Dropropizine
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Dropropizine is a peripherally acting cough suppressant.
- Generic Name
- Dropropizine
- DrugBank Accession Number
- DB13785
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Dropropizine (DB13785)
- Weight
- Average: 236.315
Monoisotopic: 236.152477892 - Chemical Formula
- C13H20N2O2
- Synonyms
- Dropropizine
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Categories
- ATC Codes
- R05DB19 — Dropropizine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Diazinanes
- Sub Class
- Piperazines
- Direct Parent
- Phenylpiperazines
- Alternative Parents
- N-arylpiperazines / Dialkylarylamines / Aniline and substituted anilines / N-alkylpiperazines / 1,3-aminoalcohols / Trialkylamines / Secondary alcohols / 1,2-diols / 1,2-aminoalcohols / Azacyclic compounds show 3 more
- Substituents
- 1,2-aminoalcohol / 1,2-diol / 1,3-aminoalcohol / Alcohol / Amine / Aniline or substituted anilines / Aromatic heteromonocyclic compound / Azacycle / Benzenoid / Dialkylarylamine show 15 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- U0K8WHL37U
- CAS number
- 17692-31-8
- InChI Key
- PTVWPYVOOKLBCG-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2
- IUPAC Name
- 3-(4-phenylpiperazin-1-yl)propane-1,2-diol
- SMILES
- OCC(O)CN1CCN(CC1)C1=CC=CC=C1
References
- General References
- AIFA Package Leaflet: ACTIGRIP TOSSE SEDATIVO (dropropizine) oral syrup [Link]
- External Links
- ChemSpider
- 3057
- 23419
- ChEBI
- 93837
- ChEMBL
- CHEMBL151445
- Wikipedia
- Dropropizine
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Withdrawn Treatment Coughing / Inflammation / Rhinitis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution / drops Oral Syrup Tablet Transmucosal Pastille Oral 20 mg Syrup Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 97.1 mg/mL ALOGPS logP 0.63 ALOGPS logP 0.61 ChemAxon logS -0.39 ALOGPS pKa (Strongest Acidic) 14 ChemAxon pKa (Strongest Basic) 7.65 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 4 ChemAxon Hydrogen Donor Count 2 ChemAxon Polar Surface Area 46.94 Å2 ChemAxon Rotatable Bond Count 4 ChemAxon Refractivity 68.79 m3·mol-1 ChemAxon Polarizability 26.77 Å3 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Drug created on June 23, 2017 20:48 / Updated on May 21, 2021 10:22