Emphysema (DBCOND0019688)

Identifiers

Synonyms
Emphysema (morphologic abnormality) / Emphysema, unspecified / Pneumonectasis / Pulmonary Emphysema / Pulmonary emphysema (disorder) / Emphysema pulmonary

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Albuterol
A beta-2 adrenergic receptor agonist used to treat asthma, bronchitis, COPD, as well as prevent exercise induced bronchospasms.
Alpha-1-proteinase inhibitor
A purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency.
Bambuterol
A long acting beta2-adrenoceptor agonist for the management of lung diseases associated with bronchospasm.
Carbocisteine
A expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity.
Carmoterol
A long acting beta-2 agonist indicated in the treatment of COPD, asthma, and chronic bronchitis.
Dyphylline
A theophylline derivative used to treat asthma, bronchospasm, and COPD.
Fluticasone propionate
A glucocorticoid used to treat asthma, inflammatory pruritic dermatoses, and nonallergic rhinitis.
Glycopyrronium
An anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.
Guaifenesin
An expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.
Ipratropium
An anticholinergic drug used in the control of symptoms related to bronchospasm in chronic obstructive pulmonary disease (COPD).
Procaterol
A beta-2 adrenergic receptor agonist and bronchodilator used for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Terbutaline
A beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor.
Theophylline
A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.
Tiotropium
A long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00307281
Emphysema Research Registry and Biosample RepositoryNo drug interventionsNot AvailableNot Availablerecruiting
NCT04559464
Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT)No drug interventionstreatmentNot Availablecompleted
NCT06655428
The REDUCE EU Study - Endobronchial Thermal Liquid Ablation (ETLA) for the Treatment of EmphysemaNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05567562
Anti-Platelets in Chronic Obstructive Pulmonary Diseaseother2recruiting
NCT02748798
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disordersdiagnostic0terminated
NCT06528418
Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled BreathNo drug interventionsNot AvailableNot Availablerecruiting
NCT06533371
Clinical-ultrasonographic Assessment of Pulmonary EmphysemaNo drug interventionsdiagnosticNot Availablerecruiting
NCT00288964
Use of the Hattler Respiratory Assist Catheter in Severe Respiratory FailureNo drug interventionsNot Available3withdrawn
NCT00974064
The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01920321
Bronchoscopic Thermal Saline Ablation (BTSA) of Emphysematous Lung. A New Emphysema TherapyNo drug interventionstreatment1 / 2unknown_status
NCT01077102
Eccentric Exercise Training as Novel Rehabilitation for Chronic Obstructive Pulmonary Disease (COPD)No drug interventionstreatmentNot Availablecompleted
NCT00298402
Macrophages in Smokers' LungNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01615484
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant SuitabilityNo drug interventionstreatmentNot Availablecompleted
NCT01361984
Sunovion Brovana Versus Serevent Inspiratory Capacity High Resolution Computed Tomographytreatment4unknown_status
NCT00005279
Tucson Epidemiology Study of Chronic Obstructive Lung DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT04200079
Kingston Chronic Obstructive Pulmonary Disease (COPD) Multidimensional Long Term Follow up CohortNo drug interventionsNot AvailableNot Availablerecruiting
NCT01302587
A Study to Evaluate the Integrated Dose Counter on an Albuterol Hydrofluoroalkane (HFA) Metered Dose Inhaler (MDI)Not AvailableNot Availablecompleted
NCT00261833
Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiencytreatment4completed
NCT01908933
Study of the AeriSeal System Treatment in Patients With Advanced Non-Upper Lobe Predominant Heterogeneous EmphysemaNo drug interventionstreatment3withdrawn
NCT00675454
Evaluating the Effects of Surgical and Non-Surgical Treatment Options in People With EmphysemaNo drug interventionsNot AvailableNot Availableterminated
NCT03518177
Comparison of the Effectiveness of Home and Hospital-based PR in Candidate Patients With BLVRNo drug interventionstreatmentNot Availablecompleted
NCT01812447
