Complicated Urinary Tract Infection (DBCOND0040639)

Identifiers

Synonyms

Complicated Urinary Tract Infection; Cuti / Urinary Tract Infection (cUTI) / Complicated Urinary Tract Infections (cUTI) / Urinary Tract Infection, Complicated / Complicated Urinary Tract Infections (cUTIs) / Complicated UTI / Urinary Tract Infection Complicated / Complicated Urinary Tract Infections / Complicated Urinary Tract Infection (cUTI) / CUTI / Complicated Urinary Infection / Complicated urinary tract infection / Urinary tract infection (& [NOS]) / (Urethral and/or urinary disorders NOS) or (urinary infection NOS) / Urinary infection NOS (disorder) / Urinary infection / UTI / Urinary tract infection, site not specified NOS (disorder) / Urinary tract infection, site not specified / Urinary tract infection: [site not specified] or [recurrent] / Urinary tract infection NOS / Urinary tract infections / Infection urinary tract / Urinary tract infectious disease (disorder) / Urinary tract infection

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Avibactam	A non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia.	ATP-binding cassette sub-family C member 2transporter Organic anion transporter 3transporter Beta-lactamase TEMtarget Beta-lactamase CTX-Mtarget Beta-lactamasetarget Beta-lactamase SHV-1target Beta-lactamase SHV-2target Beta-lactamase SHV-1target Class D OXA-48 carbapenemasetarget Carbapenem-hydrolyzing beta-lactamase KPCtarget Beta-lactamase UOE-1target Extended-spectrum beta-lactamase PER-1target
Cefepime	A fourth-generation cephalosporin antibiotic used in the treatment of infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections.	Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Penicillin-binding protein 2target Peptidoglycan synthase FtsItarget Cell division proteintarget Penicillin-binding protein 2target Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 1Btarget
Cefiderocol	A cephalosporin antibiotic used in complicated urinary tract infections.	Cell division proteintarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target D-alanyl-D-alanine carboxypeptidase DacBtarget MexAB-OprM efflux systemtransporter Albumincarrier Catecholate siderophore receptor Fiutransporter Colicin I receptortransporter Putative outer membrane ferric siderophore receptortransporter
Ceftazidime	An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others.	Solute carrier family 22 member 6transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Albumincarrier Beta-lactamase Toho-1target
Cilastatin	A renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.	Dipeptidase 1target Solute carrier family 22 member 6transporter Organic anion transporter 3transporter
Ciprofloxacin	A second generation fluoroquinolone used to treat various susceptible bacterial infections.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Potassium voltage-gated channel subfamily H member 2target DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 4 subunit Btarget DNA gyrase subunit Atarget Multidrug resistance protein MdtKtarget Gyrase Atarget DNA gyrase subunit Atarget Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Albumincarrier Thymidylate synthasetarget DNA gyrase subunit Btarget
Doripenem	An antibiotic of the penem class used to treat complicated intra-abdominal and urinary tract infections.	Dipeptidase 1enzyme Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Cell division proteintarget Penicillin-binding protein 4target Organic anion transporter 3transporter Dihydropteroate synthasetarget
Enmetazobactam	A beta-lactamase inhibitor used to treat complicated urinary tract infections in combination with cefepime.	Cytochrome P450 2E1enzyme Extended-spectrum beta-lactamase PER-1target Beta-lactamasetarget
Fosfomycin	A broad spectrum antibiotic used to treat uncomplicated urinary tract infections.	UDP-N-acetylglucosamine 1-carboxyvinyltransferasetarget
