This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Summary
Mebhydrolin is an antihistamine indicated in the treatment of allergies.
- Generic Name
- Mebhydrolin
- DrugBank Accession Number
- DB13808
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Mebhydrolin (DB13808)
- Weight
- Average: 276.383
Monoisotopic: 276.162648652 - Chemical Formula
- C19H20N2
- Synonyms
- Mebhydrolin
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Allergies •••••••••••• ••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
Pathway Category Mebhydrolin H1-Antihistamine Action Drug action - Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareDroxidopa The therapeutic efficacy of Droxidopa can be increased when used in combination with Mebhydrolin. Ephedrine The therapeutic efficacy of Ephedrine can be increased when used in combination with Mebhydrolin. Epinephrine The therapeutic efficacy of Epinephrine can be increased when used in combination with Mebhydrolin. Levonordefrin The therapeutic efficacy of Levonordefrin can be increased when used in combination with Mebhydrolin. Norepinephrine The therapeutic efficacy of Norepinephrine can be increased when used in combination with Mebhydrolin. - Food Interactions
- Not Available
Products
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Ingredient UNII CAS InChI Key Mebhydrolin napadisylate O5G04RB25M 6153-33-9 CJUOSBUQOWKEKJ-UHFFFAOYSA-N
Categories
- ATC Codes
- R06AX15 — Mebhydrolin
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Indoles and derivatives
- Sub Class
- N-alkylindoles
- Direct Parent
- N-alkylindoles
- Alternative Parents
- 3-alkylindoles / Aralkylamines / Substituted pyrroles / Benzene and substituted derivatives / Heteroaromatic compounds / Trialkylamines / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- 3-alkylindole / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Heteroaromatic compound / Hydrocarbon derivative / Indole / Monocyclic benzene moiety
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 9SUK9B7XVY
- CAS number
- 524-81-2
- InChI Key
- FQQIIPAOSKSOJM-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
- IUPAC Name
- 5-benzyl-2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole
- SMILES
- CN1CCC2=C(C1)C1=CC=CC=C1N2CC1=CC=CC=C1
References
- General References
- FDA Thailand Product Information: MYDOLIN (mebhydrolin) capsule [Link]
- External Links
- Human Metabolome Database
- HMDB0240237
- ChemSpider
- 21129
- 29411
- ChEBI
- 135144
- ChEMBL
- CHEMBL1625607
- ZINC
- ZINC000000001651
- Wikipedia
- Mebhydrolin
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, film coated Oral 50 mg Tablet, coated Suspension 50 MG/5ML Tablet 76 MG Tablet 50 mg Capsule 50 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0367 mg/mL ALOGPS logP 3.69 ALOGPS logP 3.69 Chemaxon logS -3.9 ALOGPS pKa (Strongest Basic) 7.2 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 8.17 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 88.49 m3·mol-1 Chemaxon Polarizability 32.54 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0006-9360000000-9002610ba3e228f59aff Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-004i-0090000000-8f5af7b538e41818ae67 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-004i-0090000000-d66693c780257b9ba065 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-004i-0390000000-940f40212a09800f7024 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-004i-0090000000-b98346c4e65bff31915a Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0awa-1970000000-ee947e667f373b451d9a Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-005c-9260000000-a0dce5e335bcad074a33 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 179.0243492 predictedDarkChem Lite v0.1.0 [M-H]- 161.334 predictedDeepCCS 1.0 (2019) [M+H]+ 178.9814492 predictedDarkChem Lite v0.1.0 [M+H]+ 163.69199 predictedDeepCCS 1.0 (2019) [M+Na]+ 178.5316492 predictedDarkChem Lite v0.1.0 [M+Na]+ 169.78514 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:49 / Updated at May 21, 2021 10:23