Protein Synthesis Inhibitors
- Name
- Protein Synthesis Inhibitors
- Accession Number
- DBCAT000501
- Description
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
- Drugs
Drug Drug Description Anisomycin Anisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria Streptomyces griseolus. This drug acts to inhibit bacterial protein and DNA synthesis. Bindarit Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy. Brefeldin A A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity. Capreomycin An aminoglycoside antibiotic used as an adjunct drug in tuberculosis. Cethromycin A ketolide antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, and atypical bacteria that may be useful for treating several conditions including community-acquired pneumonia, inhalation anthrax, plague, and tularemia. Chloramphenicol A broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. Chlortetracycline The first tetracycline antibiotic most commonly used for veterinary purposes. Ciclopirox A broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients. Clarithromycin A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. Clindamycin A lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria. Cycloheximide Cycloheximide is a small molecule drug. Cycloheximide has a monoisotopic molecular weight of 281.16 Da. Dactinomycin An actinomycin used to treat a wide variety of cancers. Delpazolid Delpazolid (LCB01-0371) is under investigation in clinical trial NCT01554995 (A Clinical Study, Randomized, Double-blind, Placebo-controlled, Single Dose Study). Emetine Not Annotated Erythromycin A macrolide antibiotic used to treat and prevent a variety of bacterial infections. Fusidic acid A topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. Gentamicin An aminoglycoside used to treat a wide variety of aerobic infections in the body. Halofuginone For the treatment of scleroderma, cancer, and restenosis. Kanamycin An aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria. KRN-5500 KRN-5500 is under investigation in clinical trial NCT00002923 (KRN5500 in Treating Patients With Metastatic Solid Tumors). Lincomycin An antibiotic indicated only for the treatment of serious infections and is typically reserved for use in cases of penicillin allergy or where penicillin is inappropriate. Linezolid An oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. Mupirocin An antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. Nafithromycin Nafithromycin is under investigation in clinical trial NCT02903836 (Phase II Study of Oral Nafithromycin in CABP). Neomycin An aminoglycoside antibiotic agent used orally and topically to treat a wide variety of infections in the body. Netilmicin An aminoglycoside used to treat a wide variety of infections in the body. Omacetaxine mepesuccinate A cephalotaxine used in the treatment of Chronic Myeloid Leukemia (CML) that is intolerant to or resistant to two or more tyrosine kinase inhibitors. Plicamycin For the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer. Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... Ranpirnase For the treatment of various forms of cancer. Sisomicin Sisomicin has been used in trials studying the treatment of Pyoderma. Sparsomycin An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems. [PubChem] Streptomycin An aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections. Tavaborole An antifungal agent used to treat onychomycosis, a fungal infection of the nail. Telithromycin An ketolide used to treat community acquired pneumonia of mild to moderate severity. Tempol Tempol has been used in trials studying the treatment of Anal Cancer. Tetracycline An antibiotic used to treat a wide variety of susceptible infections. Tigecycline A glycylcycline antibiotic used to treat a number of susceptible bacterial infections. Trichostatin A Not Available Viomycin Viomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis. Virginiamycin Virginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA and virginiamycin S1. Virginiamycin is used in the fuel ethanol industry to prevent... - Drugs & Drug Targets