dry cough (DBCOND0094420)

Identifiers

Synonyms

Dry cough (finding) / Cough nonproductive / Coughing / Cough / Coughing - function (qualifier value) / Cough (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ammonium chloride	Expectorant in cough syrups. The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium...	No drug targets
Benzoic acid	An antimicrobial food additive.	Cocaine esterasetarget D-amino-acid oxidasetarget Chlorocatechol 1,2-dioxygenasetarget 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget Non-heme chloroperoxidasetarget Oxygen-insensitive NAD(P)H nitroreductasetarget Hydroxyquinol 1,2-dioxygenasetarget Replication proteintarget Solute carrier organic anion transporter family member 2B1transporter Organic anion transporter 3transporter Monocarboxylate transporter 1transporter Solute carrier family 15 member 1target Ras-related protein Rab-9Atarget
Cetylpyridinium	A compound used to reduce plaque and gingivitis, as well as whiten teeth.	No drug targets
Chlorpheniramine	A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.	Histamine H1 receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Sodium-dependent dopamine transportertarget Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter
Cloperastine	Cloperastine is a cough suppressant that acts on the central nervous system.	No drug targets
Codeine	An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.	Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Solute carrier family 22 member 1transporter UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B4enzyme
Diphenhydramine	A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Solute carrier family 22 member 2transporter Organic cation/carnitine transporter 2transporter Prostaglandin G/H synthase 1enzyme Muscarinic acetylcholine receptor M2target Histamine N-methyltransferasetarget
Dropropizine	A peripherally acting cough suppressant.	No drug targets
Ephedrine	An alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion.	Alpha-1A adrenergic receptortarget Sodium-dependent noradrenaline transportertarget Cholinesteraseenzyme Albumincarrier Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Synaptic vesicular amine transportertransporter Acetylcholinesteraseenzyme D(2) dopamine receptortarget
Guaifenesin	An expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.	NMDA receptortarget
Pholcodine	An opioid antitussive used to suppress unproductive coughing.	Mu-type opioid receptortarget Kappa-type opioid receptortarget Delta-type opioid receptortarget
Promethazine	A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.	D(2) dopamine receptortarget Histamine H1 receptortarget Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M5target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Cytochrome P450 2D6enzyme Cytochrome P450 2B6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C9enzyme Histamine H2 receptortarget Alpha adrenergic receptortarget P2 Purinoceptorstarget Voltage-gated sodium channel alpha subunittarget Voltage-gated Potassium Channelstarget ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Albumincarrier Calmodulintarget
Pseudoephedrine	An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.	Alpha-1A adrenergic receptortarget Alpha-2A adrenergic receptortarget Beta-2 adrenergic receptortarget Amine oxidase [flavin-containing] Aenzyme Beta-1 adrenergic receptortarget Sodium-dependent dopamine transportertarget Sodium-dependent noradrenaline transportertarget Sodium-dependent serotonin transportertarget Nuclear factor of activated T-cells, cytoplasmic 1target Tumor necrosis factortarget Nuclear factor NF-kappa-B p105 subunittarget activator protein 1target Interleukin-2target Albumincarrier Sodium-dependent noradrenaline transportertransporter Sodium-dependent dopamine transportertransporter Sodium-dependent serotonin transportertransporter D(2) dopamine receptortarget

Clinical Trials

Not Available