Major Depressive Disorder (MDD) (DBCOND0030181)

Identifiers

Synonyms
Major Depressive Disorder - MDD / Major Depressive Disorder (MDD / Depressive Disorder, Major Depressive Disorder / Depression; Major Depressive Disorder / Major Depression / Depressive Disorder, Major / Major Depressive Disorder / Disorder, Major Depressive / Major Depressive Disorders / MDD / Depression - Major Depressive Disorder / Major Depressive Disorder(MDD) / Major depressive disorder NOS / Major Depressive Disorder 1 / Major depressive disorder, single episode, unspecified / Major depressive illness / Major depressive disorder (disorder) / Feeling down / Mood depression / Mood depressions / Depressed mood / Depressive disorder (disorder) / Low mood / Feeling blue / Dysthymic disorder / Depression, unspecified / Depressive illness / Dysthymia (disorder) / Depressive neurosis / Depressive disorder / Depressive disorders

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Ademetionine
S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as...
Amitriptyline
A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
Aripiprazole
An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.
Brexpiprazole
A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct, schizophrenia, and agitation associated with dementia due to Alzheimer’s disease.
Bupropion
A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation.
Citalopram
A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression.
Desvenlafaxine
An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults.
Dextromethorphan
An NMDA receptor antagonist used to treat cases of dry cough.
Duloxetine
A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence.
Escitalopram
A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD).
Esketamine
A NMDA receptor antagonist used for treatment-resistant depression.
Fluoxetine
A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.
Fluvoxamine
A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder.
Gepirone
A serotonin receptor agonist used to treat major depressive disorder in adults
Levomilnacipran
A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD) in adults.
Maprotiline
A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression.
Mirtazapine
A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
Moclobemide
A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder.
Modafinil
A stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder.
Nortriptyline
A tricyclic antidepressant used in the treatment of depression.
Paroxetine
A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder.
Quetiapine
An atypical antipsychotic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder.
Reboxetine
A drug used for the acute treatment of major depression and for maintenance therapy of depression.
Selegiline
A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's.
Sertraline
A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions.
Tianeptine
An atypical tricyclic antidepressant with antidepressant and anxiolytic effects primarily used to treat major depressive disorder.
Trazodone
A serotonin uptake inhibitor used to treat major depressive disorder.
Venlafaxine
A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression, generalized or social anxiety disorder, and panic disorder.
Vilazodone
An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors.
Vortioxetine
A serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD).
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06467474
Psychoeducational Group for DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT05416762
Single Dose Study to Evaluate Dose-proportionality of Vortioxetine Hemihydrobromide Orally Disintegrating TabletsNo drug interventionstreatment1completed
NCT05745194
Influence of Nutrition in Depression Treatment (INDEPT)No drug interventionstreatmentNot Availablerecruiting
NCT00669110
Study Evaluating Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR) In The Treatment Of Child and Adolescent Outpatients With Major Depressive Disordertreatment2completed
NCT04350567
Sleep/Wake Cycle and Depression: An Imaging and Treatment StudyNo drug interventionstreatmentNot Availablerecruiting
NCT06384521
Lifestyle MIND- Feasibility of Wait-list ControlNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT02434393
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression ProjectNo drug interventionsNot AvailableNot Availablerecruiting
NCT05669703
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar DisorderNo drug interventionsNot AvailableNot Availablerecruiting
NCT06614842
Common Factors Group Psychotherapy for General Mental Health ConcernsNo drug interventionstreatment0not_yet_recruiting
NCT00419003
Research Study for Major Depressive Disorder: Investigation of Glutamate Medicationstreatment4completed
NCT03492203
Remote Cognitive Remediation for DepressionNo drug interventionstreatmentNot Availableunknown_status
NCT01313403
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive DisorderNo drug interventionsotherNot Availablewithdrawn
NCT01778790
Deep Brain Stimulation of the Superolateral Branch of the Medial Forebrain Bundle (slMFB) for the Treatment of Refractory Major DepressionNo drug interventionstreatment2completed
NCT01738464
Microbiomes of Pelvic PainNo drug interventionsNot AvailableNot Availablecompleted
NCT01492621
Effect of Antidepressants on White Matter Structurebasic_science4unknown_status
NCT01391221
Inflammatory Markers and Cognitive Function in Major Depressionbasic_science4unknown_status
NCT00460902
Evaluation of the Deep TMS H-Coil in the Treatment of Major Depression- Augmentation of Antidepressant MedicationNo drug interventionstreatment1 / 2completed
NCT05257902
Clinical Effectiveness of Choline Alphoscerate for Older Adults With Major Depression and Subjective Memory ComplaintstreatmentNot Availablenot_yet_recruiting
NCT00208702
Thyroid Medication and Antidepressants for Treating Major Depressiontreatment4completed
NCT02931487
Restoring Emotion Regulation Networks in Depression VulnerabilityNo drug interventionspreventionNot Availablecompleted
NCT03039387
Effects of tDCS on Cognitive Control and Emotion Regulation in Depressed PatientsNo drug interventionsbasic_scienceNot Availableunknown_status
NCT02622633
Epidural Stimulation for Resistant Depression TreatmentNo drug interventionstreatment2unknown_status
NCT02872454
Psychotherapeutic Text Messaging for Depression Pilot StudyNo drug interventionssupportive_careNot Availablecompleted
NCT00977353
N-methylglycine (Sarcosine) Treatment for Depressiontreatment2completed
NCT01962753
Depression in the Elderly and Cerebral Amyloid Plaques: Characterization by [18F] AV-45 Affectives Symptoms and Amyloïd Plaques (ASAP)diagnosticNot Availablecompleted
NCT00322777
Spirituality Teaching Program for Depressed AdultsNo drug interventionstreatmentNot Availablecompleted
NCT02476877
A Pilot, Proof-of-concept Cohort Study of the Prevalence of Comorbid Mental Illness and Substance AbuseNo drug interventionsNot AvailableNot Availablecompleted
NCT02238977
Bupropion for Depression in ESRD Patients on Hemodialysistreatment4terminated
NCT00174577
Risperidone Augmentation Therapy in Patients Who Have Failed or Only Partially Responded to a Trial of Antidepressanttreatment3unknown_status
NCT00295347
Mineralocorticoid Receptor in the Treatment of Severe DepressiontreatmentNot Availablecompleted
NCT01811147
Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRIdiagnostic4completed
NCT00650897
Efficacy Study of Escitalopram for Depression in Patients With Diabetestreatment4unknown_status
NCT00119028
Expanding and Testing VA Collaborative Care Models for DepressionNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01208428
Cognitive Behavioral Treatments for Depression in Chronic IllnessNo drug interventionstreatmentNot Availablecompleted
NCT01803711
Omega 3 FA Supplements as Augmentation in the Treatment of Depressiontreatment2 / 3terminated
NCT00619411
Interpersonal Psychotherapy for Depressed Adolescents and ParentsNo drug interventionstreatment1completed
NCT01244711
Open-Label Pilot Study to Examine the Value of Substituting Quetiapine for Benzodiazepinestreatment4terminated
NCT01754493
Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depressiontreatment4completed
NCT01556971
Efficacy Study of Botox for Depressiontreatment4unknown_status
NCT02520271
Ostrobothnia Depression Study (ODS). A Naturalistic Follow-up Study on Depression and Related Substance Use DisordersNo drug interventionshealth_services_researchNot Availablecompleted
NCT01830088
Family Based Treatment of Depressed Adolescents (AHUS)No drug interventionstreatmentNot Availableterminated
NCT00086307
Lexapro and Pramipexole and to Treat Major Depressiontreatment2completed
NCT01021709
Trial of Transcranial Direct Current Stimulation (tDCS) Using Alternative Electrode MontagesNo drug interventionstreatment2completed
NCT02484456
Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive DisorderNo drug interventionstreatment2completed
NCT03015285
CBT for Anxiety Sensitivity vs. Disorder-specific CBT: An RCTNo drug interventionstreatmentNot Availablecompleted
NCT00437385
Evaluation of Three Continuation Therapies After ECT Concerning Efficacy and Cognition in Severly Depressed Patientstreatment1completed
NCT04489485
Online System for Identifying and Addressing Teen Depression in Primary CareNo drug interventionsNot AvailableNot Availableunknown_status
NCT05551585
Transcranial Pulse Stimulation for DepressionNo drug interventionsbasic_scienceNot Availablerecruiting
NCT00208715
Provigil in Conjunction With SSRIs for the Treatment of Mild or Moderate Depression With Attendant Symptoms of Sleepiness and Fatigue.treatment4completed
NCT02237937
Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 GeneNot Available4unknown_status
NCT00711737
Study of the Changes in Metabolic Parameters in Patients Treated With Escitalopram for Six MonthsNo drug interventionsNot AvailableNot Availablecompleted
NCT01768052
Functional Brain Imaging Study of Response to Repetitive TMS (rTMS) Treatment of Major DepressionNo drug interventionsNot AvailableNot Availableunknown_status
NCT00695552
The Effect of Exercise on Depressive Symptoms in Unmedicated PatientsNo drug interventionstreatmentNot Availableterminated
NCT00765752
Cortical GABA Concentrations in InsomniaNo drug interventionsNot AvailableNot Availablecompleted
NCT00576875
Duke Conte Center for the Neuroscience of Depression in Late LifeNo drug interventionsNot AvailableNot Availablecompleted
NCT00088699
Rapid Antidepressant Effects of Ketamine in Major Depressionother1 / 2completed
NCT02439099
Retinoic Acid Homeostasis in Neuropsychiatric DiseasesNo drug interventionsNot AvailableNot Availableunknown_status
NCT00595699
Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsytreatment4completed
NCT00825799
Serum Markers as a Bioassay for Unipolar DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT02845349
Vortioxetine for the Treatment of Major Depression and Co-morbidities After Traumatic Brain Injury (TBI)treatment3withdrawn
NCT02507349
Person-Centered Versus Measurement-Based Care in Mental HealthNo drug interventionstreatmentNot Availablecompleted
NCT02894736
Home-Administered Trial of Direct Current StimulationNo drug interventionstreatmentNot Availablecompleted
NCT01926613
Thinking Skills for Work in Severe Mental IllnessNo drug interventionstreatmentNot Availablecompleted
NCT03913013
Technology Enhanced Family TreatmentNo drug interventionstreatment1 / 2completed
NCT02855918
Blood Biomarkers in Suicidal BehaviourNo drug interventionsotherNot Availablecompleted
NCT00699218
A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Bipolar DepressionNo drug interventionsdevice_feasibilityNot Availablecompleted
NCT01178424
My Depression Wellness Toolkit StudyNo drug interventionstreatmentNot Availablecompleted
NCT01244724
Lexapro for Major Depression in Patients With Epilepsytreatment4terminated
NCT02143024
A Family-based Primary Care Intervention to Enhance Older Men's Depression CareNo drug interventionstreatmentNot Availablecompleted
NCT02520024
Assessing the Impact of Self-directed Care, Within a Medicaid-funded Environment,on Participation and Community LivingNo drug interventionsNot AvailableNot Availablecompleted
NCT03623724
iCare4Depression: Effectiveness of a Blended Cognitive-Behavioral Therapy in Routine PracticeNo drug interventionstreatmentNot Availableunknown_status
NCT00675896
A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrometreatment4completed
NCT01135758
Study of Depression-Ketamine-Brain Functiontreatment2terminated
NCT00605358
Increasing Use of Mental Health ServicesNo drug interventionssupportive_careNot Availablecompleted
NCT00238758
A Study of Omega-3 as a Treatment for Major Depressiontreatment2unknown_status
NCT02653235
Impact of Immune Challenge on Triple Network Connectivity in HumansNo drug interventionsbasic_scienceNot Availableunknown_status
NCT01095263
Effects of Deep Brain Stimulation in Treatment Resistant Major DepressionNo drug interventionstreatment1completed
NCT05097586
RCT of At-Home tDCS for Depression in PregnancyNo drug interventionstreatmentNot Availablerecruiting
NCT01683539
Understanding How Cognitive Remediation WorksNo drug interventionstreatmentNot Availablecompleted
NCT00510822
Cimicoxib for the Treatment of Major Depression (SECIM)treatment2completed
NCT01884025
Get Moving and Get Well - Pilot StudyNo drug interventionstreatmentNot Availablecompleted
NCT04898725
Effects of Vitamin D Supplementation on Depression and Inflammatory MarkersNo drug interventionshealth_services_researchNot Availablecompleted
NCT03000530
A Study to Evaluate SAGE-217 in Participants With Moderate to Severe Major Depressive Disordertreatment2completed
NCT04388748
Stress Management and Resiliency Training for Depression vs Treatment as Usual in the Treatment of Major DepressionNo drug interventionssupportive_careNot Availablecompleted
NCT00285766
Safety, Tolerability and Efficacy of the Transdermal System in Elderly Subjects With Major Depressiontreatment3completed
NCT02648165
Secondary Prevention of Depression Through Group-based ACT-Therapy Preceded by an Experimental ABM-ProcedureNo drug interventionspreventionNot Availablecompleted
NCT03005574
Comparing Thinking Skills for Work (TSW)Home Practice Program With Traditional TSW ProgramNo drug interventionstreatmentNot Availablecompleted
NCT00222820
Depression: The Search for Treatment-Relevant Phenotypes-Pilot Studytreatment4completed
NCT01932931
Vitamin D, SSRIs and the Musculoskeletal SystemNo drug interventionspreventionNot Availablecompleted
NCT02270073
The Process Outcome Mindfulness Effects in Trainees (PrOMET)-StudyNo drug interventionstreatmentNot Availablecompleted
NCT02969876
Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetinebasic_science4terminated
NCT00472576
Antidepressant Effects of NR2B in Major Depressiontreatment1completed
NCT04093960
Escitalopram Plus PS128 vs. EscitalopramNo drug interventionstreatment4terminated
NCT05575960
Interpersonal Psychotherapy for Adolescents and Young AdultsNo drug interventionstreatmentNot Availablerecruiting
NCT00704860
Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic PolymorphismNo drug interventionstreatment4completed
NCT01652391
Modulation of Cognitive Control by Transcranial Direct Current StimulationNo drug interventionsbasic_scienceNot Availablecompleted
NCT00265291
Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Grouptreatment2completed
NCT00660062
Relapse Prevention With Escitalopram or Nortriptyline Following Electro-Convulsive Treatment (DUAG-7)treatment4terminated
NCT02122562
Ketamine Alcohol (in Treatment-Resistant Depression)treatment2recruiting
NCT03170362
PRIME Care (PRecision Medicine In MEntal Health Care)No drug interventionstreatmentNot Availablecompleted
NCT01191580
Interpersonal Therapy for Depression in Breast CancerNo drug interventionstreatment4completed
NCT01062880
Neuropattern - Assessment of a Translational Diagnostic Tool for Depression, Adjustment- and Somatoform-disordersNo drug interventionsdiagnosticNot Availableunknown_status
NCT00693680
Zinc Supplementation of Imipramine TherapyNo drug interventionstreatmentNot Availablecompleted
NCT02998580
Conventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life DepressionNo drug interventionstreatmentNot Availablecompleted
NCT01542229
PTSD (PostTraumatic Stress Disorder) Services for Veterans With SMI (Severe Mental Illness)No drug interventionshealth_services_researchNot Availablecompleted
NCT01663844
New Clinical Applications for Internet-based Cognitive Behavior Therapy for Insomnia and DepressionNo drug interventionstreatmentNot Availablecompleted
NCT02062840
The Brain on Whole Body Hyperthermia: A Neuroimaging StudyNo drug interventionstreatmentNot Availablecompleted
NCT03060967
Assessment of Hedonic and Motivational States in Major Depression ( MOODDIS)No drug interventionsscreeningNot Availableunknown_status
NCT02379767
Effects of ECT on Monoamine Oxidase A in Depression Investigated With PETNo drug interventionsNot AvailableNot Availablecompleted
NCT02086201
Comparing Engage to PST for Late Life DepressionNo drug interventionstreatmentNot Availablecompleted
NCT04352101
Bupropion Versus Escitalopram on Reward Circuitry and Motivational Deficitstreatment4completed
NCT00797901
Depression Treatment in General Medical SettingsNo drug interventionstreatmentNot Availablecompleted
NCT01150604
Depression Management ProjectNo drug interventionstreatmentNot Availablecompleted
NCT00792168
Physiologic Monitoring of Antidepressant Treatment Responsetreatment4completed
NCT03973268
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionNo drug interventionsbasic_science1recruiting
NCT02276469
Peer Support for Severe Mental DisordersNo drug interventionstreatmentNot Availablecompleted
NCT02914769
Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant DepressionNo drug interventionstreatment1 / 2completed
NCT00286546
Testosterone and Major DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT04235712
Implementation of Harmonized Depression Outcome Measures in a Health SystemNo drug interventionsNot AvailableNot Availablecompleted
NCT00565110
Treating Depression Among Low-Income Patients With CancerNo drug interventionstreatmentNot Availablecompleted
NCT00167310
Decreasing Risk of Coronary Artery Disease in Schizophrenia by Omega-3 Fatty Acid Supplementationtreatment2completed
NCT01309581
Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in DepressiontreatmentNot Availableterminated
NCT05497414
Neuroimaging Sleep and Mood in DepressionNo drug interventionsbasic_scienceNot Availableunknown_status
NCT03927950
Investigation of Genetic Predictors of the Response to Selective Serotonin Re-uptake Inhibitors (SSRI) Treatmenttreatment4completed
NCT03062150
Mineralocorticoid Receptor, NMDA Receptor and Cognitive Function in Depressionbasic_scienceNot Availablecompleted
NCT00203723
Use of Risperidone in ECT for Treatment Resistant Depressiontreatment4terminated
NCT02171923
Multicenter Comparative Study of the Activity of the Medial Prefrontal Cortex in Vulnerability to DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT00953108
Quetiapine Prolong, Escitalopram and Hypothalamic-pituitary-adrenocortical (HPA) Axis Activity in Depressed Patientstreatment3completed
NCT03472638
Dorsomedial rTMS For Depression In Borderline Personality DisorderNo drug interventionstreatmentNot Availableunknown_status
NCT00806143
Bilateral Versus Monolateral Repetitive Transcranial Stimulation in DepressionNo drug interventionstreatment4completed
NCT00781703
Evaluation of a Natural Experiment to Improve Statewide Depression Care in Minnesota (MN)No drug interventionshealth_services_researchNot Availablecompleted
NCT00158990
Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.treatment3completed
NCT02891564
ESTIA: Computerized Intervention Targeting Cognitive Control Deficits in Depressed AdultsNo drug interventionstreatmentNot Availablecompleted
NCT00523302
A Pilot Study of TMS Effects on Pain and Depression in Patients With FibromyalgiaNo drug interventionstreatmentNot Availablecompleted
NCT05894902
Open-Label Dose-Ranging Study of Oral SM-001 in Healthy AdultsNo drug interventionstreatment1not_yet_recruiting
NCT00289484
A Study of Omega-3 as an Augmentor of Antidepressant Treatment for Major Depressiontreatment2unknown_status
NCT00461279
Attachment Security as Mediator and Moderator of Outcome in Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT02441387
Predictors of the Outcome of Late Life DepressionNot AvailableNot Availableunknown_status
NCT03092687
Procedures for Sample Acquisition and Distribution for The Human Brain Collection CoreNo drug interventionsNot AvailableNot Availableterminated
NCT01358487
Healthy Mood Internet Intervention Research ProjectNo drug interventionspreventionNot Availablecompleted
NCT03043833
Internet-Delivered Cognitive Behavior Therapy for Anxiety and Depression Amongst French CanadiansNo drug interventionstreatmentNot Availablecompleted
NCT06500533
Combining rTMS and tDCS in Depression: an Exploratory Clinical TrialNo drug interventionstreatmentNot Availablerecruiting
NCT01824433
Comparison of Venlafaxine and Fluoxetine in the Treatment of Postmenopausal Women With Major Depressiontreatment4completed
NCT03484754
Infiltrations of OnaBotulinum Toxin A in Resistant Depression: Comparison of Two Facial Injection Sites.No drug interventionstreatmentNot Availableunknown_status
NCT00817154
Individually Based Psychosocial Rehabilitation for Older People With Serious Mental Illness (SMI)No drug interventionshealth_services_research1completed
NCT00961454
Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major DepressionNo drug interventionstreatment1completed
NCT00296777
Treatment of Depression Following Multiple Brain Teststreatment4completed
NCT01980147
Skills for WellnessNo drug interventionspreventionNot Availablerecruiting
NCT01230047
Mindfulness and Lifestyle Interventions for Depression and Anxiety: A Pilot StudyNo drug interventionstreatmentNot Availableunknown_status
NCT00982345
Brain Imaging of Quetiapine Response in Anxious Depressiontreatment4completed
NCT00357045
Antidepressant Prophylaxis for Interferon-Induced Depression: Efficacy of ParoxetineNot Available4completed
NCT06580145
Leucine in Midlife Depressiontreatment2not_yet_recruiting
NCT00345098
A Study of SR58611A in the Prevention of Depression Relapse in Patients With Major Depressive Disordertreatment3completed
NCT01529905
Longitudinal Study of People Presenting for First Treatment of a Mood DisorderNo drug interventionsNot AvailableNot Availableunknown_status
NCT01561105
Improving Depression Care for Elders: Coordinating CenterNo drug interventionstreatmentNot Availablecompleted
NCT00965497
Escitalopram (Lexapro) for Depression MS or ALStreatment3completed
NCT00570583
Neurocognitive Outcomes of Depression in the ElderlyNo drug interventionsNot AvailableNot Availablecompleted
NCT00770783
Magnetic Seizure Therapy (MST) for Treatment Resistant Major DepressionNo drug interventionstreatment3completed
NCT00427128
Prozac Treatment of Major Depression: Discontinuation Studytreatment4completed
NCT01594528
Behavior During Experimentally Induced PainNo drug interventionspreventionNot Availablecompleted
NCT01571011
Chicago Urban Resiliency Building (CURB)No drug interventionspreventionNot Availablecompleted
NCT00168493
The Neurobiology of Depressive IllnesstreatmentNot Availableunknown_status
NCT00149071
Transcranial Magnetic Stimulation (rTMS) Accelerates the Response to Escitalopram in Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT04134871
Walking for Health: an Intervention to Increase Physical Activity and Reduce Sedentary Behaviour in People With SMINo drug interventionstreatmentNot Availablecompleted
NCT01399671
Study of the Effectiveness of Vestibular Stimulation as a Coadjuvant Treatment in Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT00209807
Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disordertreatment4unknown_status
NCT01667809
CBT vs RTW Intervention for Patients With Common Subclinical Mental Illness in Primary CareNo drug interventionstreatment3completed
NCT00700609
Family Based Treatment of Depressed AdolescentsNo drug interventionstreatment2terminated
NCT01851356
Brain Inflammation in Major Depressive Disorder BackgroundNo drug interventionsNot AvailableNot Availablecompleted
NCT04575285
Using EEG to Predict Depression Treatment Response to rTMS in Patients With Major DepressionNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00105885
Telephone Care as a Substitute for Routine Psychiatric MedicationNo drug interventionstreatmentNot Availablecompleted
NCT00078715
Rapid Antidepressant Effects of Yohimbine in Major Depressionother2completed
NCT00445237
Evaluation of Deep Transcranial Magnetic Stimulation (TMS) H-Coil in the Treatment of Major DepressionNo drug interventionstreatment1completed
NCT01368432
Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditionstreatment2completed
NCT00178932
Improving Outcome in Schizophrenia Through Identification of Genetic Risk FactorsNo drug interventionsdiagnosticNot Availablerecruiting
NCT00169052
Health Care Management and Rehabilitation Skills Training for Treating Serious Mental Illness in Older PeopleNo drug interventionstreatmentNot Availablecompleted
NCT00325000
Interpersonal Psychotherapy for Severely Depressed InpatientstreatmentNot Availableterminated
NCT01027559
fMRI Study of Treatment Changes in Major DepressionotherNot Availablecompleted
NCT00616759
The Effect on Cognition of Terminating ECT Induced Seizures With PropofoltreatmentNot Availablecompleted
