Pheochromocytoma (DBCOND0002904)

Identifiers

Synonyms
Adrenal Gland Pheochromocytoma / Pheochromocytomas / Phaeochromocytoma / Pheochromocytoma (morphologic abnormality) / Phaeochromocytoma [Ambiguous]

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Acebutolol
A selective β1-receptor antagonist used for the management of hypertension and ventricular premature beats in adults.
Clonidine
An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines.
Dacarbazine
An antineoplastic agent used to treat malignant melanoma and Hodgkin's disease.
Iobenguane sulfate I-123
For use in the diagnostic imaging of adrenergically inervated tissues for the purposes of detecting metastatic pheochromocytoma or neuroblastoma [FDA Label]. Also used to assess the sympathetic inervation of the...
Labetalol
An alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome.
Metyrosine
A tyrosine 3-monooxygenase inhibitor used to treat excessive sympathetic stimulation in pheochromocytoma.
Phenoxybenzamine
An alpha adrenergic antagonist used to treat pheochromocytoma and episodes of hypertension and sweating.
Phentolamine
An alpha-adrenergic blocker used to treat hypertensive episodes, diagnose pheochromocytoma, treat norepinephrine administration site reactions, and reverse soft tissue anesthesia and mydriasis.
Propranolol
A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma.
Vincristine
A vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02834013
Nivolumab and Ipilimumab in Treating Patients With Rare Tumorstreatment2active_not_recruiting
NCT05142241
Testing the Combination of Anti-Cancer Drugs Talazoparib and Temozolomide in Patients With Advanced Stage Rare Cancers, RARE 2 Trialtreatment2suspended
NCT02402244
Project: Every Child for Younger Patients With CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT02186678
Comparison of Diagnostic Performances of 68Ga-DOTATATE PET-CT and 18F-FDOPA PET-CT in Paragangliomas and Pheochromocytomas EvaluationNo drug interventionsdiagnosticNot Availablecompleted
NCT05944237
HTL0039732 in Participants With Advanced Solid Tumourstreatment1 / 2recruiting
NCT05636618
Targeted Alpha-Particle Therapy for Advanced SSTR2 Positive Neuroendocrine TumorsNo drug interventionstreatment1 / 2recruiting
NCT06427798
Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapytreatment1 / 2not_yet_recruiting
NCT06503146
18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer DetectionNo drug interventionsdiagnostic2not_yet_recruiting
NCT06607692
Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined with the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).treatment2recruiting
NCT00107289
Iodine I 131 Metaiodobenzylguanidine in Treating Patients with Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paragangliomatreatment2recruiting
NCT06233903
18F-mFBG Expression in Neural Crest Tumors and Organs Innervated by the Sympathetic Nervous Systemdiagnostic2not_yet_recruiting
NCT00004847
Diagnosis of PheochromocytomaNo drug interventionsdiagnostic1recruiting
NCT03206060
Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paragangliomatreatment2recruiting
NCT06573723
Institutional Registry of Rare DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT01413503
A Phase II Study of 131I- Metaiodobenzylguanidine (MIBG) for Treatment of Metastatic or Unresectable Pheochromocytoma and Related TumorsNo drug interventionstreatment2completed
NCT05446779
Postmortem Evaluation of Adrenal and Other Endocrine Tumors in Patients With Sudden DeathNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01838187
Expanded Access Protocol Using 131I-MIBG Therapy +/- Vorinostat for Refractory Neuroblastoma, Pheochromocytoma, or ParagangliomaNot AvailableNot Availableno_longer_available
NCT06377033
Using the EHR to Advance Genomic Medicine Across a Diverse Health SystemNo drug interventionshealth_services_researchNot Availablerecruiting
NCT00001147
Blood Sampling for Neurochemical and Genetic TestingNo drug interventionsNot AvailableNot Availablecompleted
NCT00002947
Indium In 111 Pentetreotide in Treating Patients With Refractory CancerNo drug interventionstreatment1terminated
NCT03839498
Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Pheochromocytoma/Paragangliomatreatment2recruiting
NCT05456997
Metabolic Myopathy in EndocrinopathyNo drug interventionsNot AvailableNot Availableterminated
NCT04071561
Prevention of Conversion in Posterior Retroperitoneal Adrenalectomy by Measuring Preoperative Anatomical ConditionsNo drug interventionsNot AvailableNot Availablecompleted
NCT05082311
Cardiac and Vascular Changes in Pheochromocytoma and ParagangliomaNo drug interventionsNot AvailableNot Availablecompleted
NCT05053685
Metanephrines in Obstructive Sleep ApnoeaNo drug interventionsNot AvailableNot Availablecompleted
NCT01022515
Specificity of Elevated Plasma EM66 Levels in PheochromocytomaNo drug interventionsNot AvailableNot Availablecompleted
NCT03474237
