UGT1A1 Inhibitors

Name

UGT1A1 Inhibitors

Accession Number

DBCAT002664

Description

Not Available

Drugs

Drug	Drug Description
Adenine	A purine base which forms a component of DNA among other functions and is present in many multivitamins.
Propofol	A medication used in general anesthesia and for sedation.
Nilotinib	A kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib.
Pazopanib	An antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy.
Regorafenib	A kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma.
Flunitrazepam	A benzodiazepine used to manage anxiety disorders and insomnia.
Erlotinib	An EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
Sorafenib	A kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma.
Enasidenib	An isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
Pibrentasvir	A Hepatitis C NS5A inhibitor used to treat Hepatitis C.
Glecaprevir	A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C.
Rucaparib	A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat recurrent ovarian and prostate cancers in previously treated adults.
Ertugliflozin	An SGLT2 inhibitor used to treat type 2 diabetes mellitus alone or in combination with other antidiabetic drugs.
Fostamatinib	A spleen tyrosine kinase inhibitor used to treat chronic immune thrombocytopenia after attempting one other treatment.
Ketoconazole	A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
Indinavir	A protease inhibitor used to treat HIV infection.
Valproic acid	An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
Flurbiprofen	An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.
Eltrombopag	A thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies.
Silibinin	A flavonolignan with hepatoprotective effects used to treat toxic liver damage and as an adjunct in the management of chronic conditions such as cirrhosis and hepatitis.
Sodium aurothiomalate	A disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
Atazanavir	An antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV.
Gemfibrozil	A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
Ombitasvir	A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections.
Deferasirox	An iron chelator used to treat chronic iron overload caused by blood transfusions. Also used in patients with non-transfusion-dependent thalassemia syndromes, and in patients with elevated liver iron concentration and serum ferritin.
Dacomitinib	A medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution.
Probenecid	A medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia.
Amitriptyline	A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
Dasabuvir	A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.
Paritaprevir	A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections.
Indomethacin	A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants.
Pexidartinib	An antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor.
Ubrogepant	An oral CGRP antagonist used in the acute treatment of migraine with or without aura.
Belumosudil	An oral inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK) used in the treatment of chronic graft-versus-host disease (GVHD).
Asciminib	An inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation.
Olaparib	A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer.
Dabrafenib	A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
Momelotinib	A Janus Kinase inhibitor used to treat intermediate or high-risk myelofibrosis.
Quizartinib	A FLT3 inhibitor used in combination with cytarabine and anthracycline to treat acute myeloid leukemia with FLT3 internal tandem duplication
Encorafenib	A kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations.
Repotrectinib	A tyrosine kinase inhibitor used to treat locally active or metastatic non-small cell lung cancer
Aprocitentan	An endothelin receptor antagonist used for the treatment of uncontrolled hypertension in patients inadequately controlled on other treatments.
Lazertinib	A tyrosine kinase inhibitor used in combiantion with amivantamab to treat non-small cell lung cancer with EGFR mutations.
Osilodrostat	An oral inhibitor of cortisol synthesis used to treat Cushing's disease by normalizing hypercortisolism.

Drugs & Drug Targets

Drug	Target	Type
Adenine	Adenine phosphoribosyltransferase	target
Adenine	DNA	target
Adenine	S-methyl-5'-thioadenosine phosphorylase	target
Adenine	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	target
Adenine	Acetyl-CoA carboxylase 2	target
Adenine	Low molecular weight phosphotyrosine protein phosphatase	target
Adenine	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	target
Adenine	Peroxisomal trans-2-enoyl-CoA reductase	target
Adenine	Adenine DNA glycosylase	target
Adenine	Nucleoside 2-deoxyribosyltransferase	target
Adenine	SRSF protein kinase 2	target
Adenine	Holliday junction ATP-dependent DNA helicase RuvB	target
Adenine	UDP-glucuronosyltransferase 1A1	enzyme
Propofol	Cytochrome P450 2B6	enzyme
Propofol	UDP-glucuronosyltransferase 1A1	enzyme
Propofol	UDP-glucuronosyltransferase 1A9	enzyme
Propofol	Gamma-aminobutyric acid receptor subunit beta-2	target
Propofol	Gamma-aminobutyric acid receptor subunit beta-3	target
Propofol	Albumin	carrier
Propofol	Sodium channel protein type 4 subunit alpha	target
Propofol	Sodium channel protein type 2 subunit alpha	target
Propofol	Fatty-acid amide hydrolase 1	enzyme
Propofol	Cytochrome P450 2C9	enzyme
Propofol	UDP-glucuronosyltransferase 1A8	enzyme
Propofol	Cytochrome P450 2E1	enzyme
Propofol	Cytochrome P450 1B1	enzyme
Propofol	Cytochrome P450 1A1	enzyme
Propofol	Cytochrome P450 1A2	enzyme
Propofol	Cytochrome P450 2C18	enzyme
Propofol	Cytochrome P450 2C19	enzyme
Propofol	Cytochrome P450 2C8	enzyme
Propofol	UDP-glucuronosyltransferase 1-6	enzyme
Propofol	GABA(A) Receptor	target
Propofol	ATP-dependent translocase ABCB1	transporter
Nilotinib	Tyrosine-protein kinase ABL1	target
Nilotinib	Mast/stem cell growth factor receptor Kit	target
Nilotinib	Cytochrome P450 2D6	enzyme
Nilotinib	Cytochrome P450 2C8	enzyme
Nilotinib	Cytochrome P450 2C9	enzyme
Nilotinib	Cytochrome P450 3A4	enzyme
Nilotinib	ATP-dependent translocase ABCB1	transporter
Nilotinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Nilotinib	UDP-glucuronosyltransferase 1A1	transporter
Nilotinib	Cytochrome P450 2B6	enzyme
Nilotinib	Solute carrier organic anion transporter family member 1B1	transporter
Pazopanib	Vascular endothelial growth factor receptor 1	target
Pazopanib	Vascular endothelial growth factor receptor 2	target
Pazopanib	Vascular endothelial growth factor receptor 3	target
Pazopanib	Platelet-derived growth factor receptor alpha	target
Pazopanib	Platelet-derived growth factor receptor beta	target
Pazopanib	Mast/stem cell growth factor receptor Kit	target
Pazopanib	Cytochrome P450 3A4	enzyme
Pazopanib	Cytochrome P450 2D6	enzyme
Pazopanib	Cytochrome P450 2C8	enzyme
Pazopanib	Cytochrome P450 1A2	enzyme
Pazopanib	ATP-dependent translocase ABCB1	transporter
Pazopanib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Pazopanib	Solute carrier organic anion transporter family member 1B1	transporter
Pazopanib	UDP-glucuronosyltransferase 1A1	transporter
Pazopanib	Fibroblast growth factor receptor 3	target
Pazopanib	Tyrosine-protein kinase ITK/TSK	target
Pazopanib	Fibroblast growth factor 1	target
