Castleman Disease (DBCOND0054709)

Identifiers

Synonyms
Giant Lymph Node Hyperplasia / Angiofollicular Lymph Node Hyperplasia / Castleman's Disease (CD) / Castleman's Disease / Castleman disease / Angiofollicular lymph node hyperplasia (morphologic abnormality) / [D] Castleman's disease (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Siltuximab
An interleukin antagonist used to treat multicentric Castleman's disease (MCD) in patients who are HIV and HHV-8 negative.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00412321
A Safety and Efficacy Study of CNTO 328 in Patients With B-Cell Non-Hodgkin's Lymphoma, Multiple Myeloma, or Castleman's Diseasetreatment1completed
NCT00361933
Valganciclovir to Treat HHV-8 Associated Multicentric Castleman's Diseasetreatment4withdrawn
NCT02817997
International Registry for Patients With Castleman DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT01441063
Tocilizumab for KSHV-Associated Multicentric Castleman Diseasetreatment2completed
NCT02853968
Unlock the Cell: Castleman's Disease Flow Cytometry StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT00127569
Rituximab in the Treatment of HIV Associated Multicentric Castleman Disease Dependent on Chemotherapytreatment2terminated
NCT02871050
Castleman Disease Collaborative Network BiobankNo drug interventionsNot AvailableNot Availablewithdrawn
NCT05028621
Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms and Castleman DiseaseNo drug interventionsscreeningNot Availablesuspended
NCT06643091
Nintedanib Treatment in Unicentric Castleman Diseasetreatment2not_yet_recruiting
NCT05440305
Unicentric Form of Castleman Disease - Surgery Therapy BenefitNo drug interventionsNot AvailableNot Availablecompleted
NCT02080416
Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumorstreatment0terminated
NCT03933904
Sirolimus in Previously Treated Idiopathic Multicentric Castleman Diseasetreatment2active_not_recruiting
NCT05081141
HHV8 and Solid Organ TransplantationNo drug interventionsNot AvailableNot Availablerecruiting
NCT01552434
Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Diseasetreatment1active_not_recruiting
NCT03300830
Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT01183598
A Study to Provide RoActemra/Actemra (Tocilzumab) to Patients With Multicentric Castleman's Disease Who Demonstrated Benefit From Previous RoActemra/Actemra Treatmenttreatment1completed
NCT03717844
Registry for Adults With Plasma Cell Disorders (PCD's)No drug interventionsNot AvailableNot Availablerecruiting
NCT05283993
A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFHNo drug interventionsNot AvailableNot Availablerecruiting
NCT00891280
Dose-escalation Study of Oral CX-4945treatment1unknown_status