NCT01750359
Efficacy and Safety Curcumin in Depressiontreatment4completed
NCT01263275
Trial of Transcranial Direct Current Stimulation (tDCS) for DepressionNo drug interventionstreatment2completed
NCT02119975
A Working Memory Training to Decrease Rumination in Depressed and Anxious IndividualsNo drug interventionstreatmentNot Availablecompleted
NCT00577070
Evaluation of the H-Coil Transcranial Magnetic Stimulation(TMS) Device- Augmentation for Drug Resistant DepressionNo drug interventionstreatment2completed
NCT00343070
Functional Neuroimaging in Depressiontreatment2completed
NCT01731899
Agomelatine in Depressed Patients With FibromyalgiaNot AvailableNot Availablecompleted
NCT01346306
Trial of Transcranial Direct Current Stimulation (tDCS)No drug interventionstreatmentNot Availablecompleted
NCT02633449
Psychotherapy Plus: Combining Cognitive Behavioral Therapy With tDCSNo drug interventionstreatmentNot Availablecompleted
NCT01893749
Primary Care Internet Based Depression Prevention for Adolescents (CATCH-IT) Also Known as Promoting AdolescenT HealthNo drug interventionspreventionNot Availablecompleted
NCT01147913
Computerized Information-Processing Bias Retraining in Depressed AdolescentsNo drug interventionstreatment2completed
NCT00005013
Treatment of Major Depression With St. John's Wort (Hypericum)treatmentNot Availablecompleted
NCT04480918
University of Iowa Interventional Psychiatry Service Patient RegistryNot AvailableNot Availablerecruiting
NCT01566318
Depression Agency-Based CollaborationNo drug interventionspreventionNot Availablecompleted
NCT01870219
Effects of Sevoflurane and Ketamine on QT in Electroconvulsive Therapytreatment4completed
NCT01114334
Motivational Interviews for Depression in Primary CareNo drug interventionshealth_services_researchNot Availablecompleted
NCT00269334
Clinical Pharmacogenomics of Antidepressant Responsetreatment4unknown_status
NCT01749124
My Coach Connect: An Automated Telephone-based Reporting System for Patients With Mental IllnessNo drug interventionshealth_services_researchNot Availableunknown_status
NCT01559324
Electroconvulsive Therapy (ECT) for Elderly Patients With Major DepressionNo drug interventionstreatment4completed
NCT02988024
Pilot BA Study of New LY03005 vs Pristiqtreatment1completed
NCT02213016
Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed PatientsNo drug interventionstreatment4unknown_status
NCT00177996
Pharmacotherapy in Depression With Panic Spectrumtreatment4completed
NCT00944996
Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major Depressionbasic_scienceNot Availablecompleted
NCT02594696
Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental IllnessNo drug interventionshealth_services_researchNot Availablecompleted
NCT00515658
Antidepressant Effect of Theta-Burst rTMSNo drug interventionstreatment2unknown_status
NCT05608135
AI-based Multi-center Research on Identification/Classification/Aided Diagnosis of Mood DisorderNo drug interventionsNot AvailableNot Availablerecruiting
NCT00566735
The Use of Galantamine HBr (Reminyl) in Electroconvulsive Therapy: Impact on Mood and Cognitive Functioningtreatment3completed
NCT01469663
Event Related Potentials in Borderline Personality Disorder and Major DepressionNo drug interventionsNot AvailableNot Availableterminated
NCT00707863
Study of Brain Response to Emotional Pictures Using a Magnetic Resonance Imaging (fMRI) While on Escitalopramtreatment4completed
NCT00296686
Sequential Tranylcypromine (TC), TC + Dextroamphetamine and TC + Triiodothyronine for Refractory Depressiontreatment4terminated
NCT00249886
Discontinuation Study Of Citalopram (Antidepressant) in Depressed Adolescentstreatment3withdrawn
NCT04446039
Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in KoreaNot AvailableNot Availablecompleted
NCT00291239
Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major DepressionNo drug interventionstreatment4unknown_status
NCT01153139
Long-term Bilateral Theta Burst Stimulation for the Treatment of Major DepressionNo drug interventionstreatment2 / 3completed
NCT01667822
Cognitive Behavioral Therapy, Guided Self Help Versus Individual TherapyNo drug interventionstreatment3completed
NCT04235725
Implementation of Harmonized Depression Outcome Measures in a Primary Care Registry and a Mental Health RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT02253225
Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT00296725
Dichotic Listening as a Predictor of Medication Response in Depressiontreatment1 / 2completed
NCT01119430
Fluoxetine Versus Fluoxetine Plus DU125530 in Major Depressive Disordertreatment2terminated
NCT01201148
Open Pilot Trial of TES for DepressionNo drug interventionstreatment2completed
NCT00194948
Treatment Choices for Improving Adherence and OutcometreatmentNot Availablecompleted
NCT01788657
iCBT for Depression - Standard Versus Condensed Treatment MaterialNo drug interventionstreatmentNot Availablecompleted
NCT00541957
Randomized Trial of Psychotherapy for Persistently Depressed Primary Care PatientsNo drug interventionstreatment1completed
NCT01458626
Effectiveness Study of Mirtazapine Combined With Paroxetine in Major Depressive Patients Without Early Improvementtreatment4completed
NCT00481026
A Double Blind Sham Controlled Trial of tDCS in Treating Schizophrenia and DepressionNo drug interventionstreatmentNot Availablecompleted
NCT00374426
Preventing Depression Recurrence in Diabetestreatment4completed
NCT04872465
TBS Over DLPFC in Elderly Refractory DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT00844974
Cognitive Deficits in Major Depressive Disorder and Bipolar Disorder, Depressed Type: Prevalence and Improvement With Treatment of Depressive SymptomsNo drug interventionsNot AvailableNot Availablecompleted
NCT00330174
Acamprosate in Alcoholics With Comorbid Anxiety or Depressiontreatment4completed
NCT00105820
Evaluation Study of TIDES Depression Care Quality Improvement InterventionNo drug interventionsNot AvailableNot Availablecompleted
NCT02658682
Secondary Prevention of Depression Applying an Experimental Attentional Bias Modification ProcedureNo drug interventionspreventionNot Availablecompleted
NCT00482482
Yoga in Unipolar and Bipolar DisordersNo drug interventionstreatmentNot Availablecompleted
NCT01325831
Changes of Functional Connectivity After rTMS in DepressionNo drug interventionstreatment4completed
NCT01636791
CBT Versus a Return to Work Intervention for Patients With Common Mental Illness in Primary CareNo drug interventionstreatment3completed
NCT00532480
Study of Brain Response to Emotional Pictures Using a fMRI While on Duloxetinetreatment4completed
NCT00627029
Evaluation of Programs of Coordinated Care and Disease ManagementNo drug interventionshealth_services_researchNot Availableunknown_status
NCT05964192
Added Value of a Neuroendocrine Test Battery in the Response to Repetitive Transcranial Magnetic Stimulation (rTMS) TreatmentNo drug interventionstreatmentNot Availablerecruiting
NCT01124344
Safety and Pharmacology Study of BMS-866949No drug interventionstreatment1terminated
NCT00579267
Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)No drug interventionsNot AvailableNot Availablecompleted
NCT00067301
PUFA Augmentation in Treatment of Major Depressiontreatment3completed
NCT03156504
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.basic_science4completed
NCT00300404
Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Schizophrenia or Major Depressiontreatment3completed
NCT05477472
Low Dose St John's Wort for DepressionNot AvailableNot Availablecompleted
NCT00151372
Treatment of Depressed Chronic Obstructive Pulmonary Disease PatientsNo drug interventionstreatmentNot Availablecompleted
NCT01132872
PET Whole Body Distribution Studies Using [11C]CUMINo drug interventionsNot AvailableNot Availablecompleted
NCT00260468
Brain Abnormalities in Late-Onset Major DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT02047968
Wake and Light Therapy to In-patients With Major Depression: Efficacy, Predictors and Patient ExperiencesNo drug interventionstreatmentNot Availablecompleted
NCT01786746
Adapting Cognitive Behavioral Therapy (CBT) for Chinese AmericansNo drug interventionstreatmentNot Availablecompleted
NCT00159146
Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major DepressiontreatmentNot Availableterminated
NCT02890212
Selenium as Augmentation Treatment for Sertraline Resistant Major DepressionNo drug interventionstreatmentNot Availablesuspended
NCT02085512
Prevention of PTSD III: Neurocognitive Training of Emotional RegulationNo drug interventionspreventionNot Availablecompleted
NCT00256412
Essential Fatty Acids for Major DepressiontreatmentNot Availablecompleted
NCT05703412
Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental IllnessNo drug interventionstreatmentNot Availableenrolling_by_invitation
NCT00447512
Effects of Ghrelin on the Sleep-EEG and Nocturnal Secretion of Hormonesbasic_scienceNot Availablecompleted
NCT01575912
Past Pain Experience and Perception of Experimental PainNo drug interventionsNot AvailableNot Availablecompleted
NCT00296712
Are Two Antidepressants a Good Initial Treatment for Depression?treatment4completed
NCT00149110
Chronos: the Use of Chronobiological Treatment in DepressiontreatmentNot Availablecompleted
NCT01034995
A Trial Evaluating the Efficacy and Tolerability of SSR125543 in Outpatients With Major Depressive Disordertreatment2completed
NCT00531895
An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headachetreatment4completed
NCT01792414
Transcranial Electrical Stimulation (TES) for the Treatment of Depression.No drug interventionstreatmentNot Availablecompleted
NCT01178255
Efficacy and Safety of Homeopathy for Moderate Depression (Acute Phase)No drug interventionstreatment3terminated
NCT05964023
pBFS Guided VS "5-cm Rule" rTMS Over DLPFC for MDDNo drug interventionstreatmentNot Availablerecruiting
NCT00466323
The Effectiveness of FMPO in Improving the Quality of Care for Persons With Severe Mental Illness.No drug interventionstreatmentNot Availablecompleted
NCT00220623
Efficacy of 18-Months of Antidepressive Medication Plus CBT or Dynamic or Supportive Psychotherapy for Recurrent Major DepressionNo drug interventionstreatment3unknown_status
NCT02119923
Tackling Depression and Anxiety: A Working Memory InterventionNo drug interventionstreatmentNot Availablecompleted
NCT03670823
Prediction of SSRI Treatment in Major Depression.No drug interventionsNot AvailableNot Availableunknown_status
NCT02916238
Measurement-based Care for Depression in Resource-Poor Settingstreatment4completed
NCT03429075
Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanismstreatment2completed
NCT05518149
A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)treatment3recruiting
NCT05550532
A Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapytreatment3recruiting
NCT05841030
A Study in Participants With Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI)No drug interventionsNot AvailableNot Availablerecruiting
NCT06511908
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionNo drug interventionstreatment2not_yet_recruiting
NCT06514742
A Study of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and Long-term Extension Treatment With Aticapranttreatment3recruiting
NCT06558344
A Study to Test Different Doses of BI 1569912 in People With DepressionNo drug interventionstreatment2recruiting
NCT06559306
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptomstreatment3recruiting
NCT06580041
Precision Care for Major Depressive Disordertreatment4enrolling_by_invitation
NCT06635135
A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasuretreatment3recruiting
NCT05211466
Digital Care Chains in Health Care - a Study of Care Consumption, Care Quality, Work Environment and Well-beingNo drug interventionsNot AvailableNot Availablerecruiting
NCT06280235
A Study to Test Different Doses of BI 1569912 in People With Depression Who Take Anti-depressive MedicineNo drug interventionstreatment2recruiting
NCT06308653
Psilocybin for Major Depressive Disorder (MDD)treatment3recruiting
NCT05616559
Precision Medicine in the Depression TreatmentNo drug interventionsNot AvailableNot Availablerecruiting
NCT06621394
The Effect of Mediterranean Diet and Mindfulness Eating on Depression Severity in People with Obesity and Major Depressive DisorderNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04513912
A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapytreatment3completed
NCT05455684
A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapytreatment3recruiting
NCT05553353
Dosing rTMS for Depression Post-SCINo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06005194
InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBINo drug interventionstreatmentNot Availablerecruiting
NCT06012916
Brain Network Dynamics of Depression During Esketamine TreatmentNot AvailableNot Availablecompleted
NCT06035159
The Feasibility, Usability and Satisfaction of an Online Tool for Perinatal Mental Health ProblemsNo drug interventionsotherNot Availablecompleted
NCT06152705
Comparing the Efficacy of FMRI-Guided Vs. Standard ITBS in Treating DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT03971903
Attention Bias Modification Treatment for Young Adults With Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT00186264
Does Concurrent Hydrocortisone With Venlafaxine XR Speed Antidepressant Response?treatmentNot Availablecompleted
NCT02943564
A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-02)treatment3completed
NCT00795821
A Study in Adult Patients With Major Depressive Disordertreatment2 / 3completed
NCT01033084
Efficacy Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disordertreatment2 / 3completed
NCT05306184
Prospective Assessment of Cost-effectiveness and Side-effects of Depressive Patients Treated With ECT or TCANo drug interventionsNot AvailableNot Availablerecruiting
NCT01568684
Brain Imaging, Genetics and Treatment for Major DepressionNo drug interventionstreatment1withdrawn
NCT02919579
A Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Participants With Major Depressive Disordertreatment1completed
NCT00445679
Paroxetine-referenced Study Evaluating Three Doses of DVS SR in Outpatients With MDDtreatment3completed
NCT00384033
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) In The Treatment Of Major Depressive Disordertreatment3completed
NCT03097133
54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicidetreatment3completed
NCT05988333
Psychoeducational Intervention for Families With a Member Affected by Major DepressionNo drug interventionssupportive_careNot Availablerecruiting
NCT04021433
Ketamine for Treatment Resistant MDDtreatmentNot Availableunknown_status
NCT02994433
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuitstreatment1terminated
NCT00421954
Open-label Ziprasidone Study for Psychosis Treatment in Adolescentstreatment3completed
NCT03795051
Coil Positioning in Navigated Transcranial Magnetic Stimulation Feasibility in Depression Patients TrialNo drug interventionstreatmentNot Availablecompleted
NCT02698553
A Study to Evaluate Pharmacokinetics, Safety and Tolerability of Extended-release Bupropion Hydrochloride Tablets in Chinese Healthy Volunteerstreatment1completed
NCT05210153
Personalized Sertraline Dosing in Patients With DepressionNot AvailableNot Availablerecruiting
NCT02466477
Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive DisorderNo drug interventionstreatment4completed
NCT03002077
Long-term Safety Study of Rapastinel as Adjunctive Therapy in Patients With Major Depressive Disordertreatment3completed
NCT02943577
A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-03)treatment3completed
NCT00186498
Memantine to Reduce Neurocognitive Deficits Following Unilateral ECT for the Treatment of a Major DepressionpreventionNot Availablecompleted
NCT00962598
The Role Of Omega-3 Fatty Acids In Adolescent Depressiontreatment2completed
NCT01814098
An Efficacy and Safety Study of Escitalopram Long-Term Treatment in Major Depressive Disorder With Associated Anxiety Symptomstreatment4completed
NCT00456898
Study Evaluating the Potential of DVS SR to Inhibit the CYP2D6 Pathwaytreatment1completed
NCT02489305
Study to Evaluate Potential Predictors of Relapse in Participants With Major Depressive Disorder (MDD)No drug interventionsNot AvailableNot Availablecompleted
NCT02871297
Long-term, Open-label, Flexible-dose, Extension Study of Vortioxetine in Child and Adolescent Participants With Major Depressive Disorder (MDD) From 7 to 18 Years of Agetreatment3terminated
NCT04171193
Efficacy of Deep Anaesthesia With Isoflurane as a Fast-response Antidepressant Agenttreatment2unknown_status
NCT03405493
Sleep, Wake and Light Therapy for DepressionNo drug interventionstreatmentNot Availablecompleted
NCT04301271
Simvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major Depressiontreatment2active_not_recruiting
NCT03674671
Ketamine Versus Electroconvulsive Therapy in Depressiontreatment3suspended
NCT04521478
A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depressiontreatment2completed
NCT03854578
A Study in People With Depression to Test the Effects of BI 1358894 on Parts of the Brain That Are Involved in Emotionstreatment1completed
NCT03721588
Clinical and Suicidal Features of Urban, Turkish Middle Age Depressive Patients With Comorbid ADHDNo drug interventionsNot AvailableNot Availablecompleted
NCT00093288
Major Depressive Disorder In The Elderlytreatment3completed
NCT00223288
Impact of Caregiver Depression on Asthma in the ChildNot AvailableNot Availablecompleted
NCT01460407
A Study to Evaluate the Effect of Clarithromycin on LY2216684treatment1completed
NCT04963907
Alpha-Stim AID and Major Depressive DisorderNo drug interventionstreatmentNot Availableunknown_status
NCT00551109
SA4503 8-Week Study in Major Depressive Disorder (MDD)treatment2completed
NCT01153009
Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disordertreatment3completed
NCT04951609
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapytreatment1terminated
NCT03614156
Study of Monotherapy Rapastinel in the Prevention of Relapse in Patients With Major Depressive Disorder (MDD)treatment3terminated
NCT00208156
A United States Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depressiontreatment3completed
NCT00218556
Preventing Depression in Methadone Maintenance Patients Receiving Hepatitis C Treatment - 1No drug interventionspreventionNot Availablecompleted
NCT00191685
Duloxetine in the Treatment of Melancholic Depressiontreatment3completed
NCT02659085
Ketamine as an Alternative Treatment to ECT in Major Depressive Disordertreatment2 / 3completed
NCT00671515
Pioglitazone for the Treatment of Major Depressive Disorder Comorbid With Metabolic Syndrometreatment2completed
NCT03287037
The Effects of tDCS on Depressive Symptoms,Neurocognitive Function and HRV in Unipolar Depression and Bipolar DepressionNo drug interventionstreatmentNot Availablecompleted
NCT02739932
Adolescent Mental Health: Canadian Psychiatric Risk and Outcome StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01909232
A Clinical Trial for the Treatment of Depression With Repetitive Transcranial Magnetic Stimulation (rTMS)No drug interventionstreatmentNot Availablecompleted
NCT01360632
Study of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Polaris Trial)treatment3completed
NCT05232032
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulationbasic_science2not_yet_recruiting
NCT01129752
Mothers With a History of Depression and Their 10-14 Year Old DaughtersNo drug interventionsNot AvailableNot Availablecompleted
NCT01389752
A Study to Evaluate the Effect of Activated Charcoal on the Absorption of LY2216684 in Healthy Subjectstreatment1completed
NCT00406952
Study for Evaluating Different Methods of Measuring Depression Treatment ResponsetreatmentNot Availablecompleted
NCT03668600
Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)treatment3terminated
NCT01141400
The Effect of Patient Cost-Sharing on Antidepressant and Adjunctive Therapy UseNo drug interventionsNot AvailableNot Availablecompleted
NCT00163059
The Antidepressant Effects Of The NMDA Antagonist, CP-101,606, In Patients With MDDtreatment2completed
NCT05047159
The Role of Neuromodulation Technique In Depression DisorderNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT01407575
Buprenorphine for Treatment Resistant Depressiontreatment3completed
NCT03374475
A Study to Investigate the Antidepressant Mechanism-of-action of JNJ-42847922 in Participants With Major Depressive Disordertreatment1completed
NCT03288675
Stepped Care aiTBS 2 Depression Study (Ghent)treatmentNot Availablecompleted
NCT04994470
Web-based Self-help Intervention for Adolescents With Acute or Remitted Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT02067299
A Study to Investigate the Effect of JNJ-42847922 on Polysomnography Measures in Patients With Major Depressive Disorder With Insomnia Who Are Stably Treated With Antidepressantstreatment1completed
NCT04015206
Effectiveness of IPT-G in Major DepressionNo drug interventionstreatmentNot Availableterminated
NCT00220636
Abilify as an Adjunctive Treatment for Refractory Depressiontreatment4completed
NCT06311136
Effectiveness of an Ecological Momentary Emotion Regulation InterventionNo drug interventionstreatmentNot Availablerecruiting
NCT01106313
Insulin Resistance in Patients With Major DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT03944213
Resting-state Functional Connectivity Throughout a Course of iTBS in Major DepressionNo drug interventionsNot AvailableNot Availableunknown_status
NCT01145313
Impact of Atypical Antipsychotic Therapy on Health Outcomes and Costs Among Patients With Major Depressive DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT03560518
Study of Rapastinel as Monotherapy in Patients With MDDtreatment3terminated
NCT04829318
A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatmenttreatment4completed
NCT06417619
The Effect of Mindfulness-Based PsychoeducationNo drug interventionstreatmentNot Availablerecruiting
NCT03185819
Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for Suicidetreatment2completed
NCT00191919
A Randomized Double Blind Study Evaluating Duloxetine in Outpatients With MDD and Paintreatment3completed
NCT02667041
NeuroQore rTMS (Monophasic vs. Biphasic) for Major Depressive Disorder: A Randomized Controlled Pilot TrialNo drug interventionstreatmentNot Availablecompleted
NCT06546917
bWell-D Pilot Randomized Controlled TrialNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03227224
A Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapytreatment2completed
NCT03605524
Olfactory Training and Emotional StateNo drug interventionsotherNot Availableunknown_status
NCT02546024
Predictors of Treatment Response in Late-onset Major Depressive DisorderNo drug interventionsNot AvailableNot Availablesuspended
NCT02740296
Depression and Immune Function in Multiple Sclerosis (MS)No drug interventionsNot AvailableNot Availablecompleted
NCT01152996
Safety and Tolerability of Vortioxetine (LuAA21004) - Open Label Extension Studytreatment3completed
NCT00370058
Study on the Influence of Electroconvulsive Therapy (ECT) on Homocysteine LevelsNo drug interventionsdiagnostic4completed
NCT00691535
Genetics of Symptomatology and Treatment Response in Psychotic Major DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT06470035
Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Major Depressive Disorder (MDD)No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT02945735
Gaze Contingent Feedback in Major Depressive Disorder (MDD)No drug interventionstreatmentNot Availablecompleted
NCT00892463
Identifying Very Early Response to Seroquel Extended Release (XR) Augmentation for Major Depressive Disordertreatment4completed
NCT04469322
Pharmacogenetic Implementation Trial in Veterans With Treatment Refractory DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05708222
Sleep Signal Analysis for Current Major Depressive Episode (SAMDE)No drug interventionsNot AvailableNot Availablecompleted
NCT02288325
A Multicenter, Relapse Prevention Study With Levomilnacipran Extended Release (ER) in Participants With Major Depressive Disordertreatment4completed
NCT02229825
Study to Assess Clinical Response of Duloxetine in Patients Hospitalized for Severe Depressiontreatment4completed
NCT00368030
A Study of Eszopiclone in Subjects With Insomnia Related to Major Depressive Disordertreatment3completed
NCT01331330
European Deep Brain Stimulation (DBS) Depression StudyNo drug interventionstreatmentNot Availablecompleted
NCT03321526
A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapytreatment2completed
NCT00401726
Open-Label, Randomized Study Evaluating Treatment With Venlafaxine Extended-Release Plus Dialogues Time to Talk Programtreatment4completed
NCT01727726
A Study of Flexible-dose Brexpiprazole as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Delphinus Trialtreatment3completed
NCT04701866
Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in DepressionNo drug interventionstreatmentNot Availablecompleted
NCT01163266
Efficacy and Safety Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disordertreatment3completed
NCT01038765
Mindfulness Based Cognitive Therapy for Recurrent DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05111665
Decentering and Relapse/Recurrence in MBCT for Depression in AdultsNo drug interventionstreatmentNot Availablecompleted
NCT03855865
Study of Rapastinel as Monotherapy in Major Depressive Disorder (MDD)treatment3withdrawn
NCT04669665
A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicidetreatment2completed
NCT01389765