Pazopanib	SH2B adapter protein 3	target
Regorafenib	Cytochrome P450 3A4	enzyme
Regorafenib	UDP-glucuronosyltransferase 1A9	enzyme
Regorafenib	Proto-oncogene tyrosine-protein kinase receptor Ret	target
Regorafenib	Vascular endothelial growth factor receptor 1	target
Regorafenib	Vascular endothelial growth factor receptor 2	target
Regorafenib	Vascular endothelial growth factor receptor 3	target
Regorafenib	Mast/stem cell growth factor receptor Kit	target
Regorafenib	Platelet-derived growth factor receptor alpha	target
Regorafenib	Platelet-derived growth factor receptor beta	target
Regorafenib	Fibroblast growth factor receptor 1	target
Regorafenib	Fibroblast growth factor receptor 2	target
Regorafenib	Angiopoietin-1 receptor	target
Regorafenib	Discoidin domain-containing receptor 2	target
Regorafenib	High affinity nerve growth factor receptor	target
Regorafenib	Ephrin type-A receptor 2	target
Regorafenib	RAF proto-oncogene serine/threonine-protein kinase	target
Regorafenib	Serine/threonine-protein kinase B-raf	target
Regorafenib	Cytochrome P450 2C8	enzyme
Regorafenib	Cytochrome P450 2C9	enzyme
Regorafenib	Cytochrome P450 2B6	enzyme
Regorafenib	Mitogen-activated protein kinase 11	target
Regorafenib	Tyrosine-protein kinase FRK	target
Regorafenib	Tyrosine-protein kinase ABL1	target
Regorafenib	ATP-dependent translocase ABCB1	transporter
Regorafenib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Regorafenib	UDP-glucuronosyltransferase 1A1	enzyme
Regorafenib	Cytochrome P450 2C19	enzyme
Flunitrazepam	Cytochrome P450 2C19	enzyme
Flunitrazepam	UDP-glucuronosyltransferase 2B7	enzyme
Flunitrazepam	Cytochrome P450 2A6	enzyme
Flunitrazepam	Cytochrome P450 2B6	enzyme
Flunitrazepam	Cytochrome P450 2C9	enzyme
Flunitrazepam	Cytochrome P450 3A4	enzyme
Flunitrazepam	Cytochrome P450 2E1	enzyme
Flunitrazepam	UDP-glucuronosyltransferase 1A1	enzyme
Flunitrazepam	UDP-glucuronosyltransferase 1A3	enzyme
Flunitrazepam	GABA(A) Receptor	target
Flunitrazepam	GABA(A) Receptor Benzodiazepine Binding Site	target
Erlotinib	Epidermal growth factor receptor	target
Erlotinib	Cytochrome P450 3A4	enzyme
Erlotinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Erlotinib	ATP-dependent translocase ABCB1	transporter
Erlotinib	Nuclear receptor subfamily 1 group I member 2	target
Erlotinib	Cytochrome P450 3A5	enzyme
Erlotinib	Cytochrome P450 1A1	enzyme
Erlotinib	Cytochrome P450 1A2	enzyme
Erlotinib	Cytochrome P450 1B1	enzyme
Erlotinib	Cytochrome P450 2D6	enzyme
Erlotinib	Cytochrome P450 2C8	enzyme
Erlotinib	UDP-glucuronosyltransferase 1A1	enzyme
Erlotinib	Albumin	carrier
Erlotinib	Alpha-1-acid glycoprotein 1	carrier
Erlotinib	Solute carrier organic anion transporter family member 2B1	transporter
Erlotinib	Epidermal growth factor receptor	enzyme
Sorafenib	Serine/threonine-protein kinase B-raf	target
Sorafenib	Receptor-type tyrosine-protein kinase FLT3	target
Sorafenib	RAF proto-oncogene serine/threonine-protein kinase	target
Sorafenib	Vascular endothelial growth factor receptor 3	target
Sorafenib	Platelet-derived growth factor receptor beta	target
Sorafenib	Mast/stem cell growth factor receptor Kit	target
Sorafenib	Vascular endothelial growth factor receptor 2	target
Sorafenib	Cytochrome P450 3A4	enzyme
Sorafenib	UDP-glucuronosyltransferase 1A9	enzyme
Sorafenib	Cytochrome P450 2B6	enzyme
Sorafenib	Cytochrome P450 2C8	enzyme
Sorafenib	Cytochrome P450 3A5	enzyme
Sorafenib	Cytochrome P450 3A7	enzyme
Sorafenib	Cytochrome P450 2C9	enzyme
Sorafenib	ATP-binding cassette sub-family C member 4	transporter
Sorafenib	ATP-dependent translocase ABCB1	transporter
Sorafenib	ATP-binding cassette sub-family C member 2	transporter
Sorafenib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Sorafenib	Cytochrome P450 1A2	enzyme
Sorafenib	Cytochrome P450 2C19	enzyme
Sorafenib	Cytochrome P450 2D6	enzyme
Sorafenib	UDP-glucuronosyltransferase 1A1	enzyme
Sorafenib	RalA-binding protein 1	transporter
Sorafenib	Fibroblast growth factor receptor 1	target
Sorafenib	Proto-oncogene tyrosine-protein kinase receptor Ret	target
Sorafenib	Vascular endothelial growth factor receptor 1	target
Sorafenib	Solute carrier organic anion transporter family member 1B1	transporter
Sorafenib	Epidermal growth factor receptor	target
Enasidenib	Cytochrome P450 1A2	enzyme
Enasidenib	Cytochrome P450 2B6	enzyme
Enasidenib	Isocitrate dehydrogenase [NADP], mitochondrial	target
Enasidenib	Cytochrome P450 2C8	enzyme
Enasidenib	Cytochrome P450 2C9	enzyme
Enasidenib	Cytochrome P450 2C19	enzyme
Enasidenib	Cytochrome P450 2D6	enzyme
Enasidenib	Cytochrome P450 3A4	enzyme
Enasidenib	UDP-glucuronosyltransferase 1A1	enzyme
Enasidenib	UDP-glucuronosyltransferase 1A3	enzyme
Enasidenib	UDP-glucuronosyltransferase 1A4	enzyme
Enasidenib	UDP-glucuronosyltransferase 1A9	enzyme
Enasidenib	UDP-glucuronosyltransferase 2B7	enzyme
Enasidenib	UDP-glucuronosyltransferase 2B15	enzyme
Enasidenib	ATP-dependent translocase ABCB1	transporter
Enasidenib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Enasidenib	Solute carrier family 22 member 6	transporter
Enasidenib	Solute carrier organic anion transporter family member 1B1	transporter
Enasidenib	Solute carrier family 22 member 2	transporter
Enasidenib	Solute carrier organic anion transporter family member 1B3	transporter
Enasidenib	Organic anion transporter 3	transporter
Enasidenib	Albumin	carrier
Enasidenib	Isocitrate dehydrogenase [NADP] cytoplasmic	target
Enasidenib	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	target
Enasidenib	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	target
Enasidenib	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	target
Pibrentasvir	Nonstructural protein 5A	target
Pibrentasvir	Cytochrome P450 3A Subfamily	enzyme
Pibrentasvir	UDP-glucuronosyltransferase 1A1	enzyme
Pibrentasvir	ATP-dependent translocase ABCB1	transporter
Pibrentasvir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Pibrentasvir	Solute carrier organic anion transporter family member 1B1	transporter
Pibrentasvir	Solute carrier organic anion transporter family member 1B3	transporter
Glecaprevir	Cytochrome P450 3A Subfamily	enzyme
Glecaprevir	UDP-glucuronosyltransferase 1A1	enzyme
Glecaprevir	ATP-dependent translocase ABCB1	transporter
Glecaprevir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Glecaprevir	Solute carrier organic anion transporter family member 1B1	transporter
Glecaprevir	Solute carrier organic anion transporter family member 1B3	transporter
Glecaprevir	NS3 protease	target
Glecaprevir	Cytochrome P450 3A4	enzyme
Glecaprevir	Genome polyprotein	target
Rucaparib	Poly [ADP-ribose] polymerase 1	target
Rucaparib	Poly [ADP-ribose] polymerase 2	target
Rucaparib	Protein mono-ADP-ribosyltransferase PARP3	target
Rucaparib	Cytochrome P450 2D6	enzyme
Rucaparib	Cytochrome P450 1A2	enzyme
Rucaparib	Cytochrome P450 3A4	enzyme
Rucaparib	ATP-dependent translocase ABCB1	transporter
Rucaparib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Rucaparib	Multidrug and toxin extrusion protein 1	transporter
Rucaparib	Multidrug and toxin extrusion protein 2	transporter
Rucaparib	Solute carrier family 22 member 1	transporter
Rucaparib	ATP-binding cassette sub-family C member 4	transporter
Rucaparib	Solute carrier organic anion transporter family member 1B1	transporter
Rucaparib	Solute carrier organic anion transporter family member 1B3	transporter
