Reactive Oxygen Species

Name
Reactive Oxygen Species
Accession Number
DBCAT001389
Description

Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.

Drugs
DrugDrug Description
ArtesunateArtesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
Hydrogen peroxideA compound used as a disinfectant and sterilizer.
Carbamide peroxideA medication used to loosen ear wax, whiten teeth, and clean oral wounds.
Hypochlorous acidAn oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.
HypochloriteAn antimicrobial used to treat and prevent infections of the skin and tissue.
Prostaglandin G2A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem]
ArtefenomelArtefenomel has been investigated for the treatment of Malaria.
Magnesium peroxideNot Annotated
Drugs & Drug Targets
DrugTargetType
ArtesunateMalaria protein EXP-1target
ArtesunateCytochrome P450 2A6enzyme
ArtesunateUDP-glucuronosyltransferase 2B7enzyme
ArtesunateUDP-glucuronosyltransferase 1-9enzyme
ArtesunateATP-binding cassette sub-family G member 2transporter
ArtesunateP-glycoprotein 1transporter
ArtesunateSolute carrier organic anion transporter family member 1B1transporter
ArtesunateSolute carrier family 22 member 8transporter
ArtesunateSerum albumincarrier
Hydrogen peroxideGlutathione peroxidase 1enzyme
Hydrogen peroxideCatalaseenzyme
Hydrogen peroxideAlkaline phosphatase, placental-likeenzyme
Prostaglandin G2Prostaglandin G/H synthase 2target