Stomatitis (DBCOND0010432)

Identifiers

Synonyms

Other forms of stomatitis / Stomatitis (disorder) / Mucositis oral / Mucositis NOS / Mucosal inflammation / Inflammation mucous membrane / Mucous inflammation (morphologic abnormality) / Inflammatory disease of mucous membrane (disorder) / Mucositis / Mucosal inflammation NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amylmetacresol	An antiseptic used to treat infections in the mouth and throat.	Sodium channel protein type 2 subunit alphatarget
Amylocaine	A local and topical anaesthetic agent.	Voltage-gated sodium channel alpha subunittarget
Benzamidine	A drug used to treat painful and inflammatory conditions of the oral cavity, such as infections and gingivitis.	Urokinase-type plasminogen activatortarget Serine protease 1target Casein kinase II subunit alphatarget Kallikrein-6target Trypsin-2target Trypsin-3target Copper transport protein ATOX1target Enoyl-CoA delta isomerase 1, mitochondrialtarget Trypsintarget Suppressor of tumorigenicity 14 proteintarget Kallikrein-1target
Benzocaine	A topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations.	Sodium channel protein type 10 subunit alphatarget ATP-dependent translocase ABCB1transporter Liver carboxylesterase 1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Albumincarrier alpha1-acid glycoproteincarrier
Cetylpyridinium	A compound used to reduce plaque and gingivitis, as well as whiten teeth.	No drug targets
Cetyltrimethylammonium naproxenate	An anti-inflammatory and antiseptic agent indicated to treat mouth inflammation and pain , including that caused by tooth extraction.	No drug targets
Chamaemelum nobile flower	Chamaemelum nobile flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.	No drug targets
Chlorhexidine	An antiseptic used to sterilize for surgeries and in healthcare practice, to reduce pocket depth in periodontitis, and to treat gingivitis.	Bacterial outer membranetarget Albumincarrier
Dequalinium	A quaternary ammonium cation antimicrobial agent used to treat common infections of the mouth and throat, as well as vaginal candidiasis.	E3 ubiquitin-protein ligase XIAPtarget Cyclic nucleotide-gated channel alpha-1target Calcium-activated potassium channel subunit alpha-1target HTH-type transcriptional regulator QacRtarget Response regulator RamRtarget Multidrug efflux pump subunit AcrBtransporter Small conductance calcium-activated potassium channel protein 3target Protein kinase Ctarget Alpha-synucleintarget L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligasetarget Small conductance calcium-activated potassium channel protein 1target Small conductance calcium-activated potassium channel protein 2target Calmodulintarget Cyclic nucleotide-gated channel alpha-2target
Difluocortolone	A topical corticosteroid used for the symptomatic treatment of inflammatory skin disorders like eczema, seborrheic eczema, lichen planus and psoriasis.	Annexin A3target Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme
Silver proteinate	A nasal decongestant and antiseptic of the nasal and ear canals.	No drug targets
Tyrothricin	A topical antibiotic with broad spectrum activity against Gram positive bacteria and some fungal infections.	Acetylcholinesterasetarget Beta-galactosidasetarget Phospholipid membranetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00031551	Evaluation of Efficacy and Mechanisms of an Antiinflammatory Intervention for Chemotherapy Related Mucosal Injury	Etanercept	treatment	2	terminated
NCT05878405	Methylene Blue Mouthwash for the Treatment of Oral Mucositis Pain in Patients with Cancer	No drug interventions	supportive_care	3	recruiting
NCT05010928	Using Tea-based Mouthwash Relieve Stomatitis and Oral Ulcers	No drug interventions	treatment	2	not_yet_recruiting