Rucaparib	Solute carrier family 22 member 6	transporter
Rucaparib	Organic anion transporter 3	transporter
Rucaparib	Cytochrome P450 3A5	enzyme
Rucaparib	Cytochrome P450 3A7	enzyme
Rucaparib	Cytochrome P450 3A43	enzyme
Rucaparib	Cytochrome P450 2C19	enzyme
Rucaparib	Cytochrome P450 2C9	enzyme
Rucaparib	Cytochrome P450 2C8	enzyme
Rucaparib	UDP-glucuronosyltransferase 1A1	enzyme
Ertugliflozin	UDP-glucuronosyltransferase 1A9	enzyme
Ertugliflozin	UDP-glucuronosyltransferase 2B7	enzyme
Ertugliflozin	Sodium/glucose cotransporter 2	target
Ertugliflozin	ATP-dependent translocase ABCB1	transporter
Ertugliflozin	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Ertugliflozin	Albumin	carrier
Ertugliflozin	UDP-glucuronosyltransferase 1A1	enzyme
Ertugliflozin	UDP-glucuronosyltransferase 1A4	enzyme
Fostamatinib	Adenosine receptor A3	target
Fostamatinib	Synaptic vesicular amine transporter	target
Fostamatinib	Fatty-acid amide hydrolase 1	target
Fostamatinib	Equilibrative nucleoside transporter 1	target
Fostamatinib	UDP-glucuronosyltransferase 1A1	target
Fostamatinib	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Fostamatinib	Polyunsaturated fatty acid 5-lipoxygenase	target
Fostamatinib	Cathepsin S	target
Fostamatinib	Procathepsin L	target
Fostamatinib	Tyrosine-protein kinase ABL1	target
Fostamatinib	Calcium-dependent protein kinase 1	target
Fostamatinib	Serine/threonine-protein kinase PknB	target
Fostamatinib	Ribosomal protein S6 kinase alpha-6	target
Fostamatinib	Non-receptor tyrosine-protein kinase TYK2	target
Fostamatinib	Atypical kinase COQ8A, mitochondrial	target
Fostamatinib	Tyrosine-protein kinase JAK1	target
Fostamatinib	Hepatocyte growth factor receptor	target
Fostamatinib	Serine/threonine-protein kinase NIM1	target
Fostamatinib	Serine/threonine-protein kinase 26	target
Fostamatinib	cAMP-dependent protein kinase catalytic subunit alpha	target
Fostamatinib	Serine/threonine-protein kinase 24	target
Fostamatinib	Serine/threonine-protein kinase 3	target
Fostamatinib	Tyrosine-protein kinase Tec	target
Fostamatinib	Tyrosine-protein kinase SYK	target
Fostamatinib	Serine/threonine-protein kinase 33	target
Fostamatinib	Serine/threonine-protein kinase 35	target
Fostamatinib	Serine/threonine-protein kinase 36	target
Fostamatinib	Serine/threonine-protein kinase 38	target
Fostamatinib	Serine/threonine-protein kinase 38-like	target
Fostamatinib	STE20/SPS1-related proline-alanine-rich protein kinase	target
Fostamatinib	Serine/threonine-protein kinase TAO1	target
Fostamatinib	Serine/threonine-protein kinase TAO2	target
Fostamatinib	Serine/threonine-protein kinase TAO3	target
Fostamatinib	Serine/threonine-protein kinase TBK1	target
Fostamatinib	Angiopoietin-1 receptor	target
Fostamatinib	Dual specificity testis-specific protein kinase 1	target
Fostamatinib	TGF-beta receptor type-1	target
Fostamatinib	TGF-beta receptor type-2	target
Fostamatinib	Tyrosine-protein kinase receptor Tie-1	target
Fostamatinib	Serine/threonine-protein kinase tousled-like 1	target
Fostamatinib	Serine/threonine-protein kinase tousled-like 2	target
Fostamatinib	TRAF2 and NCK-interacting protein kinase	target
Fostamatinib	Non-receptor tyrosine-protein kinase TNK1	target
Fostamatinib	Activated CDC42 kinase 1	target
Fostamatinib	Serine/threonine-protein kinase TNNI3K	target
Fostamatinib	Testis-specific serine/threonine-protein kinase 1	target
Fostamatinib	Dual specificity protein kinase TTK	target
Fostamatinib	Tyrosine-protein kinase TXK	target
Fostamatinib	Tyrosine-protein kinase receptor TYRO3	target
Fostamatinib	Serine/threonine-protein kinase ULK1	target
Fostamatinib	Serine/threonine-protein kinase ULK2	target
Fostamatinib	Serine/threonine-protein kinase ULK3	target
Fostamatinib	Wee1-like protein kinase	target
Fostamatinib	Tyrosine-protein kinase Yes	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 19	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 20	target
Fostamatinib	Tyrosine-protein kinase ZAP-70	target
Fostamatinib	AP2-associated protein kinase 1	target
Fostamatinib	Tyrosine-protein kinase ABL2	target
Fostamatinib	Activin receptor type-1	target
Fostamatinib	Activin receptor type-1B	target
Fostamatinib	Atypical kinase COQ8B, mitochondrial	target
Fostamatinib	ALK tyrosine kinase receptor	target
Fostamatinib	Ankyrin repeat and protein kinase domain-containing protein 1	target
Fostamatinib	Aurora kinase A	target
Fostamatinib	Aurora kinase B	target
Fostamatinib	Aurora kinase C	target
Fostamatinib	Tyrosine-protein kinase receptor UFO	target
Fostamatinib	Tyrosine-protein kinase Blk	target
Fostamatinib	BMP-2-inducible protein kinase	target
Fostamatinib	Bone morphogenetic protein receptor type-1B	target
Fostamatinib	Bone morphogenetic protein receptor type-2	target
Fostamatinib	Cytoplasmic tyrosine-protein kinase BMX	target
Fostamatinib	Serine/threonine-protein kinase B-raf	target
Fostamatinib	Tyrosine-protein kinase BTK	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type 1	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type 1D	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type 1G	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit alpha	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit beta	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit delta	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit gamma	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase kinase 1	target
Fostamatinib	Calcium/calmodulin-dependent protein kinase kinase 2	target
Fostamatinib	Peripheral plasma membrane protein CASK	target
Fostamatinib	Kappa-casein	target
Fostamatinib	Cyclin-dependent kinase 1	target
Fostamatinib	Serine/threonine-protein kinase MRCK gamma	target
Fostamatinib	Cyclin-dependent kinase 4	target
Fostamatinib	Cyclin-dependent kinase-like 1	target
Fostamatinib	Cyclin-dependent kinase-like 2	target
Fostamatinib	Serine/threonine-protein kinase Chk1	target
Fostamatinib	Serine/threonine-protein kinase Chk2	target
Fostamatinib	Citron Rho-interacting kinase	target
Fostamatinib	Dual specificity protein kinase CLK1	target
Fostamatinib	Dual specificity protein kinase CLK2	target
Fostamatinib	Dual specificity protein kinase CLK3	target
Fostamatinib	Dual specificity protein kinase CLK4	target
Fostamatinib	Macrophage colony-stimulating factor 1 receptor	target
Fostamatinib	Tyrosine-protein kinase CSK	target
Fostamatinib	Casein kinase I isoform alpha	target
Fostamatinib	Casein kinase II subunit alpha	target
Fostamatinib	Casein kinase II subunit alpha'	target
Fostamatinib	Death-associated protein kinase 1	target
Fostamatinib	Death-associated protein kinase 2	target
Fostamatinib	Death-associated protein kinase 3	target
Fostamatinib	Serine/threonine-protein kinase DCLK1	target
Fostamatinib	Serine/threonine-protein kinase DCLK2	target
Fostamatinib	Serine/threonine-protein kinase DCLK3	target
Fostamatinib	Epithelial discoidin domain-containing receptor 1	target
Fostamatinib	Discoidin domain-containing receptor 2	target
Fostamatinib	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	target
Fostamatinib	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	target
Fostamatinib	Epidermal growth factor receptor	target
Fostamatinib	Eukaryotic translation initiation factor 2-alpha kinase 1	target
Fostamatinib	Interferon-induced, double-stranded RNA-activated protein kinase	target
