Vitamin B12 Deficiency (DBCOND0034596)

Identifiers

Synonyms

Vitamin B-12 Deficiency / Vitamin B 12 Deficiency / B12 Deficiency Vitamin / Cobalamin Deficiency / Vitamin B12 deficiency / Deficiency of other specified B group vitamins / Hypocobalaminaemia / Hypocobalaminemia / Cobalamin deficiency (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cobamamide	An ingredient found in a variety of supplements and vitamins.	No drug targets
Cocarboxylase	The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.	Acetolactate synthase, catabolictarget Pyruvate dehydrogenase E1 componenttarget Pyruvate synthasetarget Indole-3-pyruvate decarboxylasetarget N(2)-(2-carboxyethyl)arginine synthasetarget Transketolase 1target RNAtarget Benzoylformate decarboxylaseenzyme Pyruvate oxidaseenzyme
Cyanocobalamin	A vitamin available in many formulations to correct vitamin B12 deficiency.	Methionine synthase reductasetarget Methylmalonic aciduria type A protein, mitochondrialtarget Methylmalonyl-CoA mutase, mitochondrialtarget Cyanocobalamin reductase / alkylcobalamin dealkylasetarget Methionine synthasetarget Methylenetetrahydrofolate reductase (NADPH)target Protein amnionlesstransporter Transcobalamin-1transporter Transcobalamin-2transporter Corrinoid adenosyltransferase MMABenzyme Cobalamin binding intrinsic factortransporter Cubilintransporter Bifunctional adenosylcobalamin biosynthesis protein CobUenzyme Low-density lipoprotein receptor-related protein 2transporter Multidrug resistance-associated protein 1transporter Pancreatic proteasesenzyme
Fursultiamine	Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative.	No drug targets
Hydroxocobalamin	A synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning.	Methylmalonic aciduria type A protein, mitochondrialtarget Protein amnionlesstarget Transcobalamin-1target Methylmalonyl-CoA mutase, mitochondrialtarget Methionine synthasetarget Cubilintarget Cyanocobalamin reductase / alkylcobalamin dealkylasetarget Transcobalamin-2carrier
Mecobalamin	Not Available	Methionine synthasetarget
Menadione	The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.	Prothrombintarget Vitamin K epoxide reductase complex subunit 1target Coagulation factor IXtarget Vitamin K-dependent gamma-carboxylasetarget Vitamin K-dependent protein Ctarget Vitamin K-dependent protein Starget NAD(P)H dehydrogenase [quinone] 1target Ribosyldihydronicotinamide dehydrogenase [quinone]target Vitamin K epoxide reductase complex subunit 1-like protein 1target Xanthine dehydrogenase/oxidaseenzyme Aldehyde oxidaseenzyme Methylenetetrahydrofolate reductase (NADPH)enzyme Cytochrome P450 1A1enzyme Osteocalcintarget Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Aldehyde oxidasetarget
NADH	A nutrient used in some supplement products.	UDP-glucose 6-dehydrogenasetarget Alcohol dehydrogenase 1Atarget Sorbitol dehydrogenasetarget All-trans-retinol dehydrogenase [NAD(+)] ADH4target Alcohol dehydrogenase 1Ctarget All-trans-retinol dehydrogenase [NAD(+)] ADH1Btarget All-trans-retinol dehydrogenase [NAD(+)] ADH7target Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget L-lactate dehydrogenase A-like 6Atarget Alcohol dehydrogenase class-3target Aldo-keto reductase family 1 member B1target 3-hydroxyacyl-CoA dehydrogenase type-2target Malate dehydrogenase, mitochondrialtarget L-lactate dehydrogenase A chaintarget NAD-dependent malic enzyme, mitochondrialtarget Peroxisomal multifunctional enzyme type 2target L-lactate dehydrogenase A-like 6Btarget L-lactate dehydrogenase C chaintarget L-lactate dehydrogenase B chaintarget Peroxisomal bifunctional enzymetarget Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialtarget NADP-dependent malic enzyme, mitochondrialtarget D-beta-hydroxybutyrate dehydrogenase, mitochondrialtarget Malate dehydrogenase, cytoplasmictarget 3-hydroxyisobutyrate dehydrogenase, mitochondrialtarget 17-beta-hydroxysteroid dehydrogenase type 3target 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget NADP-dependent malic enzymetarget D-3-phosphoglycerate dehydrogenasetarget 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7target Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialtarget Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget 17-beta-hydroxysteroid dehydrogenase type 1target 17-beta-hydroxysteroid dehydrogenase type 2target Retinol dehydrogenase 5target GDH/6PGL endoplasmic bifunctional proteintarget (3R)-3-hydroxyacyl-CoA dehydrogenasetarget Aldo-keto reductase family 1 member C4target Inosine-5'-monophosphate dehydrogenase 2target Aldo-keto reductase family 1 member C3target 