Imipenem	A carbapenem antibiotic normally administered with cilastatin to treat a variety of infections.	Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Penicillin-binding protein 3target Dipeptidase 1enzyme Penicillin-binding protein 4target Beta-lactamase SHV-1enzyme Beta-lactamase TEMenzyme Beta-lactamase CTX-Menzyme Beta-lactamaseenzyme Beta-lactamasetarget
Ofloxacin	An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Organic cation/carnitine transporter 2transporter Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 2transporter Solute carrier family 22 member 4transporter Bile salt export pumptransporter DNA gyrase subunit Atarget DNA gyrase subunit Btarget
Plazomicin	An aminoglycoside antibiotic used to treat complicated urinary tract infections.	Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter 30S ribosomal protein S14target 30S ribosomal protein S11target
Relebactam	A beta-lactamase inhibitor used to prevent hydrolysis of beta-lactam antibiotics, leading to increased effectiveness.	Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Beta-lactamase TEMtarget Beta-lactamase SHV-1target Beta-lactamase CTX-Mtarget Beta-lactamasetarget Beta-lactamasetarget Beta-lactamasetarget
Tazobactam	A beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy.	Beta-lactamase TEMtarget Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Beta-lactamase Ohio-1target Beta-lactamase SHV-1target Beta-lactamasetarget
Teicoplanin	A glycopeptide antibiotic with a similar mechanism of action and spectrum of activity to vancomycin used to treat various infections caused by gram-positive bacteria.	D-Ala-D-Ala moiety of NAM/NAG peptide subunits of peptidoglycantarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01978938	Efficacy and Safety Study of Eravacycline Compared With Levofloxacin in Complicated Urinary Tract Infections	Eravacycline Levofloxacin	treatment	3	completed
NCT04476407	Pharmacokinetics of Benapenem in Subjects With Renal Impairment	Benapenem	treatment	1	completed
NCT02714595	Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens	Cefiderocol	treatment	3	completed
NCT04335539	A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Cefiderocol in Hospitalized Pediatric Participants	Cefiderocol	treatment	2	completed
NCT04215991	A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Pediatric Participants	Cefiderocol	treatment	2	recruiting
NCT03377426	LYS228 PK, Clinical Response, Safety and Tolerability in Patients With Complicated Urinary Tract Infection (cUTI)	No drug interventions	basic_science	2	withdrawn
NCT03032510	Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Participants With Complicated Urinary Tract Infections	Eravacycline Ertapenem Levofloxacin	treatment	3	completed
NCT03357614	Sulopenem Followed by Sulopenem-etzadroxil/Probenecid vs Ertapenem Followed by Cipro for Complicated UTI in Adults	Amoxicillin Ciprofloxacin Clavulanic acid Ertapenem Probenecid Sulopenem Sulopenem etzadroxil	treatment	3	completed
NCT02497781	Evaluation of Safety, Pharmacokinetics and Efficacy of Ceftazidime and Avibactam (CAZ-AVI ) Compared With Cefepime in Children From 3 Months to Less Than 18 Years of Age With Complicated Urinary Tract Infections (cUTIs)	Avibactam Cefepime Ceftazidime	treatment	2	completed
NCT02168946	Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults	Carbapenem Meropenem Vaborbactam	treatment	3	completed
NCT03477422	CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative Bacteria	Ceftriaxone Meropenem Sulbactam	treatment	3	completed
NCT02166476	Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP	Carbapenem Levofloxacin Meropenem Piperacillin Tazobactam Vaborbactam	treatment	3	completed
NCT02753946	Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections	Fosfomycin Piperacillin Tazobactam	treatment	2 / 3	completed
NCT05826990	A Study to Investigate PK, Safety, Tolerability of Cefepime-enmetazobactam in Pediatric Participants With cUTI	Cefepime Enmetazobactam	treatment	2	recruiting
NCT00690378	Comparative Study of NXL104/Ceftazidime Versus Comparator in Adults With Complicated Urinary Tract Infections	Avibactam Ceftazidime Cilastatin Imipenem	treatment	2	completed
