OATP1B1/SLCO1B1 Substrates
- Name
- OATP1B1/SLCO1B1 Substrates
- Accession Number
- DBCAT002658
- Description
Not Available
- Drugs
Drug Drug Description Ambrisentan A selective type A endothelin receptor antagonist used to treat primary pulmonary arterial hypertension and pulmonary arterial hypertension based on diagnostic classifications. Asunaprevir An NS3 protease inhibitor used to treat hepatitis C genotype 1b. Atogepant An oral CGRP antagonist used for the preventative therapy of episodic migraine headaches. Atorvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Atrasentan An endothelin A receptor antagonist used to reduce proteinuria in patients with primary IgA nephropathy. Avenciguat Avenciguat is under investigation in clinical trial NCT05282121 (A Study to Test Whether BI 685509 Alone or in Combination With Empagliflozin Helps People With Liver Cirrhosis Caused by Viral Hepatitis... Axitinib An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. Belantamab mafodotin An anti B-cell maturation antigen antibody conjugated to a microtubule inhibitor to treat relapsed or refractory multiple myeloma. Belzutifan An inhibitor of hypoxia-inducible factor 2α used as an antineoplastic in the treatment of certain cancers associated with von Hippel-Lindau (VHL) disease. Benzylpenicillin A penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. Bosentan A dual endothelin receptor antagonist used to treat pulmonary arterial hypertension. Brincidofovir An oral lipid prodrug of cidofovir used in the treatment of human smallpox disease. Caspofungin An echinocandin used to treat a variety of fungal infections. Cerivastatin A statin (or HMG CoA reductase inhibitor) used with dietary changes to decrease lipid levels and reduce the risk of cardiovascular events. Cholecystokinin For use as a diagnostic aid for evaluation of gallbladder disorders. It is also used in conjunction with secretin in pancreatic insufficiency . Cholic Acid A bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. Clotrimazole A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. Conjugated estrogens A mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis. Cyclosporine A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis. Dabrafenib A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. Datopotamab deruxtecan An antibody-drug conjugate carrying a topoisomerase-I inhibitor payload for use in patients with previously treated HR+, HER2- breast cancer and EGFR+ non-small cell lung cancer. Digoxin A cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. Dinoprostone A prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. Elagolix A gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis. Eluxadoline A mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea. Empagliflozin An SGLT2 inhibitor used to manage type 2 diabetes mellitus. Enalapril A prodrug of an ACE inhibitor used to treat hypertension and congestive heart failure. Erythromycin A macrolide antibiotic used to treat and prevent a variety of bacterial infections. Etripamil An L-type calcium channel blocker used to convert acute symptomatic episodes of paroxysmal supraventricular tachycardia to sinus rhythm in adults. Ezetimibe A cholesterol absorption inhibitor used to lower total cholesterol, LDL-C, Apo-B, and non-HDL-C in primary hyperlipidemia and familial cholesterolemia. Fexofenadine A selective H1-antagonist for the symptomatic treatment of seasonal allergic rhinitis and chronic idiopathic urticaria. Fimasartan An angiotensin II receptor antagonist (ARB) used to treat hypertension and heart failure. Firsocostat Firsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)). Fluvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Gadoxetic acid A gadolinium-based contrast agent (GBCA) used with contrasted magnetic resonance imaging (MRI) to detect and visualize the liver. Gimatecan Gimatecan is an orally available 7-t-butoxyiminomethyl-substituted lipophilic camptothecin derivative. Glecaprevir A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. Grazoprevir An antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections. Hydroxyurea An antimetabolite used to treat sickle cell anemia crisis, resistant chronic myeloid leukemia, and Locally advanced squamous cell carcinomas of the head and neck (excluding the lip). Iodine (131I) norcholesterol A radioiodine-labeled cholesterol analogue that accumulates in areas where steroid hormones are produced and is used in certain diagnostic procedures. Letermovir An antiviral medication used for prophylaxis in adult transplant recipients at risk of cytomegalovirus (CMV) infection and disease. Levomenol Levomenol has been known to elicit a number of potentially beneficial pharmacological effects, including anti-irritant, anti-inflammatory, and anti-microbial actions. Bisabolol is also demonstrated to enhance the percutaneous absorption of certain... Levosalbutamol A beta-2 adrenergic receptor agonist used to treat COPD and asthma. Levothyroxine A synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. Linzagolix A selective gonadotropin-releasing hormone (GnRH) receptor antagonist used for the symptomatic treatment of uterine fibroids. Liothyronine A thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. Liotrix May be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic... Lovastatin An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke. Mesalazine An aminosalicylate drug used to treat mild to moderate active ulcerative colitis and also to maintain remission once achieved. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Momelotinib A Janus Kinase inhibitor used to treat intermediate or high-risk myelofibrosis. Mycophenolate mofetil An inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants. Olmesartan An angiotensin receptor blocker (ARB) used in the treatment of hypertension. Orforglipron An oral, small molecule GLP-1 receptor agonist used as part of a weight management regimen. Ouabain For the treatment of atrial fibrillation and flutter and heart failure Pafolacianine An optical imaging agent indicated in adult patients with ovarian cancer as an adjunct for intraoperative identification of malignant lesions. Paritaprevir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Penicillamine A chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis. PF-06835919 PF-06835919 is under investigation in clinical trial NCT05463575 (Ketohexokinase Inhibition in NAFLD). Phenolsulfonphthalein Phenolsulfonphthalein or otherwise called phenol red is a pH indicator commonly used in cell biology laboratories. Phenolsulfonphthalein is being investigated for use clinically due to its weak estrogen mimicking actions... Pitavastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Prasterone A steroid formulated as a vaginal insert indicated for the treatment of moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy. Pravastatin An HMG-CoA reductase inhibitor used to lower lipid levels and to reduce the risk of cardiovascular events, including myocardial infarction and stroke. Raloxifene A selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women. Remdesivir A nucleoside analog used to treat RNA virus infections including COVID-19. Repaglinide A antihyperglycemic used to improve glycemic control in diabetes. Resmetirom A thyroid hormone receptor-beta agonist used to treat noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis in adults. Revefenacin An anticholinergic agent used to treat COPD. Rosuvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Selexipag A non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension. Simeprevir A direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4. Simvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke. Sulfobromophthalein Sulfobromophthalein or otherwise called bromsulphthalein is used as a test of liver function in humans . Sumatriptan A serotonin receptor agonist used to treat migraines and cluster headaches. Taurocholic acid The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats... Tebipenem pivoxil An oral carbapenem antibacterial indicated for complicated urinary tract infections, including pyelonephritis, caused by susceptible Enterobacterales and Enterococcus faecalis in adults with limited or no alternative oral treatment options. Technetium Tc-99m mebrofenin A diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests. Temocapril Temocapril is an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction). Tenofovir alafenamide A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease. Tezacaftor A CFTR corrector used to treat cystic fibrosis in patients with susceptible mutations (e.g. F508del). TL-895 TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively. TL-895 is under investigation... Torasemide A diuretic used to treat hypertension and edema associated with heart failure, renal failure, or liver disease. Ubrogepant An oral CGRP antagonist used in the acute treatment of migraine with or without aura. Valsartan An angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors. Voxilaprevir A nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. Zoliflodacin A spiropyrimidinetrione bacterial type II topoisomerase inhibitor indicated for the treatment of uncomplicated urogenital gonorrhea caused by Neisseria gonorrhoeae. - Drugs & Drug Targets