Fostamatinib	eIF-2-alpha kinase GCN2	target
Fostamatinib	Ephrin type-A receptor 1	target
Fostamatinib	Ephrin type-A receptor 2	target
Fostamatinib	Ephrin type-A receptor 3	target
Fostamatinib	Ephrin type-A receptor 4	target
Fostamatinib	Ephrin type-A receptor 5	target
Fostamatinib	Ephrin type-A receptor 6	target
Fostamatinib	Ephrin type-A receptor 7	target
Fostamatinib	Ephrin type-A receptor 8	target
Fostamatinib	Ephrin type-B receptor 1	target
Fostamatinib	Ephrin type-B receptor 2	target
Fostamatinib	Ephrin type-B receptor 4	target
Fostamatinib	Ephrin type-B receptor 6	target
Fostamatinib	Receptor tyrosine-protein kinase erbB-2	target
Fostamatinib	Receptor tyrosine-protein kinase erbB-4	target
Fostamatinib	Serine/threonine-protein kinase/endoribonuclease IRE1	target
Fostamatinib	Tyrosine-protein kinase Fer	target
Fostamatinib	Tyrosine-protein kinase Fes/Fps	target
Fostamatinib	Fibroblast growth factor receptor 1	target
Fostamatinib	Fibroblast growth factor receptor 2	target
Fostamatinib	Fibroblast growth factor receptor 3	target
Fostamatinib	Tyrosine-protein kinase Fgr	target
Fostamatinib	Vascular endothelial growth factor receptor 1	target
Fostamatinib	Receptor-type tyrosine-protein kinase FLT3	target
Fostamatinib	Vascular endothelial growth factor receptor 3	target
Fostamatinib	Serine/threonine-protein kinase mTOR	target
Fostamatinib	Tyrosine-protein kinase FRK	target
Fostamatinib	Tyrosine-protein kinase Fyn	target
Fostamatinib	Cyclin-G-associated kinase	target
Fostamatinib	Glycogen synthase kinase-3 alpha	target
Fostamatinib	Glycogen synthase kinase-3 beta	target
Fostamatinib	Tyrosine-protein kinase HCK	target
Fostamatinib	Homeodomain-interacting protein kinase 2	target
Fostamatinib	Homeodomain-interacting protein kinase 3	target
Fostamatinib	Serine/threonine-protein kinase ICK	target
Fostamatinib	Inhibitor of nuclear factor kappa-B kinase subunit beta	target
Fostamatinib	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	target
Fostamatinib	Insulin receptor	target
Fostamatinib	Insulin receptor-related protein	target
Fostamatinib	Interleukin-1 receptor-associated kinase 1	target
Fostamatinib	Interleukin-1 receptor-associated kinase 3	target
Fostamatinib	Interleukin-1 receptor-associated kinase 4	target
Fostamatinib	Tyrosine-protein kinase ITK/TSK	target
Fostamatinib	Tyrosine-protein kinase JAK2	target
Fostamatinib	Tyrosine-protein kinase JAK3	target
Fostamatinib	Vascular endothelial growth factor receptor 2	target
Fostamatinib	Serine/threonine-protein kinase SIK3	target
Fostamatinib	Mast/stem cell growth factor receptor Kit	target
Fostamatinib	Serine/threonine-protein kinase LATS1	target
Fostamatinib	Tyrosine-protein kinase Lck	target
Fostamatinib	LIM domain kinase 1	target
Fostamatinib	LIM domain kinase 2	target
Fostamatinib	Leucine-rich repeat serine/threonine-protein kinase 2	target
Fostamatinib	Leukocyte tyrosine kinase receptor	target
Fostamatinib	Tyrosine-protein kinase Lyn	target
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 2	target
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 3	target
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 5	target
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 6	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 1	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 10	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 11	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 12	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 13	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 15	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 2	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 3	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 4	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 6	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase 9	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 1	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 2	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 3	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 4	target
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 5	target
Fostamatinib	Mitogen-activated protein kinase 10	target
Fostamatinib	Mitogen-activated protein kinase 13	target
Fostamatinib	Mitogen-activated protein kinase 14	target
Fostamatinib	Mitogen-activated protein kinase 15	target
Fostamatinib	Mitogen-activated protein kinase 4	target
Fostamatinib	Mitogen-activated protein kinase 7	target
Fostamatinib	Mitogen-activated protein kinase 9	target
Fostamatinib	MAP kinase-activated protein kinase 5	target
Fostamatinib	Serine/threonine-protein kinase MARK1	target
Fostamatinib	Serine/threonine-protein kinase MARK2	target
Fostamatinib	MAP/microtubule affinity-regulating kinase 3	target
Fostamatinib	MAP/microtubule affinity-regulating kinase 4	target
Fostamatinib	CLIP-associating protein 1	target
Fostamatinib	Microtubule-associated serine/threonine-protein kinase 1	target
Fostamatinib	Megakaryocyte-associated tyrosine-protein kinase	target
Fostamatinib	Maternal embryonic leucine zipper kinase	target
Fostamatinib	Tyrosine-protein kinase Mer	target
Fostamatinib	Misshapen-like kinase 1	target
Fostamatinib	MAP kinase-interacting serine/threonine-protein kinase 1	target
Fostamatinib	MAP kinase-interacting serine/threonine-protein kinase 2	target
Fostamatinib	Macrophage-stimulating protein receptor	target
Fostamatinib	Muscle, skeletal receptor tyrosine-protein kinase	target
Fostamatinib	Myosin light chain kinase, smooth muscle	target
Fostamatinib	Myosin light chain kinase 2, skeletal/cardiac muscle	target
Fostamatinib	Myosin light chain kinase 3	target
Fostamatinib	Myosin light chain kinase family member 4	target
Fostamatinib	Myosin-IIIa	target
Fostamatinib	Serine/threonine-protein kinase Nek1	target
Fostamatinib	Serine/threonine-protein kinase Nek11	target
Fostamatinib	Serine/threonine-protein kinase Nek2	target
Fostamatinib	Serine/threonine-protein kinase Nek3	target
Fostamatinib	Serine/threonine-protein kinase Nek4	target
Fostamatinib	Serine/threonine-protein kinase Nek5	target
Fostamatinib	Serine/threonine-protein kinase Nek9	target
Fostamatinib	High affinity nerve growth factor receptor	target
Fostamatinib	BDNF/NT-3 growth factors receptor	target
Fostamatinib	NT-3 growth factor receptor	target
Fostamatinib	NUAK family SNF1-like kinase 1	target
Fostamatinib	NUAK family SNF1-like kinase 2	target
Fostamatinib	Serine/threonine-protein kinase OSR1	target
Fostamatinib	Serine/threonine-protein kinase PAK 1	target
Fostamatinib	Serine/threonine-protein kinase PAK 2	target
Fostamatinib	Serine/threonine-protein kinase PAK 3	target
Fostamatinib	Serine/threonine-protein kinase PAK 4	target
Fostamatinib	Serine/threonine-protein kinase PAK 6	target
Fostamatinib	Serine/threonine-protein kinase PAK 5	target
Fostamatinib	Cyclin-dependent kinase 16	target
Fostamatinib	Cyclin-dependent kinase 17	target
Fostamatinib	Platelet-derived growth factor receptor alpha	target
Fostamatinib	Platelet-derived growth factor receptor beta	target
Fostamatinib	3-phosphoinositide-dependent protein kinase 1	target
Fostamatinib	Cyclin-dependent kinase 15	target
Fostamatinib	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	target
Fostamatinib	Phosphatidylinositol 4-kinase beta	target