A Prospective Cohort Study for Patients With Adrenal DiseasesNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT00028106
131MIBG to Treat Malignant PheochromocytomaNo drug interventionstreatment2completed
NCT04566406
Pheochromocytoma and Hemodynamic InstabilityNo drug interventionsNot AvailableNot Availablecompleted
NCT01373736
123I-MIBG Scintigraphy in Patients Being Evaluated for Neuroendocrine TumorsNo drug interventionsdiagnostic3unknown_status
NCT00188019
Hereditary Paraganglioma: Evaluation of Screening Methods to Detect Tumors in SDH Positive CarriersNo drug interventionsdiagnosticNot Availablecompleted
NCT05451134
Predictors and Outcomes of Dysglycemia in Pheochromocytoma and ParagangliomaNo drug interventionsNot AvailableNot Availableunknown_status
NCT04119024
Gene Modified Immune Cells (IL13Ralpha2 CAR T Cells) After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumorstreatment1recruiting
NCT04573816
Development of a Tele-monitoring Program for Patients Undergoing Surgery for Pheochromocytoma and / or ParagangliomaNo drug interventionsNot AvailableNot Availableunknown_status
NCT00590096
I-123-MIBG for Imaging of Neuroblastoma and PheochromocytomaNo drug interventionsNot AvailableNot Availablecompleted
NCT04711135
Study to Evaluate Safety and Dosimetry of Lutathera in Adolescent Patients With GEP-NETs and PPGLstreatment2active_not_recruiting
NCT04605848
Infrared Thermography Associated With Cutaneous Microcirculation for Detection of Brown-adipose Tissue (MICROBAT)No drug interventionsdiagnosticNot Availableterminated
NCT00669266
Adrenal Tumors - Pathogenesis and TherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT03160274
Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated ConditionsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04400474
Trial of Cabozantinib Plus Atezolizumab in Advanced and Progressive Neoplasms of the Endocrine System. The CABATEN Studytreatment2active_not_recruiting
NCT03541720
18F-Fluorodopamine PET Studies of Neuroblastoma and PheochromocytomaNo drug interventionsdiagnostic0recruiting
NCT06523582
Genetic Bases of Neuroendocrine Neoplasms in Mexican PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04788927
Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort StudyNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03946527
LAnreotide in Metastatic Pheochromocytoma / PARAganglioma (LAMPARA)treatment2recruiting
NCT02618694
Efficacy and Safety of Posterior Retroperitoneoscopic Adrenalectomy: A Comparative StudyNo drug interventionstreatmentNot Availablecompleted
NCT00911729
Content Validation of Quality of Life and Symptom Questionnaires for Pheochromocytoma and ParagangliomaNo drug interventionsNot AvailableNot Availableterminated
NCT00001229
Diagnosis and Treatment of PheochromocytomaNo drug interventionsNot AvailableNot Availablecompleted
NCT04320589
the Effect of Dexmedetomidine and Magnesium Sulfate in Open Resection of Pheochromocytomaprevention2completed
NCT04890444
China Adrenal Disease RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT03015844
A Compassionate Use/Expanded Access Protocol Using 131I-MIBG Therapy for Patients With Refractory Neuroblastoma and Metastatic PheochromocytomaNot AvailableNot Availableavailable
NCT04187404
A Novel Therapeutic Vaccine (EO2401) in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paragangliomatreatment1 / 2active_not_recruiting
NCT04557072
Selective Versus Nonselective Alpha-blockade Prior to Pheochromocytoma Resection - Systematic Review and Meta-analysisNot AvailableNot Availablecompleted
NCT01425710
Non-invasive Evaluation of Fluid Status and Cardiac Output During Operative Treatment of PheochromcytomaNo drug interventionsNot AvailableNot Availablecompleted
NCT01949714
Effect of Chronic Catecholamine Overproduction on Brown Adipose TissueNo drug interventionsNot AvailableNot Availablecompleted
NCT00049023
Radiolabeled Octreotide in Treating Children With Advanced or Refractory Solid TumorsNo drug interventionstreatment1completed
NCT00002764
Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcomatreatment3completed
NCT03165721
A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancertreatment2terminated
NCT04028479
The Registry of Oncology Outcomes Associated With Testing and TreatmentNo drug interventionsNot AvailableNot Availablerecruiting
NCT01379898
Phenoxybenzamine Versus Doxazosin in PCC Patientstreatment4completed
NCT06229405
Development of Clinical Evidence for Optimal Management of Adrenal Diseases Based on Real-World DataNo drug interventionsNot AvailableNot Availablerecruiting
NCT04276597
Phase-II Study of Lu177DOTATOC in Adults With STTR(+)Pulmonary, Pheochromocytoma, Paraganglioma, Unknown Primary, Thymus NETs (PUTNET), or Any Other Non-.GEP-NET.treatment2withdrawn
NCT06429397
First-line Anlotinib Combined With Penpulimab for Advanced Pheochromocytoma: A Single-arm, Multicenter, Prospective Phase II Studytreatment2recruiting
