronosyltransferase 1-4enzyme
ProtriptylineSodium-dependent noradrenaline transportertarget
ProtriptylineSodium-dependent serotonin transportertarget
ProtriptylineP-glycoprotein 1transporter
ImipramineSodium-dependent noradrenaline transportertarget
ImipramineSodium-dependent serotonin transportertarget
ImipramineCytochrome P450 1A2enzyme
ImipramineCytochrome P450 2C19enzyme
ImipramineCytochrome P450 2D6enzyme
ImipramineHistamine H1 receptortarget
ImipramineAlpha-1A adrenergic receptortarget
Imipramine5-hydroxytryptamine receptor 2Atarget
ImipramineMuscarinic acetylcholine receptor M1target
ImipramineMuscarinic acetylcholine receptor M2target
ImipramineMuscarinic acetylcholine receptor M3target
ImipramineMuscarinic acetylcholine receptor M4target
ImipramineMuscarinic acetylcholine receptor M5target
ImipraminePotassium voltage-gated channel subfamily D member 2target
ImipraminePotassium voltage-gated channel subfamily D member 3target
ImipramineAlpha-1D adrenergic receptortarget
ImipramineAlpha-1-acid glycoprotein 1carrier
ImipramineSolute carrier family 22 member 2transporter
ImipramineSolute carrier family 22 member 3transporter
ImipramineP-glycoprotein 1transporter
ImipramineSolute carrier family 22 member 4transporter
ImipramineCytochrome P450 3A4enzyme
ImipramineCytochrome P450 2B6enzyme
ImipramineCytochrome P450 2C18enzyme
ImipramineCytochrome P450 2E1enzyme
ImipramineCytochrome P450 3A7enzyme
Imipramine5-hydroxytryptamine receptor 2Ctarget
ImipramineAlpha-1B adrenergic receptortarget
Imipramine5-hydroxytryptamine receptor 7target
ImipramineD(1) dopamine receptortarget
ImipramineDopamine D2 receptortarget
ImipraminePotassium voltage-gated channel subfamily H member 2target
ImipramineSodium-dependent dopamine transportertarget
Imipramine5-hydroxytryptamine receptor 1Atarget
Imipramine5-hydroxytryptamine receptor 6target
ImipraminePotassium voltage-gated channel subfamily H member 1target
ImipramineSerum albumincarrier
ImipramineAlpha-1-acid glycoprotein 2target
NortriptylineSodium-dependent serotonin transportertarget
NortriptylineSodium-dependent noradrenaline transportertarget
NortriptylineCytochrome P450 1A2enzyme
NortriptylineCytochrome P450 2D6enzyme
NortriptylineSerum albumincarrier
NortriptylineAlpha-1-acid glycoprotein 1carrier
NortriptylineHistamine H1 receptortarget
Nortriptyline5-hydroxytryptamine receptor 2Atarget
NortriptylineAlpha-1A adrenergic receptortarget
Nortriptyline5-hydroxytryptamine receptor 1Atarget
NortriptylineCytochrome P450 3A4enzyme
NortriptylineCytochrome P450 3A5enzyme
NortriptylineAlpha-1D adrenergic receptortarget
NortriptylineCytochrome P450 2C19enzyme
NortriptylineCytochrome P450 2E1enzyme
Nortriptyline5-hydroxytryptamine receptor 2Ctarget
NortriptylineAlpha-1B adrenergic receptortarget
NortriptylineAlpha-2 adrenergic receptorstarget
NortriptylineBeta adrenergic receptortarget
NortriptylineDopamine D2 receptortarget
NortriptylineSigma receptortarget
Nortriptyline5-hydroxytryptamine receptor 1Ctarget
NortriptylineSodium-dependent noradrenaline transportertransporter
NortriptylineMuscarinic acetylcholine receptortarget
NortriptylineP-glycoprotein 1transporter
AmoxapineSodium-dependent serotonin transportertarget
AmoxapineSodium-dependent noradrenaline transportertarget
AmoxapineAlpha-2A adrenergic receptortarget
AmoxapineDopamine D2 receptortarget
AmoxapineAlpha-1A adrenergic receptortarget
AmoxapineDopamine D1 receptortarget
AmoxapineMuscarinic acetylcholine receptor M1target
AmoxapineGamma-aminobutyric acid receptor subunit alpha-1target
AmoxapineAlpha-1-acid glycoprotein 1carrier
AmoxapineCytochrome P450 2D6enzyme
Amoxapine5-hydroxytryptamine receptor 2Atarget
Amoxapine5-hydroxytryptamine receptor 2Ctarget
Amoxapine5-hydroxytryptamine receptor 6target
Amoxapine5-hydroxytryptamine receptor 7target
AmoxapineDopamine D3 receptortarget
AmoxapineDopamine D4 receptortarget
AmoxapineHistamine H1 receptortarget
