Voltage-Gated Sodium Channel Blockers

Name
Voltage-Gated Sodium Channel Blockers
Accession Number
DBCAT000615
Description

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.

Drugs
DrugDrug Description
PhenytoinAn anticonvulsant drug used in the prophylaxis and control of various types of seizures.
DisopyramideA class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias.
LidocaineA local anesthetic used in a wide variety of superficial and invasive procedures.
MexiletineA class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment.
MoricizineAn antiarrhythmic used to treat arrhythmias.
OxcarbazepineAn anti-epileptic used in the treatment of partial-onset seizures.
QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
ProcainamideA medication used to treat life threatening ventricular arrhythmias.
TocainideAn orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias.
PropafenoneA Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias.
FlecainideA class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT).
EncainideA voltage-gated sodium channel blocker used for management of atrial or ventricular fibrillation, atrial flutter, and ventricular tachycardia, that is no longer used due to proarrhythmic adverse effects.
AjmalineAn antiarrhythmic used to manage a variety of forms of tachycardias.
AprindineAprindine is a cardiac depressant used in arrhythmias.
Eslicarbazepine acetateAn anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy.
EslicarbazepineAn antiepileptic indicated as a monotherapy or adjunct therapy in the treatment of epilepsy.
EthotoinA hydantoin antiepileptic used to control tonic-clonic and complex partial seizures.
RufinamideAn antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS).
LacosamideAn antiepileptic drug used to treat partial onset seizures in adults.
CenobamateA small molecule drug indicated to treat partial onset seizures in adults.
Drugs & Drug Targets
DrugTargetType
PhenytoinSodium channel protein type 5 subunit alphatarget
PhenytoinSodium channel protein type 1 subunit alphatarget
PhenytoinCytochrome P450 2C8enzyme
PhenytoinCytochrome P450 2C19enzyme
PhenytoinCytochrome P450 2C9enzyme
PhenytoinCytochrome P450 2B6enzyme
PhenytoinCytochrome P450 3A5enzyme
PhenytoinSerum albumincarrier
PhenytoinCytochrome P450 3A4enzyme
PhenytoinSolute carrier organic anion transporter family member 1C1transporter
PhenytoinP-glycoprotein 1transporter
PhenytoinCanalicular multispecific organic anion transporter 1transporter
PhenytoinCytochrome P450 11B1, mitochondrialenzyme
PhenytoinCytochrome P450 3A7enzyme
PhenytoinNuclear receptor subfamily 1 group I member 2target
PhenytoinSodium channel subunit beta-1target
PhenytoinSodium channel protein type 3 subunit alphatarget
PhenytoinUDP-glucuronosyltransferase 1-1enzyme
PhenytoinUDP-glucuronosyltransferase 1-6enzyme
PhenytoinUDP-glucuronosyltransferase 1-9enzyme
PhenytoinThyroxine-binding globulincarrier
PhenytoinPotassium voltage-gated channel subfamily H member 2target
PhenytoinVoltage-dependent L-type calcium channeltarget
PhenytoinSodium channel protein type 2 subunit alphatarget
PhenytoinSodium channel protein type 8 subunit alphatarget
PhenytoinGABA(A) Receptortarget
PhenytoinCytochrome P450 1A2enzyme
PhenytoinCytochrome P450 2A6enzyme
PhenytoinCytochrome P450 2D6enzyme
PhenytoinCytochrome P450 2E1enzyme
PhenytoinEpoxide hydrolase 1enzyme
PhenytoinUDP-glucuronosyltransferase 1-4enzyme
PhenytoinCatechol O-methyltransferaseenzyme
PhenytoinNAD(P)H dehydrogenase [quinone] 1enzyme
PhenytoinCytochrome P450 2C18enzyme
DisopyramideSodium channel protein type 5 subunit alphatarget