NCT03583528
DOTATOC PET/CT for Imaging NET PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT01959711
Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic AdrenalectomyNo drug interventionstreatment4completed
NCT03176693
Preoperative Alpha Blockade for Pheochromocytomatreatment3completed
NCT03986593
Cryoablation of Bone Metastases From Endocrine TumorsNo drug interventionstreatmentNot Availableterminated
NCT06444607
Hereditary Pheochromocytoma Assessment of Tumour ImmunologiesNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00466856
Internal Radiation Therapy in Treating Patients With Liver Metastases From Neuroendocrine Tumorstreatment2terminated
NCT05883085
A Study on the Safety and Effectiveness of Anlotinib for Neoadjuvant Treatment of PPGLtreatment2recruiting
NCT02431715
18F-FDOPA PET in Neuroendocrine TumoursNo drug interventionsNot AvailableNot Availableno_longer_available
NCT00843037
Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytomatreatment2completed
NCT05948137
F-18 FDOPA PET/CT Versus I-123 MIBG Scintigraphy With SPECT/CT for the Diagnosis of Pheochromocytoma and ParagangliomaNo drug interventionsNot AvailableNot Availableterminated
NCT01377532
Compassionate Use of 131I-MIBG for Patients With Malignant PheochromocytomaNot AvailableNot Availableapproved_for_marketing
NCT00458952
Phase 1 Study of Iobenguane (MIBG) I 131 in Patients With Malignant Pheochromocytoma/Paragangliomatreatment1 / 2completed
NCT00970970
Visualizing Vascular Endothelial Growth Factor (VEGF) Producing Lesions in Von Hippel-Lindau DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03158870
Surgeon-Anesthesiologist CollaborationNo drug interventionsNot AvailableNot Availableunknown_status
NCT00002641
Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcomatreatment3completed
NCT03344016
Multicenter Pheochromocytoma and Paraganglioma EvaluationNo drug interventionshealth_services_researchNot Availablerecruiting
NCT06037135
Dexmedetomidine Infusion During Laparoscopic Adrenalectomysupportive_careNot Availablecompleted
NCT05885386
A Study on the Safety and Effectiveness of Temozolomide for Neoadjuvant Treatment of PPGLtreatment2recruiting
NCT06440122
The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue (aBAT) in Patients With Pheochromocytoma or Paraganglioma (PPGLs)No drug interventionsNot AvailableNot Availablerecruiting
NCT06050057
Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted AdrenalectomyNo drug interventionsNot AvailableNot Availablerecruiting
NCT03923257
Dosimetry Guided PRRT With 177Lu-DOTATATE in Children and Adolescentstreatment1 / 2withdrawn
NCT05069220
18F-MFBG PET/CT in the Evaluation of Neural Crest Tumordiagnostic0recruiting
NCT06062082
Intraoperative Hemodynamic Instability During Unilateral Adrenalectomy for PheochromocytomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT00339131
ULTRATRACE Iobenguane I 131 in Patients With Malignant Pheochromocytoma, Paraganglioma, or Metastatic Carcinoiddiagnostic1completed
NCT01152827
RAD001 in Pheochromocytoma or Nonfunctioning Carcinoidtreatment2completed
NCT01967576
Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paragangliomatreatment2completed
NCT06045260
"Receptor Radionuclide Therapy With 177Lu-DOTATOCtreatment2recruiting
NCT02961491
Expanded Access Program of Ultratrace Iobenguane I131 for Malignant Relapsed/Refractory Pheochromocytoma/ParagangliomaNot AvailableNot Availableapproved_for_marketing
NCT01590680
Expanded Access Protocol Using 131I-MIBGNo drug interventionsNot AvailableNot Availableavailable
NCT05702944
The Effect and Safety of Omitting Preoperative Alpha-adrenergic Blockade for Normotensive Pheochromocytomaprevention4recruiting
NCT05636540
In Vivo PARP-1 Expression With 18F-FluorThanatrace PET/CT in Patients With Pheochromocytoma and ParagangliomaNo drug interventionsdiagnostic0recruiting
NCT05158712
Genetic Factors and Pheochromocytomas in Neoplasia Type 2No drug interventionsNot AvailableNot Availablerecruiting
NCT00126412
Meta-Iodobenzylguanidine (123I mIBG) Scintigraphy in Patients Being Evaluated for Phaeochromocytoma or Neuroblastomadiagnostic3completed
NCT04891081
Plasma Metanephrines in Patients With Cyanotic and Acyanotic Congenital Heart DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT00923481
A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H...treatment2completed
NCT00874614
A Study Evaluating Ultratrace Iobenguane I131 in Patients With Malignant Relapsed/Refractory Pheochromocytoma/ParagangliomaNo drug interventionstreatment2unknown_status
NCT00002608
Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumorstreatment2completed
NCT00436735
Nelfinavir in Treating Patients With Metastatic, Refractory, or Recurrent Solid Tumorstreatment1active_not_recruiting
NCT01941849
Phase I Trial of Vandetanib Combined With 131I-mIBG to Treat Patients With Advanced Phaeochromocytoma and Paragangliomatreatment1withdrawn