Calcium Deficiency (DBCOND0052248)

Identifiers

Synonyms

Calcium deficiency / Calcium deficiency (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Calcium	A mineral found in over-the-counter supplements or prescription formulations used for the treatment of specific medical conditions related to calcium deficiency.	Protein S100-Btarget Calpastatintarget Cartilage oligomeric matrix proteintarget Spectrin beta chain, non-erythrocytic 1target Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Troponin C, skeletal muscletarget Troponin C, slow skeletal and cardiac musclestarget Calcium-transporting ATPase type 2C member 1target Diamine oxidase [copper-containing]target Protein S100-A13target Alkaline phosphatase, placental typetarget Protein S100-A8target Protein S100-A9target Protein S100-A2target Ceruloplasmintarget Bone morphogenetic protein 4target Matrix Gla proteintarget Protocadherin-19target Programmed cell death protein 6target Calmodulintarget
Calcium Phosphate	A compound used in supplements and antacids.	Sodium-dependent phosphate transporter 1transporter Sodium-dependent phosphate transporter 2transporter Sodium-dependent phosphate transport protein 2Atransporter Sodium-dependent phosphate transport protein 2Btransporter Sodium-dependent phosphate transport protein 2Ctransporter Transient receptor potential cation channel subfamily V member 6transporter Calbindincarrier Protein S100-Gcarrier Sodium/calcium exchanger 1transporter Transient receptor potential cation channel subfamily V member 5transporter Extracellular calcium-sensing receptortarget Calreticulintarget Calcium and integrin-binding protein 1target Programmed cell death protein 6target Sorcintarget Calcineurin B homologous protein 1target SPARCtarget Calnexintarget Fibrillin-2target Protein S100-Btarget Calsequestrin-2target Regucalcintarget Peflintarget Protein S100-A6target Translationally-controlled tumor proteintarget Calcium and integrin-binding family member 2target Protein S100-A13target Calsequestrin-1target Nucleobindin-1target Nucleobindin-2target Fibrillin-3target Grancalcintarget Calcium-dependent secretion activator 1target Albumincarrier Calmodulin-2target Calmodulin-3target Protein S100-A16target Calretinintarget Calcyphosintarget Calcium-dependent secretion activator 2target Calreticulin-3target Ryanodine receptor 1transporter Ryanodine receptor 2transporter Polycystin-2-like protein 1transporter Neurexin-1target Neuronal calcium sensor 1target Ryanodine receptor 3transporter Polycystin-1-like protein 3transporter Cation channel sperm-associated protein 1transporter Voltage-dependent L-type calcium channeltransporter Voltage-dependent P/Q-type calcium channeltransporter Voltage-dependent T-type calcium channeltransporter Voltage-dependent R-type calcium channeltransporter Calmodulintarget
Calcium carbonate	An ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.	No drug targets
Calcium citrate	An ingredient found in a variety of supplements and vitamins.	Transient receptor potential cation channel subfamily V member 6transporter Calbindincarrier Protein S100-Gcarrier Sodium/calcium exchanger 1transporter Transient receptor potential cation channel subfamily V member 5transporter Extracellular calcium-sensing receptortarget Calreticulintarget Calcium and integrin-binding protein 1target Programmed cell death protein 6target Sorcintarget Calcineurin B homologous protein 1target SPARCtarget Calnexintarget Fibrillin-2target Protein S100-Btarget Calsequestrin-2target Regucalcintarget Peflintarget Protein S100-A6target Translationally-controlled tumor proteintarget Calcium and integrin-binding family member 2target Protein S100-A13target Calsequestrin-1target Nucleobindin-1target Nucleobindin-2target Fibrillin-3target Grancalcintarget Calcium-dependent secretion activator 1target Albumincarrier Calmodulin-2target Calmodulin-3target Protein S100-A16target Calretinintarget Calcyphosintarget Calcium-dependent secretion activator 2target Calreticulin-3target Ryanodine receptor 1transporter Ryanodine receptor 2transporter Polycystin-2-like protein 1transporter Neurexin-1target Neuronal calcium sensor 1target Ryanodine receptor 3transporter Polycystin-1-like protein 3transporter Cation channel sperm-associated protein 1transporter Voltage-dependent L-type calcium channeltransporter Voltage-dependent P/Q-type calcium channeltransporter Voltage-dependent T-type calcium channeltransporter Voltage-dependent R-type calcium channeltransporter Calmodulintarget