15-hydroxyprostaglandin dehydrogenase [NAD(+)]target GDP-L-fucose synthasetarget Aldo-keto reductase family 1 member C1target 11-beta-hydroxysteroid dehydrogenase 1target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target Inosine-5'-monophosphate dehydrogenase 1target Trifunctional enzyme subunit alpha, mitochondrialtarget Aldehyde dehydrogenase, mitochondrialtarget 11-beta-hydroxysteroid dehydrogenase type 2target Aldo-keto reductase family 1 member C2target Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingtarget Aldehyde dehydrogenase family 3 member B2target Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrialtarget Aldehyde dehydrogenase, dimeric NADP-preferringtarget Aldehyde dehydrogenase 1A1target Glyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget 4-trimethylaminobutyraldehyde dehydrogenasetarget Retinaldehyde dehydrogenase 3target Aldehyde dehydrogenase X, mitochondrialtarget Aldehyde dehydrogenase family 3 member B1target Glyceraldehyde-3-phosphate dehydrogenasetarget Retinal dehydrogenase 2target Aldehyde dehydrogenase family 3 member A2target Succinate-semialdehyde dehydrogenase, mitochondrialtarget Alpha-aminoadipic semialdehyde dehydrogenasetarget Flavin reductase (NADPH)target Pyrroline-5-carboxylate reductase 2target Pyrroline-5-carboxylate reductase 1, mitochondrialtarget Glutamate dehydrogenase 1, mitochondrialtarget Pyruvate dehydrogenase E1 component subunit beta, mitochondrialtarget Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrialtarget Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialtarget Biliverdin reductase Atarget Short-chain specific acyl-CoA dehydrogenase, mitochondrialtarget Dihydrofolate reductasetarget 2-oxoglutarate dehydrogenase complex component E1target Glutamate dehydrogenase 2, mitochondrialtarget 7-dehydrocholesterol reductasetarget Ribosyldihydronicotinamide dehydrogenase [quinone]target NADH-ubiquinone oxidoreductase chain 2target Alpha-aminoadipic semialdehyde synthase, mitochondrialtarget NADH-ubiquinone oxidoreductase chain 3target NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialtarget C-1-tetrahydrofolate synthase, cytoplasmictarget Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialtarget Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialtarget NADH-cytochrome b5 reductase 3target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11target NADH-ubiquinone oxidoreductase chain 4target Dihydropteridine reductasetarget NADH-ubiquinone oxidoreductase chain 1target NAD(P) transhydrogenase, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialtarget NADH-ubiquinone oxidoreductase chain 4Ltarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1target NADH-ubiquinone oxidoreductase chain 6target NADH-ubiquinone oxidoreductase chain 5target Cytochrome c oxidase subunit NDUFA4target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6target Acyl carrier protein, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8target NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 subunit C2target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1target NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7target NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9target NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6target NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialtarget Dihydrolipoyl dehydrogenase, mitochondrialtarget NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialtarget Glutathione reductase, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12target NADH dehydrogenase [ubiquinone] iron-sulfur protein 5target NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialtarget NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialtarget NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13target Cysteine dioxygenase type 1target NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialtarget NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2target NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialtarget Cytochrome P450 4A11target Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialtarget Aminomethyltransferase, mitochondrialtarget Methylsterol monooxygenase 1target Heme oxygenase 1target Heme oxygenase 2target Steroid 17-alpha-hydroxylase/17,20 lyasetarget Tyrosinasetarget Xanthine dehydrogenase/oxidaseenzyme Aldehyde oxidaseenzyme Alcohol dehydrogenase 6enzyme Aldo-keto reductase family 1 member A1enzyme Alcohol dehydrogenase 1Aenzyme All-trans-retinol dehydrogenase [NAD(+)] ADH1Benzyme All-trans-retinol dehydrogenase [NAD(+)] ADH4enzyme Alcohol dehydrogenase class-3enzyme All-trans-retinol dehydrogenase [NAD(+)] ADH7enzyme
