cold or flu syndrome (DBCOND0095207)

Identifiers

Synonyms

Common Cold/Flu

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetaminophen	An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2D6enzyme Cytochrome P450 2A6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B15enzyme Sulfotransferase 1A1enzyme Sulfotransferase 1A3enzyme Arylamine N-acetyltransferase 2enzyme Prostaglandin E synthase 3target Transient receptor potential cation channel subfamily V member 1target Albumincarrier Fatty-acid amide hydrolase 1enzyme Glutathione S-transferase Penzyme Glutathione S-transferase Mu 1enzyme Sodium-dependent noradrenaline transportertarget Sodium-dependent serotonin transportertarget
Acetylsalicylic acid	A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme 5'-AMP-activated protein kinasetarget Endothelin-1 receptortarget Cellular tumor antigen p53target Endoplasmic reticulum chaperone BiPtarget Ribosomal protein S6 kinase alpha-3target NF-kappa-B inhibitor alphatarget Tumor necrosis factor-inducible gene 6 proteintarget Caspase-1target Caspase-3target Inhibitor of nuclear factor kappa-B kinase subunit betatarget Extracellular signal-regulated kinase (ERK)target G1/S-specific cyclin-D1target Myc proto-oncogene proteintarget Proliferating cell nuclear antigentarget Cyclin Atarget UDP-glucuronosyltransferase 1-6enzyme Arylamine N-acetyltransferase 2enzyme Organic anion transporter 3transporter Sialidase-1target 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
Ammonium chloride	Expectorant in cough syrups. The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium...	No drug targets
Cetylpyridinium	A compound used to reduce plaque and gingivitis, as well as whiten teeth.	No drug targets
Chlorpheniramine	A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.	Histamine H1 receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Sodium-dependent dopamine transportertarget Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter
Choline salicylate	The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due...	Choline-phosphate cytidylyltransferase Btarget Acetylcholinesterasetarget Choline-phosphate cytidylyltransferase Atarget Phospholipase D2target Cholinesterasetarget Phospholipase D1target Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 4transporter Choline/ethanolaminephosphotransferase 1enzyme Choline transporter-like protein 1transporter Choline transporter-like protein 4transporter Choline transporter-like protein 3transporter Choline/ethanolamine kinaseenzyme Choline O-acetyltransferaseenzyme Choline kinase alphaenzyme Choline dehydrogenase, mitochondrialenzyme High affinity choline transporter 1transporter Neuronal acetylcholine receptor subunit alpha-7target
Dextromethorphan	An NMDA receptor antagonist used to treat cases of dry cough.	Sigma non-opioid intracellular receptor 1target Neuronal acetylcholine receptor subunit alpha-2target Sodium-dependent serotonin transportertarget Glutamate receptor ionotropic, NMDA 3Atarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Membrane-associated progesterone receptor component 1target Neuronal acetylcholine receptor subunit alpha-3target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-4target Neuronal acetylcholine receptor subunit beta-2target Neuronal acetylcholine receptor subunit alpha-7target Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget NADPH oxidasetarget Sodium-dependent noradrenaline transportertarget UDP-glucuronosyltransferase 2B4enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme UDP-glucuronosyltransferase 2B17enzyme Aromatasetarget
Diphenhydramine	A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Solute carrier family 22 member 2transporter Organic cation/carnitine transporter 2transporter Prostaglandin G/H synthase 1enzyme Muscarinic acetylcholine receptor M2target Histamine N-methyltransferasetarget
Ibuprofen	An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Cytochrome P450 2C9enzyme Albumincarrier ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 2B1transporter ATP-dependent translocase ABCB1transporter UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Apoptosis regulator Bcl-2target Thrombomodulintarget Fatty acid-binding protein, intestinaltarget Peroxisome proliferator-activated receptor gammatarget Cystic fibrosis transmembrane conductance regulatortarget Peroxisome proliferator-activated receptor alphatarget Platelet glycoprotein Ib alpha chaintarget Protein S100-A7target Alpha-methylacyl-CoA racemaseenzyme Cytochrome P450 3A4enzyme C-X-C chemokine receptor type 1target C-X-C chemokine receptor type 2target Interleukin-8target
Phenylephrine	An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.	Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Amine oxidase [flavin-containing] Aenzyme Alpha-1D adrenergic receptortarget Cytochrome P450 1A2enzyme Sulfotransferase 1A3enzyme Amine oxidase [flavin-containing] Benzyme D(2) dopamine receptortarget
Pseudoephedrine	An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.	Alpha-1A adrenergic receptortarget Alpha-2A adrenergic receptortarget Beta-2 adrenergic receptortarget Amine oxidase [flavin-containing] Aenzyme Beta-1 adrenergic receptortarget Sodium-dependent dopamine transportertarget Sodium-dependent noradrenaline transportertarget Sodium-dependent serotonin transportertarget Nuclear factor of activated T-cells, cytoplasmic 1target Tumor necrosis factortarget Nuclear factor NF-kappa-B p105 subunittarget activator protein 1target Interleukin-2target Albumincarrier Sodium-dependent noradrenaline transportertransporter Sodium-dependent dopamine transportertransporter Sodium-dependent serotonin transportertransporter D(2) dopamine receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00495976	Study to Investigate the Effects of Hot Drinks on Nasal Airway Resistance and Symptoms of Common Cold	No drug interventions	treatment	Not Available	completed