Castleman Disease (DBCOND0054709)

Identifiers

Synonyms

Giant Lymph Node Hyperplasia / Angiofollicular Lymph Node Hyperplasia / Castleman's Disease (CD) / Castleman's Disease / Castleman disease / Angiofollicular lymph node hyperplasia (morphologic abnormality) / [D] Castleman's disease (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Siltuximab	An interleukin antagonist used to treat multicentric Castleman's disease (MCD) in patients who are HIV and HHV-8 negative.	Interleukin-6target Cytochrome P450 3A4enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00412321	A Safety and Efficacy Study of CNTO 328 in Patients With B-Cell Non-Hodgkin's Lymphoma, Multiple Myeloma, or Castleman's Disease	Siltuximab	treatment	1	completed
NCT00361933	Valganciclovir to Treat HHV-8 Associated Multicentric Castleman's Disease	Valganciclovir	treatment	4	withdrawn
NCT02817997	International Registry for Patients With Castleman Disease	No drug interventions	Not Available	Not Available	recruiting
NCT01441063	Tocilizumab for KSHV-Associated Multicentric Castleman Disease	Tocilizumab Valganciclovir Zidovudine	treatment	2	completed
NCT02853968	Unlock the Cell: Castleman's Disease Flow Cytometry Study	No drug interventions	Not Available	Not Available	completed
NCT00127569	Rituximab in the Treatment of HIV Associated Multicentric Castleman Disease Dependent on Chemotherapy	Rituximab	treatment	2	terminated
NCT02871050	Castleman Disease Collaborative Network Biobank	No drug interventions	Not Available	Not Available	withdrawn
NCT05028621	Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms and Castleman Disease	No drug interventions	screening	Not Available	suspended
NCT06643091	Nintedanib Treatment in Unicentric Castleman Disease	Nintedanib	treatment	2	not_yet_recruiting
NCT05440305	Unicentric Form of Castleman Disease - Surgery Therapy Benefit	No drug interventions	Not Available	Not Available	completed
NCT02080416	Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors	Nelfinavir	treatment	0	terminated
NCT03933904	Sirolimus in Previously Treated Idiopathic Multicentric Castleman Disease	Sirolimus	treatment	2	active_not_recruiting
NCT05081141	HHV8 and Solid Organ Transplantation	No drug interventions	Not Available	Not Available	recruiting
NCT01552434	Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease	Bevacizumab Cetuximab Menthol Sirolimus Temsirolimus Valproic acid	treatment	1	active_not_recruiting
NCT03300830	Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease	No drug interventions	Not Available	Not Available	recruiting
NCT01183598	A Study to Provide RoActemra/Actemra (Tocilzumab) to Patients With Multicentric Castleman's Disease Who Demonstrated Benefit From Previous RoActemra/Actemra Treatment	Tocilizumab	treatment	1	completed
NCT03717844	Registry for Adults With Plasma Cell Disorders (PCD's)	No drug interventions	Not Available	Not Available	recruiting
NCT05283993	A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFH	No drug interventions	Not Available	Not Available	recruiting
NCT00891280	Dose-escalation Study of Oral CX-4945	Silmitasertib	treatment	1	unknown_status