Bone and Joint Infections (DBCOND0051086)
Identifiers
- Synonyms
- Bone and joint infection / Bone and joint infections
Associated Data
- Indicated Drugs and Targets
Drug Description Targets Amikacin An aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria.Amoxicillin A penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.- Solute carrier family 15 member 1transporter
- Solute carrier family 15 member 2transporter
- Solute carrier family 22 member 6transporter
- Cytochrome P450 2C8enzyme
- Albumincarrier
- Beta-lactamase 2enzyme
- Penicillin binding proteintarget
Aztreonam A beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria.- Penicillin-binding protein 3target
- Beta-lactamasetarget
- Beta-lactamase Toho-1target
- Peptidoglycan synthase FtsItarget
Cefoperazone A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, including the respiratory tract, abdomen, skin, and female genital tracts.- Albumincarrier
- Solute carrier family 22 member 6transporter
- Organic anion transporter 3transporter
- Solute carrier family 22 member 11transporter
- Solute carrier family 22 member 7transporter
- Peptidoglycan synthase FtsItarget
- Penicillin-binding protein 1Btarget
- Penicillin-binding protein 2target
- Penicillin-binding protein 1Atarget
- D-alanyl-D-alanine carboxypeptidase DacCtarget
- D-alanyl-D-alanine carboxypeptidase DacAtarget
- D-alanyl-D-alanine carboxypeptidase DacBtarget
- Penicillin-binding protein 1Atarget
- Penicillin-binding protein 1Btarget
Cefotetan An antibiotic medication used for the prophylaxis and treatment of various bacterial infections, including urinary tract infections, bone and joint infection, and lower respiratory tract infections.- Albumincarrier
- Penicillin-binding protein 3target
Cefoxitin A semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection.- Penicillin-binding protein 1Atarget
- Penicillin-binding protein 1Btarget
- Peptidoglycan synthase FtsItarget
- D-alanyl-D-alanine carboxypeptidase DacAtarget
- D-alanyl-D-alanine carboxypeptidase DacBtarget
- D-alanyl-D-alanine carboxypeptidase DacCtarget
- D-alanyl-D-alanine endopeptidasetarget
- Beta-lactamaseenzyme
- Penicillin-binding protein 3target
- Penicillin-binding protein 1btarget
- Penicillin-binding protein 2atarget
- Penicillin-binding protein 1Atarget
- Penicillin-binding protein 2Btarget
Ceftazidime An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others.- Solute carrier family 22 member 6transporter
- Peptidoglycan synthase FtsItarget
- Penicillin-binding protein 1Atarget
- Penicillin-binding protein 1Btarget
- Penicillin-binding protein 2target
- Albumincarrier
- Beta-lactamase Toho-1target
Ceftriaxone A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract.- Albumincarrier
- Solute carrier family 15 member 1transporter
- Solute carrier family 15 member 2transporter
- Solute carrier family 22 member 6transporter
- Organic anion transporter 3transporter
- Solute carrier family 22 member 11transporter
- Penicillin-binding protein 2Btarget
- Glutamine synthetaseenzyme
- Solute carrier family 22 member 11target
- Solute carrier family 22 member 6target
- Organic anion transporter 3target
- Solute carrier family 15 member 1target
- ATP-dependent translocase ABCB1transporter
Cefuroxime A cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo.- Penicillin-binding protein 1Atarget
- Solute carrier family 15 member 1transporter
- Solute carrier family 15 member 2transporter
Cilastatin A renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.- Dipeptidase 1target
- Solute carrier family 22 member 6transporter
- Organic anion transporter 3transporter
Ciprofloxacin A second generation fluoroquinolone used to treat various susceptible bacterial infections.- DNA gyrase subunit Atarget
- DNA topoisomerase 4 subunit Atarget
- DNA topoisomerase 2-alphatarget
- Cytochrome P450 1A2enzyme
- Cytochrome P450 3A4enzyme
- Cytochrome P450 3A5enzyme
- Cytochrome P450 3A7enzyme
- ATP-dependent translocase ABCB1transporter
- Potassium voltage-gated channel subfamily H member 2target
- DNA gyrase subunit Atarget
- DNA topoisomerase 4 subunit Atarget
