- Accession Number
Unsaturated derivatives of the ESTRANES with methyl groups at carbon-13, with no carbon at carbon-10, and with no more than one carbon at carbon-17. They must contain one or more double bonds.
Drug Drug Description Estradiol An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. Mifepristone A cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. Fulvestrant An estrogen receptor antagonist used to treat HR+ breast cancer that may also be HER2-. Allylestrenol A steroid used to prevent premature labour in pregnant women. Metribolone A synthetic non-aromatizable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate... Nandrolone decanoate An anabolic steroid indicated for the management of the anemia of renal insufficiency by increasing hemoglobin and red cell mass. Trenbolone Trenbolone, also known as trienolone or trienbolone, is a steroid used on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is administered as a prodrug... Estetrol An estrogen used in combination with drospirenone for oral contraception. Epimestrol Not Annotated Trenbolone acetate Not Annotated Estrone An estrogen used to treat perimenopausal and postmenopausal symptoms. Equilin For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and... Equilenin Equilenin is an estrogenic steroid produced by horses. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the urine... Estriol A weak estrogen used to treat vaginal dryness and estrogen deficiency conditions, such as vaginitis and vulvar itching. Nandrolone An anabolic steroid indicated to increase bone density and muscle mass in patients with osteoporosis. Estradiol valerate An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception. Nandrolone phenpropionate For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the... Estramustine An antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting. Bolandiol Not Available EM-1745 Not Available 2-Methoxyestradiol For the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis. ICI-164384 Not Available Estrone sulfate An estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders. Oleoyl-estrone For the treatment of obesity. Trestolone Investigated for use/treatment in contraception and male hormonal deficiencies/abnormalities. Estradiol sulfamate Investigated for use/treatment in endometriosis. 2-Hydroxyestradiol 2-Hydroxyestradiol is classified as an endogenous steroid, catechol estrogen, and metabolite of estradiol. It is also a positional isomer of estriol. Dienogest An oral progestin used for the treatment of endometriosis as monotherapy or contraception in combination with ethinylestradiol. Polyestradiol phosphate Polymeric phosphoric acid ester of estradiol. Altrenogest Altrenogest, also known as allyltrenbolone, is a steroidal progestin that is widely used in veterinary medicine to suppress estrus in animals. Mibolerone Mibolerone is a potent anabolic steroid which is both higher affinity and more selective for the androgen receptor than metribolone. Promestriene A synthetic estrogen applied topically for the treatment of vulvovaginal atrophic symptoms and to speed wound healing following vulvovaginal surgery or trauma (e.g. post-partum). Oxabolone cipionate Used as a performance enhancing drug illicitly in athletes. Estradiol benzoate An estrogen indicated in combination with progesterone for the treatment of irregular menstruation. Estradiol cypionate An estradiol prodrug used to treat vasomotor symptoms and hypoestrogenisms from hypogonadism. Estradiol dienanthate An estrogen used in some combined hormonal oral contraceptives. Trestolone acetate Trestolone acetate is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. It is an androgen ester – specifically, the C17 acetate... Estramustine phosphate A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
- Drugs & Drug Targets