A Study to Evaluate the Effect of Food on LY2216684treatment1completed
NCT00584974
A Safety, Efficacy and Tolerability Study of SEP-225289treatment2completed
NCT03595020
Probing Prefrontal Cortex Hemodynamic Alterations for Major Depression DisorderNo drug interventionsNot AvailableNot Availableunknown_status
NCT00440427
Study Evalutating the Pharmacokinetics (PK) and Safety of a Single Dose of Desvenlafaxine Sustained Release (DVS SR)treatment1completed
NCT00285727
Ropinirole Controlled Release (CR) as an Adjunctive Agent in the Treatment of Major DepressiontreatmentNot Availablecompleted
NCT05146427
Pilot Study: Investigating Mood Changes After Slow-wave EnhancementNo drug interventionsbasic_scienceNot Availablenot_yet_recruiting
NCT05554627
VA Aripiprazole vs Esketamine for Treatment Resistant Depressiontreatment4withdrawn
NCT04272476
The Activation on Prefrontal Cortex With Acupuncture and Moxibustion for Major Depressive Disorder: A Study of Functional Near Infrared Spectroscopytreatment2completed
NCT03675776
Study of Rapastinel as Monotherapy in Patients With Major Depressive Disorder (MDD)treatment3terminated
NCT06303076
Tizanidine vs. Zolpidem in Primary Insomnia: A Randomized Trialtreatment4not_yet_recruiting
NCT03027362
Cognitive Therapy to Sustain the Antidepressant Effects of Intravenous Ketamine in Treatment-resistant DepressionNo drug interventionstreatmentNot Availablecompleted
NCT00617162
Deep Brain Stimulation for Major Depressive DisorderNo drug interventionstreatmentNot Availableterminated
NCT00179062
Effects of Risperidone and Olanzapine on Patients With Schizophrenia, Schizoaffective Disorder, Major Depression or Bipolar DisordertreatmentNot Availablecompleted
NCT03679962
Triple Chronotherapy in AdolescentsNo drug interventionstreatmentNot Availablecompleted
NCT01564862
Efficacy of Lu AA21004 on Cognitive Dysfunction in Major Depressive Disordertreatment2completed
NCT00733980
A Study of the Effects of a New Antidepressant Treatment (GSK561679) in Females With Major Depressive Disordertreatment2completed
NCT00928980
Mindfulness Based Cognitive Therapy and Antidepressant Medication in Recurrent DepressionNo drug interventionstreatmentNot Availablecompleted
NCT04533529
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexanttreatment3completed
NCT03039192
54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicidetreatment3completed
NCT03559192
A Study to Explore the Efficacy of JNJ-67953964 in the Treatment of DepressionNo drug interventionstreatment2completed
NCT00102492
Study Of GW679769 In Major Depressive Disordertreatment2completed
NCT02452892
Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD)No drug interventionstreatmentNot Availablecompleted
NCT00067444
Depression Study In Elderly Patientstreatment3completed
NCT06254144
Neuroimaging Study for Decoding Emotional States and Identifying Neural Circuits to Disengage From Negative ThinkingNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03001440
A 7-year Assessment on Subject Understanding of ZYBAN/ WELLBUTRIN Associated RisksNo drug interventionsNot AvailableNot Availablecompleted
NCT02737540
Neuropsychological Factors Associated With Vulnerability to Suicidal Behavior in Depressed Elderly PatientsNo drug interventionsNot AvailableNot Availableterminated
NCT02023567
Objective Diagnostic Markers and Personalized Intervention in MDD Patientsbasic_scienceNot Availableunknown_status
NCT05909267
Dopamine Modulation of Motivation and Motor Function in Major Depression & Inflammationbasic_scienceNot Availablerecruiting
NCT05701267
Neuro MRI Biomarkers for Treatment Navigation in DepressionNo drug interventionsNot AvailableNot Availablerecruiting
NCT02664467
Chronobiology, Sleep Related Risk Factors and Light Therapy in Perinatal Depression: the Life-ON ProjectNo drug interventionstreatmentNot Availablecompleted
NCT02314767
A Finnish Community Randomized Psychotherapy Effectiveness Study for Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05870501
Synaptic Imaging and Network Activity in Treatment Resistant Depressionbasic_scienceNot Availablerecruiting
NCT00048204
A Study Of A New Medicine (GW597599B) For The Treatment Of Major Depressive Disordertreatment2completed
NCT05100004
Rapid Acting TMS for Suicide Ideation in DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT03016572
Promote Access to Stop Suicide: Comparison of Follow up Services for Youth at Risk for SuicideNo drug interventionstreatmentNot Availablecompleted
NCT03899168
Confirmation Bias Towards Treatments of Depressive Disorders in Social TaggingNo drug interventionshealth_services_researchNot Availablecompleted
NCT00636246
A Comparison of Sertraline-reboxetine Combination Therapy Versus Sertraline or Reboxetine Monotherapy in the Treatment of Major Depression.treatment2completed
NCT06136546
Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximabother2not_yet_recruiting
NCT00227812
Integrated Treatment for Cocaine and Mood Disorders - 1treatment2completed
NCT04984512
The Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive DisorderNo drug interventionstreatment2 / 3unknown_status
NCT01460381
A Study to Evaluate the Effect of Genotype on LY2216684treatment1completed
NCT06219681
Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With DepressionNo drug interventionsbasic_scienceNot Availablerecruiting
NCT03758495
Rescuing the Ruminating Brain: Identifying Biomarkers of Rumination and Mindfulness Through Concurrent EEG and Functional Magnetic Resonance Imaging (fMRI) Studies of Schizophrenia and DepressionNo drug interventionsNot AvailableNot Availablewithdrawn
NCT03288714
Adaptive Design Study of NEST sTMS in Subjects With Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT00229450
Estrogen and Perimenopausal Depressiontreatment4completed
NCT03436823
Does Nurse Semi Structured Interview Added to a rTMS Improve Patients With Major Depressive Disorder?No drug interventionstreatmentNot Availablecompleted
NCT04463108
A Study to Describe Routine Treatment Pathways in Participants With Major Depression and Active Suicidal Ideation With Intent in ItalyNo drug interventionsNot AvailableNot Availablecompleted
NCT06528938
Comparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents DepressionNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05491538
Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental IllnessNo drug interventionstreatmentNot Availablerecruiting
NCT02932943
A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-01)treatment3completed
NCT01870843
A Study to Evaluate the Impact of Escitalopram on Quality of Life and Social Functionality in Patients With Major Depressive Disorder With Anxiety Symptomtreatment4completed
NCT00369343
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) Versus Placebo in Peri- and Postmenopausal Womentreatment3completed
NCT00149643
Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependencetreatment2completed
NCT03207503
Neurobehavioral Mechanisms of Emotion Regulation in Depression Across the Adult LifespanNo drug interventionsNot AvailableNot Availablecompleted
NCT00368303
A Local Register Study For Major Depression Of Paroxetine Controlled Releasetreatment3completed
NCT03155503
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-911 in Healthy SubjectsNo drug interventionstreatment1completed
NCT04442490
A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)treatment3completed
NCT00451490
The Effect of Agomelatine or Fluoxentine on Heart Rate Variability in Patients With Major Depressive Disorderhealth_services_researchNot Availablewithdrawn
NCT04013464
Effects of Escitalopram on the Sleep EEG Power in Patients With Major Depressive DisordertreatmentNot Availablecompleted
NCT04772664
Probiotics and the Gut Brain Axis- Do Probiotics Interact With the Vagal Nerve?No drug interventionsbasic_scienceNot Availablecompleted
NCT04338321
A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disordertreatment3completed
NCT04581902
Biomarkers of Depression and Treatment ResponseNo drug interventionstreatmentNot Availablerecruiting
NCT01255787
Efficacy and Safety Study of Vortioxetine (Lu AA21004) for Treatment of Major Depressive Disordertreatment2 / 3completed
NCT01141387
Outcomes in MEasurement-Based TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT04451187
A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorderother1completed
NCT00627887
Randomised Controlled Trial of Electroconvulsive Therapy (ECT) in Relapse Prevention of Depressiontreatment4completed
NCT03367533
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Responsebasic_science1completed
NCT00246233
CONCERTA® (Methylphenidate Hydrochloride) as add-on Therapy in the Treatment of Adult Major Depressive Disorder.treatment3completed
NCT04770454
Evaluate the Quality of Life and Treatment of Anxiety Symptoms of Buspirone in Patients With Depression Disorders(BASIS)No drug interventionsNot AvailableNot Availablecompleted
NCT00629551
An Eight-week Study of Saredutant and Paroxetine as Combination Treatment for Major Depressive Disordertreatment3completed
NCT02340351
Auricular Acupuncture vs. Progressive Muscle Relaxation in Patients With Anxiety Disorders or Major Depressive Disorder.No drug interventionstreatmentNot Availablecompleted
NCT03352453
A Study of Rapastinel for Rapid Treatment of Depression and Suicidality in Major Depressive Disordertreatment2terminated
NCT00116077
Dopamine Receptor Imaging in Mood DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT05544877
An Energetic View on Creativity, Psychopathology and Intelligence: The Brain2Business StudyNo drug interventionssupportive_careNot Availablecompleted
NCT05041647
Cannabinoids as a Treatment for Insomnia in Major DepressionNo drug interventionstreatment2recruiting
NCT04695145
Aerobic Group Exercise for Adolescents With DepressionNo drug interventionstreatmentNot Availablecompleted
NCT01360645
Study of the Safety and Efficacy of Fixed Dose OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Pyxis Trial)treatment3completed
NCT05423405
The Efficacy of Acupressure Therapy on Patient With DepressionNo drug interventionssupportive_careNot Availableunknown_status
NCT05415397
Treating Immuno-metabolic Depression With Anti-inflammatory Drugstreatment3recruiting
NCT02191397
Study to Evaluate the Efficacy, Safety and Tolerability of Bupropion Hydrochloride Extended-release Tablet, and Escitalopram Oxalate Capsule in Subjects With Major Depressive Disordertreatment3completed
NCT04498897
Vortioxetine for Treatment of Depressive Mood and Alcohol Usetreatment2unknown_status
NCT00275197
A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD)treatment2completed
NCT03832283
Patient Outcomes Reporting for Timely Assessments of Life With Depression: PORTAL-DepressionNo drug interventionshealth_services_researchNot Availablecompleted
NCT06398561
Peer-led Intervention for Individuals With Major Depression.No drug interventionstreatmentNot Availablerecruiting
NCT01155661
A Safety Study in Participants With Major Depressive Disordertreatment3completed
NCT02116361
OnabotulinumtoxinA as Treatment for Major Depressive Disorder in Adult Femalestreatment2completed
NCT06320028
Altering Default Mode Network Activity With Transcranial Focused Ultrasound to Reduce Depressive SymptomsNo drug interventionstreatment1 / 2active_not_recruiting
NCT03877393
The Effect of Probiotic Supplementation on the Mental Status, Inflammation, and Intestinal Barrier in Major Depressive Disorder Patients Using Gluten-free or Gluten-containing DiettreatmentNot Availableunknown_status
NCT04099771
Ketamine for Mood Disorders With Suicidal Ideationtreatment0unknown_status
NCT05901571
Acupuncture and Escitalopram for Treating Major Depression Clinical StudyNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00300378
Study Evaluating the Efficacy and Safety of Desvenlafaxine Tablets in Adult Outpatients With Major Depressive Disordertreatment3completed
NCT04057378
Optimal Electrical Stimulus During Electroconvulsive TherapyNo drug interventionstreatment4recruiting
NCT02752178
Peripheral Immunomarker Validation in Treatment-resistant DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT02951988
A Study of Rapastinel as Adjunctive Therapy in the Prevention of Relapse in Patients With Major Depressive Disordertreatment3completed
NCT03040388
Exploring Effects of Electroconvulsive Therapy on the Human Brain in Depression - The Danish ECT/MRI StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01138007
A Fixed Dose Study of 323U66 SR in the Treatment of Major Depressive Disorder (MDD)No drug interventionstreatment3completed
NCT03051256
Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDDtreatment2completed
NCT06110585
Transcranial Magnetic Stimulation in Patients With Depression and Non-suicidal Self-injuryNo drug interventionstreatmentNot Availablerecruiting
NCT05280015
Microbiotherapy in Characterized Depressive DisorderNo drug interventionstreatment2recruiting
NCT03121937
Feasibility of a Technology-Based Treatment Support SystemNo drug interventionstreatmentNot Availableterminated
NCT05194332
Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive FunctionNo drug interventionsbasic_scienceNot Availablenot_yet_recruiting
NCT00366652
Study Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in Healthy Subjectstreatment3completed
NCT01583400
Enhanced Collaborative Depression Treatment in Primary Care: The RESPECT-D-E TrialNo drug interventionstreatmentNot Availablecompleted
NCT02938559
Can the Memory Support Intervention Improve Depression Outcome Following Cognitive Therapy?No drug interventionstreatmentNot Availablecompleted
NCT04661475
Dexmedetomidine Adjuvant Treatment for Depressed Patients Undergoing ECTtreatment4unknown_status
NCT00097175
Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT03548675
Pharmacogenetics Informed Tricyclic Antidepressant Dosing (PITA)No drug interventionstreatment4completed
NCT06389175
Non-invasive Vagus Nerve Stimulation as a Tool to Modulate Stomach-Brain Coupling in DepressionNo drug interventionsbasic_scienceNot Availableenrolling_by_invitation
NCT00725270
Treatment of Schizoaffective Disorder Using Mifepristonetreatment2 / 3terminated
NCT03283670
Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategiestreatment2completed
NCT00880399
A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disordertreatment2terminated
NCT00559299
Patient Tolerability Study of GSK163090No drug interventionstreatment1completed
NCT02196506
Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distresstreatment3completed
NCT04179006
Effects of Nutrients Supplementation in Antidepressant Treated Depressive Disorder PatientsNo drug interventionstreatmentNot Availableunknown_status
NCT04116606
Antidepressant Trial With P2X7 Antagonist JNJ-54175446treatment2unknown_status
NCT04532749
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapytreatment3terminated
NCT05212636
Using Repetitive Transcranial Magnetic Stimulation to Study the Role of Frontostriatal Circuit in Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT00057213
An 8 Week Study Of Depression In Adults Diagnosed With Major Depressive Disordertreatment2completed
NCT03165513
Dialogue to Empower Traditional and Faith Healers to Deliver mhGAP-IG Adapted Psychosocial Interventions in KenyaNo drug interventionstreatmentNot Availablecompleted
NCT05915013
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Responsebasic_science1recruiting
NCT05488418
Clinical Study of Biomarkers of Stress Resilience: Role of ELK1 and GPR56No drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT01284218
Retrospective Database Study of Real World Abilify Outcomes in Major Depressive Disorder (MDD)No drug interventionsNot AvailableNot Availablecompleted
NCT02983318
Molecular Imaging of Brain Inflammation in Depressive DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT00931619
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT04081519
Stimulation of Parieto-hippocampal Connectivity in Patients With Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT01744041
Mommy-Baby Treatment for Perinatal DepressionNo drug interventionstreatmentNot Availablecompleted
NCT00840034
A Study of Adjunctive Treatment to Antidepressant Therapy for Adults With Major Depressive Disordertreatment2completed
NCT02410616
E-Compared-CH: Comparative Effectiveness Research on Internet-based Depression Treatment - Swiss TrialNo drug interventionstreatmentNot Availablecompleted
NCT00451516
St. John's Wort And Kava In The Treatment Of Major Depressive Disorder With Comorbid Anxietytreatment2completed
NCT01179516
Safety and Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disordertreatment3completed
NCT06398496
The Effects of Exercise on Gut Bacteria, Mood and Cognition in DepressionNo drug interventionsbasic_scienceNot Availablerecruiting
NCT01241435
A Study of LY2216684 in Participants With Impaired Hepatic Functiontreatment1completed
NCT00229463
Study of Genetic Differences in People With DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT06431386
Behavioural Activation Therapy and Esketamine for Resistant DepressiontreatmentNot Availablerecruiting
NCT05008939
Sevoflurane for Treatment-Resistant DepressiontreatmentNot Availableunknown_status
NCT00150839
Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapytreatment4completed
NCT04486222
Accelerated Bilateral rTMS on Geriatric DepressionNo drug interventionstreatmentNot Availableterminated
NCT02741622
Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.No drug interventionstreatmentNot Availablecompleted
NCT03489122
A Randomized Control Trial Treating Depression With Yoga and Coherent Breathing Versus Walking in VeteransNo drug interventionstreatmentNot Availableterminated
NCT03932825
Nitrous Oxide for Major Depressive Disordertreatment2completed
NCT03108625
Continuation With Vortioxetine in Child and Adolescent Patients With Major Depressive Disorder (MDD) From 7 to 17 Years of Agetreatment3completed
NCT02076425
A Randomized Controlled Trial of PCIT-ED for Preschool DepressionNo drug interventionstreatmentNot Availablecompleted
NCT00763230
A Study of Transcranial Direct Current Stimulation (tDCS) to Treat DepressionNo drug interventionstreatment2 / 3completed
NCT01718730
Cortical Excitability and Inhibition in MDDNo drug interventionsNot AvailableNot Availablecompleted
NCT04790630
Cognitive Fitness for Depression in Older AdultsNo drug interventionstreatmentNot Availablerecruiting
NCT04476030
A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disordertreatment3completed
NCT04423757
A Home-based Study Using Mobile Technology to Test Whether BI 1358894 is Effective in People With DepressionNo drug interventionstreatment2terminated
NCT04761757
Antidepressant Decision Aid for Major Depressive Disorder PatientsNo drug interventionshealth_services_researchNot Availablecompleted
NCT00655226
Prevention of Depression in HIV/HCV Co-infected Substance Abuse PatientsNo drug interventionstreatmentNot Availableterminated
NCT00057226
An 8 Week Study Of Adults Diagnosed With Major Depressive Disordertreatment2completed
NCT00762866
Psychiatric Genotype/Phenotype Project RepositoryNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT01360866
Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)treatment3completed
NCT02342366
Characterization of the Prosocial and Prosexual Effects of GHBotherNot Availablecompleted
NCT02997865
Stepped Care for Depression in Heart FailureNo drug interventionstreatmentNot Availablecompleted
NCT03866174
A Study of Psilocybin for Major Depressive Disorder (MDD)treatment2completed
NCT00497874
An Expert System to Reduce Depression in Primary CareNo drug interventionstreatment2completed
NCT00696774
Switching to Duloxetine in Patients With Depressiontreatment4completed
NCT00046020
Study Evaluating Venlafaxine ER in Recurrent Depressiontreatment4completed
NCT00644982
A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depressiontreatment4completed
NCT01373931
A Study of LY2216684 in Healthy Femalestreatment1completed
NCT03414931
NMDA Modulation in Major Depressive Disorder in Late- Lifetreatment2completed
NCT01477931
Interventional Study of Wellbutrin XL in Major Depressive Disorder With Atypical Featurestreatment4completed
NCT05267873
Combining Data Sources to Identify Effect Moderation for Personalized Mental HealthNot AvailableNot Availableactive_not_recruiting
NCT05680727
Individualized Functional Connectivity Targeting in aiTBS for DepressionNo drug interventionstreatment2recruiting
NCT03586427
AGN-241751 in the Treatment of Major Depressive Disordertreatment2completed
NCT03715127
Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concepttreatment2completed
NCT00229476
Study of Medication and Placebo Response in Major Depressiontreatment4completed
NCT00285376
Effectiveness Study of Vilazodone to Treat Depression and to Discover Genetic Markers Associated With Responsetreatment3completed
NCT02370576
The Effect of Traumatic Childbirth on the Incidence of PTSD and Other Major Postpartum PsychopathologyNo drug interventionsNot AvailableNot Availableunknown_status
NCT02039960
PRJ2215: Assessment of Buproprion Misuse/Abuse 2004-2011Not AvailableNot Availablecompleted
NCT00316160
Sexual Functioning Study With Antidepressantstreatment4completed
NCT00976560
Clinical Study to Test a New Drug to Treat Major Depressiontreatment2completed
NCT00844194
Duloxetine in Patients With Diabetic in Peripheral Neuropathic Pain With or Without Co-morbid Major Depressive Disordertreatment4completed
NCT00143091
Multicentre Trial to Evaluate the Safety and Efficacy of CP-316,311 in Major Depressive Disordertreatment2terminated
NCT00824291
Study Evaluating Desvenlafaxine Succinate Sustained Release In Outpatients With Major Depressive Disordertreatment3completed
NCT02529462
Trial to Evaluate Efficacy of Pharmacogenetic Information Obtained With NEUROPHARMAGEN in Treatment of MDD PatientsNo drug interventionstreatment3completed
NCT00569062
A Study of GW856553X For the Treatment of Depressiontreatment2terminated
NCT00220480
A Naturalistic Study of the Efficacy and Safety of Escitalopram in Treatment Resistant DepressiontreatmentNot Availableunknown_status
NCT04937829
A Study to Test How Well Different Doses of BI 1569912 Are Tolerated and How Well They Work in People With Depression Who Take Anti-depressive MedicationNo drug interventionstreatment1completed
NCT05121129
Treatment of Major Depression by rTMS on Dorsolateral Prefrontal Cortex: Study of Underlying MechanismsNo drug interventionstreatmentNot Availablerecruiting
NCT00105989
Duloxetine Versus Placebo in the Prevention of Recurrence of Major Depressive Disordertreatment3completed
NCT02473289
An Efficacy and Safety Study of Sirukumab in Participants With Major Depressive Disordertreatment2completed
NCT03872492
Major Depressive Disorder: Early Prediction of Non-response to Antidepressant Therapy Via a Mobile Digital ScaleNo drug interventionsotherNot Availableterminated
NCT03014544
Study to Evaluate the Performance Validity and Test-Retest Reliability of a Computer-Administered Cognitive Test Battery in Participants With Major Depressive Disorder (MDD)No drug interventionsNot AvailableNot Availablecompleted
NCT05210140
Personalized Escitalopram Dosing in Patients With DepressionNot AvailableNot Availableunknown_status
NCT00406640
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Womentreatment3completed
NCT02845440
Integrated Smoking Cessation Treatment for Smokers With Serious Mental IllnessNo drug interventionstreatmentNot Availablecompleted
NCT04526067
In-person vs. Remote Wellness SupportNo drug interventionstreatmentNot Availablecompleted
NCT02219867
Ketamine Infusions for Major Depression DisordertreatmentNot Availableunknown_status
NCT02919501
Study of the Efficacy and Safety of Initial Administration of 17 mg Vortioxetine Intravenously With 10 mg/Day Vortioxetine Orally in Patients With Major Depressive Disordertreatment2completed
NCT02902601
A Study to Investigate the Safety, Tolerability, and Pharmacodynamics of JNJ-54175446 in Participants With Major Depressive Disordertreatment1completed
NCT02407704
A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercisetreatment4completed
NCT05630469
Prediction of Antidepressant Effects of Electroconvulsive TherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04829669
A Study of Participants With Moderate or Severe Major Depressive Disorder (MDD) Requiring Urgent Symptom Control in a Psychiatric EmergencyNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00304746
AndroGel in Men With Major Depression and Incomplete Response to Antidepressant Treatmenttreatment4completed
NCT02709746
Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder (MDD)treatment3completed
NCT01625546
Whole Body Hyperthermia and Major Depression (MDD)No drug interventionstreatmentNot Availablecompleted
NCT04159012
NESBID: Neuro-Stimulation of the Brain in DepressionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT00613912
Advanced MRI in Major DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT04148612
A Study to Evaluate the Benefit of Opti-Me Application to Different Treatments of MDDNo drug interventionssupportive_careNot Availableunknown_status
NCT00044681
A Study of the Effectiveness and Safety of Risperidone to Augment SSRI Therapy in Patients With Treatment-resistant Depressiontreatment3completed
NCT04893395
Assessment of the Impact of Clinical Pharmacogenomics on Real and Potential Medication Use in VeteransNo drug interventionsscreeningNot Availablewithdrawn
NCT00576095
Clinical and Biological Characteristics of Psychotic DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT05109195