Pregabalin	An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.	Excitatory amino acid transporter 3transporter Voltage-dependent calcium channel subunit alpha-2/delta-1target Large neutral amino acids transporter small subunit 1transporter
Pyridoxine	A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.	Pyridoxal kinasetarget Cytochrome P450 1A1enzyme Albumincarrier Pyridoxal kinaseenzyme Chronophinenzyme Alkaline phosphatase, tissue-nonspecific isozymetransporter Alkaline phosphatase, tissue-nonspecific isozymeenzyme Aromatic-L-amino-acid decarboxylasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02446873	Cracking the Egg Potential: Improving Young Child Nutrition in Ecuador	No drug interventions	treatment	Not Available	completed
NCT01399164	Cobalamin Absorption From Fortified Food	No drug interventions	basic_science	Not Available	completed
NCT06223854	Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid	No drug interventions	prevention	Not Available	active_not_recruiting
NCT06441721	Vitamin B12 Status and Its Impact on Chronic Haemodialysis Patient	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT00479479	Cobalamin Supplementation During Infancy; Effect on B-vitamin Status, Growth and Psychomotor Development	Cobalamin Cyanocobalamin Hydroxocobalamin	basic_science	Not Available	completed
NCT03365583	The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota	No drug interventions	Not Available	Not Available	completed
NCT04632771	Nutritional Status and Bouillon Use in Northern Ghana	No drug interventions	Not Available	Not Available	completed
NCT04243707	Cobalamin Deficiency - Diagnosis and Therapy	No drug interventions	Not Available	Not Available	completed
NCT00710359	Cobalamin Status in Young Children With Gastrointestinal Symptoms or Feeding Problems	No drug interventions	treatment	Not Available	completed
NCT03447275	The Vitamin B Status in Type 2 Diabetes (VITA) Study	No drug interventions	Not Available	Not Available	completed
NCT03071666	Vitamin B12 Supplementation During Pregnancy on Cognitive Development	No drug interventions	prevention	2 / 3	active_not_recruiting
NCT03284840	Adults Nutrition as a Protective or Health-risk Factor	No drug interventions	Not Available	Not Available	completed
NCT03853304	Quadruple Fortified Salt Trial in India	No drug interventions	prevention	Not Available	active_not_recruiting
NCT06100146	Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls	No drug interventions	prevention	Not Available	recruiting
NCT00710138	Cobalamin Status in Young Children With Developmental Delay	No drug interventions	treatment	Not Available	completed
NCT03489538	Homocysteine After Laparoscopic Roux-enY Gastric Bypass	No drug interventions	Not Available	Not Available	completed
NCT05315843	Cobalamin Supply and Metabolism in Healthy Children From Birth to the Age of 12 Months and in Their Mothers (Cbl_Neo)	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT06046703	Diet Quality of Pregnant Women With a Strict Plant-based Diet Versus an Omnivorous Diet	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT03376490	Study of the Association of Muscle Strength, Balance and Other Factors With Vitamin Levels Among Elderly Diabetics	No drug interventions	Not Available	Not Available	completed
NCT05005897	Early Infant Micronutrition and Development	Cyanocobalamin	treatment	2 / 3	recruiting
NCT05178407	Effect of Household Use of Multiple Micronutrient-fortified Bouillon on Micronutrient Status Among Women and Children in Two Districts in the Northern Region of Ghana	No drug interventions	other	Not Available	completed
NCT01476007	Oral/Intramuscular B12 to Treat Cobalamin Deficiency	Cobalamin Cyanocobalamin	treatment	Not Available	completed
NCT05661006	ETOL-Elderly Study of the Efficiency of the Innovative Food Supplement in Elderly Adults	No drug interventions	treatment	Not Available	completed
NCT05389618	Dietary Challenges in the Population of Nursing Homes' Residents	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT03437824	Effects of Vitamin B12 Treatment in Singers	Cyanocobalamin	treatment	0	completed
NCT01312831	Efficacy and Safety Study of Oral Eligen® B12 in Subjects With Low Serum Cobalamin	No drug interventions	treatment	Not Available	completed
NCT05614960	Dried Purple Laver (Nori) as a Food Source of Vitamin B12 in Vegetarians	No drug interventions	prevention	Not Available	completed
NCT04083560	A Comparison of Two Different Doses of Maternal B12 Supplementation in Improving Infant B12 Deficiency and Neurodevelopment	Cyanocobalamin	prevention	Not Available	completed
