Capreomycin

DB00314ApprovedInvestigationalSmall moleculeAntimycobacterials

Capreomycin is an aminoglycoside antibiotic used as an adjunct drug in tuberculosis. Cyclic peptide antibiotic similar to viomycin.

Mechanism: Little is known about capreomycin's exact mechanism of action, but it is thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Capreomycin also binds to components in the bacterial cell which result in the production of abnormal proteins. These proteins are necessary for the bacteria's survival. Therefore the production of these abnormal proteins is ultimately fatal to the bacteria.
Curator reviewed
Primary indication: Used in the treatment of tuberculosis in combination with other drugs.Curator reviewed · 1 structured indication
Formula / weight: C₅₀H₈₈N₂₈O₁₅ · 1321.4123 g/mol (avg)
First approval: Canada, 1994 · United States, 1971
Brand names: Capastat

Resolves to

Compound

UNII232HYX66HCCAS11003-38-6ChEMBLCHEMBL2303634ChEBI3371PubChem3000502KEGGD00135

Clinical / RWD

RxNorm78903ATCJ04AB30PharmGKBPA164746226

Structure

InChIKeyVCOPTHOUUNAYKQ-WBTCAYNUSA-NSMILES

[H][C@@]1(CCN=C(N)N1)[C@]1([H])NC(=O)\C(NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](C)NC(=O)[C@@H](N)CNC1=O)=C/NC(N)=O.[H][C@@]1(CCN=C(N)N1)[C@]1([H])NC(=O)\C(NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC1=O)=C/NC(N)=O

Targets

P9WJ63tlyA

What you can answer from here — as of August 30, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

928Drug interactionsStructured to mechanism, not free text

5Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

4Marketed productsAcross 2 countries and 3 labellers

1ATC codeIncluding every combination product, plus 18 drug categories

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Capreomycin, and which of those have an active Phase 3 trial?

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