A Standard of Care Study of Patients With Major Depressive Disorder Who Have Had an Inadequate Response to a Selective Serotonin Reuptake/Serotonin-Norepinephrine Reuptake Inhibitor AntidepressantNo drug interventionsNot AvailableNot Availableterminated
NCT05450614
Smartphone App Based CBT Versus Online Group CBT: Randomized, Non-inferiority Clinical TrialNo drug interventionstreatmentNot Availableunknown_status
NCT05076214
Aerobic Versus Leisure Group for Adolescents With DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT04870255
Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMSNo drug interventionstreatmentNot Availablerecruiting
NCT05716555
Deep Brain Stimulation for Treatment Resistant DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT02709655
Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Participants Aged 7 to 11 Years With Major Depressive Disorder (MDD)treatment3completed
NCT02232555
Study to Evaluate the Efficacy of Duloxetine in Outpatients With Major Depressive Disorder and Paintreatment3completed
NCT04260750
ICBT for Depression - A Factorial Investigation of Kinds of Therapist Support and Self-/Expert-selected ContentNo drug interventionstreatmentNot Availablecompleted
NCT00413023
Study Of The Effects Of A New Antidepressant Therapy In Patients With Major Depressive Disorder (MDD)treatment2completed
NCT05686408
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)treatment2completed
NCT03207438
Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depressiontreatment4completed
NCT05933538
Effectiveness of Cariprazine Monotherapy for Treatment of Major Depressive Disordertreatment4not_yet_recruiting
NCT06655623
A Multiple Case Study of Schema Therapy for Difficult-to-treat Depression- DEPRE-ST*CaseNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00018057
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorderstreatment2recruiting
NCT06658795
Treating Loneliness In The Older Adult With Depression With tDCSNo drug interventionstreatmentNot Availablerecruiting
NCT03065335
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disordertreatment1recruiting
NCT03265808
Allogeneic Human Mesenchymal Stem Cell Infusion vs Placebo in Alcohol Use Disorder and Major Depression.No drug interventionstreatment1 / 2active_not_recruiting
NCT04032301
Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veteransdiagnostic1active_not_recruiting
NCT04239963
Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT04678232
Positive Processes and Transition to HealthNo drug interventionstreatmentNot Availablecompleted
NCT04827901
XEN1101 for Major Depressive DisorderNo drug interventionstreatment2active_not_recruiting
NCT04828226
Clonidine to Prevent Delirium After Electroconvulsive Therapy.prevention4recruiting
NCT05536414
Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disordertreatment2recruiting
NCT05538910
Defining Neurobiological Links Between Substance Use and Mental Illnessbasic_scienceNot Availablerecruiting
NCT05652465
Transcranial Magnetic Stimulation for Youth With Treatment-Resistant Major Depressive DisorderNo drug interventionstreatment2recruiting
NCT05724953
Alexithymia Intervention for SuicideNo drug interventionstreatment1recruiting
NCT05910957
Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative AnalyticsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT06029439
Study to Assess the Safety and Effectiveness of NMRA-335140-501treatment3recruiting
NCT06058013
Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disordertreatment3recruiting
NCT06058039
Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disordertreatment3recruiting
NCT06402955
Imaging Depression in Parkinson's DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT06419608
Efficacy and Safety Study of BHV-7000 Monotherapy in Major DepressionNo drug interventionstreatment2recruiting
NCT06592833
Psilocybin Mechanism of Action (MOA)treatment2not_yet_recruiting
NCT06644833
Effective of Transcranial Magnetic Stimulation (TMS) vs Treatment as Usual for First-Episode Depression in AdultsNo drug interventionstreatment4not_yet_recruiting
NCT00581009
The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patientstreatment1 / 2completed
NCT04293341
Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic DisorderNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT04770285
Trial to Evaluate the Effectiveness of a Digital Therapeutics in Adults Diagnosed With Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT05317481
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily RhythmsNo drug interventionspreventionNot Availablerecruiting
NCT05644301
INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive Disordertreatment3recruiting
NCT05717439
Feasibility and ML Training Investigation of the Senseye DT for Diagnosis of Adults with PTSDNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06293781
Application of the Web-based Acceptance and Commitment Therapy for DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT06476509
A Study to Assess Serotonin Transporter Occupancy of Healthy Adults Using 11C-DASB PETtreatment1active_not_recruiting
NCT04225624
Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive ThoughtsNo drug interventionstreatmentNot Availablerecruiting
NCT05009511
MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical DepressionNo drug interventionsbasic_scienceNot Availablerecruiting
NCT06633016
Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)treatment2recruiting
NCT05655507
Zuranolone Pharmacokinetics (PK) and Safety Study Adolescent Participants With Major Depressive Disorder (MDD)treatment1active_not_recruiting
NCT05811897
RESILIENT : a Self-Managed Online Platform for Victims of Sexual AssaultNo drug interventionstreatmentNot Availablerecruiting
NCT06247839
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disordertreatment3not_yet_recruiting
NCT06462196
Natural History of Depression, Bipolar Disorder and Suicide RiskNo drug interventionsNot AvailableNot Availablerecruiting
NCT02960763
Optimizing Outcomes of Treatment-Resistant Depression in Older Adultstreatment4completed
NCT03242213
Patient Management of Depression Through Technology: a Study of Digitally Enabled EngagementNo drug interventionssupportive_careNot Availablecompleted
NCT03322774
Sleep To Reduce Incident Depression EffectivelyNo drug interventionspreventionNot Availablecompleted
NCT06252701
Diet and DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT06626152
Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trialtreatment2recruiting
NCT04638231
Supportive Text Messaging Versus Supportive E-mail Messaging for Patients with Major Depressive DisorderNo drug interventionssupportive_careNot Availablecompleted
NCT04675593
Using MHealth to Improve Adherence and Reduce Blood Pressure in Individuals with Hypertension and Mood DisordersNo drug interventionstreatmentNot Availablerecruiting
NCT04846829
Effects of Intravenous (IV) Citalopram Hydrochloride During Transcranial Magnetic Stimulation in Major Depressive Disorder (MDD)No drug interventionstreatment0active_not_recruiting
NCT06605105
Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)No drug interventionstreatment3not_yet_recruiting
NCT05172271
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRDNo drug interventionsdevice_feasibilityNot Availablerecruiting
NCT05202119
Empower: tDCS for Major Depressive Disorder at HomeNo drug interventionstreatmentNot Availablecompleted
NCT05376150
A Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 in Major Depressive DisorderNo drug interventionstreatment2completed
NCT05773755
DBS for TRD with the Medtronic Percept PCNo drug interventionsbasic_scienceNot Availablerecruiting
NCT06001346
CBT+ for DepressionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT06029426
Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disordertreatment3recruiting
NCT06043401
Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation TherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT06093906
Positive Processes and Transition to Health (PATH)No drug interventionstreatmentNot Availablerecruiting
NCT06110897
RESISTance Exercise for Depression TrialNo drug interventionstreatmentNot Availablerecruiting
NCT06610305
Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depressionother4recruiting
NCT06254612
A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults with Major Depressive DisorderNo drug interventionstreatment2recruiting
NCT06357832
New Investigational Stimulation Protocol for Treatment of Major Depression Disorder (MDD)No drug interventionstreatmentNot Availablerecruiting
NCT06404320
Physical Activity Program for TRDNo drug interventionstreatmentNot Availablerecruiting
NCT06423781
Long-term Safety Study of BHV-7000 in Participants With Major Depressive Disorder (MDD)No drug interventionstreatment2enrolling_by_invitation
NCT06559826
Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depressiontreatment2recruiting
NCT06570369
A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major DepressionNo drug interventionstreatment1recruiting
NCT01567943
Contingency Management of Alcohol Abuse in the Severely Mentally ILLNo drug interventionstreatmentNot Availablecompleted
NCT05353543
Acupuncture Therapy Based on Biological Specificity of Acupoints for Major Depressive DisorderNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05439603
ANC-501 in the Treatment of Adults With Major Depressive Disordertreatment2active_not_recruiting
NCT02037503
The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major Depressiontreatment3unknown_status
NCT04698603
Clinical Study of GH001 in Depressiontreatment1 / 2completed
NCT05312203
Alleviating Stress by Mobile Application' for DepressionNo drug interventionssupportive_careNot Availablerecruiting
NCT00367003
Deep Brain Stimulation for Treatment Resistant DepressionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT01971203
Efficacy of Extended-release Quetiapine (Seroquel XR) as Adjunctive Therapy to Cognitive Behavioral Therapy in the TreattreatmentNot Availablecompleted
NCT01397903
Description of Treatment Management of Patients With Major Depressive Disorder and Inadequate ResponseNo drug interventionsNot AvailableNot Availablecompleted
NCT05134103
Mindbeacon Therapist Assisted Internet Delivered CBT for DepressionNo drug interventionstreatmentNot Availablewithdrawn
NCT00705003
Efficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD)treatment2completed
NCT01699490
Role of Inflammation Factors and Insulin Resistance in Major Depressive Disordertreatment4unknown_status
NCT00321490
Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo and Active Control in Major Depressive Disordertreatment3completed
NCT01920490
Blame Rebalance fMRI Feedback Proof-of-conceptNo drug interventionspreventionNot Availablecompleted
NCT05425290
Emotion Regulation Training to Reduce Cardiovascular Disease Risk Among Depressed Young Adults in Southern MississippiNo drug interventionstreatmentNot Availablecompleted
NCT01360190
Neurophysiologic Monitoring of Antidepressant Treatmentbasic_science4completed
NCT01369290
Electroencephalography (EEG) Signal ProcessingNot AvailableNot Availableunknown_status
NCT03666390
Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and SuicidetreatmentNot Availableunknown_status
NCT06266390
Individualized (fMRI-guided) TMS Treatment for DepressionNo drug interventionsbasic_scienceNot Availablerecruiting
NCT05525390
Extended Reality Behavioral Activation: An Intervention for Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT02458690
eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patientsprevention2completed
NCT03113890
McLean and Genomind Prospective StudyNo drug interventionssupportive_careNot Availablecompleted
NCT04166864
Spectral Correlation Coefficient-determine TMS for DepressionNo drug interventionstreatmentNot Availableenrolling_by_invitation
NCT02046564
Assess the Efficacy and Safety of ASC-01 in Patients With Major Depressive DisorderNo drug interventionstreatment3completed
NCT03771664
A Study to Evaluate the Safety, Tolerability, and Efficacy of SAGE-217 Compared to Placebo in Adult Participants With Comorbid Major Depressive Disorder (MDD) and Insomniatreatment3terminated
NCT02530164
Transcranial Direct Current Stimulation (tDCS) As Treatment for Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT00548964
Continuation Ketamine in Major Depressiontreatment1completed
NCT04688164
A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)treatment3completed
NCT04714164
Cognitive Behavioral Therapy Group for Older Adults Delivered by TelethealthNo drug interventionstreatmentNot Availableterminated
NCT00135421
Study of BMS-562086 in the Treatment of Outpatients With Major Depressive Disordertreatment1 / 2completed
NCT03128021
Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response (NEMO)treatment4completed
NCT06537921
Comorbid Obesity and Depression With an Anti-inflammatory MedicationotherNot Availablenot_yet_recruiting
NCT01371721
A 6-Month Open-Label Extension Study to the B2061014 Study to Evaluate the Safety, Tolerability and Efficacy of DVS SR in the Treatment of Children and Adolescents With MDDtreatment3completed
NCT05772221
The Role of Social Determinants in Cardiovascular Health and Vascular FunctionNo drug interventionsscreeningNot Availablerecruiting
NCT04619121
Near-infrared Radiation-transcranial Photobiomodulation for Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT04352621
Study to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD)treatment4unknown_status
NCT03624621
Integral Remediation for Major Depression ("Rehabilitación Integral Para la Depresión Mayor", RIDEM)No drug interventionstreatmentNot Availablecompleted
NCT00035321
The Study of Olanzapine Plus Fluoxetine in Combination for Treatment of Treatment Resistant Depressiontreatment3completed
NCT01931202
Mechanisms of Antidepressant Non-Response in Late-Life DepressiontreatmentNot Availablecompleted
NCT04388202
Leveraging EEG for Antidepressant Prediction With Sertraline and Escitalopramtreatment4withdrawn
NCT01803802
Effects of Early Abuse on Adult Intimate RelationshipsNo drug interventionstreatmentNot Availablecompleted
NCT01601002
LEPR Polymorphism Weight Gain by Mirtazapine in Late Life DepressionNot Available4completed
NCT00566202
A Safety and Effectiveness Study of JNJ-18038683 in Patients With Moderate to Severe Depressiontreatment2completed
NCT01110902
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder (MDD)treatment3completed
NCT01710202
Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone AdministrationNot AvailableNot Availablecompleted
NCT02959502
Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life DepressionNo drug interventionsotherNot Availableactive_not_recruiting
NCT05411302
Augmenting Mental Health Support Through a Supportive Text Messaging ProgramNo drug interventionssupportive_careNot Availablerecruiting
NCT04526002
The Utility of Concurrent TBS/fNIRS for Antidepressant Treatment OptimizationNo drug interventionsbasic_scienceNot Availablerecruiting
NCT05537584
SMART Trial to Predict Anhedonia Response to Antidepressant Treatmenttreatment4recruiting
NCT03452384
Acupuncture in Depression: From the Clinical Trial, Biomarkers to Molecular BiologyNo drug interventionstreatmentNot Availablecompleted
NCT04041284
A Study to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of Migraine in Patients With Major Depressive Disorderprevention4completed
NCT02361684
e-Compared-S: Comparative Effectiveness Research on Internet-based Depression Treatment - Spanish TrialNo drug interventionstreatmentNot Availablecompleted
NCT02980484
fMRI-neuronavigated rTMS for the Treatment of Major Depression Associated With TBINo drug interventionstreatment2terminated
NCT00592384
Project to Improve Symptoms and Mood in People With Spinal Cord Injurytreatment4completed
NCT05271084
Pentoxifylline as an Adjunct to Citalopram in Adult Patients With Major Depressive Disordertreatment1 / 2completed
NCT04255784
High Dose Accelerated iTBS for DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT01121484
Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) In The Treatment Of Peri- And Postmenopausal Women With Major Depressive Disorder (DVS 3364)treatment4completed
NCT06013384
Low-Intensity Focused Ultrasound for Treatment-Resistant DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT06028984
Self-guided Treatment for DepressionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT00593879
Flexible Dose Titration Add-on Study to Treat Major Depressive Disordertreatment2completed
NCT03595579
Assessing Symptomatic Clinical Episodes in Depressiontreatment2completed
NCT01537679
Meditation to Reduce Caregiver StressNo drug interventionssupportive_careNot Availablecompleted
NCT03449979
Single Session of tACS in a Depressive EpisodeNo drug interventionsbasic_scienceNot Availablecompleted
NCT00435279
A Study of Eszopiclone Co-administered With Venlafaxine in Subjects With Major Depressive Disorder and Insomniatreatment3completed
NCT00714779
Fluoxetine vs. Brief Psychotherapy for Major DepressiontreatmentNot Availablecompleted
NCT02579343
Adjunctive Treatment of Major Depression Utilizing Auricular AcupuncturetreatmentNot Availablecompleted
NCT01392287
Treatment Resistant Geriatric Depression in Primary Carebasic_science1completed
NCT05712187
Phase 2b Study of ALTO-100 in MDDNo drug interventionstreatment2active_not_recruiting
NCT06299787
Cognitive Dysfunction in the Addictions Study - Project 4 (P4)No drug interventionstreatmentNot Availablerecruiting
NCT03329287
Simplified Cognitive Behavioral Therapy for Generalized Anxiety Disorder and DepressionNo drug interventionstreatmentNot Availableunknown_status
NCT05666687
An Open-label, Adaptive Design, Positron Emission Tomography Study in Healthy Male Participants to Characterize Receptor Occupancy by MIJ821 in the BrainNo drug interventionsbasic_science1completed
NCT00984087
rTMS for Adolescents and Young AdultsNo drug interventionstreatment2withdrawn
NCT05004987
Aβ Dynamics in LLMDtreatment4recruiting
NCT04990687
Vagal Nerve Stimulation for Treatment Resistant Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT00943033
Study of Mindfulness-Based Cognitive TherapyNo drug interventionstreatmentNot Availablecompleted
NCT00182533
Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood Disorderstreatment4terminated
NCT00205933
Behavioral Processes Underlying Reward Processing in DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT00296933
Memory Functioning and Antidepressant Treatmenttreatment3completed
NCT01344733
A Non Interventional Study to Investigating the Ratio of Mis-diagnosed Bipolar Symptoms in Patient With Major Depressive Disorder (MDD)No drug interventionsNot AvailableNot Availablecompleted
NCT00789854
Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patientstreatment3completed
NCT00239954
Escitalopram Combination Comparison Study for Adult Patients With Major Depressive Disordertreatment3unknown_status
NCT01733654
Investigate Efficacy & Safety of RO4995819 vs. Placebo as Adjunct Tx in Patients w/Major Depressive Disordertreatment2withdrawn
NCT01244854
Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental IllnessNo drug interventionshealth_services_researchNot Availablecompleted
NCT00125554
Metyrapone as Additive Treatment in Major Depressiontreatment2completed
NCT01808651
A Study of Fluoxetine in Major Depressive Disorder (MDD) Long-Term Dosingtreatment3completed
NCT05527951
Enhanced Measurement-Based Care Effectiveness for Depression (EMBED) StudyNo drug interventionsotherNot Availableunknown_status
NCT01874951
Low-Dose Naltrexone (LDN) for Depression Relapse and Recurrencetreatment2completed
NCT01990053
Pilot Study Assessing Computerized Cognitive Behavioral Therapy for DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05138653
A Single and Multiple Ascending Dose Trial of CVL-354 in Healthy ParticipantsNo drug interventionstreatment1completed
NCT04679753
Brainsway DTMS for Treatment of MDD Using iTBSNo drug interventionstreatment4completed
NCT01571453
Study of Vortioxetine (Lu AA21004) in Major Depressive Disorder in Asian Countriestreatment3completed
NCT04244253
A Phase 2 Trial of OPC-64005 for Major Depressive DisorderNo drug interventionstreatment2completed
NCT03228953
Pharmacogenomic Testing in Major Depressive DisorderNo drug interventionshealth_services_researchNot Availableterminated
NCT03620253
Modafinil's Effects on Cognition in Remitted MDDtreatment3terminated
NCT01818453
Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?No drug interventionstreatmentNot Availablecompleted
NCT03388177
Yoga for Young Women With DepressionNo drug interventionstreatmentNot Availableunknown_status
NCT06027177
Personalized, Predictive, Precise & Preventive Medicine for Major DepressionNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02398877
HPA Axis Activity Due To Early Traumatic Stress and Metabolic SymptomsNo drug interventionsbasic_scienceNot Availablecompleted
NCT02809677
Treating Caregiver Depression to Improve Childhood Asthma: Impact and MediatorsNo drug interventionsdiagnosticNot Availablecompleted
NCT06011577
Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDDtreatment3recruiting
NCT05591677
D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation (iTBS) in Depression (COGENT)treatment2recruiting
NCT00781677
Using Neuroimaging to Investigate Major Depressive DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT01457677
ARTDeCo Study: A Study of RO4995819 in Patients With Major Depressive Disorder And Inadequate Response to Ongoing Antidepressant Treatmenttreatment2completed
NCT03068247
Neurobiology of Treatment Responses in MDDother3withdrawn
NCT05585047
Treatment Response Biomarkers in MDDNo drug interventionsNot AvailableNot Availablerecruiting
NCT01395147
Long-Term Extension Study of Lu AA21004 in Participants With Major Depressive Disordertreatment3completed
NCT02935647
Burst Suppression Anesthesia for Treatment of Severe Depressiontreatment1completed
NCT00531947
Phase IV:Safety and Efficacy of EMSAM in Adolescents With Major Depressiontreatment4completed
NCT04855747
A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)treatment3recruiting
NCT05895747
5-HTP and Creatine for Depression R33 Phasetreatment2recruiting
NCT05157945
ALTO-300 in Depression (ALTO-300-004)No drug interventionstreatment2completed
NCT04466345
Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disordertreatment2active_not_recruiting
NCT00305045
Treating Refractory Major Depressive Disorder With Repetitive Transcranial Magnetic StimulationNo drug interventionstreatmentNot Availablecompleted
NCT02004145
Trial of a Positive Psychology Intervention in Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT00953745
Dopaminergic Effects of Adjunctive Aripiprazole on the Brain in Treatment-Resistant DepressionotherNot Availablecompleted
NCT03548545
tDCS as add-on Treatment to Cognitive-Behavior Therapy in People With MDDNo drug interventionstreatmentNot Availableunknown_status
NCT01217645
Study to Assess the Distribution, Metabolism and Excretion of [14C]AZD6765 After a Single-Dose Intravenous AdministrationNo drug interventionsbasic_science1completed
NCT00095745
A Long-Term Study of Aripiprazole in Patients With Major Depressive Disordertreatment3completed
NCT01625845
Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED)treatment2completed
NCT03711045
An Eye Tracking Study of Affective Disorder Patients With Suicide RiskNo drug interventionsNot AvailableNot Availableunknown_status
NCT04199845
8-week of PS128 RCT in Patients With Major Depressive DisorderNo drug interventionstreatmentNot Availableunknown_status
NCT05976945
Imagery Rescripting as Treatment for DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT04847245
Esketamine Adjuvant Therapy for Patients With Chronic Visceral Pain Comorbid Major Depressive DisordertreatmentNot Availableunknown_status
NCT01774045
A Dose Escalation Phase I Study of PDC-1421 Capsule Targeting in DepressionNo drug interventionsother1completed
NCT00863798
Study Evaluating Desvenlafaxine Succinate Sustained Release In Adults With Major Depressive Disordertreatment3completed
NCT06126198
rTMS Feasibility Study on Adolescent Depression StimulationNo drug interventionstreatmentNot Availableenrolling_by_invitation
NCT04841798
MAO-B Occupancy in Depressed PatientsNo drug interventionsotherNot Availablecompleted
NCT03193398
BTRX-246040 Administered Once Daily to Patients With Major Depressive Disordertreatment2completed
NCT05859698
Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesiatreatment4active_not_recruiting
NCT02720198
Levomilnacipran ER vs. Adjunctive Quetiapine for Adults With Inadequate Relief With SSRIs in MDDtreatment3completed
NCT00229398
Medical and Psychiatric Co-Morbidity Among Treatment Resistant Patients With Major Depression DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT05399498
Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disordertreatment2recruiting
NCT05643898
"Mamá, te Entiendo" App-based Intervention for Reducing Depressive Symptoms in Postpartum WomenNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00369798
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patientstreatment1completed
NCT01573598
Safety and Efficacy of Vilazodone in Major Depressive Disordertreatment4completed
NCT04632498
Investigating Biological Markers, Targets, and Intervention for Mood DisordersNo drug interventionsbasic_scienceNot Availableterminated
NCT02811198
Pain, Reward, Attention and Neurocircuitry: Biomarkers of SuicidalityNo drug interventionsNot AvailableNot Availablerecruiting
NCT01715805
Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD)treatment3completed
NCT00807105
Evaluation of the H-coil Transcranial Magnetic Stimulation TMS Device - Safety and Feasibility Study for Acute and Maintenance Treatment in Major Depressive EpisodeNo drug interventionstreatment2completed
NCT00870805
Ultrabrief Pulsewidth Electroconvulsive Therapy (ECT)No drug interventionstreatment4completed
NCT00335205
A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression.treatment4unknown_status
NCT04711005
Phase 1 Evaluation of (2R,6R)-HydroxynorketamineNo drug interventionstreatment1completed
NCT00209105
Characterizing Psychological Consequences of Childhood TraumaNo drug interventionsNot AvailableNot Availablecompleted
NCT03183505
Comparison of Anyu Peibo With Placebo in Treatment of MDD,ⅡbNo drug interventionstreatment2completed
NCT02615405
Phospholipid Hypothesis of Depression: From Molecular Biology, Neuroimaging to BehaviourNo drug interventionstreatmentNot Availablecompleted
NCT00326105
Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in Combination With an Antidepressant in the Treatment of Major Depressive Disorderstreatment3completed
NCT01254305
Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Adults With Fatigue Associated With Major Depressive Disordertreatment2completed
NCT02507297
Sleep-Disordered Breathing and PAP in Perinatal DepressionNo drug interventionstreatmentNot Availablecompleted
NCT04364997
Study of Desvenlafaxine in Treating Major Depressive Disorder.treatment3completed
NCT00223197
Pregnenolone Trial for Depression in Bipolar Disorders or Recurrent Major Depressive Disorder With Substance Abusetreatment4completed
NCT00555997
A 12-Week, Placebo Controlled Trial of Ziprasidone as Monotherapy for Major Depressive Disordertreatment2completed
NCT05137197
Confirm the Effectiveness of Predictix Genetics Antidepressant -Guided Treatment in Adults With MDDNo drug interventionssupportive_careNot Availablerecruiting
NCT05135897
The Neurobiological Fundaments of Depression and Its Relief Through Neurostimulation TreatmentsNo drug interventionsNot AvailableNot Availablerecruiting
NCT01426997
Phenotype Depression StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT06126497
Study Evaluating Safety and Efficacy of Ropanicant in MDD Patientstreatment2active_not_recruiting
NCT06045897
EEG Microstates Across At-Risk Mental StatesNo drug interventionsdiagnosticNot Availablerecruiting
NCT05385783
A Study of a Psilocybin Analog (CYB003) in Healthy Participants With and Without Major Depressive DisorderNo drug interventionstreatment1 / 2completed
NCT01357083
The Study of Serum Melatonin Rhythm Levels in Patients With Major Depressive DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT04395183
5-HTP and Creatine for DepressionNo drug interventionstreatment2completed
NCT00034983
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-066)(COMPLETED)treatment3completed
NCT02473783
The Serotonin Transporter Availability for Prognosing Major Depressive Disorder (MDD) Treatment and Detecting MDDother2completed
NCT05682183
Multi-domain Psychoeducation Self-management Program for Adults With MDD in SingaporeNo drug interventionshealth_services_researchNot Availablerecruiting
NCT02709161
Effects of Amygdala Neurofeedback on Depressive SymptomsNo drug interventionstreatmentNot Availablecompleted
NCT05950061
Sertraline Versus Escitalopram in South Asian Participants With Moderate to Severe Major Depressive Disordertreatment3completed
NCT04981561
Safety and Tolerability of GATE-251 in Normal Human Volunteerstreatment1completed
NCT05041361
HypErthermia as an Additional Treatment for the Biology and Experience of DepressionNo drug interventionstreatmentNot Availablecompleted
NCT01428661
Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disordertreatment2 / 3completed
NCT01198561
Repetitive Transcranial Magnetic Stimulation(rTMS) in the Treatment of DepressionNo drug interventionsNot AvailableNot Availableunknown_status
NCT04116528
Opiate Suicide Study in Patients With Major Depressiontreatment3recruiting
NCT00519428
Does Dual Therapy Hasten Antidepressant Response?treatment4completed
NCT02661828
Tapering Off AntidepressantsNo drug interventionstreatmentNot Availableterminated
NCT04528628
Optimization of Diagnosis and Treatment of Depression Based on Multidimensional Clinical Assessment ClassificationtreatmentNot Availableunknown_status
NCT02579928
Ketamine Infusion for Adolescent Depression and Anxietytreatment4completed
NCT02214511
Biomarkers of Social Sensitivity in Major DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT00599911
Dose-finding Study With Lu AA24530 in Major Depressive Disordertreatment2completed
NCT05017311
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)treatment4recruiting
NCT00104611
Study of a Repetitive Transcranial Magnetic Stimulation (rTMS) Device for the Treatment of Major Depressive DisorderNo drug interventionstreatment3completed
NCT03623711
A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depressiontreatment0unknown_status
NCT01424111
Exploring Biomarkers for DepressionNot AvailableNot Availablecompleted
NCT05547711
Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Recruited in an Outpatient SettingNo drug interventionsotherNot Availablenot_yet_recruiting
NCT02369393
Efficacy of Two Internet Delivered Intervention Programs for Depression: Behavioral Activation vs Physical ActivityNo drug interventionstreatmentNot Availablecompleted
NCT02266693
Transdiagnostic iCBT for Depression and AnxietyNo drug interventionstreatmentNot Availablecompleted
NCT01263093
A Pharmacokinetic Study on the Effect of LY2216684 on the Active Metabolite of Clopidogreltreatment1completed
NCT05813093
Interleaved TMS-fMRI in Ultra-treatment Resistant DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT06391593
PD, PK, and Safety of ALTO-203 in Patients With MDDNo drug interventionstreatment2recruiting
NCT03187093
Cognitive Dysfunction in MDD Patientstreatment4unknown_status
NCT02058693
Adjunctive Mixed Salts Amphetamine for Depressed Adults With Incomplete Response to Current Antidepressant Therapytreatment4completed
NCT04751071
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patientstreatment1 / 2recruiting
NCT04423471
Neuroinflammation, Affective and Cognitive Symptoms in Major Depression and PsoriasisNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01488071
A Study of Vortioxetine (Lu AA21004) in Comparison to Agomelatine in Adults Suffering From Major Depression With Inadequate Response to Previous Medicationtreatment3completed
NCT04091971
Ketamine Treatment Effects on Synaptic Plasticity in Depressionother4completed
NCT05571878
Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescentsbasic_scienceNot Availablerecruiting
NCT01977378
A Study of Sustained-Release Desvenlafaxine Hydrochloride for the Treatment of Major Depressive Disordertreatment2 / 3unknown_status
NCT04721678
Internet-administered Interpersonal Psychotherapy for Depressive SymptomsNo drug interventionstreatmentNot Availablecompleted
NCT05045378
Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depressiontreatment4recruiting
NCT03237078
Lactobacillus Plantarum PS128 in Patients With Major Depressive Disorder and High Level of InflammationNo drug interventionstreatmentNot Availableunknown_status
NCT04425278
tDCS Intervention on Motivational Anhedonia of Major Depressive DisorderNo drug interventionstreatmentNot Availableunknown_status
NCT02715778
Translational Investigation of Gestational Environment on Neurobehavioral Function in ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT04832178
Sumor as Adjuvant Therapy in Treatment-resistant Major DepressionNo drug interventionstreatment4recruiting
NCT01323478
Open-label Safety Extension Study of 15 and 20 mg of Vortioxetine (Lu AA21004) in Long-term Treatment of Major Depressive Disorder in Adultstreatment3completed
NCT06095778
rTMS Therapy for Treatment-Resistant Depression With Different Targets Guided by pBFSNo drug interventionstreatmentNot Availablerecruiting
NCT01973478
Deep Brain Stimulation in Patients With Chronic Treatment Resistant DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05295888
Temporal Interference and DepressionNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05437588
Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in AdolescentsNo drug interventionspreventionNot Availablerecruiting
NCT02586688
Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed AdolescentsNo drug interventionstreatmentNot Availableunknown_status
NCT03812588
Contact: Developing New Clinical Management Strategiestreatment4completed
NCT03861988
Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgerytreatment4completed
NCT02356107
5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Femalestreatment4completed
NCT00108407
Study Comparing Two Types of Psychotherapy for Treating Depression and Substance AbuseNo drug interventionsNot AvailableNot Availablecompleted
NCT00385307
Efficacy and Safety of SR58611A in Patients With Major Depressive Disorder (SIRIUS)treatment3completed
NCT00048607
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-062)(COMPLETED)treatment3completed
NCT02959307
Transcranial Laser Therapy, Continuous and Pulsed Light, for Major Depressive Disorder (ELATED-3)No drug interventionstreatmentNot Availablecompleted
NCT05932407
A Database Survey of Comparison The Risk of Haemorrhage Between Vortioxetine Tablet Treatment and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment in Participants With DepressionNot AvailableNot Availablecompleted
NCT00612807
Treatment of Mood and Marriage Study (TOMMS)treatment1 / 2completed
NCT04159207
A Longitudinal Study of Inflammatory Pathways in DepressionNo drug interventionsNot AvailableNot Availableunknown_status
NCT04598607
Tolerability and Pharmacokinetics of Hypidone Hydrochloride in Healthy SubjectsNo drug interventionstreatment1completed
NCT00561509
Multi-Country Observational Study to Collect the Frequency of Sexual Dysfunction With Antidepressant Treatment, Either With SSRIs or Duals at 8 Weeks and 6 MonthsNo drug interventionsNot AvailableNot Availablecompleted
NCT06003309
Frequency and E-field Enhancement of ITBS for Depression (FREED)No drug interventionstreatmentNot Availablerecruiting
NCT05249309
Naturalistic Study of Ketamine in the Treatment of DepressionNot AvailableNot Availableactive_not_recruiting
NCT05976009
pBFS-Guided rTMS Therapy Over Different Targets for Treatment-Resistant DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT01385709
The Influence of the Menstrual Cycle on Lithium and Sertraline Blood LevelsNo drug interventionsNot AvailableNot Availablecompleted
NCT05950009
Relationship Between Major Depression and Periodontal DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT06306209
Inflammatory Control of Antidepressant Efficacy: a Pharmaco-epigenetic ApproachNo drug interventionsNot AvailableNot Availablerecruiting
NCT00035009
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-059)treatment3completed
NCT03152409
Salicylic Augmentation in Depressiontreatment2terminated
NCT01337609
Study of Probiotic GanedenBC30 for Irritable Bowel Syndrome and Major Depressive DisorderNo drug interventionstreatment4terminated
NCT03889756
Ketamine for Severe Adolescent Depression: Intermediate-term Safety and Efficacytreatment2 / 3terminated
NCT01211756
Oxytocin Add-on for Stable Depressed PatientstreatmentNot Availableterminated
NCT04977856
Efficacy and Cost-effectiveness of Internet-delivered CBT for Adolescents With DepressionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT04785456
rTMS for Suicidality in Opioid Use DisorderNo drug interventionstreatmentNot Availablecompleted
NCT01890356
Maintenance Transcranial Electrical Stimulation for DepressionNo drug interventionstreatmentNot Availablecompleted
NCT02308956
Task Sharing for the Care of Severe Mental Disorders in a Low-income CountryNo drug interventionshealth_services_research3completed
NCT02922556
Piloting a Novel, Mobile Cognitive Training Tool for Patients With Major Depressive Disorder (MDD)No drug interventionstreatmentNot Availablecompleted
NCT05703256
Amygdala Neurofeedback for Depression - Large Scale Clinical TrialNo drug interventionstreatmentNot Availablerecruiting
NCT00517985
Duloxetine for Perimenopausal Depressiontreatment4completed
NCT01330485
Deficits in Emotion Regulation Skills as a Maintaining Factor in Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT03790085
Identification of Multi-modal Bio-markers for Early Diagnosis and Treatment Prediction in Schizophrenia Individualsdiagnostic0unknown_status
NCT04923685
MicroRNA Correlates of Childhood Maltreatment and SuicidalityNo drug interventionsNot AvailableNot Availablerecruiting
NCT03899285
Citalopram Titration in Early Non-responder Patients With Major Depressive Disorderstreatment2completed
NCT04437485
eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risktreatment2completed
NCT05725785
Technology-Assisted Implementation of a Mobile Health Program for Serious Mental IllnessNo drug interventionssupportive_careNot Availablerecruiting
NCT06323785
Whole-body Hyperthermia for DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT02339285
Transcranial Alternating Current Stimulation for Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT01533285
Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patientstreatment0completed
NCT06203015
The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects With Depressive DisorderNo drug interventionsNot AvailableNot Availablerecruiting
NCT01156415
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD)treatment3terminated
NCT04032015
rTMS Study in Depression to Evaluate the Relationship Between Brain Plasticity and Clinical OutcomeNo drug interventionsbasic_scienceNot Availablewithdrawn
NCT04602715
The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major DepressionNo drug interventionstreatment2unknown_status
NCT01894815
Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trialtreatment3completed
NCT01719315
Neurophysiologic Correlates of HypersomniaNo drug interventionsNot AvailableNot Availablecompleted
NCT01443715
A Stepped Care Model of Adolescent Depression Treatment in Primary CareNo drug interventionstreatment2 / 3completed
NCT02440815
Multimodal MRI Characteristics of Psychotherapy Response in Late Life DepressionNo drug interventionsbasic_scienceNot Availablecompleted
NCT04711915
Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humansother1active_not_recruiting
NCT03835715
Study With Vortioxetine on Emotional Functioning in Patients With Depressiontreatment4completed
NCT04285515
Clinical Trial Evaluating Lumateperone Monotherapy in the Treatment of Bipolar Depression or Major Depressive Disordertreatment3completed
NCT01582815
A Study of JNJ-40411813 as Supplementary Treatment to an Antidepressant in Adults With Depression and Anxiety Symptomstreatment2completed
NCT01473615
Mindfulness Based Cognitive Therapy for Chronic Pain and Comorbid Unipolar DepressionNo drug interventionstreatmentNot Availableunknown_status
NCT01082237
Biomarkers for Outcomes In Late-life Depression (BOLD)treatment4completed
NCT04217837
Treatment of Major Depressive Disorder in the UK Using TMS TherapyNo drug interventionsNot AvailableNot Availablewithdrawn
NCT04031937
Sensory and Psychomotor Profile in DepressionNo drug interventionsscreeningNot Availablecompleted
NCT05720637
The Efficacy and Cerebral Mechanism of Intradermal Acupuncture for Major Depressive DisordertreatmentNot Availablecompleted
NCT04593537
Action Tendencies and Prognosis in Major Depressive DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT04208932
A Kynurenine Pathway-based Molecular Imaging Study of Individualized Diagnosis and Treatment for Major Depressive DisorderNo drug interventionsNot AvailableNot Availableunknown_status
NCT00919932
Using a Text-message System to Engage Depressed Adolescents in Cognitive-behavioral Therapy HomeworkNo drug interventionstreatmentNot Availablecompleted
NCT03062332
The Gut Microbiota of Bipolar and DepressionNo drug interventionsNot AvailableNot Availableunknown_status
NCT02972632
Goal Achievement After a Change to Vortioxetine in Adults With Major Depressive Disordertreatment4completed
NCT01325532
Efficacy and Safety of Cranial Electrical Stimulation (CES) for Major Depressive Disorder (MDD)No drug interventionstreatmentNot Availablecompleted
NCT01742832
Double-Blind Treatment of Major Depressive Disorder With Vilazodonetreatment2completed
NCT03739632
Study to Explore the Effective Doses and to Assess the Safety and Efficacy of Hypidone Hydrochloride TabletsNo drug interventionstreatment2completed
NCT01022632
Effect of Curcumin as Nutraceutical in Patients of DepressiontreatmentNot Availablecompleted
NCT04422652
Combination of Novel Therapies for CKD Comorbid Depressiontreatment2recruiting
NCT00521352
Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Panic Disorder With Comorbid Major DepressionNo drug interventionstreatment2completed
NCT03222752
Efficacy of Cranial Electrotherapy Stimulation (CES) for the Treatment of Major Depressive DisorderNo drug interventionstreatmentNot Availableterminated
NCT04780152
TDCS in Pediatric and Teenage Patients With Major Depressive Disorder During COVID-19 Pandemictreatment2 / 3unknown_status
NCT04479852
A Study of the Safety and Efficacy of SP-624 in the Treatment of Adults With Major Depressive DisorderNo drug interventionstreatment2completed
NCT06229652
Stress Management in Depressive Disorder: Resilience Training vs. Yoga: Biological, Epigenetic, and Brain CorrelatesNo drug interventionshealth_services_researchNot Availablenot_yet_recruiting
NCT00683852
A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant Therapytreatment3completed
NCT00204152
Treatment for Chronic DepressionNo drug interventionstreatment3terminated
NCT05149352
RESET-psychotherapy: the Effectiveness of Trauma-focused Therapy in Patients With Depression and Childhood TraumaNo drug interventionstreatmentNot Availableunknown_status
NCT01882452
A Randomised Controlled Clinical Trial of Memory Specificity Training (MEST) for DepressionNo drug interventionstreatmentNot Availablecompleted
NCT06480500
i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trialtreatment2recruiting
NCT05675800
Psilocybin for Major Depressive Disordertreatment2withdrawn
NCT05996900
Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in HumansNo drug interventionsbasic_scienceNot Availableactive_not_recruiting
NCT00854100
Safety and Efficacy of Cariprazine As Adjunctive Therapy In Major Depressive Disordertreatment2completed
NCT04358900
Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01500200
A Study to Evaluate ALKS 5461 in Subjects With Major Depressive Disorder (MDD)No drug interventionstreatment2completed
NCT02055300
Safety, Tolerability and Pharmacokinetics Study of LY03005treatment1completed
NCT00998959
Stress Reduction Intervention for Enhancing Treatment Outcome for Depressed Minority PatientsNo drug interventionstreatmentNot Availablecompleted
NCT06345859
Regulation of Affect and Physiology in DepressionNo drug interventionsbasic_science2recruiting
NCT00715559
Cysteamine Therapy for Major Depressive DisordertreatmentNot Availableterminated
NCT04276259
Rapid Antidepressant Improvement Secondary to Excitatory Brain Responsesother4recruiting
NCT06183359
Self-Identification ProgramNo drug interventionspreventionNot Availablenot_yet_recruiting
NCT01001559
Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective AnalysisNot AvailableNot Availablecompleted
NCT04014959
Mini Theta Burst TMS in MDD PatientsNo drug interventionsbasic_scienceNot Availablecompleted
NCT05815459
Mobile Observation Of DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT03569475
Efficacy, Safety, and Tolerability of Levomilnacipran ER in Pediatric Patients (7-17 Years) With Major Depressive Disordertreatment3completed
NCT06168175
Feasibility of Conducting a Clinical Trial Assessing Efficacy of Lactate as Adjunctive Therapy in Patients With Major Depressive Disordertreatment2not_yet_recruiting
NCT04657575
Optimisation of ECT Based on ASTI vs NarcotrendNo drug interventionsbasic_scienceNot Availablecompleted
NCT04410575
Mental Health Assessment and Prescribing by Alberta PharmacistsNo drug interventionstreatmentNot Availablerecruiting
NCT05645575
In-patient SCC TMSNo drug interventionstreatmentNot Availableenrolling_by_invitation
NCT03504475
Bioequivalence Study of Paroxetine Tablets and Paxil® Under Fasting and Fed Conditions in Chinese Healthy Volunteersprevention1completed
NCT01976975
Brain Mechanisms of Human MotivationNo drug interventionsNot AvailableNot Availablecompleted
NCT03977675
The Role of HNKs in the Antidepressant Effect of Ketaminebasic_science1terminated
NCT05866575
Prediction of the Therapeutic Response in Depression Based on Neuro-computational Modeling Assessment of MotivationNo drug interventionstreatmentNot Availablerecruiting
NCT06113575
Practical Application of Accelerated iTBS for MDDNo drug interventionstreatmentNot Availablecompleted
NCT00042575
Dose Escalation, Double-Blind Treatment With Duloxetine Hydrochloride Once Daily Dosing for Evaluation of Safety in Major Depressiontreatment3completed
NCT00931775
Citalopram Versus Citalopram Plus Pindolol in Major Depressive Disordertreatment2completed
NCT00489775
Duloxetine Versus Paroxetine for Major Depressiontreatment3completed
NCT01804270
rTMS for Depressed Teens: A Sham-Controlled Trial, Part 1No drug interventionstreatmentNot Availableterminated
NCT03307070
Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain InjuryNo drug interventionstreatmentNot Availablecompleted
NCT00621270
Safety and Effectiveness Study of BCI-540 Versus Placebo in the Treatment of Major Depressive Disorder With Concomitant AnxietyNo drug interventionstreatment2completed
NCT06050070
Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) NeurofeedbackNo drug interventionsbasic_scienceNot Availablerecruiting
NCT00809770
Contingency Management of Psychostimulant Abuse in the Severely Mentally IllNo drug interventionstreatmentNot Availablecompleted
NCT04399070
The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)treatmentNot Availableunknown_status
NCT05866042
Boosting Psychotherapy Effects by Means of Transcranial Direct Current StimulationNo drug interventionstreatmentNot Availablecompleted
NCT04337242
Blended Care Versus Face-to-Face Therapy for DepressionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT06518642
Transcranial Direct Current Stimulation (tDCS) in Young Individuals With Major Depressive Disorder: a Literature Review and Feasibility StudyNo drug interventionstreatmentNot Availablecompleted
NCT02612142
Physical EXercise as an Adjunct Treatment for DepressionNo drug interventionstreatmentNot Availablecompleted
NCT03254342
MRS and Medication Response: A Pilot StudyNo drug interventionsNot AvailableNot Availableterminated
NCT01438242
An Open Label Study of the Genecept™ Assay in Treatment Resistant DepressionNo drug interventionssupportive_careNot Availablewithdrawn
NCT05530642
An Augmented Training Program for Preventing Post-Traumatic Stress Injuries Among Diverse Public Safety PersonnelNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT00096642
Cognitive Behavioral Therapy for Early-Onset DepressionNo drug interventionstreatmentNot Availablecompleted
NCT00188942
A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorderdiagnostic4completed
NCT03685942
Efficacy of Light Therapy Device LUMINETTE® in Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT04985942
Clinical Trial of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disordertreatment3completed
NCT01421342
VA Augmentation and Switching Treatments for Improving Depression Outcomestreatment3completed
NCT03084042
Emotional Brain Networks & Cognitive Functioning in Depression and AnxietyNo drug interventionsNot AvailableNot Availableunknown_status
NCT00377299
A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or DependencetreatmentNot Availablecompleted
NCT01370499
A Study of LY2216684 in Participants With Major Depression Disordertreatment3completed
NCT00411099
Efficacy, Safety and Tolerability of Agomelatine in the Treatment of Major Depressive Disordertreatment3completed
NCT01020799
AZD7268 Safety and Tolerability Studytreatment2completed
NCT02192099
Open Label Extension for GLYX13-C-202, NCT01684163treatment2terminated
NCT03511599
Cycloserine rTMS Plasticity Augmentation in Depressionbasic_science1completed
NCT05461599
Digital Therapeutic for Adolescent Depressive Symptoms in Cardiology and GastroenterologyNo drug interventionstreatmentNot Availableterminated
NCT06410599
Pharmacologic Treatment Augmentation in Chronic Depressiontreatment2not_yet_recruiting
NCT02372799
Safety and Efficacy of Vilazodone in Pediatric Patients With Major Depressive Disorder (VLZ-MD-22)treatment3completed
NCT05054699
Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority StudyNo drug interventionstreatment2 / 3recruiting
NCT05707299
The Effect of Intradermal Acupuncture on Gallbladder Meridian Points on Cerebral Hemodynamics in Relevant Brain Regions for Major Depressive Disorder Based on fNIRS TechnologyNo drug interventionsbasic_scienceNot Availablenot_yet_recruiting
NCT02141399
A Long-Term Safety Study of ALKS 5461No drug interventionstreatment3completed
NCT00633399
Ziprasidone Augmentation of SSRIs for Patients With Major Depressive Disorder (MDD) That do Not Sufficiently Respond to Treatment With SSRIstreatment2completed
NCT02830399
Clinical Trial on Efficacy of rTMS to Improve ECT in Treatment-Resistant DepressionNo drug interventionstreatmentNot Availablecompleted
NCT02431806
