Tumor Necrosis Factor Blockers
- Name
- Tumor Necrosis Factor Blockers
- Accession Number
- DBCAT003245 (DBCAT001648, DBCAT002087)
- Description
Compounds or agents that bind to and inhibit the synthesis or activity of TUMOR NECROSIS FACTOR-alpha. Such agents are used to treat inflammatory bowel diseases and other inflammatory diseases.
- Drugs
Drug Drug Description (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE Not Available Adalimumab A monoclonal anti-tumor necrosis factor alpha antibody used in the treatment of a wide variety of inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis. Afelimomab Investigated for use/treatment in sepsis and septicemia. Amrinone A positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure. AN0128 Investigated for use/treatment in acne, atopic dermatitis, pediatric indications, and psoriasis and psoriatic disorders. Astegolimab Astegolimab is under investigation in clinical trial NCT04386616 (A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia). Atacicept A TACI-Fc fusion protein and dual BAFF/APRIL inhibitor indicated to reduce proteinuria in adults with primary IgA nephropathy at risk for progression. Baicalein Baicalein is under investigation in clinical trial NCT03830684 (A Randomized, Double-blind, Placebo-controlled, Multicenter and Phase ⅡA Clinical Trial for the Effectiveness and Safety of Baicalein Tablets in the Treatment of... Balinatunfib Balinatunfib is a small molecule drug. Balinatunfib has a monoisotopic molecular weight of 502.19 Da. Camobucol Camobucol is a small molecule drug. Camobucol has a monoisotopic molecular weight of 574.32 Da. Certolizumab pegol A tumor necrosis factor (TNF) blocker used to treat a variety of autoimmune and autoinflammatory conditions like Crohn's disease, rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, axial spondyloarthritis, and plaque psoriasis. Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. CP1-1189 CPI-1189 has been used in trials studying the treatment of HIV Infections and AIDS Dementia Complex. Deupirfenidone Deupirfenidone is under investigation in clinical trial NCT05321420 (LYT-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF)). Etanercept A protein therapy based on the binding fragment of the tumour necrosis factor alpha receptor used to treat severe rheumatoid arthritis and moderate to severe plaque psoriasis. Golimumab A TNFα inhibitor used in the symptomatic treatment of various active inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. Infliximab A monoclonal anti tumor necrosis factor alpha antibody used in the treatment of a wide variety of inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis. ISIS 104838 ISIS 104838 is under investigation in clinical trial NCT00048321 (ISIS 104838, an Inhibitor of Tumor Necrosis Factor, for Active Rheumatoid Arthritis). Isopropyl alcohol An antiseptic and disinfectant used in a variety of clinical and domestic settings. Lenabasum Ajulemic acid has been used in trials studying the treatment of Cystic Fibrosis, Dermatomyositis, and Diffuse Cutaneous Systemic Sclerosis. Lenalidomide A thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome. Lenercept Not Annotated Licaminlimab Licaminlimab is under investigation in clinical trial NCT05896670 (Safety and Efficacy of Licaminlimab Ophthalmic Suspension for the Treatment of Dry Eye Disease). Ortataxel Ortataxel has been used in trials studying the treatment of Lymphoma, Lung Cancer, Glioblastoma, and Kidney Cancer. Ozoralizumab Ozoralizumab has been used in trials studying the treatment of Rheumatoid Arthritis and Active Rheumatoid Arthritis. Pegsunercept Investigated for use/treatment in rheumatoid arthritis. Pirfenidone An agent used for the treatment of idiopathic pulmonary fibrosis (IPF). Placulumab Placulumab has been used in trials studying the treatment of Rheumatoid Arthritis. Polaprezinc Peptic ulcer disease, dyspepsia . Pomalidomide A thalidomide analogue used in combination with dexamethasone to treat patients with multiple myeloma. Pseudoephedrine An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis. RDP58 Investigated for use/treatment in ulcerative colitis and crohn's disease. Remtolumab Remtolumab is under investigation in clinical trial NCT02433340 (Phase 2, Multicenter, Open-Label Extension (OLE) Study With ABT-122 in Rheumatoid Arthritis Subjects Who Have Completed the Preceding M12-963 Study). Senlizumab Not Annotated Sibeprenlimab A APRIL-directed monoclonal antibody used to reduce proteinuria in adults with primary immunoglobulin A nephropathy (IgAN). TAK-715 TAK-715 is under investigation in clinical trial NCT00760864 (Safety and Efficacy of TAK-715 in Subjects With Rheumatoid Arthritis). Tanfanercept Tanfanercept is under investigation in clinical trial NCT06400589 (A Study to Evaluate the Efficacy and Safety of Tanfanercept (HL036) in Dry Eye Disease). Thalidomide A medication used to treat cancers, particularly newly diagnosed multiple myeloma, and erythema nodosum leprosum. Tiamulin Tiamulin is a pleuromutilin antibiotic drug that is used in veterinary medicine particularly for pigs and poultry. XPro1595 XPro1595 is an investigational dominant-negative protein that neutralizes soluble TNF. XTMAB-16 XTMAB-16 is a monoclonal antibody directed against tumour necrosis factor-alpha (TNFα). Yisaipu Not Annotated Zofin Zofin, previously known as Organicell Flow, is a nanoparticle-based therapeutic derived from perinatal sources which is manufactured in a way that retains the naturally occurring microRNAs without the addition of... - Drugs & Drug Targets