Calcium glubionate anhydrous	A calcium salt indicated in the treatment of hypocalcemia, hyperkalemia, lead poisoning, and as an adjunct in the treatment of exudative skin conditions.	No drug targets
Calcium gluconate	An ingredient found in a variety of supplements and vitamins, and is used to lower potassium in the blood or treat magnesium poisoning.	No drug targets
Calcium lactate	An ingredient found in a variety of nutritional products.	No drug targets
Calcium lactate gluconate	A calcium salt indicated in the treatment of rickets, osteomalacia, and the treatment and prevention of calcium deficiency	No drug targets
Cholecalciferol	A form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.	Vitamin D-binding proteincarrier Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Vitamin D 25-hydroxylaseenzyme Sterol 26-hydroxylase, mitochondrialenzyme Cytochrome P450 2J2enzyme Cytochrome P450 3A4enzyme Vitamin D3 receptortarget Cytochrome P450 1A1enzyme Cytochrome P450 2C8enzyme
Genistein	Currently Genistein is being studied in clinical trials as a treatment for prostate cancer.	Estrogen receptor betatarget DNA topoisomerase 2-alphatarget Protein-tyrosine kinase 2-betatarget ATP-dependent translocase ABCB1transporter Multidrug resistance-associated protein 1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A2enzyme Nuclear receptor coactivator 1target Estrogen receptortarget Nuclear receptor coactivator 2target Transthyretincarrier Steroid hormone receptor ERR2target Steroid hormone receptor ERR1target Nuclear receptor subfamily 1 group I member 2target RAC-alpha serine/threonine-protein kinasetarget G-protein coupled estrogen receptor 1target Cytochrome P450 1B1target Sex hormone-binding globulintarget Cytochrome P450 1A1enzyme Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 2B1transporter Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A1enzyme Cytochrome P450 3A2enzyme Cytochrome P450 3A4enzyme Cystic fibrosis transmembrane conductance regulatortarget
Magnesium	A medication used for many purposes including constipation, indigestion, magnesium deficiency, and pre-eclampsia.	Albumincarrier Claudin-16transporter Transient receptor potential cation channel subfamily M member 6transporter Transient receptor potential cation channel subfamily M member 7transporter Solute carrier family 41 member 1transporter Solute carrier family 41 member 3transporter Magnesium transporter MRS2 homolog, mitochondrialtransporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04823156	The Effect of Calcium Intake on Calcium and Bone Metabolism During Load Carriage in Women	No drug interventions	prevention	Not Available	recruiting
NCT01639222	Human Pharmacology Trial of Calcium-vitamin D3 Tablet in Healthy Participants	Calcium carbonate Cholecalciferol	treatment	1	completed
NCT05430932	Effect Of Laparoscopic Sleeve Gastrectomy on Vitamin D, Parathormone and Calcium Levels	No drug interventions	treatment	Not Available	completed
NCT05863949	Clinical Trial of Vit D and Calcium for Recurrent BPPV	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT04405141	Uroflowmetry Results and Vitamin D Levels	No drug interventions	Not Available	Not Available	completed
NCT01508689	Effect of Calcium-fortified Cereal Bars on Dietary Calcium Intake in Women	No drug interventions	prevention	Not Available	completed
NCT01363167	Identifying Vitamin D Deficiency in Very Low Birth Weight Infant (VLBW) Infants Part 2	No drug interventions	treatment	Not Available	completed
NCT04396912	Post-thyroidectomy Vocal Cord Paralysis Along With Hypocalcemia: STROBE - Guided Prospective Cohort	No drug interventions	Not Available	Not Available	unknown_status