Safety and Efficacy of Levomilnacipran ER in Adolescent Participants With Major Depressive Disordertreatment3completed
NCT00761306
Open-label Safety Extension Study of 5 and 10 mg of Vortioxetine (Lu AA21004) in Long-term Treatment of Major Depressive Disorder in Adultstreatment2completed
NCT03833206
A Phase I/II Study of PDC-1421 for Treating Depression in Cancer PatientsNo drug interventionstreatment1 / 2not_yet_recruiting
NCT01655706
Canadian Biomarker Integration Network for Depression Studydiagnostic3completed
NCT01263106
A Study of LY2216684 and Theophylline in Healthy Subjectstreatment1completed
NCT00744406
Patient Dimensions as Predictors of Varied Treatment Responses and Outcomes in Patients With Major Depressiontreatment2completed
NCT05224206
Neural Mechanisms of Intermittent Theta Burst Stimulation in the Core Depression NetworkNo drug interventionstreatmentNot Availablerecruiting
NCT01506206
ON/OFF Stimulation and Impulsivity in Patients With Deep Brain StimulatorsNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00063206
Study Evaluating DVS-233 in Adult Outpatients With Major Depressive Disordertreatment3completed
NCT01140906
Randomised Placebo-controlled Duloxetine-referenced Study of Efficacy and Safety of 15 and 20 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder in Adultstreatment3completed
NCT02165449
Biomarkers of Fast Acting Therapies in Major Depressiontreatment1completed
NCT00090649
Study Evaluating DVS-233 SR And Venlafaxine ER In Adult Outpatients With Major Depressive Disordertreatment3completed
NCT04721249
D-serine Supplementation for DepressionNo drug interventionstreatmentNot Availablecompleted
NCT01867749
Group Interpersonal Psychotherapy for Treatment of Major Depressive Disorder Following Perinatal LossNo drug interventionstreatmentNot Availablecompleted
NCT02021149
Enhancing Psychotherapy for Mood Disorders With Whole Body HyperthermiaNo drug interventionstreatmentNot Availableterminated
NCT03573349
Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:treatment0active_not_recruiting
NCT02646449
Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trialtreatment2completed
NCT03481049
Individualizing Incentives for Alcohol in the Severely Mentally IllNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02053649
Integrated Chronotherapy for Perinatal DepressionNo drug interventionstreatmentNot Availablecompleted
NCT02616549
Multicomponent Yoga Intervention for Major Depressive DisorderNo drug interventionstreatment2completed
NCT03881449
DIMES - DIgital MEdicine Study for Adults With Schizophrenia, Bipolar I Disorder, or Major Depression Currently Using Aripiprazoletreatment4unknown_status
NCT05024149
Assessing the Impact of Electroacupuncture on Facial Thermal Characteristics of Major Depressive Disorder Patients Based on Infrared Thermal Imaging TechnologyNo drug interventionsdiagnosticNot Availableenrolling_by_invitation
NCT04972136
rTMS for Depression in Young Adults With AutismNo drug interventionstreatmentNot Availablerecruiting
NCT05120336
tVNS Effects on Motivation in DepressionNo drug interventionsbasic_scienceNot Availablecompleted
NCT02948036
A Closed-loop Assessment and Treatment Platform for Unipolar Depression and AnxietyNo drug interventionstreatmentNot Availablecompleted
NCT01263236
A Study of LY2940094 in Major Depressive Disorderother1completed
NCT02149836
Study to Treat Major Depressive Disorder (MDD) With a New Medicationtreatment2completed
NCT04181736
The BIomarker Guided Study for Depressiontreatment4recruiting
NCT03026036
Neuroimaging Studies of Reward Processing in DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT03555136
Real-life Effectiveness of Vortioxetine in DepressionNot AvailableNot Availablecompleted
NCT05964036
pBFS-guided High-dose TMS Over DMPFC for Treatment-resistant Major Depressive DisorderNo drug interventionstreatmentNot Availablerecruiting
NCT02801513
Maintaining Mechanisms of Chronic Depression and Their ChangeabilityNo drug interventionsbasic_scienceNot Availablecompleted
NCT02051413
Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder (MDD) (DEPARRESTCLIN)treatment4completed
NCT02815813
Lifestyle Intervention for Young Adults With Serious Mental IllnessNo drug interventionstreatmentNot Availablecompleted
NCT01149213
Follow-up Study of Transcranial Direct Current Stimulation to Treat Major Depressive DisorderNo drug interventionstreatment2 / 3completed
NCT01422213
Efficacy Study of Vortioxetine on Cognitive Dysfunction in Adult Patients With Major Depressive Disordertreatment3completed
NCT05575713
The Effect of Soluble Epoxide Hydrolase (SEH) on DepressionNo drug interventionsNot AvailableNot Availableunknown_status
NCT01478113
Stimulant Enhancement of Well-Being Therapy for DepressiontreatmentNot Availableterminated
NCT00688818
Quetiapine in Co-Morbid Depressive and Anxiety DisorderstreatmentNot Availablecompleted
NCT05051618
Exercise Training for Managing Major Depressive Disorder in Multiple SclerosisNo drug interventionstreatmentNot Availablerecruiting
NCT05193318
KAP for Depression in Abstinent Opioid Userstreatment2terminated
NCT04471818
Ketamine or Placebo in Patients With Major Depression and Advanced Cancertreatment1 / 2completed
NCT05816018
Improving Health Care in Major Depressive DisorderNo drug interventionsNot AvailableNot Availablerecruiting
NCT03363919
Biomarkers in Repetitive Transcranial Magnetic Stimulation (rTMS) for Adolescent DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05988619
iCBT With TMS in Patients With MDDNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT05832619
Intradermal Acupuncture Versus Sham Acupuncture and SSRI for Treating Adolescents With Major Depressive DisordertreatmentNot Availablerecruiting
NCT05603819
Clinical Validation Study for EDIT-B Test: an Aid for Differential Diagnosis of Bipolar Disorder, Based on RNA Editing Blood BiomarkersNo drug interventionsNot AvailableNot Availablerecruiting
NCT04311619
Does rTMS Induce Synaptic Plasticity?other1suspended
NCT04935619
Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT04510519
Scaling Mental Healthcare in COVID-19 With Voice BiomarkersNo drug interventionsNot AvailableNot Availablecompleted
NCT05671419
Mindful Self-Compassion for Anxiety Disorders and DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT00635219
Randomised Placebo-controlled Duloxetine-referenced Efficacy and Safety Study of 2.5, 5 and 10 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disordertreatment3completed
NCT02615119
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosabasic_scienceNot Availablecompleted
NCT01263119
A Study of LY2216684 and Warfarin in Healthy Subjectstreatment1completed
NCT05597241
Multiple Ascending Dose and Electroencephalography Trial of GATE-202 in Healthy VolunteersNo drug interventionstreatment1completed
NCT00367341
Imaging Predictors of Treatment Response in DepressiontreatmentNot Availablecompleted
NCT05384041
Cranial Electrotherapy Stimulation for the Treatment of Major Depressive Disorder in AdultsNo drug interventionstreatmentNot Availablecompleted
NCT02283541
Gait, Depression, and Mind-body Therapy in SeniorsNo drug interventionstreatmentNot Availablecompleted
NCT05957341
pBFS Guided 20min Inter-session Interval rTMS Treatment for MDDNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03774641
A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant WomenNot AvailableNot Availablerecruiting
NCT00313417
Creatine as a New Therapeutic Strategy in DepressionNo drug interventionstreatment4terminated
NCT06026917
Assessing Dopamine Transporter Occupancy in the Patients With Depression Brain With Toludesvenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET)No drug interventionstreatment4recruiting
NCT02078817
Ketamine in Adolescents With Treatment-Resistant Depressiontreatment2completed
NCT00745017
Stress Generation and Recurrent Depression: The Role of Differential Treatment ResponseNo drug interventionstreatment1completed
NCT02307617
Glutamate Probes in Adolescent DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT02272517
Efficacy of Vortioxetine Versus Escitalopram on Cognitive Function in Patients With Inadequate Response to Current Antidepressant Treatment of Major Depressive Disordertreatment3completed
NCT06076317
Relevance of a Telemedicine Monitoring in the Management of DepressionNo drug interventionssupportive_careNot Availablerecruiting
NCT05422417
Dorsomedial Prefrontal Neuromodulation in Treatment-resistant DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT05523817
Targeting Specific Brain Networks to Treat Specific Symptoms in DepressionNo drug interventionsotherNot Availablerecruiting
NCT05598034
Evaluating tDCS Brain-stimulation in Depression Using MRINo drug interventionsbasic_scienceNot Availablerecruiting
NCT02747134
Combining Emotion Regulation and Mindfulness Skills for Preventing Depression RelapseNo drug interventionstreatmentNot Availablecompleted
NCT01318434
A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)treatment2 / 3completed
NCT04615234
Clinical Validation of a Combinatorial Pharmacogenomic Approach in Major Depressive DisorderNo drug interventionsNot AvailableNot Availableunknown_status
NCT01371734
A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDDtreatment3completed
NCT05889234
Multimodal Magnetic Resonance Imaging-based Study of Electroconvulsive Efficacy Prediction in Adolescents With Depression: a Multicenter Prospective Cohort StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT03632434
Transcranial Direct Current Stimulation Therapy for Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT06372834
Adjuvant Accelerated piTBS for Reducing Suicidal Ideation in TRD PatientsNo drug interventionstreatmentNot Availablerecruiting
NCT03143634
The Modular Protocol for Mental Health (MPMH)No drug interventionstreatment1 / 2completed
NCT04623034
Evaluation of the Safety and Pharmacokinetics of MSI-195 to a Commercial S-Adenosylmethionineother1completed
NCT01070134
Mindfulness-based Behavioural Therapy (MIBT) Versus Psychodynamic Therapy for Patients With Major Depressive Disorder in Psychotherapeutic Day Treatment. A Randomised Clinical Pilot TrialNo drug interventionstreatmentNot Availableunknown_status
NCT00905424
Exploratory Study of SPD489 in Adults With Major Depressive Disorder (MDD) as Augmentation Therapy to an Antidepressanttreatment2completed
NCT05084924
Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With AnhedoniaNo drug interventionsbasic_scienceNot Availablecompleted
NCT04891224
Use of a Digitally Enabled App With Clinical Team Interface in the Management of DepressionNo drug interventionshealth_services_researchNot Availablecompleted
NCT04975724
Safety of Liposom With Citalopram in Elderly Patients With Major Depressive Disordertreatment4recruiting
NCT01671124
The Study of Antidepressant Properties and Safety of Fer-01(Soline®) on the Patients With DepressionNo drug interventionsNot AvailableNot Availableunknown_status
NCT04788524
Neural Correlates of Stress and Perceived Control in Adolescent DepressionNo drug interventionsbasic_scienceNot Availablerecruiting
NCT06213324
Neural Circuit Effects of Ketamine in Depressionbasic_science4recruiting
NCT01793324
EMR Data to Assess Monitoring of Patients Treated With QuetiapineNo drug interventionsNot AvailableNot Availablecompleted
NCT02752724
Ketamine Anesthesia for Improvement of Depression in ECTtreatmentNot Availablecompleted
NCT01721824
The Effect of IPS-MA- A Modified Early Supported Employment Intervention for Individuals With Mood or Anxiety DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT03556124
Transcranial Direct Current Stimulation in Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT04594616
Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD)No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03822416
Treating Smokers With Mental Illnesstreatment2completed
NCT01919216
Placebo Effects in the Treatment of Depression: Cognitive and Neural Mechanismstreatment4completed
NCT06336616
Getting Out of the House: Using Behavioral Activation to Increase Community ParticipationNo drug interventionssupportive_careNot Availablerecruiting
NCT01175616
Creatine Augmentation in Veterans With SSRI-Resistant Major Depressiontreatment4withdrawn
NCT04268316
Virtual Reality Behavioral Activation: An Intervention for Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT03937596
Adjunctive D-Cycloserine in Major Depressive Disordertreatment2completed
NCT02943096
Flavanol Augmentation for Antidepressant Non-Responsive Late Life DepressionNo drug interventionstreatmentNot Availableterminated
NCT05273996
Predictors of Cognitive Outcomes in Geriatric Depressionother4recruiting
NCT01409096
Study Using Pregnenolone to Treat Bipolar Depressiontreatment4completed
NCT01804296
rTMS for Depressed Teens: A Sham-Controlled Trial, Part 2No drug interventionstreatmentNot Availableterminated
NCT04608396
Mechanistic Evaluation of Response in TRD (MERIT)No drug interventionstreatment2completed
NCT00075296
FMRI Study of Performance During a Probabilistic Reversal Learning Task in DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT04633096
The Efficacy of Automated Feedback After Internet-based Depression ScreeningNo drug interventionsscreeningNot Availablecompleted
NCT04209296
Chart Review of Patients Undergoing Ketamine InfusionsNot AvailableNot Availablecompleted
NCT00095758
A Study of Adjunctive Aripiprazole in Patients With Major Depressive Disordertreatment3completed
NCT05217758
RESET-medication Glucocorticoid Receptor (GR) Blockade as Disease Modifying Treatment for Depression With Childhood Traumatreatment2unknown_status
NCT02476058
A Safety, Efficacy and Biomarker Study of JNJ-42847922 in Participants With Major Depressive Disordertreatment1completed
NCT00644358
A One Year Open Label Study Assessing the Safety and Tolerability of Vilazodone in Patients With Major Depressive Disorder (MDD)treatment3completed
NCT03726658
AGN-241751 in the Treatment of Major Depressive Disordertreatment1 / 2completed
NCT02793258
Impact of tDCS on Emotional Processing in Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT06451835
Evaluation of Response to a Course of Repetitive Transcranial Magnetic Stimulation Using Vocal BiomarkersNo drug interventionsNot AvailableNot Availablerecruiting
NCT02869035
Treatment Outcome in Major Depressive Disorderother1completed
NCT00285935
Cellular Aging and Neurobiology of Depression StudyNo drug interventionshealth_services_researchNot Availablerecruiting
NCT00926835
Effect of Antidepressants on the Treatment for Korean Major Depressive Disorder Patientstreatment4terminated
NCT04009135
The Internet Therapy for Depression TrialNo drug interventionstreatmentNot Availablecompleted
NCT03959735
High Intensity Interval Training in Severe Mental IllnessNo drug interventionstreatmentNot Availablecompleted
NCT01514435
Changes in Cerebral Glucose Metabolism After Electroconvulsive Therapy (ECT)No drug interventionstreatmentNot Availablecompleted
NCT04825535
Non-Inferiority RCT Comparing Online and On-Site CBT in MDDiNo drug interventionstreatmentNot Availablesuspended
NCT04541563
Fisher Wallace Neurostimulation & Depression StudyNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02029963
Can Magnetic Brain Stimulation Help Prevent Relapse in Depression?No drug interventionstreatmentNot Availableterminated
NCT04618263
Safety and Tolerability of Single and Multiple Ascending Doses of GATE-101 in Normal Human VolunteersNo drug interventionstreatment1terminated
NCT01353963
Desvenlafaxine Succinate (Pristiq): Postmarketing Surveillance Study Among Filipino PatientsNot AvailableNot Availableterminated
NCT03833063
Glabellar Botulinum Toxin Injections for the Treatment of Geriatric Depressiontreatment1withdrawn
NCT00988663
The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems?treatmentNot Availablewithdrawn
NCT03096886
Novel Neural Circuit Biomarkers of Major Depression Response to CCBTNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT05260086
Pre-mapping Networks for Brain Stimulation 2No drug interventionstreatmentNot Availablecompleted
NCT04621786
Electroconvulsive Therapy Amplitude TitrationNo drug interventionstreatmentNot Availablecompleted
NCT02132286
Serotonin Transporter Genetic Variation and Amygdala Responses to Antidepressant Medications in Major DepressionNot Available4completed
NCT00518986
Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depressiontreatment4completed
NCT03688139
Reward Function and Therapy for Late-Life DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05388539
TBS Treatment for Treatment-Resistant DepressionNo drug interventionstreatmentNot Availablecompleted
NCT02805439
Efficacy and Safety of S 47445 Versus Placebo as Adjunctive Treatment in Depressed Patients Not Fully Recovered From Depressive Symptoms With a Current Antidepressant Treatmenttreatment2completed
NCT01427439
A Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT05948839
pBFS Guided rTMS Over DMPFC for Treatment-Resistant DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT04039022
Open-Label Safety Study of AXS-05 in Subjects With Depressiontreatment3completed
NCT03078322
AV-101 as Adjunct Antidepressant Therapy in Patients With Major Depressiontreatment2completed
NCT04000022
Repetitive Transcranial Magnetic Stimulation in Pharmaco-naïve Patients With Major DepressionNo drug interventionsNot AvailableNot Availableunknown_status
NCT00885222
Antidepressant Effect of Deep Brain Stimulation in Parkinson's Disease PatientsNo drug interventionstreatmentNot Availablecompleted
NCT01312922
Pipamperone/Citalopram (PNB01) Versus Citalopram (CIT) and Versus Pipamperone (PIP) in Major Depressive Disorder (MDD)treatment3completed
NCT01598922
Internet Based Cognitive Behavioral Therapy Effects on Depressive Cognitions and Brain FunctionNo drug interventionstreatmentNot Availablecompleted
NCT05435222
Evaluation of a Male-specific Psychotherapeutic Program for Major Depressive DisordersNo drug interventionstreatmentNot Availablerecruiting
NCT05976022
pBFS Guided rTMS Therapy Over Different Targets for Treatment-Resistant DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT00816322
The Effect of Fish Oil in Major Depressive DisorderNo drug interventionspreventionNot Availablecompleted
NCT02156622
CID 0911 - Adaptation of A Depression Treatment Intervention for HIV Patients in CameroonNo drug interventionsNot AvailableNot Availablecompleted
NCT04162522
Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Studydiagnostic3completed
NCT00243425
Patient-Centered Depression Care for African AmericansNo drug interventionstreatmentNot Availableunknown_status
NCT04156425
The Role of PKC Activation in the Immune-inflammatory Mechanism of Major Depressive DepressiontreatmentNot Availablenot_yet_recruiting
NCT00149825
Combining Antidepressant Medication and Psychotherapy for Insomnia to Improve Depression Outcometreatment2completed
NCT02238730
Ultrabrief Right Unilateral and Brief Pulse Bitemporal Electroconvulsive TherapyNo drug interventionstreatmentNot Availablewithdrawn
NCT01109030
Pioglitazone as an Adjunct for Moderate to Severe Depressive Disordertreatment2 / 3completed
NCT00252330
Efficacy and Safety of SR58611A in Patients With Major Depressive Disordertreatment3completed
NCT02099630
Functional and Metabolic Changes in the Course of Antidepressive TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT03053830
Open Label Ketamine Treatment for Major Depressive Disorder in Veteranstreatment2completed
NCT04447430
Light Therapy to Improve Symptoms in Pregnant Women With Major Depressive DisorderNo drug interventionstreatmentNot Availableunknown_status
NCT05601648
PET Synaptogenesis After Psilocybin In DEpression Recoverytreatment2withdrawn
NCT00807248
Short-term Study of Combination Treatment of Escitalopram and Gaboxadol in Major Depressive Disordertreatment2completed
NCT02263248
Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphinetreatment1 / 2completed
NCT03998748
Electrophysiological Correlates of Cognition in DepressionNo drug interventionsbasic_scienceNot Availableterminated
NCT05933148
Network Neurofeedback Using 7-Tesla MRI to Reduce Rumination Levels in DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT05615948
Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depressiontreatment4completed
NCT02456948
Adjunct Minocyline in Treatment-resistant Depressiontreatment2completed
NCT06306248
Immune Activation, Neural Plasticity and DepressionNo drug interventionsNot AvailableNot Availablerecruiting
NCT01725048
Pilot Study to Evaluate Individualized Choice of Antidepressants in Patients With Cancersupportive_care0completed
NCT03009448
The Experience of Older Adults Facing Depression for the First Time in Old AgeNo drug interventionsNot AvailableNot Availableunknown_status
NCT01556048
Pilot Study of Behavioral Activation for Prolonged GriefNo drug interventionstreatment1completed
NCT04924257
ECT vs. Esketaminetreatment3withdrawn
NCT04031157
Controlled Study to Evaluate the Safety and Efficacy of the Predictix Antidepressant Clinician Support ToolNo drug interventionssupportive_careNot Availableunknown_status
NCT01542957
Cognitive Therapy for Unipolar Depression: Efficacy of a Dilemma-Focused InterventionNo drug interventionstreatmentNot Availablecompleted
NCT04824157
Ketamine IV Classic Protocol : Five Years Follow upNo drug interventionsNot AvailableNot Availablecompleted
NCT01437657
MARIGOLD Study: A Study of RO4917523 Versus Placebo as Adjunctive Therapy in Patients With Major Depressive Disorder and an Inadequate Response to Ongoing Antidepressant Therapytreatment2completed
NCT00245557
Magnetic Resonance Imaging Study of Geriatric DepressiontreatmentNot Availablecompleted
NCT02376257
Improving Therapeutic Learning in Depression: Proof of Concepttreatment2completed
NCT03088657
Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT06230757
Psilocybin for Treatment-Resistant Depressiontreatment2enrolling_by_invitation
NCT01559857
Pioglitazone in Patients With Mood Disorderstreatment4completed
NCT05271357
Transcranial Magnetic Stimulation for Depression in Autism Spectrum ConditionsNo drug interventionstreatmentNot Availablecompleted
NCT02028026
The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressivestreatment4withdrawn
NCT02176226
IntelliCare: Artificial Intelligence in a Mobile Intervention for Depression and Anxiety (AIM)No drug interventionstreatmentNot Availablecompleted
NCT02800226
Pilot Study Comparing 10hz vs Theta Burst StimulationNo drug interventionstreatment3completed
NCT03601026
Genetic Counselling in the Prevention of Mental Health Consequences of Cannabis UseNo drug interventionspreventionNot Availablerecruiting
NCT02614326
MemFlex to Prevent Depressive RelapseNo drug interventionsprevention2completed
NCT04179526
Transdiagnostic Internet-delivered REBT Intervention for Adolescents' Internalizing ProblemsNo drug interventionstreatmentNot Availablecompleted
NCT00479726
Lilly's Emotional and Physical Symptoms of Depression Study (LEAPS)treatment4completed
NCT06341426
Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of Psilocybintreatment2recruiting
NCT02470026
Noradrenergic Activity, Cognition and Major Depressive Disorderbasic_scienceNot Availablecompleted
NCT06070766
RIVER At Home Ketamine ProtocolsNot AvailableNot Availablerecruiting
NCT01488266
Aripiprazole Augmentation Versus Switching to Different Class of Antidepressants in Major Depressive DisordertreatmentNot Availableunknown_status
NCT05786066
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effectsbasic_science2recruiting
NCT02256566
Cognitive Training for Mood and Anxiety DisordersNo drug interventionstreatmentNot Availablecompleted
NCT00209066
Treatment of Reduced Heart Rate Variability Associated With Major Depression With Electroconvulsive TherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT02415166
Influenza Challenge in Mood DisordersNo drug interventionsbasic_scienceNot Availableterminated
NCT01051466
A Study of the Neurobiology of Depressionbasic_science4completed
NCT01594866
Lexapro®'s Efficacy After Dose Escalation in Remission Studytreatment4completed
NCT00869765
Transcranial Direct Current Stimulation (tDCS) Augmentation by D-Cycloserine as a Treatment for Depressiontreatment2completed
NCT01829165
Brain Imaging of rTMS Treatment for DepressionNo drug interventionstreatmentNot Availablecompleted
NCT03822065
A Relative Bioavailability Food Effect Study of LY03005treatment1completed
NCT00514865
Placebo-Controlled Study of ONO-2333Ms in Patients With Recurrent Major Depressive DisorderNo drug interventionstreatment2completed
NCT05136365
A Study of Xiongdan Wan Treating DepressionNo drug interventionstreatment2completed
NCT01465165
Use of Multiple Brain Imaging Modalities (PET and MRS) to Identify Metabolic Abnormalities in Major DepressionNo drug interventionsNot AvailableNot Availableterminated
NCT04384965
Accelerated iTBS for Depressed Patients During the COVID-19 PandemicNo drug interventionstreatmentNot Availablecompleted
NCT05426265
The Effects of Videogames on Depression Symptoms and Brain DynamicsNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02568865
Noninvasive Physiologic Sensors to Assess DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT05695365
Feasibility of Resistance Exercise to Treat Major Depression Via Cerebrovascular MechanismsNo drug interventionstreatmentNot Availablecompleted
NCT04114565
Prevalence of Major Depression Among Immigrants in Santiago, ChileNo drug interventionsNot AvailableNot Availablecompleted
NCT00262665
Randomized, Placebo-controlled Trial of an AMPAkine in Major Depressive Disordertreatment2withdrawn