DisopyramideAlpha-1-acid glycoprotein 1carrier
DisopyramideCytochrome P450 3A4enzyme
DisopyramideMuscarinic acetylcholine receptor M1target
DisopyramideMuscarinic acetylcholine receptor M2target
DisopyramideMuscarinic acetylcholine receptor M3target
DisopyramidePotassium voltage-gated channel subfamily D member 2target
DisopyramidePotassium voltage-gated channel subfamily D member 3target
DisopyramideSolute carrier family 22 member 2transporter
DisopyramideSolute carrier family 22 member 1transporter
DisopyramidePotassium voltage-gated channel subfamily H member 2target
DisopyramideAlpha-1-acid glycoprotein 2target
DisopyramideCytochrome P450 1A2enzyme
LidocaineSodium channel protein type 5 subunit alphatarget
LidocaineSodium channel protein type 10 subunit alphatarget
LidocaineEpidermal growth factor receptortarget
LidocaineSodium channel protein type 9 subunit alphatarget
LidocaineCytochrome P450 1A2enzyme
LidocaineCytochrome P450 2D6enzyme
LidocaineCytochrome P450 3A4enzyme
LidocaineCytochrome P450 3A5enzyme
LidocaineCytochrome P450 3A7enzyme
LidocaineSolute carrier family 22 member 5transporter
LidocaineP-glycoprotein 1transporter
LidocaineCytochrome P450 2A6enzyme
LidocaineCytochrome P450 2B6enzyme
LidocaineCytochrome P450 2C8enzyme
LidocaineCytochrome P450 2C9enzyme
LidocaineSodium channel protein type 4 subunit alphatarget
LidocaineAlpha-1-acid glycoprotein 1target
LidocaineAlpha-1-acid glycoprotein 2target
MexiletineSodium channel protein type 5 subunit alphatarget
MexiletineCytochrome P450 1A2enzyme
MexiletineCytochrome P450 2D6enzyme
MexiletineCytochrome P450 2B6enzyme
MexiletineCytochrome P450 2E1enzyme
MexiletineCytochrome P450 3A4enzyme
MexiletineAryl hydrocarbon receptortarget
MoricizineSodium channel protein type 5 subunit alphatarget
OxcarbazepineCytochrome P450 2C19enzyme
OxcarbazepineCytochrome P450 3A4enzyme
OxcarbazepineCytochrome P450 3A5enzyme
OxcarbazepineSerum albumincarrier
OxcarbazepineP-glycoprotein 1transporter
OxcarbazepineAldo-keto reductase family 1 member C1enzyme
OxcarbazepineAldo-keto reductase family 1 member C2enzyme
OxcarbazepineAldo-keto reductase family 1 member C3enzyme
OxcarbazepineAldo-keto reductase family 1 member C4enzyme
OxcarbazepineCarbonyl reductase [NADPH] 1enzyme
OxcarbazepineCarbonyl reductase [NADPH] 3enzyme
OxcarbazepineSodium channel proteintarget
QuinidineSodium channel protein type 5 subunit alphatarget
QuinidineAlpha-1-acid glycoprotein 1carrier
QuinidinePotassium voltage-gated channel subfamily H member 2target
QuinidinePotassium channel subfamily K member 1target
QuinidinePotassium channel subfamily K member 6target
QuinidineCytochrome P450 1A2enzyme
QuinidineCytochrome P450 2E1enzyme
QuinidineCytochrome P450 1A1enzyme
QuinidineCytochrome P450 2D6enzyme
QuinidineCytochrome P450 3A4enzyme
QuinidineCytochrome P450 3A7enzyme
QuinidineSolute carrier family 22 member 2transporter
QuinidineSolute carrier family 22 member 1transporter
QuinidineSolute carrier family 22 member 5transporter
QuinidineP-glycoprotein 1transporter
QuinidineSolute carrier organic anion transporter family member 1A2transporter
QuinidineSolute carrier family 22 member 8transporter
QuinidineCanalicular multispecific organic anion transporter 1transporter
QuinidineSolute carrier family 22 member 4transporter
QuinidineSolute carrier organic anion transporter family member 1B1transporter
QuinidineCytochrome P450 2B6enzyme
QuinidineCytochrome P450 2C9enzyme
QuinidineAlpha-1A adrenergic receptortarget
QuinidineAlpha-1B adrenergic receptortarget
QuinidineAlpha-1D adrenergic receptortarget
