- Indole Alkaloids
- Accession Number
Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)
Drug Drug Description Physostigmine A cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. Rauwolfia serpentina root Rauwolfia alkaloids are indicated in the treatment of hypertension . Rauwolfia alkaloids have been used for relief of symptoms in agitated psychotic states such as schizophrenia; however, use as antipsychotics... Ajmaline An antiarrhythmic used to manage a variety of forms of tachycardias. Staurosporine An indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20) Metoserpate Not Annotated Psilocybin Psilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. In November, 2019, it was granted Breakthrough Therapy status by the FDA. Raubasine Not Annotated Reserpine For the treatment of hypertension Vindesine A vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL). Vinorelbine A vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC. Vincristine A vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. Vinblastine A vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma. Tadalafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Alosetron A 5-HT3 antagonist used to treat diarrhea-predominant IBS. Deserpidine An alkaloid that has been used to manage hypertension. Rescinnamine For the treatment of hypertension. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Almitrine For the treatment of chronic obstructive pulmonary disease. 7-Hydroxystaurosporine Not Available Deacetoxyvinzolidine Not Available Voacamine For the treatment of malaria. Also under investigation for the modulation of multidrug resistance in cancer cells. Phenserine For the treatment of Alzheimer's disease (AD). Vintafolide Investigated for use/treatment in solid tumors. Midostaurin An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). Harmine Not Available Metralindole Investigated for the treatment of depression. Vinflunine A vinca alkaloid used to treat advanced or metastatic transitional cell carcinoma of the urothelial tract after a platinum containing treatment has failed. Orantinib Orantinib has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Kidney Cancer, Gastric Cancer, and Prostate Cancer, among others. Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Lurbinectedin A chemotherapeutic DNA alkylating agent used in the treatment of metastatic small-cell lung cancer. TAK-901 TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others. Vincamine Vincamine is a monoterpenoid indole alkaloid obtained from the leaves of Vinca minor with a vasodilatory property. Studies indicate that vincamine increases the regional cerebral blood flow. Tenidap Not Annotated Prajmaline Not Annotated Bietaserpine Not Annotated Lorajmine Not Annotated Vinburnine Not Annotated Mebhydrolin An antihistamine indicated in the treatment of allergies. Harmaline Not Annotated Flortaucipir F-18 A small lipophilic tracer containing [18F]fluoride capable of crossing the blood-brain barrier and binding to aggregated tau protein; used in PET imaging for the diagnosis of Alzheimer's disease. Flortaucipir Flortaucipir is under investigation in clinical trial NCT03507257 (Longitudinal Early-onset Alzheimer's Disease Study Protocol). 18-methoxycoronaridine 18-methoxycoronaridine is under investigation in clinical trial NCT03084952 (Phase 2 Trial to Evaluate 18-Methoxycoronaridine Efficacy, Safety and Tolerability in Cutaneous Leishmaniasis Patients). Posiphen Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease). Strychnine Not Annotated Ellipticine Ellipticine is a potent antineoplastic agent. ZK-93423 ZK-93423 is a beta-carboline with muscle relaxant activity with agonistic properties at the benzodiazepine receptor.
- Drugs & Drug Targets