- DNA topoisomerase 4 subunit Btarget
- DNA gyrase subunit Atarget
- Multidrug resistance protein MdtKtarget
- Gyrase Atarget
- DNA gyrase subunit Atarget
- Multidrug and toxin extrusion protein 1transporter
- Multidrug and toxin extrusion protein 2transporter
- Albumincarrier
- Thymidylate synthasetarget
- DNA gyrase subunit Btarget
Clavulanic acid A beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.- Bacterial beta-lactamase enzymestarget
- Sodium/glucose cotransporter 1transporter
- Beta-lactamasetarget
Imipenem A carbapenem antibiotic normally administered with cilastatin to treat a variety of infections.- Penicillin-binding protein 1Atarget
- Penicillin-binding protein 1Btarget
- Penicillin-binding protein 2target
- Penicillin-binding protein 3target
- Dipeptidase 1enzyme
- Penicillin-binding protein 4target
- Beta-lactamase SHV-1enzyme
- Beta-lactamase TEMenzyme
- Beta-lactamase CTX-Menzyme
- Beta-lactamaseenzyme
- Beta-lactamasetarget
Metronidazole A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.- Oxygen-insensitive NADPH nitroreductasetarget
- Cytochrome P450 2C9enzyme
- Cytochrome P450 3A4enzyme
- Cytochrome P450 2C8enzyme
- UDP-glucuronosyltransferase 1A1enzyme
- Anaerobic bacterial DNAtarget
- Protozoal DNAtarget
- ATP-dependent translocase ABCB1transporter
- Cytochrome P450 2A6enzyme
- Cytochrome P450 3A5enzyme
- Cytochrome P450 3A7enzyme
Piperacillin A penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase generating strains of several bacteria.- Solute carrier family 22 member 6transporter
- Penicillin-binding protein 3target
- Penicillin-binding protein 2Btarget
- Penicillin-binding protein 2atarget
- Penicillin-binding protein 1btarget
- Organic anion transporter 3transporter
Teicoplanin A glycopeptide antibiotic with a similar mechanism of action and spectrum of activity to vancomycin used to treat various infections caused by gram-positive bacteria.- Clinical Trials
Identifier Title Drug(s) Purpose Phase Status NCT01306825 Clinical Evaluation of Daptomycin Bone Penetration No drug interventions Not Available Not Available unknown_status NCT01431326 Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care - Alfentanil
- Amikacin
- Aminocaproic acid
- Bosentan
- Cefepime
- Cidofovir
- Ciprofloxacin
- Clozapine
- Fosfomycin
- Haloperidol
- Labetalol
- Lurasidone
- Methylprednisolone
- Molindone
- Nafcillin
- Nifedipine
- Oxycodone
- Pentobarbital
- Piperacillin
- Rocuronium
- Sevelamer
- Spironolactone
- Tazobactam
- Tobramycin
- Tranexamic acid
- Vancomycin
- Vecuronium
- Warfarin
- Ziprasidone
- Zolpidem
Not Available Not Available completed NCT06418048 INfectious DIsease REgistry BIObank No drug interventions Not Available Not Available recruiting NCT04724603 Phage Safety Retrospective Cohort Study No drug interventions Not Available Not Available recruiting NCT05248490 Impact of Pharmaceutical Interviews Regarding the Management of Adverse Effects Related to the Antibiotic Therapy Used to Treat Osteoarticular Infections During Return Home No drug interventions supportive_care Not Available completed NCT03750721 Staphylococcal Acute Post-Operative PJI Treated With 'DAIR' And Impact Of Rifampin No drug interventions Not Available Not Available completed NCT03852784 Osteoarticular Infections With Pneumococcal No drug interventions Not Available Not Available completed NCT04538053 BonE and Joint Infections - Simplifying Treatment in Children Trial treatment 4 recruiting NCT04373278 Infection After Free Fibula Flap Reconstruction of the Mandible: a Retrospective Cohort Study No drug interventions Not Available Not Available completed NCT03627000 Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection No drug interventions Not Available Not Available completed NCT03768635 Necrotizing External Otitis : Study in a Regional Bone and Joint Infection Reference Center No drug interventions Not Available Not Available completed NCT03850548 Chronic Infections on Articular Prostheses With C. Acnes Diagnosed by Specific PCR No drug interventions Not Available Not Available completed NCT04418882 Septic Management