Name
Stilbenes
Accession Number
DBCAT000618
Description

Organic compounds that contain 1,2-diphenylethylene as a functional group.

Drugs
DrugDrug Description
DiethylstilbestrolUsed in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery.
ChlorotrianiseneUsed to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female sexual characteristics and some types of infertility), and in rare cases, prostate cancer. Chlorotrianisene may also...
RaloxifeneA selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women.
ToremifeneA first generation nonsteroidal selective estrogen receptor modulator used to treat certain breast cancers.
TamoxifenA selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
ClomifeneA medication used to induce ovulation.
AfimoxifeneFor the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring.
OspemifeneA non-hormonal estrogen receptor modulator (SERM) used to treat moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause.
FispemifeneInvestigated for use/treatment in male hormonal deficiencies/abnormalities.
EnclomipheneNot Annotated
HydroxystilbamidineUsed in the treatment of nonprogressive blastomycosis of the skin and other mycoses.
ResveratrolBeing investigated for the treatment of Herpes labialis infections (cold sores).
DroloxifeneDroloxifene, a derivative of the triphenylethylene drug tamoxifen, is a novel selective estrogen receptor modulator (SERM). Droloxifene also exhibits more rapid pharmacokinetics, reaching peak concentrations and being eliminated much more...
DienestrolA non steroidal estrogen used to treat atrophic vaginitis and kraurosis vulvae.
HexestrolA synthetic estrogen that has been used as a hormonal antineoplastic agent.
Dienestrol diacetateNot Annotated
Drugs & Drug Targets
DrugTargetType
DiethylstilbestrolEstrogen receptortarget
DiethylstilbestrolEstrogen-related receptor gammatarget
DiethylstilbestrolTransthyretincarrier
DiethylstilbestrolCatechol O-methyltransferaseenzyme
DiethylstilbestrolAromataseenzyme
DiethylstilbestrolBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DiethylstilbestrolATP-dependent translocase ABCB1transporter
DiethylstilbestrolEstrogen receptor betatarget
DiethylstilbestrolCytochrome P450 3A4enzyme
DiethylstilbestrolCytochrome P450 2C8enzyme
DiethylstilbestrolCytochrome P450 2C9enzyme
DiethylstilbestrolCytochrome P450 2E1enzyme
DiethylstilbestrolSteroid hormone receptor ERR1target
DiethylstilbestrolSteroid hormone receptor ERR2target
DiethylstilbestrolNuclear receptor coactivator 2target
DiethylstilbestrolNuclear receptor subfamily 1 group I member 2target
DiethylstilbestrolAndrogen receptortarget
DiethylstilbestrolSex hormone-binding globulintarget
DiethylstilbestrolSolute carrier organic anion transporter family member 1B1transporter
DiethylstilbestrolSolute carrier organic anion transporter family member 2B1transporter
DiethylstilbestrolBile salt export pumptransporter
ChlorotrianiseneEstrogen receptortarget
ChlorotrianiseneAromataseenzyme
RaloxifeneEstrogen receptortarget
RaloxifeneEstrogen receptor betatarget
RaloxifeneAldehyde oxidaseenzyme
RaloxifeneCytochrome P450 2C8enzyme
RaloxifeneCytochrome P450 2B6enzyme
RaloxifeneAromataseenzyme
RaloxifeneCytochrome P450 3A4enzyme
RaloxifeneSerpin B9target
RaloxifeneTrefoil factor 1target
RaloxifeneUDP-glucuronosyltransferase 1A1enzyme
RaloxifeneAlbumincarrier
RaloxifeneAlpha-1-acid glycoprotein 1carrier
RaloxifeneSolute carrier organic anion transporter family member 1B1transporter
RaloxifeneSolute carrier organic anion transporter family member 1B3transporter
RaloxifeneATP-dependent translocase ABCB1transporter
RaloxifeneBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
RaloxifeneATP-binding cassette sub-family C member 2transporter
RaloxifeneATP-binding cassette sub-family C member 3transporter
RaloxifeneATP-binding cassette sub-family C member 4transporter
RaloxifeneUDP-glucuronosyltransferase 1A10enzyme
RaloxifeneUDP-glucuronosyltransferase 1A8enzyme
ToremifeneEstrogen receptortarget
ToremifeneCytochrome P450 3A4enzyme
ToremifeneATP-dependent translocase ABCB1transporter
ToremifeneCytochrome P450 1A1enzyme
ToremifeneSex hormone-binding globulintarget
TamoxifenEstrogen receptortarget
TamoxifenEstrogen receptor betatarget
TamoxifenCytochrome P450 2C9enzyme
TamoxifenCytochrome P450 3A4enzyme
TamoxifenCytochrome P450 2D6enzyme
TamoxifenCytochrome P450 2C8enzyme