Evaluation of the Spiration® Valve System for Emphysema to Improve Lung FunctionNo drug interventionstreatmentNot Availablecompleted
NCT02713347
Advancing Symptom Alleviation With Palliative TreatmentNo drug interventionshealth_services_researchNot Availablecompleted
NCT03837847
Mechanistic Effects of Health Coaching to Reduce Chronic Obstructive Pulmonary Disease (COPD) HospitalizationsNo drug interventionstreatmentNot Availablecompleted
NCT00413205
TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist)No drug interventionstreatment2completed
NCT02687997
Prevalence of Sleep Disordered Breathing in a Lung Cancer Screening CohortNo drug interventionsdiagnosticNot Availablecompleted
NCT05825261
Exploring Novel Biomarkers for Emphysema DetectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT01744093
Doxycycline for COPD in HIV-Infected PatientstreatmentNot Availablecompleted
NCT00843271
Endothelial Dysfunction, Biomarkers, and Lung Function -Ancillary to MESANo drug interventionsNot AvailableNot Availableunknown_status
NCT04786171
4D Medical X-ray Velocimetry for Bronchoscopic Lung Volume Reduction TargetingNo drug interventionsNot AvailableNot Availablecompleted
NCT01217671
International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysematreatment2 / 3completed
NCT03111888
Evaluating the Clinical Effectiveness of 3D Printing for a Patient-specific Silicone Stent Airway ImplantNo drug interventionssupportive_careNot Availablewithdrawn
NCT01334307
Randomized Comparison of the RePneu Lung Volume Reduction Coil (LVRC) to Standard of Care for the Treatment of Emphysema (RESET Study)No drug interventionstreatment1completed
NCT00670007
Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.treatment4completed
NCT00137956
Endobronchial Valve for Emphysema PalliatioN Trial (VENT) Cost-effectiveness Sub-StudyNo drug interventionstreatment3terminated
NCT00104637
Sildenafil for Chronic Obstructive Pulmonary Diseasetreatment2completed
NCT05330637
Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.No drug interventionsNot AvailableNot Availablerecruiting
NCT02895152
Activity Monitor Use in COPD Patients Undergoing RehabilitationNo drug interventionsotherNot Availablecompleted
NCT02935452
Implementing and Evaluating the Genie Tool in COPDNo drug interventionssupportive_careNot Availablecompleted
NCT00650559
Thorax Enlarging Surgery: a Novel Surgical Approach to EmphysemaNo drug interventionstreatmentNot Availableterminated
NCT02877459
Clinical Investigation of a Modified Staged Treatment Algorithm Using the AeriSeal SystemNo drug interventionstreatmentNot Availablecompleted
NCT04467242
Right Ventricular Diastolic DysfunctionNo drug interventionsNot AvailableNot Availableunknown_status
NCT01328899
Feasibility Study of PneumRx's Lung Volume Reduction Coil (LVRC)No drug interventionstreatment1 / 2completed
NCT00000606
National Emphysema Treatment Trial (NETT)No drug interventionstreatment3completed
NCT03382106
Smoking Cessation and Functional CT Assessmentbasic_science4recruiting
NCT02273349
Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin DeficiencyNo drug interventionstreatmentNot Availablewithdrawn
NCT03010449
LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial ValvesNo drug interventionstreatmentNot Availableunknown_status
NCT02232841
Electrical Impedance Imaging of Patients on Mechanical VentilationNo drug interventionsNot AvailableNot Availablecompleted
NCT05087641
A Multicenter, Prospective Trial of the IAB in Adults Suffering From COPD/EmphysemaNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT00680641
Simvastatin in Chronic Obstructive Pulmonary Disease (COPD)treatment4unknown_status
NCT00005717
Medication Adherence in COPD--A Self-Regulation StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01719263
Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) StudyNo drug interventionstreatmentNot Availablecompleted
NCT00188825
Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplanttreatment3completed
NCT01431625
Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Obstructive Chronic Pulmonary Disease (COPD) PhenotypeNo drug interventionstreatment4unknown_status
NCT03263130
Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD OverlapNo drug interventionsNot AvailableNot Availablerecruiting
NCT00145548
Pilot Study of the Spiration IBV™ SystemNo drug interventionstreatment2completed
NCT00870857