and Outcome of Open Fracture No drug interventions Not Available Not Available completed NCT04933344 Pharmacokinetics and Toxicodynamics of Daptomycin in Bone and Joint Infections No drug interventions Not Available Not Available unknown_status NCT03177369 Teicoplanin-based Antimicrobial Therapy in Staphylococcus Aureus Bone and Joint Infection: Tolerance, Efficacy and Experience With Subcutaneous Administration No drug interventions Not Available Not Available completed NCT03624855 Implant-Associated P. Aeruginosa Bone And Joint Infections : Experience In A Regional Reference Center In France No drug interventions Not Available Not Available completed NCT04712123 Recurrent S. Aureus Infections in Osteoarticular Infections No drug interventions Not Available Not Available unknown_status NCT03177343 Pristinamycin in the Treatment of MSSA Bone and Joint Infection No drug interventions Not Available Not Available completed NCT03209921 Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections No drug interventions Not Available Not Available completed NCT03011502 InterventiOnal Study of Bone and Joint Infections Related Gut dysbiosIS No drug interventions screening Not Available completed NCT03009045 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections (OTTER) No drug interventions treatment 2 completed NCT02817711 Lyon BJI Cohort Study No drug interventions Not Available Not Available unknown_status NCT04625478 Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections No drug interventions Not Available Not Available completed NCT03808285 Denosumab Related Osteonecrossi of the Jaw : : an Emergent and Potentially Complex Bone and Joint Infection No drug interventions Not Available Not Available completed NCT05753215 Controlled Trial of Omadacycline Randomized Treatment Given for Bone and Joint Infection No drug interventions treatment 2 recruiting NCT04414137 Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycin No drug interventions Not Available Not Available unknown_status NCT04662736 Tedizolid Suppressive Antimicrobial Therapy in a Reference Center No drug interventions Not Available Not Available completed NCT03311113 Adherence to Oral Antibiotics In Patients With Osteoarticular Infections No drug interventions Not Available Not Available completed NCT03209934 Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Center No drug interventions Not Available Not Available completed NCT03611634 Consitution Of A Biological Collection From Samples From The Gut Microbiote In Patients Having A Bone Or Joint Infection Treated By A Suppressive Subcutaneous Antibiotherapy With Betalactamine No drug interventions Not Available Not Available unknown_status NCT04496024 Ofloxacin Concentration-toxicity Relationship in the Elderly No drug interventions treatment Not Available recruiting NCT04563325 Oral-only Antibiotics for Bone and Joint Infections in Children No drug interventions treatment 4 active_not_recruiting NCT04722926 Lyon PJI Retrospective Cohort Study No drug interventions Not Available Not Available unknown_status NCT03850860 Comparison of Two Empirical Antimicrobial Therapies of Prosthetic Joint Infection No drug interventions Not Available Not Available completed NCT03848104 Evaluation of the Use of Cefoxitin in Combination in Continuous Parenteral Administration in the Treatment of Bone and Joint Infections No drug interventions Not Available Not Available completed NCT03796104 Prognostic Impact of Delta-haemolysin Production Deficiency in Staphylococcus Aureus on the Prognosis of Infected Implant Treated by DAIR No drug interventions Not Available Not Available recruiting NCT05977868 Comparing Oral Versus Parenteral Antimicrobial Therapy No drug interventions treatment 4 enrolling_by_invitation NCT04409769 Evaluation of the Tolerance of Ceftaroline and Ceftobiprole in the Management of BJI / PJI No drug interventions Not Available Not Available completed NCT05421312 Periarticular Penetration of Cefazolin and Clindamycin in Second Stage Revision Arthroplasty of the Hip No drug interventions prevention 4 unknown_status