NCT03978260	Preoperative Anaemia prevaLence In surgiCal patiEnts	No drug interventions	Not Available	Not Available	completed
NCT06376591	Assessing the Efficacy of Different Carrier Systems in Oral Vitamin B12 Supplementation	No drug interventions	prevention	Not Available	completed
NCT05993962	Effect of Daily Consumption of Vitamin B12 Fortified Yoghurt on Vitamin B12 Status in Older Adults	No drug interventions	prevention	Not Available	completed
NCT01832129	Vitamin B12 Acceptance and Biomarker Response Study	Cyanocobalamin	treatment	4	completed
NCT03783104	Maternal B12 Supplementation to Improve Infant B12 Deficiency and Neurodevelopment	No drug interventions	prevention	Not Available	unknown_status
NCT05426395	Vitamin B12 Dose Escalation Trial in Pregnancy	Cyanocobalamin	prevention	1	active_not_recruiting
NCT03444155	Natural Versus Synthetic Vitamin B Complexes in Human	No drug interventions	basic_science	Not Available	completed
NCT02860338	COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE	No drug interventions	Not Available	Not Available	completed
NCT05517005	An Exploratory Investigation of a B12 Vitamin to Increase Energy and Focus	No drug interventions	other	Not Available	completed
NCT05740462	Hydroponic Fortification and Dietary App Effect on Nutrients Level (Harvest)	No drug interventions	basic_science	Not Available	enrolling_by_invitation
NCT06338059	Relationship Between Vitamin D and Vitamin B12 Levels and Neuropathic Pain in Lipedema	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT05714917	Neurological Recovery Following NOS-SACD	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT04694235	Egg Intervention During Pregnancy in Indonesia	No drug interventions	prevention	Not Available	active_not_recruiting
NCT02679833	Effect of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status	No drug interventions	prevention	Not Available	completed
NCT05687474	Baby Detect : Genomic Newborn Screening	No drug interventions	Not Available	Not Available	recruiting
NCT00326833	How Many Patients Are in Need of Vitamin B12 Injections?	Cyanocobalamin	diagnostic	4	unknown_status
NCT01297361	The Association Between Religious Origin and Age, and Vitamin B12 and Folic Acid Plasma Levels in Non Jewish Population in Western Galilee	No drug interventions	diagnostic	Not Available	completed
NCT00699478	Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy	Cobalamin Mecobalamin	treatment	2	completed
NCT01661309	Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical Trial	No drug interventions	prevention	Not Available	completed
NCT01876732	Impact of Vitamin B12 Replacement on Epogen Dosing and Improvement of Quality of Life in Hemodialysis Patients	Cyanocobalamin	Not Available	Not Available	completed
NCT00279552	Can Recombinant Human Intrinsic Factor Be Used for Evaluation of the Vitamin B12 Absorption?	Gastric intrinsic factor	diagnostic	2	completed
NCT04048330	Periconceptional Surveillance in India	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT06528366	Heart Failure With Reduced Ejection Fraction: Adjuvant Therapy With Neurostimulation and Chlorella Pyrenoidosa (HD-tDCS)	No drug interventions	treatment	Not Available	active_not_recruiting
NCT01136512	Metformin Use and Vitamin B12 Deficiency	No drug interventions	Not Available	Not Available	completed
NCT00843453	Long-term Use of Proton Pump Inhibitors May Cause Vitamin B12 Deficiency in the Institutionalized Elderly	Cyanocobalamin	prevention	Not Available	completed
NCT02076347	Comparison of Two Pharmacist-led Population Management Approaches to Increase Monitoring of Vitamin B12 and Serum Creatinine Levels for Patients on Metformin	No drug interventions	screening	Not Available	completed
NCT02540642	Effect of Vitamin B12 Supplementation on Glycaemic Control in Uncontrolled Hyperhomocysteinemic Type 2 Diabetic Patients	No drug interventions	treatment	Not Available	completed
NCT02270749	Vitamin Deficiencies and Suppletion in Morbid Obesity	Cyanocobalamin Hydroxocobalamin	treatment	4	completed
NCT00826657	Vitamin B12 Supplementation Study	No drug interventions	health_services_research	Not Available	completed
NCT01876329	Autoantibodies to Gastric Parietal Cells in Rheumatoid Arthritis Patients	No drug interventions	Not Available	Not Available	completed
NCT01584050	Relative Bioavailability of Folic Acid and L-5-Methlytetrahydrofolate	No drug interventions	Not Available	Not Available	completed
NCT00467623	Holotranscobalamin Remains Unchanged During Pregnancy	No drug interventions	Not Available	Not Available	completed