Prevalence and Pathogenesis of Lung Disease in a Large HIV Cohort-coordinating CenterNo drug interventionsNot AvailableNot Availablecompleted
NCT00720226
Efficacy of Losartan in Preventing Progression of COPDtreatment4completed
NCT03008226
Spiration Valve System 9 mm European Post Market Evaluation StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT03010566
Lung Volume Reduction Coil Microbiome StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT06349174
Safety and Efficacy of Endobronchial Valve for Bronchoscopic Lung Volume Reduction Surgery: A Prospective Pilot StudyNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03114020
Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiencytreatment2completed
NCT00757120
Biomarkers and Genetic Factors Related to EmphysemaNo drug interventionsNot AvailableNot Availablecompleted
NCT04537182
Surgical Compared to Bronchoscopic Lung Volume Reduction in Patients With Severe EmphysemaNo drug interventionstreatmentNot Availablerecruiting
NCT04735731
Assessing the DIAphragM Before ANd After Endobronchial Valve TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT00000573
Emphysema: Physiologic Effects of Nutritional SupportNo drug interventionsNot Available2completed
NCT04435327
Lung Damage Caused by SARS-CoV-2 Pneumonia (COVID-19)No drug interventionsNot AvailableNot Availablecompleted
NCT00823927
Alveolar Macrophage Proteomics in HIV-associated EmphysemaNo drug interventionsNot AvailableNot Availablecompleted
NCT03673176
Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation TherapyNo drug interventionstreatmentNot Availablecompleted
NCT00633776
Perforomist Versus Foradil Evaluated by Inspiratory Capacity and High Resolution Computed Tomography (HRCT)treatment4withdrawn
NCT02042976
Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary DiseaseNo drug interventionssupportive_careNot Availablecompleted
NCT04930289
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03010592
Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPDNo drug interventionsNot AvailableNot Availableunknown_status
NCT00005292
Alpha1-antitrypsin Deficiency RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT01796392
Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)No drug interventionstreatmentNot Availablecompleted
NCT00570544
Tiotropium Induced Bronchodilation in Lung CT Scored EmphysemaNot AvailableNot Availablecompleted
NCT01969344
Study of COPD Subgroups and BiomarkersNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00528944
Single-Breath Measurement Underestimates Ventilatory Volume According to Emphysema SeverityNo drug interventionsNot AvailableNot Availablecompleted
NCT05550844
EMPHYSEMA AND FLNA MUTATIONNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00869544
Pneumocystis in Pathogenesis of HIV-associated EmphysemaNo drug interventionsNot AvailableNot Availablecompleted
NCT01528267
Bronchoscopic Lung Volume Reduction Using BloodNo drug interventionstreatment2completed
NCT02835001
Hyperinflation Assessment After Treatment by Lung Volume Reduction CoilNo drug interventionstreatmentNot Availableterminated
NCT03653104
Melodica Orchestra for Dyspnea: Safety and Feasibility PilotNo drug interventionstreatmentNot Availablewithdrawn
NCT02898272
SCCOR Minorities Observational StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02627872
Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary DiseaseNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04302272
STRIVE Post-Market Registry StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT01305668
Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD) Patients With EmphysemaNo drug interventionsNot AvailableNot Availablecompleted
NCT00147069
Leukocyte Function in Asthma and COPDNo drug interventionsNot AvailableNot Availablecompleted
NCT00034112
Efficacy of Osteopathic Manipulation in Chronic Obstructive Pulmonary DiseaseNo drug interventionstreatment2completed
NCT01102712
Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume ReductionNo drug interventionstreatmentNot Availablecompleted
NCT01949181
Blood, Hair and Lung Concentrations of Metals and Metalloids in Patients With Lung Cancer or Chronic Obstructive Pulmonary DiseaseNo drug interventionsbasic_scienceNot Availablecompleted
NCT00147095
Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04742114
Effect of EPAP Device on Emphysema and Lung BullaeNo drug interventionspreventionNot Availableunknown_status