AmoxapineAlpha-1 adrenergic receptorstarget
AmoxapineMuscarinic acetylcholine receptortarget
Amoxapine5-hydroxytryptamine receptor 2Btarget
Amoxapine5-hydroxytryptamine receptor 3Atarget
Amoxapine5-hydroxytryptamine receptor 1Atarget
Amoxapine5-hydroxytryptamine receptor 1Btarget
AmoxapineAlpha-2 adrenergic receptorstarget
AmoxapineHistamine H4 receptortarget
AmoxapineGABA(A) Receptortarget
AmoxapineSodium-dependent dopamine transportertarget
MazindolSodium-dependent noradrenaline transportertarget
MazindolSodium-dependent dopamine transportertarget
MazindolSodium-dependent serotonin transportertarget
MazindolSynaptic vesicular amine transportertarget
TrimipramineSodium-dependent serotonin transportertarget
TrimipramineSodium-dependent noradrenaline transportertarget
TrimipramineCytochrome P450 2D6enzyme
TrimipramineSodium-dependent dopamine transportertarget
Trimipramine5-hydroxytryptamine receptor 2Atarget
Trimipramine5-hydroxytryptamine receptor 1Atarget
TrimipramineAlpha-1A adrenergic receptortarget
TrimipramineAlpha-1B adrenergic receptortarget
TrimipramineDopamine D2 receptortarget
TrimipramineAlpha-2B adrenergic receptortarget
TrimipramineHistamine H1 receptortarget
TrimipramineCytochrome P450 2C19enzyme
TrimipramineP-glycoprotein 1transporter
TrimipramineCytochrome P450 2C9enzyme
Trimipramine5-hydroxytryptamine receptor 2Ctarget
Trimipramine5-hydroxytryptamine receptor 3Atarget
Trimipramine5-hydroxytryptamine receptor 1Dtarget
TrimipramineAlpha-2A adrenergic receptortarget
TrimipramineD(1) dopamine receptortarget
TrimipramineBeta adrenergic receptortarget
TrimipramineMuscarinic acetylcholine receptortarget
Trimipramine5-hydroxytryptamine receptor 1Ctarget
BenzphetamineAlpha-2A adrenergic receptortarget
BenzphetamineAlpha-1A adrenergic receptortarget
BenzphetamineCytochrome P450 3A4enzyme
BenzphetamineCytochrome P450 2B6enzyme
BenzphetamineNADPH--cytochrome P450 reductaseenzyme
BenzphetamineSynaptic vesicular amine transportertarget
BenzphetamineSodium-dependent dopamine transportertarget
MaprotilineHistamine H1 receptortarget
MaprotilineSodium-dependent noradrenaline transportertarget
MaprotilineAlpha-1 adrenergic receptorstarget
MaprotilineCytochrome P450 2D6enzyme
MaprotilineAlpha-1-acid glycoprotein 1carrier
MaprotilineMuscarinic acetylcholine receptor M1target
MaprotilineMuscarinic acetylcholine receptor M2target
MaprotilineMuscarinic acetylcholine receptor M3target
MaprotilineMuscarinic acetylcholine receptor M4target
MaprotilineMuscarinic acetylcholine receptor M5target
MaprotilineCytochrome P450 1A2enzyme
Maprotiline5-hydroxytryptamine receptor 2Atarget
Maprotiline5-hydroxytryptamine receptor 2Ctarget
Maprotiline5-hydroxytryptamine receptor 7target
MaprotilineDopamine D2 receptortarget
MaprotilineAlpha-2 adrenergic receptorstarget
DesipramineMuscarinic acetylcholine receptor M1target
DesipramineSodium-dependent noradrenaline transportertarget
DesipramineBeta-2 adrenergic receptortarget
DesipramineMuscarinic acetylcholine receptor M2target
DesipramineSodium-dependent serotonin transportertarget
DesipramineHistamine H1 receptortarget
DesipramineBeta-1 adrenergic receptortarget
DesipramineCytochrome P450 2D6enzyme
DesipramineMuscarinic acetylcholine receptor M3target
DesipramineMuscarinic acetylcholine receptor M4target
DesipramineMuscarinic acetylcholine receptor M5target
DesipramineAlpha-1 adrenergic receptorstarget
Desipramine5-hydroxytryptamine receptor 2Atarget
DesipramineAlpha-1-acid glycoprotein 1carrier
DesipramineCytochrome P450 2B6enzyme
DesipramineCytochrome P450 3A4enzyme
DesipramineSolute carrier family 22 member 2transporter
DesipramineSolute carrier family 22 member 1transporter
DesipramineSolute carrier family 22 member 3transporter
DesipramineSolute carrier family 22 member 5transporter
DesipramineP-glycoprotein 1transporter
DesipramineSolute carrier family 22 member 4transporter
