Nucleic Acid Synthesis Inhibitors
- Nucleic Acid Synthesis Inhibitors
- Accession Number
Compounds that inhibit cell production of DNA or RNA.
Drug Drug Description Idoxuridine A pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis. Mitomycin An antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies. Rimantadine An RNA synthesis inhibitor used to prevent influenza A infection. Zidovudine A dideoxynucleoside used in the treatment of HIV infection. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Efavirenz A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. Lamivudine A reverse transcriptase inhibitor used to treat HIV and hepatitis B infections. Adefovir dipivoxil A nucleotide analog used to treat chronic hepatitis B. Emtricitabine A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV. Didanosine A reverse transcriptase inhibitor used to treat HIV. Zalcitabine A dideoxynucleoside used to treat HIV. Dactinomycin An actinomycin used to treat a wide variety of cancers. Hydroxyurea An antimetabolite used to treat sickle cell anemia crisis, resistant chronic myeloid leukemia, and Locally advanced squamous cell carcinomas of the head and neck (excluding the lip). Mercaptopurine An antineoplastic agent used to treat acute lymphocytic leukemia. Rifampicin An antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis. Abacavir An antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. Telbivudine A thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST). Plicamycin For the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer. Rilpivirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1). Lobucavir Lobucavir has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections. Tenofovir A nucleotide analog indicated in the treatment of HIV infections. Fluorouracil A pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. Gemcitabine A nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. Nelarabine A purine nucleoside analog and antineoplastic agent used for the treatment of with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma with inadequate clinical response to prior chemotherapeutic treatments. Pentostatin An adenosine deaminase inhibitor used to treat hairy cell leukemia. Azathioprine An immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Cytarabine A pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. Fludarabine A purine analog antimetabolite that inhibits DNA synthesis. Clofarabine A purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old. Capecitabine A nucleoside metabolic inhibitor indicated to treat different gastrointestinal, including pancreatic cancer, and breast cancer. Azacitidine A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. Decitabine A chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression. Trifluridine A nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers. Cidofovir An antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. Acyclovir A guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. Ganciclovir A DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye. Famciclovir A nucleoside analog DNA polymerase inhibitor used for the treatment of recurrent cold sores and genital herpes in healthy patients and patients with HIV, and to manage herpes zoster. Penciclovir A topical nucleoside polymerase inhibitor used in the treatment of recurrent herpes labialis. Valaciclovir An guanine nucleoside antiviral used to treat herpes exacerbations. Valganciclovir An antiviral medication used to treat cytomegalovirus (CMV) retinitis in patients diagnosed with acquired immunodeficiency syndrome (AIDS). Echinomycin Echinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis. R-82913 Not Available Dichlororibofuranosylbenzimidazole Not Available Islatravir Islatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)). Fialuridine Fialuridine is under investigation in clinical trial NCT01337466 (Biodistribution and Dosimetry Evaluation of [124I]FIAU). Pemetrexed A folate analog used to treat mesothelioma and non-small cell lung cancer. Novobiocin For the treatment of infections due to staphylococci and other susceptible organisms 5'-S-methyl-5'-thioadenosine Not Available Anisomycin Anisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria Streptomyces griseolus. This drug acts to inhibit bacterial protein and DNA synthesis. Nevirapine A non-nucleoside reverse transcriptase inhibitor used as part of a management regimen for HIV-1 virus infection. Foscarnet An antiviral used to treat CMV, HIV, and HSV infections. Stavudine A dideoxynucleoside used in the treatment of HIV infection. Delavirdine A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection. Phosphonoacetic Acid A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent. [PubChem] Arsanilic acid An arsenical which has been used as a feed additive for enteric conditions in pigs and poultry. It causes blindness and is ototoxic and nephrotoxic in animals. [PubChem] Elvucitabine Investigated for use/treatment in hepatitis (viral, B) and HIV infection. Etravirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infections in combination with other antiretroviral agents. Emivirine Emivirine has been used in trials studying the treatment of HIV Infections. Capravirine Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections and HIV infection. Lapachone Lapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell. Atevirdine Atevirdine has been used in trials studying the treatment of HIV Infections. Dexelvucitabine Dexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus. Oltipraz Oltipraz has been used in trials studying the treatment and prevention of Lung Cancer, Liver Fibrosis, Liver Cirrhosis, and Non-alcoholic Fatty Liver Disease. Adefovir Not Annotated Rovafovir etalafenamide Rovafovir etalafenamide is under investigation in clinical trial NCT03472326 (Efficacy of GS-9131 Functional Monotherapy in HIV-1-Infected Adults Failing a Nucleos(t)Ide Reverse Transcriptase Inhibitor-Containing Regimen). Ibezapolstat Ibezapolstat is under investigation in clinical trial NCT04247542 (ACX-362E Ibezapolstat for Oral Treatment of Clostridioides Difficile Infection). Ammonium trichlorotellurate Ammonium trichlorotellurate is an investigational compound with anti-tumour and anti-inflammatory properties.
- Drugs & Drug Targets