Alkylating Activity
- Name
- Alkylating Activity
- Accession Number
- DBCAT004116
- Description
Not Available
- Drugs
Drug Drug Description Cyclophosphamide A nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma. Mechlorethamine An antineoplastic agent used to treat Hodgkin's disease, lymphosarcoma, and chronic myelocytic or lymphocytic leukemia. Procarbazine An antineoplastic agent indicated for the treatment of stage III and stage IV Hodgkin's disease in combination with other chemotherapeutic agents. Mitomycin An antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies. Streptozocin A nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma. Temozolomide An alkylating agent used to treat glioblastoma multiforme and refractory anaplastic astrocytoma. Carmustine An alkylating agent used in the treatment of various malignancies, including brain tumours and multiple myeloma, among others. Busulfan An alkylating agent used to treat chronic myelogenous leukemia. Melphalan An alkylating agent used to treat multiple myeloma, ovarian carcinoma, uveal melanoma with unresectable hepatic metastases, and for high-dose conditioning before hematopoietic stem cell transplant in patients. Lomustine An alkylating agent used as a part of chemotherapeutic regimens for the treatment of primary and metastatic brain tumors as well as refractory or relapsed Hodgkin's disease in addition to surgical and/or radiotherapeutic treatments. Estramustine An antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting. Dacarbazine An antineoplastic agent used to treat malignant melanoma and Hodgkin's disease. Ifosfamide An alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma. Thiotepa An alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas. Chlorambucil A chemotherapy agent used in the management of chronic lymphocytic leukemia and malignant lymphomas. Altretamine An antineoplastic agent used in palliative treatment of persistent or recurrent ovarian cancer. Bendamustine An antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy. Trabectedin An alkylating agent approved for the treatment of unresectable or metastatic soft tissue sarcoma (liposarcoma or leiomyosarcoma). Melphalan flufenamide A melphalan prodrug used to treat relapsed or refractory multiple myeloma. - Drugs & Drug Targets