NCT02945878	Predictive Factors of Acute Oral Mucositis Induced by Chemo-radiotherapy for Local Advanced Nasopharyngeal Carcinoma	No drug interventions	Not Available	Not Available	unknown_status
NCT00385515	Efficacy of SNX-1012 in the Treatment of Oral Mucositis	Meclocycline	treatment	2	completed
NCT01092975	Safety of Phenylephrine for Oral Mucositis Prevention	Phenylephrine	supportive_care	1	terminated
NCT02531906	Gabapentin, Methadone Hydrochloride, and Oxycodone Hydrochloride in Improving Quality of Life in Patients With Stage II-IV Head and Neck Cancer During Chemoradiation	Gabapentin Methadone Oxycodone	supportive_care	1	completed
NCT02735317	Efficacy and Safety of FORRAD® for the Management of Radiation-induced Mucositis in Patients With Nasopharyngeal Carcinoma Receiving IMRT	Cyanocobalamin Dexamethasone Gentamicin Procaine	treatment	2	unknown_status
NCT02407834	Effectiveness of Hygiene Solutions on Denture Biofilm	No drug interventions	supportive_care	4	completed
NCT00104065	Safety and Efficacy of CG53135-05 in the Prevention of Oral Mucositis in Patients Receiving Bone Marrow Transplant	Velafermin	prevention	2	completed
NCT01099891	The Clinical Study for Evaluation of Efficacy and Safety of EGF on Oral Mucositis in Radiation Therapy Patients	Nepidermin	treatment	3	unknown_status
NCT01837446	Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer	Aluminum hydroxide Diphenhydramine Lidocaine Morphine	treatment	2 / 3	completed
NCT00075023	Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related Stomatitis	Thalidomide	treatment	2	terminated
NCT03469284	MOM's PAIN (Methylene Blue for Oral Mucositis' PAIN)	Chloride ion Methylene blue	treatment	2	completed
NCT06071637	Low Power Laser Therapy As Prevention Of Oral Mucositis And Oropharyngeal Pain In Patients Undergoing Allogenetic HSCT	No drug interventions	prevention	3	recruiting
NCT02326675	Cryotherapy in the Prevention of Chemotherapy-Induced Mucositis in Stem Cell Transplant	No drug interventions	supportive_care	Not Available	terminated
NCT02229136	Miracle Mouthwash Plus Hydrocortisone vs Prednisolone Mouth Rinse for Mouth Sores Caused by Everolimus	Hydrocortisone Prednisolone acetate Prednisolone phosphate	supportive_care	2	completed
NCT00323518	A Phase II Controlled Trial of Velafermin for Prevention of Oral Mucositis	Velafermin	prevention	2	completed
NCT02762019	Laser for Oral Mucositis in Pediatric Onco-hematology	No drug interventions	treatment	3	completed
NCT00051441	Safety & Efficacy Study of Benzydamine Oral Rinse for the Treatment of Oral Mucositis (Mouth Sores) Resulting From Radiation Therapy for Cancer of the Oral Cavity, Oropharynx, or Nasopharynx	Benzydamine	treatment	3	completed
NCT05323058	The Use of Tulsi Extract for The Management of Oral Mucositis in Head & Neck Cancer Patients Undergoing Radiotherapy	Benzydamine	treatment	2	unknown_status
NCT01288625	Prospective Study of Head and Neck Cancer Radiation Treatment With or Without Amifostine	Amifostine	supportive_care	4	withdrawn
NCT00041665	Recombinant Human Keratinocyte Growth Factor to Reduce Oral Mucositis in Hematologic Malignancy Patients Undergoing Peripheral Blood Stem Cell Transplantation After Radiation and High-dose Chemotherapy	No drug interventions	prevention	3	completed
NCT00101582	Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer	Cisplatin Palifermin	treatment	3	completed
NCT03200340	EC-18 for Oral Mucositis in Patients With Concomitant Chemoirradiation	Mosedipimod	treatment	2	completed
NCT00001812	A Randomized, Double-Blind, Placebo Controlled Trial Evaluating the Impact of Nystatin on the Development of Oral Irritation in Patients Receiving High Dose Intravenous Interleukin-2	Nystatin	treatment	3	completed
NCT03778008	Recombinant Bovine Basic Fibroblast Growth Factor for the Treatment of Radiation Induced Oral Mucositis	Basic Fibroblast Growth Factor Cyanocobalamin Dexamethasone Gentamicin Lidocaine	treatment	2	unknown_status