NCT03313674
Investigation of Seasonal Variations of Brain Structure and Connectivity in SADNo drug interventionsdiagnosticNot Availablecompleted
NCT03460574
Targeting Cognitive Immunization in DepressionNo drug interventionstreatmentNot Availablecompleted
NCT03554174
Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disordertreatment1active_not_recruiting
NCT00072774
Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disordertreatment3completed
NCT03051074
Examining the Effects of Reduced Environmental Stimulation on AnxietyNo drug interventionsbasic_scienceNot Availablecompleted
NCT03737474
A Long-Term Study of Brexpiprazole in Patients With Major Depressive Disordertreatment3completed
NCT00868374
Quetiapine Extended Release (XR) Treatment of Major Depressive Disorder With Comorbid Generalized Anxiety Disordertreatment3terminated
NCT03733574
A Study of LY03005 vs Pristiqtreatment1completed
NCT05431374
Measurement-Based Care Vs. Standard Care for Major Depressive DisorderNo drug interventionstreatment3completed
NCT01613820
Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive DisordertreatmentNot Availablewithdrawn
NCT02024620
Mobile Apps for the Treatment of DepressionNo drug interventionshealth_services_researchNot Availablewithdrawn
NCT01342120
PHARMO Institute Seroquel Safety StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT00402220
A Double-blind Sham Controlled Trial of rTMS in Treatment Resistant Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT00485420
eCare for Moods: An Internet-based Management ProgramNo drug interventionshealth_services_researchNot Availablecompleted
NCT05905120
Assessing Dopamine Transporter Occupancy in the Healthy Adult Brain With Toludivenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET)No drug interventionstreatment1completed
NCT02685982
Treating Major Depressive Disorder With Music and Low-frequency Rhythmic Sensory StimulationNo drug interventionstreatmentNot Availablecompleted
NCT01725282
Study to Evaluate the Effect and Safety of Quetiapine Extended Release (XR) (FK949E) in Major Depressive Disordertreatment2completed
NCT01831882
Identifying Biological Markers for Severe DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT01162382
Repetitive Transcranial Magnetic Stimulation for Treating Depression: A Functional Magnetic Resonance Imaging StudyNo drug interventionsbasic_scienceNot Availableterminated
NCT03230682
Eealy Improvement Predicts Antidepressants Response in Adults With Major Depression DisorderNot AvailableNot Availableunknown_status
NCT03665831
Deep TMS for Comorbid Depression and Cognitive Impairment in Older AdultsNo drug interventionstreatmentNot Availablerecruiting
NCT02185131
Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD.treatment2completed
NCT01828931
Lifestyle Intervention for Diabetes and Weight Management in PsychosisNo drug interventionstreatmentNot Availablecompleted
NCT03786731
A Transdiagnostic Sleep and Circadian Treatment for Major Depressive DisorderNo drug interventionstreatmentNot Availableunknown_status
NCT05174273
Neurocognitive Effects of FMT in MDD Patients With and Without IBSother2 / 3recruiting
NCT00742573
Incorporating Patient Treatment Choice to Improve Treatment Retention in Depressed Hispanicstreatment2completed
NCT02843373
Brain-Based Biomarkers in Response to TMS in MDDNo drug interventionsNot AvailableNot Availablecompleted
NCT05893173
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Sleep DeprivationNo drug interventionsNot AvailableNot Availablerecruiting
NCT01250873
A Pharmacokinetic Study of the Coadministration of LY2216684 With Sertralinetreatment1completed
NCT03121573
Efficacy and Safety of Duloxetine Among Individuals With Depressive Disorder in a 12 Weeks Trialhealth_services_researchNot Availablecompleted
NCT02461927
Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disordertreatment1 / 2completed
NCT02348827
Family Psychoeducation for Major Depressive DisorderNo drug interventionspreventionNot Availableunknown_status
NCT00812227
Neural Correlates of Psychodynamic Psychotherapy for DepressionNo drug interventionstreatmentNot Availablecompleted
NCT03628027
The Antidepressant Advisor StudyNo drug interventionsother2unknown_status
NCT04448327
Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major DepressionNo drug interventionsbasic_scienceNot Availablerecruiting
NCT01273376
Safety and Efficacy of RX-10100 to Treat Major Depressive Disordertreatment2completed
NCT06234176
Impact of Psychomotor Therapy on the Quality of Life in DepressionNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT00168376
A Randomised Double-Blind Trial of Targeted Repetitive Transcranial Magnetic Stimulation in Major Depressive DisorderNo drug interventionseducational_counseling_trainingNot Availablecompleted
NCT01838876
Long-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive Disordertreatment3completed
NCT04124276
Evaluation of Efficacy of Lycium Barbarum Polysaccharide in Patients With Major Depressive DisorderNo drug interventionstreatmentNot Availableunknown_status
NCT04748276
Tracking Response to Antidepressants in Advance of Investigational TrialsNot AvailableNot Availablerecruiting
NCT02141776
Comparison of Anodal Transcranial Direct Current Stimulation (t-DCS) and Sham Stimulation in Patients With Treatment-resistant DepressionNo drug interventionstreatment4completed
NCT03735576
Cognitive Behavioural Therapy for the Treatment of Late Life DepressionNo drug interventionstreatmentNot Availablecompleted
NCT01309776
Comparison of Tianeptine Versus Escitalopram Patients Major Depressive Disordertreatment4completed
NCT05708976
HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2No drug interventionstreatmentNot Availableactive_not_recruiting
NCT05529576
Multi-factor Model Constraction for Early Warning and Diagnosis of MDDtreatment4unknown_status
NCT06477276
Amygdala TIS for DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT00924976
Improving Representative Payeeship for People With Psychiatric Disabilities and Their FamiliesNo drug interventionshealth_services_researchNot Availablecompleted
NCT00130676
A United States Study of Corlux for Psychotic Symptoms in Psychotic Major Depressiontreatment3completed
NCT02939560
TMS for Adults With Autism and DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05913960
Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII PathwayNo drug interventionstreatmentNot Availablerecruiting
NCT06461260
Amygdala MRI-TIS for DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT01377194
Safety and Efficacy of Levomilnacipran ER (Levomilnacipran SR) in Major Depressive Disordertreatment3completed
NCT05409794
Basal Plasma Lithium Levels and Suicidal EventsNo drug interventionsNot AvailableNot Availablerecruiting
NCT00191594
Open-Label Duloxetine Extension Phase in Patients Who Have Completed Previous Duloxetine Trialstreatment3completed
NCT06542094
Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain StimulationNo drug interventionstreatmentNot Availablerecruiting
NCT00642694
Time to Remission of Depressive Symptoms With Combined SSRI and Ramelteontreatment3terminated
NCT01473394
Safety, Efficacy, and Tolerability of Vilazodone in Major Depressive Disordertreatment4completed
NCT03191994
Impact of an Eight Week Exercise Intervention in Treating Major Depressive DisorderNo drug interventionstreatmentNot Availableunknown_status
NCT00048594
Long Term Treatment of Patients With Major Depressive Disorder With MK0869 (0869-065)(COMPLETED)treatment3completed
NCT05165394
Study to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDDNo drug interventionstreatment2completed
NCT05118594
Testing a Precision Psychotherapy System for Low-income PatientsNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT01483391
Early Intervention for Youth at Risk for Bipolar DisorderNo drug interventionspreventionNot Availablecompleted
NCT03538691
A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disordertreatment3completed
NCT04971291
An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent Patientstreatment2unknown_status
NCT01189591
Slow-wave Sleep Deprivation in DepressionNo drug interventionsbasic_scienceNot Availablecompleted
NCT01734291
Brief Multifamily Psychoeducation for Families of Patients With Chronic Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05553691
SPL026 With or Without SSRIs in Participants With MDDtreatment1completed
NCT01380691
A Study of LY2216684 in Healthy Participantstreatment1completed
NCT05757791
Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2) in Major Depressive Disorder (MDD)treatment2recruiting
NCT05657691
Xanamem® in Adults With Major Depressive Disorder and Impaired Cognition (XanaCIDD)No drug interventionstreatment2completed
NCT03053362
THINC-it Vortioxetine - Sensitivity to Changeother2 / 3completed
NCT01436162
Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disordertreatment3completed
NCT04843462
Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine SpraytreatmentNot Availableunknown_status
NCT01034462
Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disordertreatment3completed
NCT00422162
A Study Evaluating Duloxetine in Patients Hospitalized for Severe Depressiontreatment4completed
NCT04838262
Stress and the Sympathetic Nervous System in Adults With DepressionNo drug interventionsbasic_scienceNot Availablecompleted
NCT00042562
Open-Label Treatment With Duloxetine Hydrochloride Once-Daily Dosing for Evaluation of Stabilization Dose in Patients With Major Depressiontreatment3completed
NCT02998762
Long-Term Follow Up StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT05506462
An EEG Study of Intravenous Ketamine for Major Depression Disordertreatment4unknown_status
NCT06223880
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptomstreatment4recruiting
NCT02855580
Integrating Pharmacogenomic Testing Into a Child Psychiatry ClinicNo drug interventionsNot AvailableNot Availablecompleted
NCT02657980
The Effect of tDCS in Patients With Moderate to Severe Major Depressive DisorderNo drug interventionstreatment3completed
NCT05144880
Effects of Electroacupuncture With Different Frequencies for Major Depressive DisorderNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT05239780
Invasive Decoding and Stimulation of Altered Reward Computations in DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT05065580
OMT as an Adjunctive Treatment in MDDNo drug interventionstreatmentNot Availablecompleted
NCT04138680
Real-time Biofeedback With 7-Tesla MRI for Treatment of DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05921929
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)No drug interventionsother1withdrawn
NCT03327129
Identifying the Neural Basis of Capability for SuicideNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00042029
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-073)treatment3completed
NCT00242229
Study Evaluating DVS-233 SR in Elderly Outpatients With Major Depressive DisorderNot AvailableNot Availablecompleted
NCT03181529
Effects of Psilocybin in Major Depressive Disordertreatment2completed
NCT06529029
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive TherapyNo drug interventionstreatment2 / 3recruiting
NCT02362529
Biomarkers of Neuroinflammation and Anti-Inflammatory Treatments in Major Depressive Disorderbasic_science0completed
NCT04842929
Magnetic Randomized Trial in Elderly DepressedNo drug interventionstreatmentNot Availableunknown_status
NCT01070329
A Study in Depression and Associated Painful Physical Symptomstreatment4completed
NCT05593029
A Trial of the Safety and Efficacy of SEP-363856 in the Treatment of Adults With Major Depressive Disordertreatment2 / 3recruiting
NCT01305889
The Effect of Problem Solving Therapy and Antidepressant Therapy on Cerebral Perfusion and Brain Derived Neurotropic Factor (BDNF) in Depressed ElderstreatmentNot Availablecompleted
NCT01149889
Transcranial Direct Current Stimulation to Treat Major Depressive DisorderNo drug interventionstreatment2 / 3completed
NCT03779789
Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic Assessmenttreatment4completed
NCT01110889
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disordertreatment3completed
NCT06547489
GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disordertreatment2not_yet_recruiting
NCT01043289
Light Therapy for Depression During PregnancyNo drug interventionstreatmentNot Availablecompleted
NCT05850689
Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disordertreatment3recruiting
NCT02666989
Open-Label Placebo for the Treatment of DepressionNo drug interventionstreatmentNot Availableunknown_status
NCT05212389
The Pill Project - Oral Contraceptive and Serotonergic Brain SignalingNo drug interventionsbasic_scienceNot Availablerecruiting
NCT04518592
Model-based Defining of Subtypes of Depression and Optimal Treatment: an Integrated Techniques Module.No drug interventionsNot AvailableNot Availablerecruiting
NCT01691092
PET Imaging of mGLuR5 With Drug ChallengeotherNot Availablecompleted
NCT02900092
Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid AllopregnanolonetreatmentNot Availablecompleted
NCT02230592
PET Imaging of Brain mGluR1 Receptors Using [18F]FIMXNo drug interventionsNot AvailableNot Availablecompleted
NCT03435744
Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial.treatment3completed
NCT02330744
The Neurobiology of Approach Avoidance Training in DepressionNo drug interventionstreatmentNot Availablecompleted
NCT01275144
A Study of the Effect of LY2216684 on Lorazepamtreatment1completed
NCT05892744
Establishing Multimodal Brain Biomarkers for Treatment Selection in Depressiontreatment4recruiting
NCT00034944
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-063)treatment3completed
NCT00822744
An Eight-week Study of SSR411298 as Treatment for Major Depressive Disorder in Elderly Patientstreatment2completed
NCT00326144
Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in the Treatment of Major Depressive Disorderstreatment3completed
NCT01098240
A Study Of The Efficacy And Safety Of CP-601,927 Augmentation Of Antidepressant Therapy In Major Depressiontreatment2terminated
NCT03265340
Clinical Effect of dTMS in Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT01185340
A Study in Participants With Major Depressive Disorder Who Are Partial Responders to Selective Serotonin Reuptake Inhibitortreatment3completed
NCT01787240
Neurobiological Bases of Placebo Response in Major Depressive Disordertreatment4terminated
NCT06211140
Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT03979040
Comparing Group Therapies for Veterans With Depression and PTSDNo drug interventionstreatmentNot Availablecompleted
NCT02139540
Nitrous Oxide as Treatment for Major Depression - a Pilot Studytreatment2completed
NCT02269540
A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A)treatment0completed
NCT05988840
Acquisition and Analysis of Relationships Between Longitudinal Emotional Signals Produced by an Artificial Intelligence Algorithm and Self-questionnaires Used in the Psychiatric Follow-up of Patients With Mood and/or Anxiety Disorders: a Real-Environment Study.No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04068467
Evaluation of mHealth for Serious Mental IllnessNo drug interventionssupportive_careNot Availablecompleted
NCT03523767
Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine StudyNo drug interventionsbasic_science1terminated
NCT00562367
Biochemical Brain Changes Correlated With The Antidepressant Effect Of Thyroid Hormonesbasic_scienceNot Availablecompleted
NCT01851967
Effectiveness and Acceptability of MoodGYM in Treating Depressive Symptoms in Chinese AmericansNo drug interventionstreatmentNot Availablecompleted
NCT01430767
Measuring Adherence to Medication for Depression and Attention-deficit Hyperactivity DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT05194267
Intensive tDCS for MDD: Feasibility StudyNo drug interventionstreatmentNot Availablecompleted
NCT04609267
Interactive Voice-Based Administration of the PHQ-9No drug interventionsdiagnosticNot Availableunknown_status
NCT04137367
A Personalized Approach to Effects of Affective Bias Modification on Symptom Change and RuminationNo drug interventionstreatmentNot Availablecompleted
NCT04007367
A Study to Evaluate SAGE-217 for Prevention of Relapse in Adult Participants With Major Depressive Disordertreatment3terminated
NCT00849901
A Study in the Treatment of Children and Adolescents With Major Depressive Disordertreatment3completed
NCT05315401
The Efficacy of Probiotic Compared With Placebo Commitment Therapy for Treatment of Major Depressive DisorderNo drug interventionstreatment2withdrawn
NCT01957501
Detecting Depression and Bipolar Disorder in Adolescents Using a Biomarker PanelNo drug interventionsNot AvailableNot Availableterminated
NCT06480201
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depressionother1recruiting
NCT02133001
A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicidetreatment2completed
NCT04019704
A Trial of AXS-05 in Patients With Major Depressive DisorderNo drug interventionstreatment3completed
NCT04296604
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric PopulationsNo drug interventionstreatmentNot Availablerecruiting
NCT06450704
Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive DisordersNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05603104
Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failuretreatment3recruiting
NCT00694304
Open-label Safety Extension Study of 2.5, 5 and 10 mg of Vortioxetine (Lu AA21004) in Long-term Treatment of Major Depressive Disorder in Adultstreatment3completed
NCT02727972
Examination of Glutamate and mGluR5 in Psychiatric DisordersNo drug interventionsotherNot Availablerecruiting
NCT00168272
Priming rTMS In Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT06331572
Exploring Blood Plasma Metabolomics: Unraveling the Metabolic Landscape in Treatment-Resistant Adolescent DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT00049972
Major Depressive Disorder Study In Adultstreatment4completed
NCT01145872
The Effects and Mechanisms of Mindfulness Based Cognitive Therapy (MBCT) on Depressive Symptoms and Depression RelapseNo drug interventionsprevention3completed
NCT05697172
Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In DepressionNo drug interventionsotherNot Availablecompleted
NCT00320372
Treatment-Resistant Depression RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT06309472
Trial of Mirtazapine for Depression in IBDtreatment2recruiting
NCT05686668
Evolution of the Sensory Profile in DepressionNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03925168
Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life OutcomesNo drug interventionstreatmentNot Availablecompleted
NCT00320268
Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo in Major Depressive Disordertreatment3completed
NCT00733668
Efficacy of SEROQUEL in Selective Serotonin Reuptake Inhibitors (SSRI)-Resistant Major Depressive Disordertreatment2completed
NCT00578669
Sequential Use of Fluoxetine for Smokers With Elevated Depressive Symptomstreatment3completed
NCT00208169
Abilify Therapy for Reducing Comorbid Substance Abusetreatment4completed
NCT04206969
Assessment of Transcultural Psychotherapy in Child Major Depressive DisorderNo drug interventionssupportive_careNot Availableunknown_status
NCT00421369
Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response.treatmentNot Availablecompleted
NCT06063369
PEA vs. Placebo for Major Depressiondiagnostic2recruiting
NCT00889369
Duloxetine for Major Depression in Peri-/Postmenopausal Womentreatment4unknown_status
NCT04634669
Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE)treatment2completed
NCT03430869
Pathophysiology of Neurodegeneration in Late-life Depression (AV45+THK)diagnostic2completed
NCT02940769
Neurobiological Effects of Light on MDDNo drug interventionsbasic_scienceNot Availableterminated
NCT01944969
Long-term Safety and Tolerability Study of Brexpiprazole as Adjunctive Treatment in Patients With Major Depressive Disordertreatment3terminated
NCT04004169
Closed-Loop Deep Brain Stimulation for Major DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT00186446
Treatment of Nicotine Dependence and Acute Depressiontreatment4completed
NCT03748446
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disordertreatment0recruiting
NCT05733546
A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disordertreatment2recruiting
NCT06080646
Reward Processing and Depressive Subtypes: Identifying Neural BiotypesNo drug interventionsNot AvailableNot Availablerecruiting
NCT01557946
Glutamatergic and GABAergic Mediators of Antidepressant Response in Major Depressiontreatment4completed
NCT00369746
STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol AbuseNot AvailableNot Availablecompleted
NCT03446846
A Study to Evaluate the Efficacy and Safety of MIN-117 in Adult Patients With Major Depressive DisorderNo drug interventionstreatment2completed
NCT02158546
A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - the FORWARD-3 StudyNo drug interventionstreatment3completed
NCT05227612
Psilocybin-assisted CBT for Depressiontreatment0recruiting
NCT01724112
Study of the Efficacy and Safety of LY2940094 in Participants With Major Depressive Disorder (MDD)treatment2completed
NCT05785312
Development of Online EMDR Therapy System and Its Comparative Testing With Face-to-Face EMDR Therapy for Treatment of Anxiety and Depressive Disorders in PakistanNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05989412
Mobile Screening for Major Depressive Disorder in Adults From an Ethnically and Socioeconomically Diverse Population.No drug interventionsscreeningNot Availablenot_yet_recruiting
NCT01085812
Relapse-Prevention Study With Levomilnacipran ER (F2695 SR) in Patients With Major Depressive Disordertreatment3completed
NCT00351910
Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive Disordertreatment3completed
NCT02860910
Cognitive Behavioral Group Therapy for the Management of Menopause Symptoms in Mood DisordersNo drug interventionstreatmentNot Availablecompleted
NCT04979910
Targeting IL-17A for Treatment-Resistant Depressiontreatment2recruiting
NCT01999010
Mental Health Telemetry for Self-Management in Major DepressionNo drug interventionstreatmentNot Availablecompleted
NCT01269710
Second-Generation Antipsychotic Treatment Indication Effectiveness And Tolerability In Youth (Satiety) StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01601210
Dose-Ranging Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive DisorderNo drug interventionstreatment0completed
NCT01031810
PET Biomarkers in Treatment Resistant Depressiontreatment4terminated
NCT04604210
Symptom-specific TMS Targets for Depression and AnxietyNo drug interventionstreatment2completed
NCT02805881
Safety and Feasibility of Combined Trigeminal and Occipital Transcutaneous Nerve Stimulation (CTO-TNS) in Major Depressive Disorder (MDD)No drug interventionstreatmentNot Availablecompleted
NCT05427981
Anti-suicidal Effects of Buprenorphine In Depressed Individualstreatment3withdrawn
NCT01838681
Brexpiprazole as Adjunctive Treatment in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatmenttreatment3completed
NCT01582581
Study of Technology-assisted Treatment of Adolescent DepressionNo drug interventionstreatmentNot Availablecompleted
NCT04055181
Influence of rTMS on Symptoms and Cognitive Function in Patients With Psychiatric DisordersNo drug interventionstreatmentNot Availablecompleted
NCT06132581
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic DepressionNo drug interventionsbasic_scienceNot Availablerecruiting
NCT03310281
Software Treatments for Actively Reducing Severity of Cognitive Deficits in MDD (STARS-MDD)No drug interventionstreatmentNot Availablecompleted
NCT00873795
Compare the Efficacy and Tolerability of the Combination of Aripiprazole and Selective Serotonin Reuptake Inhibitors (SSRIs) Used in Major DepressiontreatmentNot Availablecompleted
NCT05558995
Ketogenic Diet Therapy Major Depressive DisorderNo drug interventionstreatmentNot Availablerecruiting
NCT00452595
Study Evaluating DVS-233 for Treatment of Outpatients With Major Depressive Disordertreatment3completed
NCT05539495
Exercise Recovery From Persistent Depression: A Thematic AnalysisNo drug interventionsNot AvailableNot Availableunknown_status
NCT01608295
Vilazodone for Treatment of Geriatric Depressiontreatment4completed
NCT06159595
Behavioral and Neuronal Correlates of Human Mood StatesNo drug interventionsbasic_scienceNot Availablerecruiting
NCT00432614
Efficacy and Safety of SR58611A co-Administered With Escitalopram in Adults With Major Depressive Disordertreatment3completed
NCT02378714
Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokerstreatment4completed
NCT00166114
Depression, Epinephrine, and Platelet Functiontreatment4completed
NCT00628914
Brain Mechanisms and Targeting Insomnia in Major Depressiontreatment4unknown_status
NCT06329414
Acceptability and Feasibility of Transcranial Magnetic Stimulation (TMS) for Depression in Multiple SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT02607514
Hyperthermic Yoga for Depressive SymptomsNo drug interventionstreatmentNot Availablecompleted
NCT04826614
Comparing Efficacy of Optimal Treatment and Conventional Treatment for Major Depressive Disorder in Viet NamNo drug interventionstreatmentNot Availablecompleted
NCT03703414
Characterization of Microbial, Immune and Epigenetic Biomarkers for Major Depressive Disorder and ECT TreatmentNo drug interventionsNot AvailableNot Availableunknown_status
NCT04536714