Fostamatinib	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	target
Fostamatinib	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	target
Fostamatinib	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	target
Fostamatinib	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	target
Fostamatinib	Serine/threonine-protein kinase pim-1	target
Fostamatinib	Serine/threonine-protein kinase pim-3	target
Fostamatinib	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	target
Fostamatinib	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	target
Fostamatinib	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	target
Fostamatinib	Serine/threonine-protein kinase N1	target
Fostamatinib	Serine/threonine-protein kinase N2	target
Fostamatinib	Serine/threonine-protein kinase PLK1	target
Fostamatinib	Serine/threonine-protein kinase PLK2	target
Fostamatinib	Serine/threonine-protein kinase PLK3	target
Fostamatinib	Serine/threonine-protein kinase PLK4	target
Fostamatinib	5'-AMP-activated protein kinase catalytic subunit alpha-1	target
Fostamatinib	5'-AMP-activated protein kinase	target
Fostamatinib	cAMP-dependent protein kinase catalytic subunit beta	target
Fostamatinib	Protein kinase C delta type	target
Fostamatinib	Protein kinase C epsilon type	target
Fostamatinib	Protein kinase C gamma type	target
Fostamatinib	Protein kinase C iota type	target
Fostamatinib	Protein kinase C theta type	target
Fostamatinib	Serine/threonine-protein kinase D1	target
Fostamatinib	cGMP-dependent protein kinase 2	target
Fostamatinib	Serine/threonine-protein kinase PRP4 homolog	target
Fostamatinib	Focal adhesion kinase 1	target
Fostamatinib	Protein-tyrosine kinase 2-beta	target
Fostamatinib	Protein-tyrosine kinase 6	target
Fostamatinib	RAF proto-oncogene serine/threonine-protein kinase	target
Fostamatinib	Proto-oncogene tyrosine-protein kinase receptor Ret	target
Fostamatinib	Serine/threonine-protein kinase RIO1	target
Fostamatinib	Serine/threonine-protein kinase RIO2	target
Fostamatinib	Serine/threonine-protein kinase RIO3	target
Fostamatinib	Receptor-interacting serine/threonine-protein kinase 1	target
Fostamatinib	Receptor-interacting serine/threonine-protein kinase 2	target
Fostamatinib	Receptor-interacting serine/threonine-protein kinase 4	target
Fostamatinib	Rho-associated protein kinase 2	target
Fostamatinib	Proto-oncogene tyrosine-protein kinase ROS	target
Fostamatinib	Ribosomal protein S6 kinase alpha-1	target
Fostamatinib	Ribosomal protein S6 kinase alpha-3	target
Fostamatinib	Serine/threonine-protein kinase SBK1	target
Fostamatinib	Uncharacterized serine/threonine-protein kinase SBK3	target
Fostamatinib	Serine/threonine-protein kinase Sgk3	target
Fostamatinib	Serine/threonine-protein kinase SIK1	target
Fostamatinib	Serine/threonine-protein kinase SIK2	target
Fostamatinib	STE20-like serine/threonine-protein kinase	target
Fostamatinib	SNF-related serine/threonine-protein kinase	target
Fostamatinib	Proto-oncogene tyrosine-protein kinase Src	target
Fostamatinib	Tyrosine-protein kinase Srms	target
Fostamatinib	Serine/threonine-protein kinase 10	target
Fostamatinib	Serine/threonine-protein kinase 16	target
Fostamatinib	Serine/threonine-protein kinase 17A	target
Fostamatinib	Serine/threonine-protein kinase 17B	target
Fostamatinib	Serine/threonine-protein kinase 32A	target
Fostamatinib	Cytochrome P450 3A4	enzyme
Fostamatinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Fostamatinib	ATP-binding cassette sub-family B member 5	transporter
Fostamatinib	UDP-glucuronosyltransferase 1A9	enzyme
Ketoconazole	Cytochrome P450 3A4	enzyme
Ketoconazole	Cytochrome P450 2C9	enzyme
Ketoconazole	Cytochrome P450 2C19	enzyme
Ketoconazole	Cytochrome P450 3A5	enzyme
Ketoconazole	Cytochrome P450 1A2	enzyme
Ketoconazole	Cytochrome P450 2C8	enzyme
Ketoconazole	Cytochrome P450 1A1	enzyme
Ketoconazole	Cytochrome P450 2D6	enzyme
Ketoconazole	Bile salt export pump	transporter
Ketoconazole	ATP-dependent translocase ABCB1	transporter
Ketoconazole	Cytochrome P450 11B1, mitochondrial	enzyme
Ketoconazole	Cytochrome P450 1B1	enzyme
Ketoconazole	Cytochrome P450 2A6	enzyme
Ketoconazole	Cytochrome P450 2B6	enzyme
Ketoconazole	Lanosterol 14-alpha demethylase	target
Ketoconazole	Androgen receptor	target
Ketoconazole	Steroid 17-alpha-hydroxylase/17,20 lyase	target
Ketoconazole	Steroid 21-hydroxylase	target
Ketoconazole	Potassium voltage-gated channel subfamily H member 2	target
Ketoconazole	Nuclear receptor subfamily 1 group I member 2	target
Ketoconazole	Nuclear receptor subfamily 1 group I member 3	target
Ketoconazole	UDP-glucuronosyltransferase 1A1	enzyme
Ketoconazole	UDP-glucuronosyltransferase 2B7	enzyme
Ketoconazole	Solute carrier organic anion transporter family member 1B1	transporter
Ketoconazole	Cytochrome P450 4F12	enzyme
Ketoconazole	Cytochrome P450 4F2	enzyme
Ketoconazole	Albumin	carrier
Ketoconazole	Sex hormone-binding globulin	carrier
Ketoconazole	Aromatase	enzyme
Ketoconazole	UDP-glucuronosyltransferase 1A7	enzyme
Ketoconazole	Lanosterol 14-alpha demethylase	target
Indinavir	Pol polyprotein	target
Indinavir	Cytochrome P450 3A4	enzyme
Indinavir	Cytochrome P450 3A5	enzyme
Indinavir	Cytochrome P450 3A7	enzyme
Indinavir	ATP-dependent translocase ABCB1	transporter
Indinavir	Solute carrier family 22 member 1	transporter
Indinavir	Multidrug resistance-associated protein 1	transporter
Indinavir	Solute carrier organic anion transporter family member 1A2	transporter
Indinavir	Solute carrier organic anion transporter family member 1B1	transporter
Indinavir	ATP-binding cassette sub-family C member 2	transporter
Indinavir	Cytochrome P450 2D6	enzyme
Indinavir	UDP-glucuronosyltransferase 1A1	enzyme
Indinavir	Solute carrier organic anion transporter family member 2B1	transporter
Indinavir	Bile salt export pump	transporter
Indinavir	Gag-Pol polyprotein	target
Valproic acid	Histone deacetylase 9	target
Valproic acid	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	target
Valproic acid	Cytochrome P450 2A6	enzyme
Valproic acid	Cytochrome P450 2B6	enzyme
Valproic acid	Cytochrome P450 2C9	enzyme
Valproic acid	Organic cation/carnitine transporter 2	transporter
Valproic acid	Solute carrier family 22 member 6	transporter
Valproic acid	Organic anion transporter 3	transporter
Valproic acid	Monocarboxylate transporter 1	transporter
Valproic acid	Solute carrier family 22 member 7	transporter
Valproic acid	Cytochrome P450 3A5	enzyme
Valproic acid	UDP-glucuronosyltransferase 1A9	enzyme
Valproic acid	Prostaglandin G/H synthase 1	enzyme
Valproic acid	Cytochrome P450 1A2	enzyme
Valproic acid	Cytochrome P450 2C19	enzyme
Valproic acid	Cytochrome P450 3A4	enzyme
Valproic acid	UDP-glucuronosyltransferase 1A4	enzyme
Valproic acid	UDP-glucuronosyltransferase 1A8	enzyme
Valproic acid	UDP-glucuronosyltransferase 1A10	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-6	enzyme
Valproic acid	UDP-glucuronosyltransferase 1A3	enzyme
Valproic acid	UDP-glucuronosyltransferase 2B7	enzyme
Valproic acid	UDP-glucuronosyltransferase 2B15	enzyme
Valproic acid	2-oxoglutarate dehydrogenase complex component E1	target
Valproic acid	Succinate-semialdehyde dehydrogenase, mitochondrial	target
Valproic acid	Sodium channel protein	target
Valproic acid	Histone deacetylase 2	target
Valproic acid	Peroxisome proliferator-activated receptor alpha	target