NCT02399514
Improvement of Sleep Quality by RePneu® Coils in Advanced Pulmonary EmphysemaNo drug interventionsbasic_scienceNot Availablecompleted
NCT05610514
Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke CigarettesNo drug interventionsbasic_science2completed
NCT01758055
Safety Study of Endobronchial Transplantation of Autologous Mesenchymal Stem Cells (MSCs) in Emphysema PatientsNo drug interventionstreatment1unknown_status
NCT00129350
Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary RehabilitationNo drug interventionstreatment1unknown_status
NCT00005123
Honolulu Heart ProgramNo drug interventionsNot AvailableNot Availablecompleted
NCT05382208
Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)treatment2recruiting
NCT02838108
The Relationship Between GOLD Risk Group and Clinical Outcomes in a Community-based COPD CohortNo drug interventionsNot AvailableNot Availableterminated
NCT01220908
Evaluation of the PneumRx Lung Volume Reduction Coil to Treat EmphysemaNo drug interventionstreatmentNot Availablecompleted
NCT01213043
Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiencytreatment2completed
NCT01608490
Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) StudyNo drug interventionstreatmentNot Availableterminated
NCT02696564
Losartan Effects on Emphysema Progressiontreatment4completed
NCT00608764
Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00000621
Feasibility of Retinoic Acid Treatment in Emphysema (FORTE)treatment2completed
NCT03657121
Mortality and Symptom Burden Post Hospitalisation With COPDNo drug interventionsNot AvailableNot Availablecompleted
NCT03049202
BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioImage StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT00064402
Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPDtreatment3completed
NCT00129584
Endobronchial Valve for Emphysema Palliation Trial (VENT)No drug interventionstreatment3completed
NCT00250679
Safety and Efficacy of Arformoterol Tartrate Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Diseasetreatment3completed
NCT00233051
Evaluating Genes in Sputum to Measure Drug Response in COPDtreatmentNot Availableterminated
NCT03636347
A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.treatment2completed
NCT03836547
Feasibility of a Multi Component Intervention in Patients With Severe Dyspnea and ObesityNo drug interventionstreatmentNot Availablecompleted
NCT02682147
Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysemabasic_science4recruiting
NCT03073798
The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitistreatment4completed
NCT00224198
Evaluation of the Lungs of Individuals With Lung DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00406705
The Effect of Breathing Helium-Hyperoxia During Pulmonary Rehabilitation in Patients With COPDNo drug interventionstreatment2completed
NCT01336283
Effectiveness of Different Exercise Training Programs to the Profile of COPD PatientsNo drug interventionstreatment4completed
NCT00395083
Bronchitis and Emphysema Advice and Training to Reduce HospitalizationNo drug interventionsprevention2terminated
NCT02439528
Genetics of the Combined Pulmonary Fibrosis and Emphysema SyndromeNo drug interventionsotherNot Availableunknown_status
NCT00424528
Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructive Pulmonary Disease (COPD)treatment4completed
NCT04932811
The Lung Microbiome and Endobronchial Valve TreatmentNo drug interventionsNot AvailableNot Availablerecruiting
NCT04761393
Characterizing Matrix Metalloproteinase-12 (MMP12) in SputumNo drug interventionsNot AvailableNot Availablerecruiting
NCT03474471
A Trial on the Effects of Bronchoscopic Lung Volume Reduction in Severe Emphysema.No drug interventionstreatmentNot Availablecompleted
NCT00475007
Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe EmphysemaNo drug interventionstreatmentNot Availablecompleted
NCT00181207
Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) ExacerbationNo drug interventionsprevention4completed
NCT00725309
Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00013156
Cost-Effectiveness of Lung Volume Reduction SurgeryNo drug interventionstreatment2completed
NCT06332885
Zephyr Valve Japan Post-Marketing SurveillanceNo drug interventionsNot AvailableNot Availablerecruiting
NCT02999685
