Central Precocious Puberty (CPP) (DBCOND0040295)

Identifiers

Synonyms

Puberty; Precocious, Central / Precocious Puberty, Central / Puberty, Central Precocious / Central Precocious Puberty / Other hyperfunction of pituitary gland / Gonadotropin dependent precocious puberty / Central precocious puberty (disorder) / Precocious puberty / Puberty precocious / Early puberty / Accelerated sexual maturation / Maturation sex accelerated / Puberty, Precocious / Precocious puberty NOS / Precocious puberty (disorder) / True precocious puberty / Accelerated sexual maturity

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Histrelin	A GnRH agonist found in subcutaneous implants used for the treatment of pediatric patients with central precocious puberty and the palliative treatment of advanced prostate cancer.	Gonadotropin-releasing hormone receptortarget
Leuprolide	A peptide-based GnRH receptor superagonist used for the palliative treatment of prostate cancer, uterine leiomyomata, endometriosis, and central precocious puberty.	Gonadotropin-releasing hormone receptortarget Progonadoliberin-1target
Nafarelin	A gonadotropin releasing hormone agonist used to treat central precocious puberty.	Gonadotropin-releasing hormone receptortarget Putative gonadotropin-releasing hormone II receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05493709	Efficacy, Safety, and Pharmacokinetics of Leuprolide Mesylate in Subjects with Central Precocious Puberty	Leuprolide	treatment	3	recruiting
NCT02974270	Analysis of Body Mass Index in Central Precocious Puberty Patients Treated With Leuprolide Acetate	Leuprolide	treatment	4	unknown_status
NCT02452931	Study of Leuprolide Acetate Injectable Suspension in the Treatment of Central Precocious Puberty	Leuprolide	treatment	3	completed
NCT03695237	A Study to Evaluate Leuprolide Acetate 45 mg 6-Month Formulation in Children With Central Precocious Puberty (CPP)	Leuprolide	treatment	3	completed
NCT00667446	Safety Extension Study Of Leuprolide Acetate (Lupron Depot) In The Treatment Of Central Precocious Puberty	Leuprolide	treatment	3	completed
NCT06129539	A Study to Assess the Efficacy, Safety and Pharmacokinetics of Debio 4326 in Pediatric Participants Receiving Gonadotropin-Releasing Hormone Agonist Therapy for Central Precocious Puberty	No drug interventions	treatment	3	recruiting
NCT00779103	Histrelin Subcutaneous Implant in Children With Central Precocious Puberty	Histrelin	treatment	3	completed
NCT01278290	Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in Girls	No drug interventions	diagnostic	3	completed
NCT01634321	The Clinical Trial to Evaluate the Efficacy and Safety of Luphere Depot Inj. 3.75mg(Leuprolide Acetate 3.75mg) in Patients With Precocious Puberty	Leuprolide	treatment	4	completed
NCT05341128	A Study of Medical Records From Children With Central Precocious Puberty (CPP) in China	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT06025409	Evaluate the Efficacy and Safety of DWJ108J	Leuprolide	treatment	3	recruiting
NCT05341115	A Study of Leuprolide Acetate Depot in Children With Central Precocious Puberty	Leuprolide	treatment	4	recruiting
NCT00438217	Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children	Gonadorelin Leuprolide Triptorelin	prevention	4	unknown_status
NCT02427958	A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty in Chinese Participants	Leuprolide	treatment	4	completed
NCT02993926	A Study to Assess the Safety and Efficacy of Enantone (Leuprorelin) in Central Precocious Puberty (CPP) Among Chinese Participants	Gonadorelin Leuprolide	Not Available	Not Available	completed
NCT06487143	Efficacy, Metabolism and BMD of the 3-month TP Compared to the 1-month TP in ICPP	Triptorelin	treatment	4	not_yet_recruiting
NCT04736602	Efficacy and Safety Study of Triptorelin 3-Month Formulation in Chinese Children With Central Precocious Puberty.	Triptorelin	treatment	3	completed
NCT02920515	Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty	Leuprolide Rehmannia glutinosa root	treatment	4	completed
NCT05029622	A Study to Assess the Efficacy and Safety of the Triptorelin 6-month Formulation in Paediatric Participants With Central Precocious Puberty.	Triptorelin	treatment	3	completed
NCT03316482	Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty	Leuprolide	treatment	4	completed
NCT01467882	Efficacy, Safety, and Pharmacokinetics (PK) of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty	Triptorelin	treatment	3	completed
NCT02006680	Markers of Pubertal Suppression During Therapy for Precocious Puberty	No drug interventions	Not Available	Not Available	terminated