Valproic acid	Peroxisome proliferator-activated receptor delta	target
Valproic acid	Peroxisome proliferator-activated receptor gamma	target
Valproic acid	Albumin	carrier
Valproic acid	UDP-glucuronosyltransferase 1A1	enzyme
Valproic acid	Solute carrier organic anion transporter family member 2B1	transporter
Valproic acid	Histone deacetylase	target
Valproic acid	Cyclin-dependent kinase inhibitor 1	target
Valproic acid	Hepatocyte growth factor	target
Valproic acid	Ornithine decarboxylase	target
Valproic acid	Programmed cell death 1 ligand 1	target
Valproic acid	4-aminobutyrate aminotransferase, mitochondrial	target
Valproic acid	Glycogen synthase kinase-3 alpha	target
Flurbiprofen	Prostaglandin G/H synthase 2	target
Flurbiprofen	Prostaglandin G/H synthase 1	target
Flurbiprofen	Cytochrome P450 2C9	enzyme
Flurbiprofen	Albumin	carrier
Flurbiprofen	ATP-binding cassette sub-family C member 4	transporter
Flurbiprofen	Solute carrier family 22 member 6	transporter
Flurbiprofen	UDP-glucuronosyltransferase 2B7	enzyme
Flurbiprofen	UDP-glucuronosyltransferase 1A1	enzyme
Flurbiprofen	UDP-glucuronosyltransferase 1A3	enzyme
Flurbiprofen	UDP-glucuronosyltransferase 1A9	enzyme
Flurbiprofen	UDP-glucuronosyltransferase 2B4	enzyme
Eltrombopag	Thrombopoietin receptor	target
Eltrombopag	Cytochrome P450 2C8	enzyme
Eltrombopag	Cytochrome P450 1A2	enzyme
Eltrombopag	UDP-glucuronosyltransferase 1A1	enzyme
Eltrombopag	UDP-glucuronosyltransferase 1A3	enzyme
Eltrombopag	Solute carrier organic anion transporter family member 1B1	transporter
Eltrombopag	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Eltrombopag	UDP-glucuronosyltransferase 1A9	enzyme
Silibinin	Solute carrier family 22 member 6	transporter
Silibinin	UDP-glucuronosyltransferase 1A1	enzyme
Silibinin	Solute carrier organic anion transporter family member 1B1	transporter
Silibinin	Solute carrier organic anion transporter family member 1B3	transporter
Silibinin	Solute carrier organic anion transporter family member 2B1	transporter
Sodium aurothiomalate	UDP-glucuronosyltransferase 1A1	enzyme
Atazanavir	Pol polyprotein	target
Atazanavir	Cytochrome P450 3A4	enzyme
Atazanavir	Cytochrome P450 2C9	enzyme
Atazanavir	ATP-dependent translocase ABCB1	transporter
Atazanavir	Multidrug resistance-associated protein 1	transporter
Atazanavir	Albumin	carrier
Atazanavir	UDP-glucuronosyltransferase 1A1	enzyme
Atazanavir	Solute carrier organic anion transporter family member 1B1	transporter
Atazanavir	Solute carrier organic anion transporter family member 1B3	transporter
Atazanavir	Cytochrome P450 2C8	enzyme
Atazanavir	Bile salt export pump	transporter
Atazanavir	alpha1-acid glycoprotein	carrier
Atazanavir	Cytochrome P450 1A2	enzyme
Atazanavir	Solute carrier organic anion transporter family member 2B1	transporter
Atazanavir	Cytochrome P450 3A5	enzyme
Atazanavir	Cytochrome P450 3A7	enzyme
Atazanavir	Gag-Pol polyprotein	target
Gemfibrozil	Peroxisome proliferator-activated receptor alpha	target
Gemfibrozil	Cytochrome P450 2C9	enzyme
Gemfibrozil	Cytochrome P450 2C8	enzyme
Gemfibrozil	Cytochrome P450 1A2	enzyme
Gemfibrozil	Cytochrome P450 2C19	enzyme
Gemfibrozil	UDP-glucuronosyltransferase 1A1	enzyme
Gemfibrozil	Cytochrome P450 3A4	enzyme
Gemfibrozil	UDP-glucuronosyltransferase 1A3	enzyme
Gemfibrozil	Solute carrier organic anion transporter family member 1B1	target
Gemfibrozil	UDP-glucuronosyltransferase 2B7	enzyme
Gemfibrozil	UDP-glucuronosyltransferase 1A9	enzyme
Gemfibrozil	UDP-glucuronosyltransferase 2B4	enzyme
Gemfibrozil	UDP-glucuronosyltransferase 2B17	enzyme
Gemfibrozil	Albumin	carrier
Gemfibrozil	Organic anion transporter 3	target
Gemfibrozil	Solute carrier organic anion transporter family member 2B1	target
Gemfibrozil	Solute carrier organic anion transporter family member 1B3	target
Gemfibrozil	Lipoprotein lipase	target
Ombitasvir	Nonstructural protein 5A	target
Ombitasvir	Cytochrome P450 2C8	enzyme
Ombitasvir	ATP-dependent translocase ABCB1	transporter
Ombitasvir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Ombitasvir	UDP-glucuronosyltransferase 1A1	enzyme
Ombitasvir	Genome polyprotein	target
Deferasirox	Iron	target
Deferasirox	Cytochrome P450 3A4	enzyme
Deferasirox	UDP-glucuronosyltransferase 1A1	enzyme
Deferasirox	UDP-glucuronosyltransferase 1A3	enzyme
Deferasirox	UDP-glucuronosyltransferase 1A9	enzyme
Deferasirox	Cytochrome P450 2C8	enzyme
Deferasirox	Cytochrome P450 1A2	enzyme
Dacomitinib	Cytochrome P450 2D6	enzyme
Dacomitinib	Albumin	carrier
Dacomitinib	Cytochrome P450 3A4	enzyme
Dacomitinib	Cytochrome P450 2C9	enzyme
Dacomitinib	UDP-glucuronosyltransferase 1A1	enzyme
Dacomitinib	ATP-dependent translocase ABCB1	transporter
Dacomitinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Dacomitinib	Solute carrier family 22 member 1	transporter
Dacomitinib	Epidermal growth factor receptor	target
Dacomitinib	Receptor tyrosine-protein kinase erbB-4	target
Dacomitinib	Receptor tyrosine-protein kinase erbB-2	target
Probenecid	Organic anion transporter 3	target
Probenecid	Solute carrier family 22 member 11	target
Probenecid	Albumin	carrier
Probenecid	Solute carrier family 22 member 2	transporter
Probenecid	Solute carrier family 22 member 1	transporter
Probenecid	ATP-binding cassette sub-family C member 3	transporter
Probenecid	ATP-binding cassette sub-family C member 4	transporter
Probenecid	ATP-binding cassette sub-family C member 5	transporter
Probenecid	Monocarboxylate transporter 2	transporter
Probenecid	Organic cation/carnitine transporter 2	transporter
Probenecid	ATP-binding cassette sub-family C member 6	transporter
Probenecid	Multidrug resistance-associated protein 1	transporter
Probenecid	Solute carrier organic anion transporter family member 1A2	transporter
Probenecid	Monocarboxylate transporter 1	transporter
Probenecid	Hepatic sodium/bile acid cotransporter	transporter
Probenecid	Solute carrier family 22 member 6	transporter
Probenecid	Solute carrier family 22 member 10	transporter
Probenecid	Organic anion transporter 3	transporter
Probenecid	ATP-binding cassette sub-family C member 2	transporter
Probenecid	ATP-binding cassette sub-family C member 11	transporter
Probenecid	Solute carrier family 22 member 11	transporter
Probenecid	Solute carrier organic anion transporter family member 1C1	transporter
Probenecid	Solute carrier family 22 member 7	transporter
Probenecid	Solute carrier family 22 member 6	target
Probenecid	Pannexin-1	target
Probenecid	Cytochrome P450 2C8	enzyme
Probenecid	Cytochrome P450 3A4	enzyme
Probenecid	Solute carrier family 22 member 12	transporter
Probenecid	Solute carrier family 2, facilitated glucose transporter member 9	transporter
Probenecid	Taste receptor type 2 member 16	target
Probenecid	UDP-glucuronosyltransferase 1A1	enzyme
Probenecid	Cytochrome P450 2C9	enzyme
Amitriptyline	Sodium-dependent serotonin transporter	target
Amitriptyline	Sodium-dependent noradrenaline transporter	target
Amitriptyline	Potassium voltage-gated channel subfamily KQT member 2	target
Amitriptyline	Alpha-2A adrenergic receptor	target
Amitriptyline	Cytochrome P450 1A2	enzyme
Amitriptyline	Cytochrome P450 2C19	enzyme
Amitriptyline	Cytochrome P450 2D6	enzyme
Amitriptyline	Albumin	carrier
Amitriptyline	Alpha-1-acid glycoprotein 1	carrier
Amitriptyline	Histamine H1 receptor	target
Amitriptyline	5-hydroxytryptamine receptor 2A	target
