Ulobetasol is a lipocortin corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses. It is structurally related to clobetasol.
- Mechanism
- Curator reviewed · 6 references
The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.
Glucocorticoids inhibit phospholipase 2 and neutrophil apoptosis and demargination, resulting in decreased formation of arachidonic acid derivatives. They also inhibit NF-Kappa B and other inflammatory transcription factors while promoting anti-inflammatory genes like interleukin-10.
Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.
- Primary indication
- Ulobetasol cream and ointment are indicated in the treatment of inflammatory and pruritic corticosteroid responsive dermatoses.Curator reviewed · 3 structured indications
- Formula / weight
- C22H27ClF2O4 · 428.9 g/mol (avg)
- First approval
- Canada, 2019 · United States, 2004
- Also known as
- 21-chloro diflorasone · Halobetasol
- Brand names
Resolves to
LEHFPXVYPMWYQD-XHIJKXOTSA-NSMILES[H][C@@]12C[C@H](C)[C@](O)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12CWhat you can answer from here — as of September 13, 2026
Which drugs share a target with Ulobetasol, and which of those have an active Phase 3 trial?
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