Iron Chelating Agents

Name
Iron Chelating Agents
Accession Number
DBCAT001107  (DBCAT003398)
Description

Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.

ATC Classification
Drugs
DrugDrug Description
DeferoxamineA chelating agent used to treat iron or aluminum toxicity and some blood transfusion dependent anemias.
DeferasiroxAn iron chelator used to treat chronic iron overload caused by blood transfusions. Also used in patients with non-transfusion-dependent thalassemia syndromes, and in patients with elevated liver iron concentration and serum ferritin.
DeferiproneAn iron chelator used to treat patients with transfusional iron overload caused by thalassemia syndromes.
1,10-PhenanthrolineNot Available
TagatoseIntended for use as a therapeutic adjunct in the treatment of type II diabetes.
Zinc picolinateZinc picolinate is a zinc salt of picolinic acid. It is available as OTC dietary supplements as a source of zinc to treat and prevent zinc deficiency. The absorption of...
Chromium picolinateChromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for...
DeferitazoleDeferitazole has been used in trials studying the treatment and basic science of Beta-thalassemia, Hepatic Impairment, Impaired Renal Function, Transfusional Iron Overload, and Iron Overload Due to Repeated Red Blood...
Sodium feredetateNot Annotated
Pentetic acidDTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It...
Edetate disodium anhydrousA polyvalent ion chelator indicated for emergency treatment of hypercalcemia and digitalis toxicity associated ventricular arrhythmias.
Edetate calcium disodium anhydrousA chelating agent used to treat lead poisoning.
Picolinic acidInvestigated for use/treatment in acne, herpes labialis infections (cold sores), and venereal disease.
Drugs & Drug Targets
DrugTargetType
DeferoxamineXanthine dehydrogenase/oxidaseenzyme
DeferoxamineIrontarget
DeferoxamineAluminumtarget
DeferoxamineAmyloid beta A4 proteintarget
DeferasiroxIrontarget
DeferasiroxCytochrome P450 3A4enzyme
DeferasiroxUDP-glucuronosyltransferase 1-1enzyme
DeferasiroxUDP-glucuronosyltransferase 1-3enzyme
DeferasiroxUDP-glucuronosyltransferase 1-9enzyme
DeferasiroxCytochrome P450 2C8enzyme
DeferasiroxCytochrome P450 1A2enzyme
DeferiproneUDP-glucuronosyltransferase 1-6enzyme
DeferiproneIrontarget
1,10-PhenanthrolineMethyl-accepting chemotaxis protein IItarget
1,10-PhenanthrolineMetallo-beta-lactamase L1target
Pentetic acidTransuranium elementstarget
Pentetic acidAlpha-1-antitrypsincarrier
Edetate disodium anhydrousLeadtarget
Edetate disodium anhydrousIrontarget
Edetate disodium anhydrousManganese cationtarget
Edetate disodium anhydrousAdenosine deaminaseenzyme
Edetate disodium anhydrousSerum paraoxonase/lactonase 3enzyme
Edetate disodium anhydrousCytochrome P450 19A1enzyme
Edetate disodium anhydrousCytochrome P450 3A4enzyme
Edetate disodium anhydrousSerum paraoxonase/arylesterase 1enzyme
Edetate calcium disodium anhydrousManganese cationtarget
Edetate calcium disodium anhydrousIrontarget
Edetate calcium disodium anhydrousLeadtarget
Edetate calcium disodium anhydrousAdenosine deaminaseenzyme
Edetate calcium disodium anhydrousSerum paraoxonase/lactonase 3enzyme
Edetate calcium disodium anhydrousCytochrome P450 19A1enzyme
Edetate calcium disodium anhydrousCytochrome P450 3A4enzyme
Edetate calcium disodium anhydrousSerum paraoxonase/arylesterase 1enzyme
Picolinic acidE3 ubiquitin-protein ligase UBR4target
Picolinic acidZinc finger Y-chromosomal proteintarget