TamoxifenCytochrome P450 2B6enzyme
TamoxifenLiver carboxylesterase 1enzyme
TamoxifenCytochrome P450 3A5enzyme
TamoxifenCytochrome P450 1A1enzyme
TamoxifenCytochrome P450 1B1enzyme
TamoxifenCytochrome P450 2C19enzyme
TamoxifenFlavin-containing monooxygenase 1enzyme
TamoxifenFlavin-containing monooxygenase 3enzyme
TamoxifenCytochrome P450 3A7enzyme
TamoxifenATP-dependent translocase ABCB1transporter
TamoxifenBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
TamoxifenAromataseenzyme
TamoxifenCytochrome P450 2A6enzyme
TamoxifenCytochrome P450 2E1enzyme
TamoxifenUDP-glucuronosyltransferase 1A10enzyme
TamoxifenSulfotransferase 1A1enzyme
TamoxifenATP-binding cassette sub-family C member 2transporter
Tamoxifen3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget
TamoxifenProtein kinase Ctarget
TamoxifenAndrogen receptortarget
TamoxifenPotassium voltage-gated channel subfamily H member 2target
TamoxifenNuclear receptor subfamily 1 group I member 2target
TamoxifenEstrogen-related receptor gammatarget
TamoxifenSex hormone-binding globulintarget
TamoxifenBile salt export pumptransporter
TamoxifenThyroxine-binding globulincarrier
TamoxifenSulfotransferase 2A1enzyme
TamoxifenCytochrome P450 1A2enzyme
TamoxifenUDP-glucuronosyltransferase 2B7enzyme
TamoxifenUDP-glucuronosyltransferase 2B17enzyme
TamoxifenSulfotransferase 1E1enzyme
TamoxifenPhospholipid-transporting ATPase ABCA1transporter
TamoxifenMitogen-activated protein kinase 8target
TamoxifenAlbumincarrier
ClomifeneEstrogen receptortarget
ClomifeneATP-dependent translocase ABCB1transporter
ClomifeneSex hormone-binding globulintarget
ClomifeneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
AfimoxifeneEstrogen receptortarget
AfimoxifeneEstrogen receptor betatarget
AfimoxifeneEstrogen-related receptor gammatarget
AfimoxifeneTrefoil factor 1target
AfimoxifeneSteroid hormone receptor ERR1target
AfimoxifeneNuclear receptor subfamily 1 group I member 2target
AfimoxifeneSex hormone-binding globulintarget
OspemifeneEstrogen receptortarget
OspemifeneCytochrome P450 3A4enzyme
OspemifeneCytochrome P450 2C9enzyme
OspemifeneCytochrome P450 2C19enzyme
OspemifeneCytochrome P450 2B6enzyme
OspemifeneCytochrome P450 2D6enzyme
EnclomipheneCytochrome P450 2D6enzyme
EnclomipheneEstrogen receptortarget
HydroxystilbamidineDNAtarget
ResveratrolTransthyretincarrier
ResveratrolRibosyldihydronicotinamide dehydrogenase [quinone]target
ResveratrolProstaglandin G/H synthase 1target
ResveratrolCasein kinase II subunit alphatarget
ResveratrolProstaglandin G/H synthase 2target
ResveratrolNAD-dependent protein deacetylase sirtuin-1target
ResveratrolCytochrome P450 1A1enzyme
ResveratrolCytochrome P450 3A4enzyme
ResveratrolCytochrome P450 1A2enzyme
ResveratrolCytochrome P450 1B1enzyme
ResveratrolPolyunsaturated fatty acid lipoxygenase ALOX15target
ResveratrolPolyunsaturated fatty acid 5-lipoxygenasetarget
ResveratrolAryl hydrocarbon receptortarget
ResveratrolPhosphatidylinositol 4-kinase type 2-betatarget
ResveratrolIntegrin alpha-5target
ResveratrolIntegrin beta-3target
ResveratrolAlbumincarrier
ResveratrolAmyloid-beta precursor proteintarget
ResveratrolAlpha-synucleintarget
ResveratrolEstrogen receptortarget
ResveratrolMelatonin receptor type 1Atarget
ResveratrolMelatonin receptor type 1Btarget
ResveratrolC-type lectin domain family 14 member Atarget
ResveratrolNuclear receptor subfamily 1 group I member 2target
ResveratrolNuclear receptor subfamily 1 group I member 3target
ResveratrolSolute carrier family 2, facilitated glucose transporter member 1target
ResveratrolCarbonyl reductase [NADPH] 1target
ResveratrolPeroxisome proliferator-activated receptor alphatarget
ResveratrolPeroxisome proliferator-activated receptor gammatarget
ResveratrolRAC-alpha serine/threonine-protein kinasetarget
ResveratrolFar upstream element-binding protein 2target
ResveratrolTyrosine--tRNA ligase, cytoplasmictarget
ResveratrolCytochrome P450 2D6enzyme
ResveratrolCytochrome P450 2B6enzyme
ResveratrolCytochrome P450 2C19enzyme
ResveratrolCytochrome P450 2C9enzyme
DroloxifeneEstrogen receptortarget
DienestrolEstrogen receptortarget
DienestrolSex hormone-binding globulintarget
HexestrolAldo-keto reductase family 1 member C1target
HexestrolEstrogen receptortarget
HexestrolNuclear receptor subfamily 1 group I member 2target
HexestrolNuclear receptor subfamily 1 group I member 3target