Pityriasis versicolor (DBCOND0021492)

Identifiers

Synonyms

Tinea versicolour / Tinea Versicolor / Pityriasis Versicolor / Pityriasis versicolour / Pityriasis versicolor (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amorolfine	A morpholine derivative commonly applied as a lacquer for onychomycosis but is also used for superficial dermatomycosis.	No drug targets
Butenafine	A topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis.	Squalene monooxygenasetarget Squalene monooxygenasetarget
Ciclopirox	A broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients.	Sodium/potassium-transporting ATPase subunit alpha-1target
Clotrimazole	A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.	Intermediate conductance calcium-activated potassium channel protein 4target Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A7enzyme Lanosterol 14-alpha demethylasetarget Nuclear receptor subfamily 1 group I member 2target Hydroxycarboxylic acid receptor 2target Bile salt export pumptransporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Ergosteroltarget C-X-C chemokine receptor type 2target
Econazole	A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.	Aromataseenzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Lanosterol 14-alpha demethylasetarget Nuclear receptor subfamily 1 group I member 2target
Fenticonazole	An imidazole antifungal used to treat a variety of topical fungal infections.	No drug targets
Flutrimazole	A topical antifungal used to treat pityriasis capitis and seborrheic dermatitis.	No drug targets
Miconazole	An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.	Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Lanosterol 14-alpha demethylasetarget Nitric oxide synthase 3target Nitric oxide synthase, inducibletarget Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2E1enzyme Nuclear receptor subfamily 1 group I member 2target Lanosterol 14-alpha demethylaseenzyme Aromataseenzyme Calcium-activated potassium channeltarget Voltage-gated Potassium Channelstarget Inward rectifier potassium channeltarget Voltage gated L-type calcium channeltarget Albumincarrier Cytochrome P450 2C8enzyme
Oxiconazole	A topical antifungal used to treat a variety of dermatophyte infections.	Lanosterol 14-alpha demethylasetarget Lanosterol synthasetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Nuclear receptor subfamily 1 group I member 2target
Selenium Sulfide	An antifungal used to treat dandruff, seborrheic dermatitis of the scalp, and tinea capitis.	No drug targets
Sulconazole	A topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains.	Cytochrome P450 1A2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Lanosterol 14-alpha demethylasetarget
Terbinafine	An allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections.	Squalene monooxygenasetarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Prostaglandin G/H synthase 1enzyme Albumincarrier alpha1-acid glycoproteincarrier ABC multidrug transporter MDR2transporter Squalene monooxygenasetarget
Tolnaftate	An antifungal agent used to treat various skin infections caused by fungi.	Squalene monooxygenasetarget Squalene monooxygenasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00830388	Ketoconazole Foam 2% for the Treatment of Versicolor	Ketoconazole	treatment	4	completed
NCT04937920	A Trial to Evaluate the Safety and Antimicrobial Efficacy of DBI-002 Probiotic in Adults With Tinea Versicolor	Bifidobacterium longum Lactobacillus acidophilus	treatment	2	completed
NCT05862714	Comparison of Efficacy of Single Oral Dose Fluconazole and Itraconazole in Patients With Pityriasis Versicolor	Fluconazole Itraconazole	treatment	1	completed
NCT06305637	A Study Comparing Ketoconazole Shampoo, 2% and Ketoconazole 2% Shampoo (RS) in the Treatment of Tinea Versicolor.	Ketoconazole	treatment	1	completed
NCT04110834	Clinical Assessment of Itraconazole Self Nano Emulsifying Drug Delivery System Intermediate Gel	Itraconazole	treatment	2	completed
NCT04110860	Clinical Assessment of Voriconazole Self Nano Emulsifying Drug Delivery System Intermediate Gel	Voriconazole	treatment	2	completed
NCT05730244	A Study of the Clinical Efficacy and Safety of 100% Cassia Alata Extract Against Tinea Versicolor	No drug interventions	treatment	1	not_yet_recruiting
NCT06170333	8% Sulphur-Aloe Vera Soap as an Adjuvant Treatment for Pityriasis Versicolor	No drug interventions	treatment	4	completed
NCT04007237	The Comparative Assessment of Mycological Efficacy, Safety, Recurrence, and Cost-effectiveness of Selenium Sulfide 1.8% Shampoo Versus Ketoconazole 2% Shampoo in Pityriasis Versicolor: a Double-blind Randomized Controlled Trial	No drug interventions	treatment	4	completed