Home-based Health Management of Chronic Obstructive Lung Disease (COPD) PatientsNo drug interventionstreatmentNot Availablecompleted
NCT01731015
Imaging Lung Function Using Oxygen Enhanced MRIdiagnostic1completed
NCT00064415
To Evaluate the Long-term Safety of (R,R)-Formoterol in Subjects With COPDtreatment3completed
NCT03008915
Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiencyother2completed
NCT00207337
Exhale (R) Stent for EmphysemaNo drug interventionstreatment2 / 3completed
NCT00373932
Real-Time Support for Exercise Persistence in COPDNo drug interventionsNot Available1 / 2completed
NCT02470052
A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the OL-BF-001 for Severe EmphysemaNo drug interventionstreatmentNot Availableterminated
NCT02100800
Assessment of Emphysema Using 1.5T MRI With UTE Pulse SequencesNo drug interventionsdiagnosticNot Availablecompleted
NCT06025500
Analysing Peripheral Skeletal Muscle Function Before and After Endobronchial Valve TreatmentNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03244059
Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodiestreatment2completed
NCT01449175
A Registry Study of the AeriSeal® System or Lung Volume Reduction in Patients With Advanced EmphysemaNo drug interventionsNot AvailableNot Availableterminated
NCT05204875
Functional Lung Imaging in Patients With Respiratory Compromise Undergoing Endobronchial Valve PlacementNo drug interventionsNot AvailableNot Availablerecruiting
NCT03733470
Hypoxic Pulmonary Vasoconstriction Pilot Studybasic_science4completed
NCT06003270
Biological Effects of Quercetin in COPD Phase IItreatment2recruiting
NCT02803242
COPD Patient-Powered Research NetworkNo drug interventionsNot AvailableNot Availablerecruiting
NCT06512142
Using Artificial Intelligence for the Detection of Respiratory Diseases Associated With PollutionNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT01241942
Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant SuitabilityNo drug interventionsdevice_feasibilityNot Availableterminated
NCT02099799
The Effect of Physical Activity Promotion on Short and Long-term Outcomes in COPDNo drug interventionstreatmentNot Availablecompleted
NCT01710449
Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With OxygenNo drug interventionsdiagnostic1completed
NCT02996149
Endoscopic Lung Volume Reduction Coil Treatment in Patients With Chronic Hypercapnic Respiratory FailureNo drug interventionsNot AvailableNot Availableterminated
NCT01806636
Post Market Observational, Prospective, Multi-center StudyNo drug interventionsNot AvailableNot Availableterminated
NCT01306513
Safety and Feasibility Study of Administration of Mesenchymal Stemcells for Treatment of Emphysematreatment1completed
NCT00147017
Regulation of the Release of Inflammatory Mediators From Lung Macrophages.No drug interventionsNot AvailableNot Availablecompleted
NCT00700934
Management of Patients With Alpha-1 Antitrypsin Deficiency Associated EmphysemaNo drug interventionsNot AvailableNot Availableunknown_status
NCT05897424
Open Label Extension Study of INBRX-101 in Adults With AATD Emphysematreatment2recruiting
NCT03360396
Study of PneumRx Endobronchial Coil System in Treatment of Subjects With Severe EmphysemaNo drug interventionstreatmentNot Availablecompleted
NCT02056158
HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary EndotheliumNo drug interventionsNot AvailableNot Availablecompleted
NCT01051258
AeriSeal System for Lung Volume ReductionNo drug interventionstreatment1 / 2completed
NCT01101958
A Study of the Use of Chartis System to Optimize Subject Selection for Endobronchial Lung Volume Reduction (ELVR)No drug interventionstreatmentNot Availablecompleted
NCT03455686
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung DiseaseNo drug interventionsbasic_scienceNot Availablerecruiting
NCT01041586
Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume ReductionNo drug interventionstreatment1completed
NCT03480386
Home Pulmonary Rehabilitation for COPDNo drug interventionssupportive_careNot Availablecompleted
NCT00785239
CryoSpray Ablation(tm)Thoracic Patient RegistryNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00018525
Lung Volume Reductions Surgery (LVRS) StudyNo drug interventionstreatmentNot Availablecompleted
NCT02059057
LVRC IDE Crossover Study (Crossover From IDE Trial CLN0009)No drug interventionstreatmentNot Availableterminated
NCT03685526