NCT04979806	Study of Cefepime-zidebactam (FEP-ZID) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)	Cefepime Meropenem Zidebactam	treatment	3	recruiting
NCT04076436	Efficacy of Intravenous Fosfomycin in the Treatment of Complicated Urinary in Real-life Conditions.	No drug interventions	Not Available	Not Available	unknown_status
NCT01345929	Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis	Levofloxacin	treatment	3	completed
NCT03788967	Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)	Ertapenem	treatment	3	completed
NCT05733104	A Study to Learn About the Study Medicine Zavicefta After it is Released Into the Markets in Korea	No drug interventions	Not Available	Not Available	recruiting
NCT03630081	Study of Cefepime-tazobactam (FEP-TAZ) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)	Ciprofloxacin Meropenem	treatment	3	not_yet_recruiting
NCT03230838	MK-7625A Versus Meropenem in Pediatric Participants With Complicated Urinary Tract Infection (cUTI) (MK-7625A-034)	Ceftolozane Meropenem Tazobactam	treatment	2	completed
NCT03293485	Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) in Japanese Participants With Complicated Intra-abdominal Infection or Complicated Urinary Tract Infection (MK-7655A-017)	Cilastatin Imipenem Relebactam	treatment	3	completed
NCT05674032	Bacterial Metallophores in the Diagnosis of Acute Pyelonephritis	No drug interventions	Not Available	Not Available	recruiting
NCT01096849	A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acute Pyelonephritis (AP)	Levofloxacin Plazomicin	treatment	2	completed
NCT05385536	Evaluating UTI Outcomes in at Risk Populations	No drug interventions	Not Available	Not Available	completed
NCT05060419	Meropenem-FL058 Phase 2 Study in the Treatment of Complicated Urinary Tract Infections	Meropenem Piperacillin Tazobactam	treatment	2	unknown_status
NCT04682834	Expanded Access Use of Sulopenem Etzadroxil/Probenecid for Complicated Urinary Tract Infection	Probenecid Sulopenem etzadroxil	Not Available	Not Available	no_longer_available
NCT00921024	Safety and Efficacy of IV CXA-101 and IV Ceftazidime in Patients With Complicated Urinary Tract Infections	Ceftazidime Ceftolozane	treatment	2	completed
NCT02024282	Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care	No drug interventions	diagnostic	Not Available	completed
NCT04876131	Single Dose Intravenous Antibiotics for Complicated Urinary Tract Infections in Children	Benzylpenicillin Cephalexin Gentamicin	treatment	4	recruiting
NCT02486627	A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP)	Levofloxacin Meropenem Plazomicin	treatment	3	completed
NCT02728089	Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014)	Ceftolozane Tazobactam	treatment	3	completed
NCT03445195	Evaluation of Safety and Efficacy of Intravenous Sulbactam-ETX2514 in the Treatment of Hospitalized Adults With Complicated Urinary Tract Infections	Cilastatin Durlobactam Imipenem Sulbactam	treatment	2	completed
NCT05905055	P3 Study to Assess Efficacy and Safety of Cefepime/Nacubactam and Aztreonam/Nacubactam Versus Best Available Therapy for Adults With Infection Due to Carbapenem Resistant Enterobacterales	Aztreonam Cefepime Nacubactam	treatment	3	recruiting
NCT05887908	Efficacy and Safety of Cefepime/Nacubactam or Aztreonam/Nacubactam Compared to Imipenem/Cilastatin in Subjects With Complicated Urinary Tract Infections or Acute Uncomplicated Pyelonephritis	Aztreonam Cefepime Cilastatin Imipenem Nacubactam	treatment	3	recruiting
NCT01644643	Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens	Avibactam Ceftazidime Metronidazole	treatment	3	completed
NCT02420366	Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae	No drug interventions	Not Available	Not Available	completed
NCT02364284	Reporting Patterns and Results of Initial Antibiotic Treatment in Patients With cUTI, cIAI,NP Including VAP	No drug interventions	Not Available	Not Available	completed
NCT00245791	Urinary Tract Infection Study With the Antibiotic Levofloxacin Given at a Higher Dose Over a Shorter Period of Time	Levofloxacin	treatment	4	terminated