Antipsoriatics

Name
Antipsoriatics
Accession Number
DBCAT002154  (DBCAT001937)
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
SecukinumabAn immunomodulating agent and interleukin antagonist used to manage plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, along with other joint inflammatory disorders.
CalcitriolAn active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia.
AcitretinAn oral retinoid used in the treatment of severe psoriasis.
MethoxsalenA furocoumarin used to treat psoriasis and vitiligo.
TazaroteneAn acetylenic retinoid used to treat fine wrinkles, mottled pigmentation of the skin, acne vulgaris, and plaque psoriasis.
EtretinateFor the treatment of severe psoriasis in adults.
Fumaric acidNot Available
CalcipotriolA topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis.
TrioxsalenA psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer.
AnthralinAn anthracene used to treat stable plaque psoriasis.
BergaptenBergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis).
TacalcitolA vitamin D analog indicated in the treatment of mild to moderate plaque psoriasis.
UlobetasolA lipocortin corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
RoflumilastA selective phosphodiesterase-4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) and to treat skin conditions such as plaque psoriasis and atopic dermatitis.
TapinarofA therapeutic aryl hydrocarbon receptor-modulating agent (TAMA) indicated for the treatment of adult psoriasis.
Drugs & Drug Targets
DrugTargetType
SecukinumabInterleukin-17Atarget
CalcitriolVitamin D3 receptortarget
Calcitriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
CalcitriolCytochrome P450 3A4enzyme
CalcitriolHomeobox protein Hox-A10target
CalcitriolVitamin D-binding proteincarrier
AcitretinRetinoic acid receptor alphatarget
AcitretinRetinoic acid receptor RXR-betatarget
AcitretinRetinoic acid receptor gammatarget
AcitretinRetinoic acid receptor betatarget
AcitretinRetinoic acid receptor RXR-gammatarget
AcitretinRetinoic acid receptor RXR-alphatarget
AcitretinAlbumincarrier
AcitretinRetinol-binding protein 1target
AcitretinRetinoic acid receptor RXRtarget
AcitretinSignal transducer and activator of transcription 3target
MethoxsalenDNAtarget
MethoxsalenCytochrome P450 2A6enzyme
MethoxsalenCytochrome P450 1A2enzyme
MethoxsalenCytochrome P450 1A1enzyme
MethoxsalenCytochrome P450 2A13enzyme
MethoxsalenCytochrome P450 2A6target
TazaroteneRetinoic acid receptor alphatarget
TazaroteneRetinoic acid receptor RXR-betatarget
TazaroteneRetinoic acid receptor gammatarget
TazaroteneRetinoic acid receptor betatarget
TazaroteneCytochrome P450 2C8enzyme
EtretinateRetinoic acid receptor alphatarget
EtretinateRetinoic acid receptor RXR-betatarget
EtretinateRetinoic acid receptor gammatarget
EtretinateRetinoic acid receptor betatarget
EtretinateRetinoic acid receptor RXR-gammatarget
EtretinateRetinoic acid receptor RXR-alphatarget
EtretinateCellular retinoic acid-binding protein 1carrier
EtretinateAromataseenzyme
Fumaric acidMalate dehydrogenasetarget
Fumaric acidFumarate reductase flavoprotein subunittarget
Fumaric acidNAD-dependent malic enzyme, mitochondrialtarget
Fumaric acidFumarylacetoacetasetarget
Fumaric acidFumarate reductase flavoprotein subunittarget
Fumaric acidInterferon gammatarget
CalcipotriolVitamin D3 receptortarget
CalcipotriolMyeloperoxidaseenzyme
Calcipotriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
TrioxsalenDNAtarget
AnthralinKeratin, type II cytoskeletal 2 epidermaltarget
AnthralinC-Jun-amino-terminal kinase-interacting protein 1target
AnthralinKeratin, type I cytoskeletal 12target
UlobetasolCorticosteroid-binding globulincarrier
UlobetasolGlucocorticoid receptortarget
UlobetasolSteroid hormone receptor ERR1target
UlobetasolSteroid hormone receptor ERR2target
UlobetasolEstrogen-related receptor gammatarget
RoflumilastCytochrome P450 3A4enzyme
RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4)target
RoflumilastCytochrome P450 1A2enzyme
TapinarofAryl hydrocarbon receptortarget
TapinarofCytochrome P450 1A2enzyme
TapinarofCytochrome P450 3A4enzyme
TapinarofCytochrome P450 2C9enzyme
TapinarofCytochrome P450 2C19enzyme
TapinarofCytochrome P450 2D6enzyme