Cinenses Lung Volume Reduction Reverser System First-in-man Study Treating Patients With Severe EmphysemaNo drug interventionstreatmentNot Availableunknown_status
NCT00175565
Inhaled Steroid Reduces Systemic Inflammation in COPDtreatment4completed
NCT01229020
Distribution of Regional Lung Function by Vibration Response ImagingNo drug interventionsNot AvailableNot Availablecompleted
NCT01421082
Evaluation of Physiologic Parameters to Study the Mechanism of Action of the Lung Volume Reduction Coil in Subjects With Homogeneous EmphysemaNo drug interventionstreatment2 / 3completed
NCT00147082
Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD)No drug interventionsNot AvailableNot Availablecompleted
NCT05856331
Study of INBRX-101 Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysematreatment2recruiting
NCT02012673
A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System.No drug interventionstreatmentNot Availablecompleted
NCT02879773
Computed Tomography Assessment of Regional Ventilation (CURVE)No drug interventionsNot AvailableNot Availablecompleted
NCT02238327
Longitudinal Evaluation of HIV-associated Lung Disease PhenotypesNo drug interventionsNot AvailableNot Availablecompleted
NCT02810327
Alpha-1 Carrier Genomics StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02006576
Prostaglandin Inhibition for Emphysematreatment2completed
NCT00613860
Sequential Endoscopic Lung Volume ReductionNo drug interventionstreatment3withdrawn
NCT00523094
Vibration Response Imaging (VRI) in Patients That Are Candidates for Undergoing Pulmonary Operation ProcedureNo drug interventionsNot AvailableNot Availablesuspended
NCT00001462
Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient IndividualsNo drug interventionsNot AvailableNot Availablecompleted
NCT02008162
Bronchoreversibility and Radiologic Morphology of EmphysemaNot AvailableNot Availableunknown_status
NCT00106080
Improving the Quality of End-of-Life Communication for Patients With Chronic Obstructive Pulmonary Disease (COPD)No drug interventionsotherNot Availablecompleted
NCT03814980
A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD PatientsNo drug interventionstreatmentNot Availablecompleted
NCT02499380
Changes in Lung Physiology and Cardiac Performance in Patients With Emphysema Post Bilateral RePneu Coil TreatmentNo drug interventionsNot AvailableNot Availableterminated
NCT00298389
Macrophage Phagocytosis in COPDNo drug interventionsNot AvailableNot Availablecompleted
NCT04347044
The Effect of Pulmonary Rehabilitation on Bronchoscopic Volume Reduction Process SuccessNo drug interventionstreatmentNot Availablecompleted
NCT02914340
REACH SVS Control Patient Cross-Over StudyNo drug interventionstreatmentNot Availablecompleted
NCT01121367
Study on Phenotypic Characterization of Combined Pulmonary Fibrosis and EmphysemaNo drug interventionsNot AvailableNot Availablecompleted
NCT00730301
EUROPT Clinical Trial to Study the Efficacy of One-Way Valve Implantation (New Treatment Algorithm) in Patients With Heterogeneous EmphysemaNo drug interventionstreatment4unknown_status
NCT01326572
Lung HIV Disease in a Large Cohort-PittNo drug interventionsNot AvailableNot Availablecompleted
NCT05118269
A Randomized Controlled Trial of InterVapor® in France - The TARGET TrialNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04186546
Zephyr Valve Registry (ZEVR)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01466712
Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Functiondiagnostic4unknown_status
NCT00391612
EASE Trial: Exhale Airway Stents for EmphysemaNo drug interventionstreatment3unknown_status
NCT01476995
Prognostic Indicators as Provided by the EPIC ClearViewNo drug interventionsNot AvailableNot Availablecompleted
NCT01822795
Lung Volume Reduction Coil Treatment in Emphysema.No drug interventionstreatment3unknown_status
NCT01682850
Pulmonary Rehabilitation Before Lung Cancer ResectionNo drug interventionssupportive_careNot Availablecompleted
NCT02823223
Endobronchial Valve in Patients With Heterogeneous EmphysemaNo drug interventionstreatmentNot Availableunknown_status
NCT01953523
Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary ConditionsNo drug interventionstreatmentNot Availablecompleted
NCT01602523
Effect of Symbicort on Sleep Quality in Patients With Emphysematreatment3unknown_status
NCT04256408
Mind The Gap - Crossing Borders StudyNo drug interventionstreatmentNot Availablecompleted