Mebhydrolin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Mebhydrolin is an antihistamine indicated in the treatment of allergies.

Generic Name
Mebhydrolin
DrugBank Accession Number
DB13808
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 276.383
Monoisotopic: 276.162648652
Chemical Formula
C19H20N2
Synonyms
  • Mebhydrolin

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Symptomatic treatment ofAllergies•••••••••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
PathwayCategory
Mebhydrolin H1-Antihistamine ActionDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
DroxidopaThe therapeutic efficacy of Droxidopa can be increased when used in combination with Mebhydrolin.
EphedrineThe therapeutic efficacy of Ephedrine can be increased when used in combination with Mebhydrolin.
EpinephrineThe therapeutic efficacy of Epinephrine can be increased when used in combination with Mebhydrolin.
LevonordefrinThe therapeutic efficacy of Levonordefrin can be increased when used in combination with Mebhydrolin.
NorepinephrineThe therapeutic efficacy of Norepinephrine can be increased when used in combination with Mebhydrolin.
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Mebhydrolin napadisylateO5G04RB25M6153-33-9CJUOSBUQOWKEKJ-UHFFFAOYSA-N

Categories

ATC Codes
R06AX15 — Mebhydrolin
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Indoles and derivatives
Sub Class
N-alkylindoles
Direct Parent
N-alkylindoles
Alternative Parents
3-alkylindoles / Aralkylamines / Substituted pyrroles / Benzene and substituted derivatives / Heteroaromatic compounds / Trialkylamines / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
3-alkylindole / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Heteroaromatic compound / Hydrocarbon derivative / Indole / Monocyclic benzene moiety
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
9SUK9B7XVY
CAS number
524-81-2
InChI Key
FQQIIPAOSKSOJM-UHFFFAOYSA-N
InChI
InChI=1S/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
IUPAC Name
5-benzyl-2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole
SMILES
CN1CCC2=C(C1)C1=CC=CC=C1N2CC1=CC=CC=C1

References

General References
  1. FDA Thailand Product Information: MYDOLIN (mebhydrolin) capsule [Link]
Human Metabolome Database
HMDB0240237
ChemSpider
21129
RxNav
29411
ChEBI
135144
ChEMBL
CHEMBL1625607
ZINC
ZINC000000001651
Wikipedia
Mebhydrolin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, film coatedOral
Tablet, coated
Tablet
Suspension
Tablet50 mg
Capsule50 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0367 mg/mLALOGPS
logP3.69ALOGPS
logP3.69Chemaxon
logS-3.9ALOGPS
pKa (Strongest Basic)7.2Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area8.17 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity88.49 m3·mol-1Chemaxon
Polarizability32.54 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0006-9360000000-9002610ba3e228f59aff
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-0090000000-8f5af7b538e41818ae67
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0090000000-d66693c780257b9ba065
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0390000000-940f40212a09800f7024
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-0090000000-b98346c4e65bff31915a
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0awa-1970000000-ee947e667f373b451d9a
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-005c-9260000000-a0dce5e335bcad074a33
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-179.0243492
predicted
DarkChem Lite v0.1.0
[M-H]-161.334
predicted
DeepCCS 1.0 (2019)
[M+H]+178.9814492
predicted
DarkChem Lite v0.1.0
[M+H]+163.69199
predicted
DeepCCS 1.0 (2019)
[M+Na]+178.5316492
predicted
DarkChem Lite v0.1.0
[M+Na]+169.78514
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:49 / Updated at May 21, 2021 10:23