Amitriptyline	5-hydroxytryptamine receptor 1A	target
Amitriptyline	Alpha-1A adrenergic receptor	target
Amitriptyline	Cytochrome P450 3A4	enzyme
Amitriptyline	Cytochrome P450 3A5	enzyme
Amitriptyline	Potassium voltage-gated channel subfamily A member 1	target
Amitriptyline	Alpha-1D adrenergic receptor	target
Amitriptyline	Delta-type opioid receptor	target
Amitriptyline	Kappa-type opioid receptor	target
Amitriptyline	High affinity nerve growth factor receptor	target
Amitriptyline	BDNF/NT-3 growth factors receptor	target
Amitriptyline	Cytochrome P450 2C9	enzyme
Amitriptyline	Cytochrome P450 2B6	enzyme
Amitriptyline	Cytochrome P450 2C8	enzyme
Amitriptyline	Histamine H2 receptor	target
Amitriptyline	Histamine H4 receptor	target
Amitriptyline	Sigma non-opioid intracellular receptor 1	target
Amitriptyline	5-hydroxytryptamine receptor 2C	target
Amitriptyline	Alpha-1B adrenergic receptor	target
Amitriptyline	5-hydroxytryptamine receptor 7	target
Amitriptyline	5-hydroxytryptamine receptor 1D	target
Amitriptyline	Mu-type opioid receptor	target
Amitriptyline	5-hydroxytryptamine receptor 1B	target
Amitriptyline	5-hydroxytryptamine receptor 6	target
Amitriptyline	Potassium voltage-gated channel subfamily KQT member 3	target
Amitriptyline	UDP-glucuronosyltransferase 2B10	enzyme
Amitriptyline	5-hydroxytryptamine receptor 2C	target
Amitriptyline	Muscarinic acetylcholine receptor	target
Amitriptyline	HERG human cardiac K+ channel	target
Amitriptyline	ATP-dependent translocase ABCB1	transporter
Amitriptyline	UDP-glucuronosyltransferase 1A4	enzyme
Amitriptyline	Glutathione S-transferases (Cytosolic)	enzyme
Dasabuvir	Nonstructural protein 5b	target
Dasabuvir	Cytochrome P450 2C8	enzyme
Dasabuvir	Cytochrome P450 3A4	enzyme
Dasabuvir	Cytochrome P450 2D6	enzyme
Dasabuvir	UDP-glucuronosyltransferase 1A1	enzyme
Dasabuvir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Dasabuvir	ATP-binding cassette sub-family B member 5	transporter
Dasabuvir	ATP-dependent translocase ABCB1	transporter
Dasabuvir	Genome polyprotein	target
Paritaprevir	Genome polyprotein	target
Paritaprevir	Cytochrome P450 3A4	enzyme
Paritaprevir	Cytochrome P450 3A5	enzyme
Paritaprevir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Paritaprevir	ATP-dependent translocase ABCB1	transporter
Paritaprevir	Solute carrier organic anion transporter family member 1B1	transporter
Paritaprevir	Solute carrier organic anion transporter family member 1B3	transporter
Paritaprevir	UDP-glucuronosyltransferase 1A1	enzyme
Paritaprevir	Gag-Pol polyprotein	target
Indomethacin	Prostaglandin G/H synthase 1	target
Indomethacin	Prostaglandin G/H synthase 2	target
Indomethacin	Cytochrome P450 2C19	enzyme
Indomethacin	UDP-glucuronosyltransferase 1A9	enzyme
Indomethacin	Phospholipase A2, membrane associated	target
Indomethacin	Prostaglandin reductase 2	target
Indomethacin	Lactoylglutathione lyase	target
Indomethacin	Prostaglandin D2 receptor 2	target
Indomethacin	Peroxisome proliferator-activated receptor gamma	target
Indomethacin	Albumin	carrier
Indomethacin	ATP-binding cassette sub-family C member 3	transporter
Indomethacin	ATP-binding cassette sub-family C member 4	transporter
Indomethacin	ATP-binding cassette sub-family C member 6	transporter
Indomethacin	ATP-dependent translocase ABCB1	transporter
Indomethacin	Multidrug resistance-associated protein 1	transporter
Indomethacin	Solute carrier organic anion transporter family member 1A2	transporter
Indomethacin	Solute carrier family 22 member 6	transporter
Indomethacin	Organic anion transporter 3	transporter
Indomethacin	ATP-binding cassette sub-family C member 2	transporter
Indomethacin	ATP-binding cassette sub-family C member 11	transporter
Indomethacin	Solute carrier family 22 member 11	transporter
Indomethacin	Hepatic sodium/bile acid cotransporter	transporter
Indomethacin	Solute carrier family 22 member 7	transporter
Indomethacin	Cytochrome P450 2C9	enzyme
Indomethacin	UDP-glucuronosyltransferase 1A1	enzyme
Indomethacin	Liver carboxylesterase 1	enzyme
Indomethacin	UDP-glucuronosyltransferase 2B7	enzyme
Indomethacin	Peroxisome proliferator-activated receptor alpha	target
Indomethacin	Aldo-keto reductase family 1 member C3	target
Indomethacin	Solute carrier organic anion transporter family member 1B1	transporter
Indomethacin	Bile salt export pump	transporter
Indomethacin	Interferon-induced, double-stranded RNA-activated protein kinase	target
Indomethacin	Human Cyclooxygenases	target
Pexidartinib	Cytochrome P450 3A4	enzyme
Pexidartinib	UDP-glucuronosyltransferase 1A4	enzyme
Pexidartinib	Macrophage colony-stimulating factor 1 receptor	target
Pexidartinib	Cytochrome P450 2B6	enzyme
Pexidartinib	Cytochrome P450 2C9	enzyme
Pexidartinib	UDP-glucuronosyltransferase 1A1	enzyme
Pexidartinib	Multidrug and toxin extrusion protein 1	transporter
Pexidartinib	Multidrug and toxin extrusion protein 2	transporter
Pexidartinib	Solute carrier organic anion transporter family member 1B1	transporter
Pexidartinib	Solute carrier organic anion transporter family member 1B3	transporter
Pexidartinib	Solute carrier organic anion transporter family member 2B1	transporter
Pexidartinib	Albumin	carrier
Pexidartinib	Alpha-1-acid glycoprotein 1	carrier
Pexidartinib	Mast/stem cell growth factor receptor Kit	target
Pexidartinib	Receptor-type tyrosine-protein kinase FLT3	target
Pexidartinib	Platelet-derived growth factor receptor beta	target
Ubrogepant	ATP-dependent translocase ABCB1	transporter
Ubrogepant	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Ubrogepant	Cytochrome P450 3A4	enzyme
Ubrogepant	Cytochrome P450 2C8	enzyme
Ubrogepant	Cytochrome P450 2C9	enzyme
Ubrogepant	Cytochrome P450 2D6	enzyme
Ubrogepant	Cytochrome P450 2C19	enzyme
Ubrogepant	Amine oxidase [flavin-containing] A	enzyme
Ubrogepant	UDP-glucuronosyltransferase 1A1	enzyme
Ubrogepant	Solute carrier organic anion transporter family member 1B1	transporter
Ubrogepant	Solute carrier organic anion transporter family member 1B3	transporter
Ubrogepant	Solute carrier family 22 member 6	transporter
Ubrogepant	Solute carrier family 22 member 2	transporter
Ubrogepant	Calcitonin gene-related peptide type 1 receptor	target
Belumosudil	Rho-associated protein kinase 2	target
Belumosudil	Albumin	carrier
Belumosudil	Alpha-1-acid glycoprotein 1	carrier
Belumosudil	Rho-associated protein kinase 1	target
Belumosudil	Cytochrome P450 3A4	enzyme
Belumosudil	Cytochrome P450 2C8	enzyme
Belumosudil	Cytochrome P450 2D6	enzyme
Belumosudil	UDP-glucuronosyltransferase 1A9	enzyme
Belumosudil	Cytochrome P450 1A2	enzyme
Belumosudil	Cytochrome P450 2C19	enzyme
Belumosudil	UDP-glucuronosyltransferase 1A1	enzyme
Belumosudil	ATP-dependent translocase ABCB1	transporter
Belumosudil	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Belumosudil	Solute carrier organic anion transporter family member 1B1	transporter
Asciminib	Cytochrome P450 3A4	enzyme
Asciminib	UDP-glucuronosyltransferase 2B7	enzyme
Asciminib	UDP-glucuronosyltransferase 2B17	enzyme
Asciminib	Tyrosine-protein kinase ABL1	target
Asciminib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Asciminib	UDP-glucuronosyltransferase 1A1	enzyme
Asciminib	Cytochrome P450 2C19	enzyme
Asciminib	ATP-dependent translocase ABCB1	transporter
Asciminib	Solute carrier organic anion transporter family member 1B1	transporter
