DB00269ApprovedWithdrawnSmall molecule
A powerful synthetic, non-steroidal estrogen. [PubChem].
- Mechanism
- Curator reviewed
Chlorotrianisene binds to the estrogen receptor on various estrogen receptor bearing cells. Target cells include cells in the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
- Primary indication
- Used to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female sexual characteristics and some types of infertility), and in rare cases, prostate cancer.Curator reviewed
- Formula / weight
- C23H21ClO3 · 380.864 g/mol (avg)
- Also known as
- Chloortrianisestrol · Chlorestrolo · Chlorotrianisine · Chlorotrianizen · Chlortrianisen
- Code names
- NSC-10108
Resolves to
Clinical / RWD
Structure
InChIKey
BFPSDSIWYFKGBC-UHFFFAOYSA-NSMILESCOC1=CC=C(C=C1)C(Cl)=C(C1=CC=C(OC)C=C1)C1=CC=C(OC)C=C1Targets
What you can answer from here — as of September 16, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Chlorotrianisene, and which of those have an active Phase 3 trial?
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