QuinidineBile salt export pumptransporter
QuinidineCytochrome P450 2C8enzyme
QuinidineSerum albumincarrier
ProcainamideSodium channel protein type 5 subunit alphatarget
ProcainamideDNA (cytosine-5)-methyltransferase 1target
ProcainamideCytochrome P450 2D6enzyme
ProcainamideCholinesteraseenzyme
ProcainamideSolute carrier family 22 member 2transporter
ProcainamideSolute carrier family 22 member 1transporter
ProcainamideSolute carrier family 22 member 3transporter
ProcainamideSolute carrier family 22 member 5transporter
ProcainamideSolute carrier family 22 member 4transporter
ProcainamidePotassium voltage-gated channel subfamily H member 2target
ProcainamideMultidrug and toxin extrusion protein 1transporter
ProcainamideMultidrug and toxin extrusion protein 2transporter
TocainideSodium channel protein type 5 subunit alphatarget
TocainideSerum albumincarrier
TocainideCytochrome P450 1A2enzyme
PropafenoneSodium channel protein type 5 subunit alphatarget
PropafenonePotassium voltage-gated channel subfamily H member 2target
PropafenoneCytochrome P450 1A2enzyme
PropafenoneCytochrome P450 2D6enzyme
PropafenoneCytochrome P450 3A4enzyme
PropafenoneP-glycoprotein 1transporter
PropafenoneBeta-1 adrenergic receptortarget
PropafenoneBeta-2 adrenergic receptortarget
FlecainideSodium channel protein type 5 subunit alphatarget
FlecainideCytochrome P450 2D6enzyme
FlecainideSodium channel protein type 4 subunit alphatarget
FlecainideCytochrome P450 2C9enzyme
FlecainidePotassium voltage-gated channel subfamily H member 2target
Flecainidealpha1-acid glycoproteincarrier
FlecainideSerum albumincarrier
FlecainideCytochrome P450 1A2enzyme
FlecainideP-glycoprotein 1transporter
FlecainideMultidrug and toxin extrusion protein 1transporter
FlecainideRyanodine receptor 2target
EncainideSodium channel protein type 5 subunit alphatarget
EncainideCytochrome P450 2D6enzyme
AjmalineAlpha-1-acid glycoprotein 1carrier
AjmalineSodium channel protein type 5 subunit alphatarget
AprindineAlpha-1-acid glycoprotein 1carrier
AprindineCalmodulintarget
AprindineSodium channel protein type 5 subunit alphatarget
AprindineCytochrome P450 2D6enzyme
Eslicarbazepine acetateCytochrome P450 2C19enzyme
Eslicarbazepine acetateCytochrome P450 3A4enzyme
Eslicarbazepine acetateP2X purinoceptor 4target
Eslicarbazepine acetateUDP-glucuronosyltransferase 1-1enzyme
EslicarbazepineUDP-glucuronosyltransferase 1-1enzyme
EslicarbazepineCytochrome P450 2C19enzyme
EslicarbazepineP2X purinoceptor 4target
EslicarbazepineCytochrome P450 3A4enzyme
EthotoinSodium channel protein type 5 subunit alphatarget
EthotoinNuclear receptor subfamily 1 group I member 2target
EthotoinThyroxine-binding globulincarrier
RufinamideMetabotropic glutamate receptor 5target
RufinamideLiver carboxylesterase 1enzyme
RufinamideSodium channel protein type 9 subunit alphatarget
RufinamideSerum albumincarrier
RufinamideCytochrome P450 2E1enzyme
RufinamideCytochrome P450 3A4enzyme
LacosamideSodium channel protein type 9 subunit alphatarget
LacosamideSodium channel protein type 3 subunit alphatarget
LacosamideSodium channel protein type 10 subunit alphatarget
LacosamideCytochrome P450 2C19enzyme
LacosamideCytochrome P450 2C9enzyme
LacosamideCytochrome P450 3A4enzyme
CenobamateUDP-glucuronosyltransferase 2B7enzyme
CenobamateUDP-glucuronosyltransferase 2B4enzyme
CenobamateCytochrome P450 2E1enzyme
CenobamateCytochrome P450 2A6enzyme
CenobamateCytochrome P450 2B6enzyme
CenobamateCytochrome P450 2C19enzyme
CenobamateCytochrome P450 3A4enzyme
CenobamateCytochrome P450 3A5enzyme
CenobamateSerum albumincarrier
CenobamateCytochrome P450 2C8enzyme