Bacterial Sinusitis (DBCOND0117152)

Identifiers

Synonyms

Acute bacterial rhinosinusitis / Sinusitis bacterial / Bacterial sinusitis / Bacterial sinusitis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Azithromycin	A macrolide antibiotic used to treat a variety of bacterial infections.	23S ribosomal RNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 3A4enzyme Protein-arginine deiminase type-4target ATP-binding cassette sub-family C member 2transporter
Beclomethasone dipropionate	An inhaled corticosteroid used as maintenance treatment in the prophylaxis of asthma attacks.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A5enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Cefixime	A third generation cephalosporin used to treat susceptible Gram-negative and Gram-positive bacterial infections.	Solute carrier family 15 member 1transporter Penicillin-binding proteintarget Penicillin-binding protein 2target Solute carrier family 22 member 7transporter Organic anion transporter 3transporter Solute carrier family 15 member 2transporter
Ceftriaxone	A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract.	Albumincarrier Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Penicillin-binding protein 2Btarget Glutamine synthetaseenzyme Solute carrier family 22 member 11target Solute carrier family 22 member 6target Organic anion transporter 3target Solute carrier family 15 member 1target ATP-dependent translocase ABCB1transporter
Fluticasone propionate	A glucocorticoid used to treat asthma, inflammatory pruritic dermatoses, and nonallergic rhinitis.	Corticosteroid-binding globulincarrier Cytosolic phospholipase A2target Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Progesterone receptortarget Mineralocorticoid receptortarget Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2C8enzyme Solute carrier organic anion transporter family member 1B1carrier ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter
Miocamycin	Miocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to...	Cytochrome P450 3A4enzyme
Mometasone	A corticosteroid with no indications.	Glucocorticoid receptortarget Cytochrome P450 2C8enzyme Progesterone receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme
Sitafloxacin	A fluoroquinolone antibiotic indicated in the treatment of susceptible bacterial infections.	Cytochrome P450 1A2enzyme
Sulbactam	An beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections.	Beta-lactamasetarget Solute carrier family 22 member 6transporter
Tyrothricin	A topical antibiotic with broad spectrum activity against Gram positive bacteria and some fungal infections.	Acetylcholinesterasetarget Beta-galactosidasetarget Phospholipid membranetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04447521	Surveillance of Non-invasive Streptococcus Pneumoniae Infections in Belgium	No drug interventions	Not Available	Not Available	recruiting
NCT03584737	Point-of-Care Immunoassay for Detection of Bacterial Sinusitis	No drug interventions	Not Available	Not Available	terminated