This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Dropropizine is a peripherally acting cough suppressant.
- Generic Name
- Dropropizine
- DrugBank Accession Number
- DB13785
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Dropropizine (DB13785)
- Weight
- Average: 236.315
Monoisotopic: 236.152477892 - Chemical Formula
- C13H20N2O2
- Synonyms
- Dropropizine
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
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Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Categories
- ATC Codes
- R05DB19 — Dropropizine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Diazinanes
- Sub Class
- Piperazines
- Direct Parent
- Phenylpiperazines
- Alternative Parents
- N-arylpiperazines / Dialkylarylamines / Aniline and substituted anilines / N-alkylpiperazines / 1,3-aminoalcohols / Trialkylamines / Secondary alcohols / 1,2-diols / 1,2-aminoalcohols / Azacyclic compounds show 3 more
- Substituents
- 1,2-aminoalcohol / 1,2-diol / 1,3-aminoalcohol / Alcohol / Amine / Aniline or substituted anilines / Aromatic heteromonocyclic compound / Azacycle / Benzenoid / Dialkylarylamine show 15 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- U0K8WHL37U
- CAS number
- 17692-31-8
- InChI Key
- PTVWPYVOOKLBCG-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2
- IUPAC Name
- 3-(4-phenylpiperazin-1-yl)propane-1,2-diol
- SMILES
- OCC(O)CN1CCN(CC1)C1=CC=CC=C1
References
- General References
- AIFA Package Leaflet: ACTIGRIP TOSSE SEDATIVO (dropropizine) oral syrup [Link]
- External Links
- ChemSpider
- 3057
- 23419
- ChEBI
- 93837
- ChEMBL
- CHEMBL151445
- Wikipedia
- Dropropizine
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Withdrawn Treatment Cough / Inflammation / Rhinitis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution / drops Oral Syrup Oral 0.3 % Syrup Oral 15 MG/5ML Tablet Transmucosal Syrup Oral 0.300 g Syrup Oral 300.000 mg Pastille Oral 20 mg Solution Oral Syrup Oral Suppository Rectal 20.000 mg Syrup Oral 0.3000 g Tablet Oral 30.000 mg Syrup Tablet Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 97.1 mg/mL ALOGPS logP 0.63 ALOGPS logP 0.61 Chemaxon logS -0.39 ALOGPS pKa (Strongest Acidic) 14 Chemaxon pKa (Strongest Basic) 7.65 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 46.94 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 68.79 m3·mol-1 Chemaxon Polarizability 26.77 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 149.57985 predictedDeepCCS 1.0 (2019) [M+H]+ 151.93784 predictedDeepCCS 1.0 (2019) [M+Na]+ 158.16322 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:48 / Updated at May 21, 2021 10:22