Asciminib	Solute carrier organic anion transporter family member 1B3	transporter
Asciminib	Solute carrier family 22 member 1	transporter
Asciminib	Cytochrome P450 2C9	enzyme
Olaparib	Poly [ADP-ribose] polymerase 1	target
Olaparib	Cytochrome P450 3A4	enzyme
Olaparib	Cytochrome P450 2B6	enzyme
Olaparib	Poly [ADP-ribose] polymerase 2	target
Olaparib	Protein mono-ADP-ribosyltransferase PARP3	target
Olaparib	Cytochrome P450 3A5	enzyme
Olaparib	ATP-dependent translocase ABCB1	transporter
Olaparib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Olaparib	Aldo-keto reductase family 1 member C3	target
Olaparib	UDP-glucuronosyltransferase 1A1	enzyme
Olaparib	Albumin	carrier
Olaparib	Alpha-1-acid glycoprotein 1	carrier
Dabrafenib	Cytochrome P450 3A4	enzyme
Dabrafenib	Cytochrome P450 2C8	enzyme
Dabrafenib	ATP-dependent translocase ABCB1	transporter
Dabrafenib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Dabrafenib	Solute carrier organic anion transporter family member 1B1	transporter
Dabrafenib	Solute carrier organic anion transporter family member 1B3	transporter
Dabrafenib	Solute carrier family 22 member 6	transporter
Dabrafenib	Organic anion transporter 3	transporter
Dabrafenib	Serine/threonine-protein kinase B-raf	target
Dabrafenib	RAF proto-oncogene serine/threonine-protein kinase	target
Dabrafenib	Serine/threonine-protein kinase SIK1	target
Dabrafenib	Serine/threonine-protein kinase Nek11	target
Dabrafenib	LIM domain kinase 1	target
Dabrafenib	Cytochrome P450 2B6	enzyme
Dabrafenib	Cytochrome P450 2C9	enzyme
Dabrafenib	Cytochrome P450 2C19	enzyme
Dabrafenib	Cytochrome P450 1A2	enzyme
Dabrafenib	Albumin	carrier
Dabrafenib	Solute carrier organic anion transporter family member 1A2	transporter
Dabrafenib	Solute carrier family 22 member 2	transporter
Dabrafenib	UDP-glucuronosyltransferase 1A1	enzyme
Momelotinib	Cytochrome P450 3A4	enzyme
Momelotinib	Cytochrome P450 2C8	enzyme
Momelotinib	Cytochrome P450 2C9	enzyme
Momelotinib	Cytochrome P450 2C19	enzyme
Momelotinib	Cytochrome P450 1A2	enzyme
Momelotinib	Cytochrome P450 2B6	enzyme
Momelotinib	UDP-glucuronosyltransferase 1A1	enzyme
Momelotinib	UDP-glucuronosyltransferase 1A9	enzyme
Momelotinib	ATP-dependent translocase ABCB1	transporter
Momelotinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Momelotinib	Solute carrier organic anion transporter family member 1B1	transporter
Momelotinib	Solute carrier organic anion transporter family member 1B3	transporter
Momelotinib	Tyrosine-protein kinase JAK1	target
Momelotinib	Tyrosine-protein kinase JAK2	target
Momelotinib	Tyrosine-protein kinase JAK3	target
Momelotinib	Non-receptor tyrosine-protein kinase TYK2	target
Momelotinib	Activin receptor type-1	target
Momelotinib	Receptor-type tyrosine-protein kinase FLT3	target
Quizartinib	Receptor-type tyrosine-protein kinase FLT3	target
Quizartinib	Cytochrome P450 3A4	enzyme
Quizartinib	Cytochrome P450 3A5	enzyme
Quizartinib	UDP-glucuronosyltransferase 1A1	enzyme
Quizartinib	ATP-dependent translocase ABCB1	transporter
Quizartinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Quizartinib	Albumin	carrier
Quizartinib	Cytochrome P450 3A7	enzyme
Encorafenib	Cytochrome P450 3A4	enzyme
Encorafenib	Cytochrome P450 2C19	enzyme
Encorafenib	Cytochrome P450 2D6	enzyme
Encorafenib	Serine/threonine-protein kinase B-raf	target
Encorafenib	G1/S-specific cyclin-D1	target
Encorafenib	UDP-glucuronosyltransferase 1A1	enzyme
Encorafenib	Albumin	carrier
Encorafenib	Cytochrome P450 1A2	enzyme
Encorafenib	Cytochrome P450 2B6	enzyme
Encorafenib	Cytochrome P450 2C8	enzyme
Encorafenib	Cytochrome P450 2C9	enzyme
Encorafenib	Cytochrome P450 3A5	enzyme
Encorafenib	Cytochrome P450 3A7	enzyme
Encorafenib	ATP-dependent translocase ABCB1	transporter
Encorafenib	Solute carrier family 22 member 2	transporter
Encorafenib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Encorafenib	Solute carrier family 22 member 6	transporter
Encorafenib	Organic anion transporter 3	transporter
Encorafenib	Solute carrier organic anion transporter family member 1B1	transporter
Encorafenib	Solute carrier organic anion transporter family member 1B3	transporter
Encorafenib	RAF proto-oncogene serine/threonine-protein kinase	target
Encorafenib	Mitogen-activated protein kinase 8	target
Encorafenib	Mitogen-activated protein kinase 9	target
Encorafenib	Mitogen-activated protein kinase 10	target
Encorafenib	LIM domain kinase 1	target
Encorafenib	LIM domain kinase 2	target
Encorafenib	Dual specificity mitogen-activated protein kinase kinase 4	target
Encorafenib	Serine/threonine-protein kinase 36	target
Repotrectinib	Proto-oncogene tyrosine-protein kinase ROS	target
Repotrectinib	High affinity nerve growth factor receptor	target
Repotrectinib	BDNF/NT-3 growth factors receptor	target
Repotrectinib	NT-3 growth factor receptor	target
Repotrectinib	Cytochrome P450 3A4	enzyme
Repotrectinib	ATP-dependent translocase ABCB1	transporter
Repotrectinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Repotrectinib	Solute carrier organic anion transporter family member 1B1	transporter
Repotrectinib	Multidrug and toxin extrusion protein 2	transporter
Repotrectinib	Cytochrome P450 2B6	enzyme
Repotrectinib	Cytochrome P450 2C8	enzyme
Repotrectinib	Cytochrome P450 2C19	enzyme
Repotrectinib	Cytochrome P450 2C9	enzyme
Repotrectinib	Cytochrome P450 3A5	enzyme
Repotrectinib	UDP-glucuronosyltransferase 1A1	enzyme
Aprocitentan	Endothelin-1 receptor	target
Aprocitentan	Endothelin receptor type B	target
Aprocitentan	UDP-glucuronosyltransferase 1A1	enzyme
Aprocitentan	UDP-glucuronosyltransferase 2B7	enzyme
Aprocitentan	Albumin	carrier
Aprocitentan	Cytochrome P450 3A4	enzyme
Aprocitentan	Cytochrome P450 2C8	enzyme
Aprocitentan	Cytochrome P450 2C9	enzyme
Aprocitentan	Cytochrome P450 2C18	enzyme
Aprocitentan	Cytochrome P450 2C19	enzyme
Aprocitentan	ATP-dependent translocase ABCB1	transporter
Aprocitentan	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Aprocitentan	Bile salt export pump	transporter
Aprocitentan	Hepatic sodium/bile acid cotransporter	transporter
Lazertinib	Cytochrome P450 3A4	enzyme
Lazertinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Lazertinib	UDP-glucuronosyltransferase 1A1	enzyme
Lazertinib	Glutathione S-transferase Mu 1	enzyme
Lazertinib	Solute carrier family 22 member 1	transporter
Lazertinib	Epidermal growth factor receptor	target
Osilodrostat	Cytochrome P450 11B1, mitochondrial	target
Osilodrostat	Cytochrome P450 11B2, mitochondrial	target
Osilodrostat	Cytochrome P450 3A4	enzyme
Osilodrostat	Cytochrome P450 2B6	enzyme
Osilodrostat	Cytochrome P450 2D6	enzyme
Osilodrostat	UDP-glucuronosyltransferase 1A4	enzyme
Osilodrostat	UDP-glucuronosyltransferase 2B7	enzyme
Osilodrostat	UDP-glucuronosyltransferase 2B10	enzyme
Osilodrostat	Cytochrome P450 3A5	enzyme
Osilodrostat	Cytochrome P450 1A2	enzyme
Osilodrostat	Cytochrome P450 2C19	enzyme
Osilodrostat	Cytochrome P450 2E1	enzyme
Osilodrostat	Solute carrier organic anion transporter family member 1B1	transporter
Osilodrostat	Solute carrier family 22 member 1	transporter
Osilodrostat	Solute carrier family 22 member 2	transporter
Osilodrostat	Solute carrier family 22 member 6	transporter
Osilodrostat	Organic anion transporter 3	transporter
Osilodrostat	Multidrug and toxin extrusion protein 1	transporter
Osilodrostat	UDP-glucuronosyltransferase 1A1	enzyme