DesipramineCytochrome P450 1A2enzyme
DesipramineCytochrome P450 2E1enzyme
DesipramineSphingomyelin phosphodiesterasetarget
Desipramine5-hydroxytryptamine receptor 1Atarget
Desipramine5-hydroxytryptamine receptor 2Ctarget
DesipramineDopamine D2 receptortarget
DesipramineAlpha-2 adrenergic receptorstarget
MidomafetamineSodium-dependent serotonin transportertarget
MidomafetamineSynaptic vesicular amine transportertarget
MidomafetamineSodium-dependent dopamine transportertarget
Midomafetamine5-hydroxytryptamine receptor 2Atarget
Midomafetamine5-hydroxytryptamine receptor 2Btarget
Midomafetamine5-hydroxytryptamine receptor 2Ctarget
MidomafetamineSodium-dependent noradrenaline transportertarget
MidomafetamineSodium-dependent noradrenaline transportertransporter
MidomafetamineSodium-dependent dopamine transportertransporter
MidomafetamineSodium-dependent serotonin transportertransporter
MidomafetamineCytochrome P450 2D6enzyme
MetamfetamineCytochrome P450 2D6enzyme
MetamfetamineSolute carrier family 22 member 3transporter
MetamfetamineSolute carrier family 22 member 5transporter
MetamfetamineSodium-dependent dopamine transportertarget
MetamfetamineSynaptic vesicular amine transportertarget
MetamfetamineTrace amine-associated receptor 1target
MetamfetamineSodium-dependent serotonin transportertarget
MetamfetamineSodium-dependent noradrenaline transportertarget
MetamfetamineChromaffin granule amine transportertarget
MetamfetamineAmine oxidase [flavin-containing] Atarget
MetamfetamineAmine oxidase [flavin-containing] Btarget
MetamfetamineAlpha-2A adrenergic receptortarget
MetamfetamineAlpha-2B adrenergic receptortarget
MetamfetamineAlpha-2C adrenergic receptortarget
MilnacipranSodium-dependent serotonin transportertarget
MilnacipranSodium-dependent noradrenaline transportertarget
MilnacipranNMDA receptortarget
MilnacipranCytochrome P450 3A4enzyme
LevomilnacipranCytochrome P450 3A4enzyme
LevomilnacipranCytochrome P450 2C8enzyme
LevomilnacipranCytochrome P450 2C19enzyme
LevomilnacipranCytochrome P450 2D6enzyme
LevomilnacipranCytochrome P450 2J2enzyme
LevomilnacipranSodium-dependent serotonin transportertarget
LevomilnacipranSodium-dependent noradrenaline transportertarget
LevomilnacipranP-glycoprotein 1transporter
Dosulepin5-hydroxytryptamine receptor 1Atarget
Dosulepin5-hydroxytryptamine receptor 2Atarget
DosulepinCytochrome P450 2D6enzyme
DosulepinCytochrome P450 1A2enzyme
DosulepinCytochrome P450 2C19enzyme
DosulepinCytochrome P450 2C9enzyme
DosulepinHistamine H1 receptortarget
DosulepinMuscarinic acetylcholine receptor M1target
DosulepinMuscarinic acetylcholine receptor M2target
DosulepinMuscarinic acetylcholine receptor M3target
DosulepinMuscarinic acetylcholine receptor M4target
DosulepinMuscarinic acetylcholine receptor M5target
DosulepinSodium-dependent noradrenaline transportertarget
DosulepinSodium-dependent serotonin transportertarget
DosulepinAlpha-1 adrenergic receptorstarget
DosulepinAlpha-2 adrenergic receptorstarget
ViloxazineSodium-dependent noradrenaline transportertarget
ViloxazineCytochrome P450 1A2enzyme
NisoxetineSodium-dependent serotonin transportertarget
SolriamfetolSolute carrier family 22 member 2transporter
SolriamfetolSolute carrier family 22 member 4transporter
SolriamfetolSolute carrier family 22 member 5transporter
SolriamfetolSodium-dependent dopamine transportertarget
SolriamfetolSodium-dependent noradrenaline transportertarget
TapentadolMu-type opioid receptortarget
TapentadolKappa-type opioid receptortarget
TapentadolDelta-type opioid receptortarget
TapentadolSodium-dependent noradrenaline transportertarget
Tapentadol5-hydroxytryptamine receptor 3Atarget
TapentadolUDP-glucuronosyltransferase 1-9enzyme
TapentadolUDP-glucuronosyltransferase 2B7enzyme
TapentadolCytochrome P450 2D6enzyme
TapentadolCytochrome P450 2C9enzyme
TapentadolCytochrome P450 2C19enzyme
TapentadolSodium-dependent serotonin transportertarget