Efficacy of Pythagorean Self-Awareness Intervention for Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT03953014
Pharmacogenetics of Antidepressant-Induced DisinhibitionNo drug interventionsNot AvailableNot Availablerecruiting
NCT01659814
Dopamine Neurotransmission in Major DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT00729755
Creatine Augmentation Treatment in Major Depressive Disorder SubjectsNo drug interventionstreatmentNot Availablecompleted
NCT04814355
The Effect of Celecoxib on Neuroinflammation in MDDtreatment4recruiting
NCT00404755
Dichotic Listening as a Predictor of Medication Response in Depressiontreatment4completed
NCT01145755
6-week Study Treatment to Evaluate the Safety and Effectiveness of AZD2066 in Patients With Major Depressive Disordertreatment2terminated
NCT01450150
Transcranial Direct Current Stimulation as an Augmenting Intervention for Major DepressionNo drug interventionstreatment2 / 3unknown_status
NCT03606850
Transcranial Magnetic Stimulation Study of Cortical Excitability as Marker of Antidepressant Response: EXCIPSY StudyNo drug interventionstreatmentNot Availableunknown_status
NCT00969150
Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disordertreatment3completed
NCT04355650
Augmented Human Intelligence in Major Depressive DisorderNo drug interventionsotherNot Availablecompleted
NCT04887350
SSIPP vs. PST vs. WLCNo drug interventionstreatment1withdrawn
NCT05855850
Deep rTMS for Depression in Older AdultsNo drug interventionshealth_services_researchNot Availablecompleted
NCT01372150
A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDDtreatment3completed
NCT00570050
Effect of Intranasal Insulin on Depressive Symptoms in Major Depressive Disordertreatment3completed
NCT04543123
Effect of Self-administered tDCS in Patients With MDDtreatment4completed
NCT03289923
Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive EpisodesNo drug interventionstreatmentNot Availablerecruiting
NCT02409823
Clinical Registry of Patients Under Treatment With Atypical AntipsychoticsNo drug interventionsNot AvailableNot Availablecompleted
NCT00277823
Study Evaluating Desvenlafaxine Sustained-Release (DVS-SR) in Adult Outpatients With Major Depressive DisorderNo drug interventionstreatment3completed
NCT00146523
An International Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depressiontreatment3completed
NCT00414323
Evaluation of the Effects of Duloxetine on Norepinephrinetreatment1completed
NCT05731323
D-Cycloserine+iTBS PK Studytreatment1completed
NCT01876823
Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairmenttreatment2 / 3completed
NCT05568823
Biomarkers of ANTidepressant RESponse and Development Risk of Bipolar DisorderNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00474708
Study Comparing the Efficacy of Venlafaxine XR Vs. SSRIs and Conventional Antidepressants in Depressed Patientstreatment4completed
NCT00739908
A Study of CX157 (TriRima) for the Treatment of Depressiontreatment2completed
NCT01371708
A 6-Month Extension Study To The B2061032 Study To Evaluate The Safety, Tolerability, And Efficacy Of DVS SR In The Treatment Of Child And Adolescent Outpatients With MDDtreatment3completed
NCT02375308
Efficacy of Cognitive Behavioral to Hypnotherapeutic Treatment of DepressionNo drug interventionstreatmentNot Availablecompleted
NCT00071708
Duloxetine Compassionate Use in Patients Who Have Completed a Previous Neuroscience Duloxetine Clinical TrialNot AvailableNot Availableno_longer_available
NCT04469608
Establishing TCM Daycare Model and Teaching Mechanism of Depression PatientsNo drug interventionstreatmentNot Availableunknown_status
NCT02285608
Partnership in Medication Management (PIMM) in Patients With Mood DisordersNo drug interventionshealth_services_researchNot Availableunknown_status
NCT01443208
Pharmacokinetics and Safety of Desvenlafaxine in Korean Healthy Subjects Following Single and Multiple Oral Doses of Desvenlafaxine Succinate Sustained Release Tabletbasic_science1completed
NCT01197508
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder.treatment3completed
NCT01752608
Efficacy of Electronic Cognitive Behavioral Therapy Application to Treat Major Depressive DisorderNo drug interventionstreatmentNot Availablewithdrawn
NCT04953208
Remotely Non-invasive Brain Stimulation and Videogame to Alleviate DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT01919008
Comparison of Plasma Concentration Changes Between Two Types of Tablets of FK949E Administration to Patients With Major Depressive Disorderother1completed
NCT02134808
Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disordertreatment4completed
NCT02983838
Research on Pathophysiology and Treatment in Depression Using Brain Derived Neurotrophic Factor and Amyloid NeuroimagingNo drug interventionsNot AvailableNot Availableunknown_status
NCT02816138
Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study)treatment4completed
NCT00433238
Screening for Mental Health Concerns for at-Risk Community Living Chinese SeniorsNo drug interventionsscreening1unknown_status
NCT03736538
Nitrous Oxide- Suicidal Ideationtreatment1enrolling_by_invitation
NCT01418638
The Metabolic Effects of Antidepressants in Patients Diagnosed With Major Depressive DisorderNo drug interventionsNot AvailableNot Availableunknown_status
NCT06025838
Positive Feedback vs. No-Feedback Games for Behavioral ChangeNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03977038
Investigation of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognition in DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT05028738
Patient-oriented Randomized Pragmatic Feasibility Trial With rTMS in Depression and AnxietyNo drug interventionstreatmentNot Availableunknown_status
NCT01226238
Online Self-help for Depressed Patients Awaiting PsychotherapyNo drug interventionstreatmentNot Availableterminated
NCT00452543
Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholismtreatment4completed
NCT05778643
TaKeTiNa in the Treatment of Depression: a Pilot Study.No drug interventionstreatmentNot Availablerecruiting
NCT05259943
Microdosing Psychedelics to Improve Moodtreatment2recruiting
NCT01921543
Deep Brain Stimulation in Treatment Refractory DepressionNo drug interventionstreatment1 / 2terminated
NCT00876343
Study of Aripiprazole as an Adjunctive Therapy in Patients With Major Depressive Disordertreatment3completed
NCT02593643
Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.treatment0completed
NCT06439043
Cultural Adaptation of EMDR for Major Depressive Disorder and Compaire Its Online and Face-to-Face TestingNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04589143
A Double-blind, Placebo-controlled Study of Antidepressant Augmentation With Agomelatinetreatment4completed
NCT03739203
The Objective of This Study is to Evaluate the Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alonetreatment3completed
NCT01182103
Epigenetic Regulation of BDNF in Major DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT04328103
Mechanisms of Emotion Regulation Underlying Successful CBT in DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT03697603
A Study of Brexpiprazole in Patients With Major Depressive Disordertreatment2 / 3completed
NCT00775203
A Randomized, Double-blind, Two-arm Study Comparing the Efficacy and Safety of Trazodone Contramid® OAD and Placebo in the Treatment of Unipolar Major Depressive Disorder.treatment3completed
NCT06009003
Individual Patient Esmethadone (REL-1017) Expanded Access ProgramNot AvailableNot Availabletemporarily_not_available
NCT02422303
Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive SymptomstreatmentNot Availableterminated
NCT00073203
A 6 Week Study to Determine the Effectiveness of R228060 in Adult Subjects With Major Depressive Disordertreatment2completed
NCT05195203
A Study of HS-10353 in Chinese Participants.No drug interventionstreatment1completed
NCT01517503
Acceptance and Commitment Therapy Versus Cognitive Therapy for the Treatment of Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT03787290
Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disordertreatment2suspended
NCT04556890
Pain and Major Depressive DisorderNo drug interventionstreatmentNot Availablerecruiting
NCT04138290
Post Marketing Study for the Evaluation of Predictix Antidepressant Clinician Software Support Tool in Prescribing Antidepressant Medication/s for the Treatment of Patients Suffering From Major Depressive DisorderNo drug interventionssupportive_care4unknown_status
NCT03899090
Floatation-REST (Reduced Environmental Stimulation Therapy) for Anxiety and DepressionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT01266590
A Study of LY2216684 and Digoxin in Healthy Subjectstreatment1completed
NCT06452290
PET Biomarker Study for Antidepressant Response Prediction in Major Depressive DisorderNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT03609190
A Multimodal Neuroimaging Study of Brain Activation Patterns Under Ketaminebasic_science0completed
NCT04630964
The Effect of Psilocybin on MDD Symptom Severity and Synaptic Densitytreatment2completed
NCT04467164
Vagus Nerve Stimulation: Integration of Behavior and Cardiac ModulationNo drug interventionsbasic_scienceNot Availablecompleted
NCT00782964
Antidepressant Incomplete Response DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT02479464
Clinical Impact of the Antidepressant Pharmacogenomic Algorithm in an Outpatient Therapy-based Clinical SettingNo drug interventionsotherNot Availablecompleted
NCT02366364
Study of Safety, Tolerability and Pharmacokinetics of NRX-1074 in Normal Healthy Volunteerstreatment1completed
NCT02184221
Deep-brain Magnetic Stimulation (DMS) in the Treatment of Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT04278521
Mechanism of Action of Transcranial Magnetic StimulationNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02188121
Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patientstreatment4completed
NCT04353921
PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive DisorderNo drug interventionsNot AvailableNot Availableterminated
NCT03432221
Switching From SSRI to Desvenlafaxine on Cognitive FunctioningNot AvailableNot Availableunknown_status
NCT05819021
Open Label Optimization StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT06054321
Psychopharmacotherapy for Depressive PatientstreatmentNot Availablerecruiting
NCT01482221
A Study to Assess the Effect and Safety of AZD6765 in Patients With Major Depressive Disordertreatment2completed
NCT02749721
The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorderother4completed
NCT05543421
Transcranial Magnetic Stimulation in Patients With a Depressive Episode - RCT TrialNo drug interventionstreatmentNot Availablerecruiting
NCT02236702
Kappa Opioid Receptor Imaging in Depression (KOR Depression)No drug interventionsNot AvailableNot Availableterminated
NCT02734602
Imaging SV2A in Mood Disordersbasic_scienceNot Availablerecruiting
NCT00467402
Efficacy, Safety and Tolerability of Agomelatine in the Prevention of Relapse of Major Depressive Disorderprevention3completed
NCT05605002
Efficacy and Safety of Intradermal Acupuncture for Major Depressive DisordertreatmentNot Availablerecruiting
NCT02624102
Efficacy of Trial-Based Cognitive Therapy and Behavioral Activation in Treatment of DepressionNo drug interventionstreatment3completed
NCT05772702
Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of DepressionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT04509102
Psychostimulant Augmentation of Repetitive TMS for the Treatment of Major Depressive Disordertreatment0enrolling_by_invitation
NCT01606384
Evaluation of the Potential Effects of SSR149415 on the Hypothalamic-pituitary-adrenal Axis in Outpatients With Major Depressive Disordertreatment2completed
NCT05046184
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targetsother2recruiting
NCT02443584
Pharmacogenetic Testing on an Outpatient Population With a Depression DiagnosisNo drug interventionssupportive_careNot Availablecompleted
NCT00128479
A United States Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depressiontreatment3completed
NCT01288079
A Study to Assess the Safety and Effect of TC-5214 in Patients With Major Depressive Disorder.treatment2terminated
NCT01670279
Phase 1 Study to Assess the Safety/Tolerability of Brexpiprazole as Adjunctive Therapy in Elderly Subjects With Major Depressive Disordertreatment1completed
NCT04041479
Biomarker-guided rTMS for Treatment Resistant DepressionNo drug interventionstreatment3recruiting
NCT02330679
Prediction of Antidepressant Treatment Response Using Machine Learning Classification Analysistreatment4unknown_status
NCT00108979
Study of Escitalopram in Adult Patients With Major Depressive Disordertreatment3completed
NCT01148979
Lisdexamfetamine Dimesylate in Residual Symptoms and Cognitive Impairment in Major Depressive Disorder.treatment4completed
NCT00059579
Brain Regulation of Emotions in People With Depression and AnhedoniaNo drug interventionsNot AvailableNot Availablecompleted
NCT02268487
Integral Assessment in Unipolar Depressiontreatment4unknown_status
NCT05710887
N2O for Acute Suicidality and Depression in the EDtreatment2not_yet_recruiting
NCT01942187
A Comparison of Medication Augmentation and PST in the Treatment of Depression in Older Adultstreatment4withdrawn
NCT01485887
Venlafaxine ER Long-Term Extension Study for Major Depressive Disorder (MDD)treatment3completed
NCT06507787
Evaluation of the Impact of the EDIT-B® Blood Test on the Health Status of Patients Presenting a Major Depressive Episode. Clinical Utility and Medico-Economic AspectsNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT02837887
Computerized Cognitive Behavior Therapy in Treating Depression in Patients With CancerNo drug interventionssupportive_careNot Availablecompleted
NCT01191333
The Effectiveness of rTMS in Depressed VA PatientsNo drug interventionstreatmentNot Availablecompleted
NCT03624933
Effects of Cannabis Abstinence on Symptoms and Cognition in DepressionNo drug interventionstreatmentNot Availablecompleted
NCT01370733
Synchronized Transcranial Magnetic Stimulation (sTMS) in Major Depressive DisorderNo drug interventionstreatment3completed
NCT02158533
A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - the FORWARD-4 StudyNo drug interventionstreatment3completed
NCT01502033
Study of Repetitive Transcranial Magnetic Stimulation (rTMS) in Depressed TeensNo drug interventionstreatmentNot Availablecompleted
NCT01415154
Maintenance NeuroStar Transcranial Magnetic Stimulation (TMS) in Patients With Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT05694754
Transcranial Magnetic Stimulation Theta Burst (TMS), Depression and Smoking.No drug interventionstreatmentNot Availablerecruiting
NCT01152554
A Study to Assess the Long- Term Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disordertreatment3completed
NCT06271954
The Relationship Between Emotion Regulation and Psychiatric Disorder in YouthNo drug interventionsNot AvailableNot Availablerecruiting
NCT03203954
Testing the Neuroscience of Guided Learning in DepressionNo drug interventionsotherNot Availablecompleted
NCT02332954
Assessment in Work Productivity and the Relationship With Cognitive Symptoms in Patients With MDD Taking Vortioxetinetreatment4completed
NCT04731454
Feasibility and Acceptability of a Healthy Nordic Diet Intervention in Depressed and Non-depressed AdultsNo drug interventionsotherNot Availablecompleted
NCT04294654
Vortioxetine in Patients With Depression and Early Dementiatreatment4completed
NCT02129751
Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disordertreatment4not_yet_recruiting
NCT05837351
The CARE (Collaborative Adolescent Running Experience) ProjectNo drug interventionstreatmentNot Availablecompleted
NCT06345651
Brain Oscillation-synchronized Stimulation of the Frontal Cortex in Major Depressive DisorderNo drug interventionstreatmentNot Availablerecruiting
NCT05973851
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.treatment3recruiting
NCT01423253
Major Depressive Disorder With Mixed Features - Extensiontreatment3completed
NCT02279953
Efficacy of Vortioxetine on Cognitive Dysfunction in Patients With Partial or Full Remission of Major Depressive Disordertreatment3completed
NCT00731653
Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD)treatment2completed
NCT04999553
Left vs. Right Non-Inferiority TrialNo drug interventionstreatmentNot Availablerecruiting
NCT00952653
Study Evaluating the Effect of Desvenlafaxine on the Pharmacokinetics of Midazolamtreatment4completed
NCT00609453
Brain Imaging of Psychotherapy for DepressionNo drug interventionsNot AvailableNot Availablecompleted
NCT04504253
A Pilot Study of Creatine Monohydrate as an Augmenting Agent for ECT in Persons With Major Depressive DisorderNo drug interventionstreatment3completed
NCT01469377
Safety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive Disordertreatment2completed
NCT00373477
A Study of the Cost Effectiveness of Generalist Care Managers for Depression Treatment in Medicaid RecipientsNo drug interventionstreatmentNot Availablecompleted
NCT06309277
A Clinical Study to Evaluate of Single and Multiple Oral Doses of GM-1020 in Patients With MDDNo drug interventionstreatment2recruiting
NCT02522377
Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant DepressiontreatmentNot Availablecompleted
NCT02562677
TNS for Treating Major Depressive Disorder in the ElderlyNo drug interventionstreatment1 / 2unknown_status
NCT01052077
Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disordertreatment2completed
NCT02634177
Genecept Assay™ vs. Treatment-as-Usual to Evaluate Efficacy of Assay-Guided Treatment in Adults With MDDNo drug interventionstreatmentNot Availablecompleted
NCT02066077
The Efficacy And Cognitive Impairment Of Modified Electroconvulsive TherapytreatmentNot Availablecompleted
NCT04347577
Intestinal Flora and Major Depressive DisordersNot AvailableNot Availableunknown_status
NCT01185977
Biomarkers of Antidepressant Treatment in Adolescents With Major Depression (The Adolescents MDD Study)treatment4completed
NCT04874077
Using Voice Biomarkers to Predict the Likelihood of Major Depressive DisorderNo drug interventionsNot AvailableNot Availablecompleted
NCT01114477
NeuroStar TMS Therapy System: Utilization and OutcomesNo drug interventionsNot AvailableNot Availablecompleted
NCT01877447
Comparison of Two tDCS Protocols for the Treatment of Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT03554447
Role of Pentoxifylline as an Adjuvant Therapy for Adult Patients With Major Depressive DisordertreatmentNot Availablecompleted
NCT00157547
Quantitative EEG (QEEG) as a Predictor of Treatment Outcome in Depressiontreatment4completed
NCT01304147
Intranasal Ketamine in Treatment-Resistant DepressiontreatmentNot Availablecompleted
NCT04724447
ANTIVIRAL TREATMENT OF CYTOMEGALOVIRUS IN DEPRESSIONtreatment1 / 2recruiting
NCT05583747
E-field Guided iTBS for Treatment Resistant DepressionNo drug interventionstreatmentNot Availablerecruiting
NCT01153347
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disordertreatment3completed
NCT02549547
Jump Step - A Participatory Approach to Physical Activity & Mental WellnessNo drug interventionstreatmentNot Availableunknown_status
NCT03537547
Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive DisorderNo drug interventionstreatment4terminated
NCT00659347
Efficacy and Safety of DOV 21,947 in the Treatment of Major Depressive DisorderNo drug interventionstreatment2terminated
NCT04392947
Treatment of Major Depressive Disorder With Bilateral Theta Burst StimulationNo drug interventionstreatmentNot Availablerecruiting
NCT01947647
Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety DisordersNo drug interventionstreatmentNot Availablecompleted
NCT05701345
Study of Virtual Reality-based Medical Device for Patients With Depressive DisorderNo drug interventionstreatmentNot Availableenrolling_by_invitation
NCT03842345
DELPhI Evaluation of Psychiatric ConditionsNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00692445
TC-5214 as add-on the Treatment of Major Depressive Disordertreatment2completed
NCT00617045
Duloxetine for the Treatment of Postpartum DepressiontreatmentNot Availablewithdrawn
NCT01582945
Ketamine Infusion for Treatment-resistant Major Depressive DisordertreatmentNot Availablecompleted
NCT03051945
Endogenous Opioid Modulation by Ketaminebasic_science3withdrawn
NCT03487198
The Safety and Efficacy of Brexpiprazole as Adjunctive Therapy in the Treatment of Major Depressive Disordertreatment3terminated
NCT05194098
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in DepressionNo drug interventionsbasic_scienceNot Availablerecruiting
NCT04104698
Cognitive, Psychological and Electrophysiological Attributes to Suicide Among Depressed PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01583998
Electronic-Measurement Based Care for Major Depressive DisorderNo drug interventionstreatmentNot Availablewithdrawn
NCT06072898
A Randomized Neuroimaging Trial of Psilocybin in Depressionbasic_science2not_yet_recruiting
NCT04183205
Predicting SSRI Efficacy in Veterans With PTSDscreening4recruiting
NCT03693105
The Effects of SAINT® Neuromodulation System on Explicit and Implicit Suicidal CognitionNo drug interventionstreatment2 / 3recruiting
NCT02294305
Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disordertreatment4unknown_status
NCT04799405
Home-based tDCS in Major Depressive DisorderNo drug interventionstreatmentNot Availablecompleted
NCT06235905
Open-Label of SPN-820 in Adults With Major Depressive Disordertreatment2recruiting
NCT05437705
Decoding and Modulating Affective Brain StatesNo drug interventionsbasic_scienceNot Availablerecruiting
NCT05384405
aiTBS for Relieving NSSI in Depressive PatientsNo drug interventionstreatmentNot Availablerecruiting
NCT01000805
A Study of Duloxetine in Major Depressive Disorder (MDD) and Associated Painful Symptomstreatment4completed
NCT00128505
An International Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depressiontreatment3completed
NCT03505905
A Neurosteroid Intervention for Menopausal and Perimenopausal Depressiontreatment1 / 2recruiting
NCT02209597
Clinical Study of Generic and Brand Bupropion in Depressiontreatment4completed
NCT03079297
Rapid Antidepressant Effects of Leucinetreatment2terminated
NCT01837797
Efficacy and Safety of Brexpiprazole as Adjunctive Treatment in Elderly Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatmenttreatment3terminated
NCT06439797
Inflammatory Markers as Predictors of the Efficacy of Electroconvulsive Therapy (ECT) in Major Depression PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT03652597
Neuro-Cardiac-Guided Transcranial Magnetic Stimulation: Replication and Dose-response.No drug interventionsbasic_scienceNot Availablecompleted
NCT00208897
Does Fluoxetine Have an Effect on the CNS CRF Systems in Women Abused in Childhood?treatmentNot Availablecompleted
NCT03898297
Imaging mGluR5 and Synaptic Density in Psychiatric DisordersNo drug interventionsNot AvailableNot Availablerecruiting
NCT01263197
A Study of LY2216684 in Healthy Participants Receiving Albuterol or Propanololtreatment1completed
NCT03859297
Mechanisms of Rumination Change in Adolescent DepressionNo drug interventionspreventionNot Availablerecruiting
NCT01203683
Testing the Effectiveness of a Computer-based Program for DepressionNo drug interventionstreatment3completed
NCT05142683
Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled TrialNo drug interventionstreatmentNot Availablerecruiting
NCT05947383
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of up to Two Doses of Psilocybin for the Treatment of Major Depressive Disorder in Adults With Cancertreatment2recruiting
NCT01890083
A Health Intervention to Prevent Depression Hepatitis C PatientsNo drug interventionsprevention2 / 3terminated
NCT05273983
Pilot Study of a Brief Behavioural Activation Intervention for Depressed Patients in Primary CareNo drug interventionstreatmentNot Availableterminated
NCT00179283
Sertraline vs. Venlafaxine XRtreatment3completed
NCT00526383
Do Antidepressants Induce Metabolic Syndromes METADAP StudyNo drug interventionstreatmentNot Availablecompleted
NCT01973283
Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adultstreatment4completed
NCT00578383
Low Field Magnetic Stimulation in Mood Disorders Using the LFMS DeviceNo drug interventionstreatmentNot Availablecompleted
NCT04673383
SPL026 (DMT Fumarate) in Healthy Subjects and MDD Patientstreatment1 / 2completed
NCT01640483
Differential Efficacy of Supportive and Interpretative Psychodynamic Techniques for Dependent and Self-critical Depressive PatientsNo drug interventionstreatmentNot Availablecompleted
NCT02661061
Ketamine for Relapse Prevention in Recurrent Depressive Disorderother1terminated
NCT06255561
pBFS Guided rTMS Over Different Targets for Treatment-Resistant DepressionNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03429361
Testing the Value of Smartphone Assessments of People With Mood DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT04768361
Behavioral Activation for Major Depression With and Without MindfulnessNo drug interventionstreatmentNot Availablecompleted
NCT06332261
Standardized Assessment in Depression Treatment in Routine Psychiatric ServicesNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06003361
Rise Study for DepressionNo drug interventionstreatmentNot Availablecompleted
NCT05840861
Using 18F-FPEB PET to Identify mGLUR5 Availability in Affective DisordersNot AvailableNot Availablerecruiting
NCT03437928
Deep Brain Stimulation (DBS) for Depression Using Directional Current Steeri