Zopiclone is a nonbenzodiazepine hypnotic used for the short-term management of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors.
- Mechanism
- Curator reviewed
Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. Both zopiclone and benzodiazepines act indiscriminately at the benzodiazepine binding site on α1, α2, α3 and α5 GABAA containing receptors as full agonists causing an enhancement of the inhibitory actions of GABA to produce the therapeutic (hypnotic and anxiolytic) and adverse effects of zopiclone.
- Primary indication
- For the short-term treatment of insomnia.Curator reviewed · 1 structured indication
- Formula / weight
- C17H17ClN6O3 · 388.808 g/mol (avg)
- First approval
- Canada, 1999
- Code names
- RP-27267
- Brand names
Resolves to
GBBSUAFBMRNDJC-UHFFFAOYSA-NSMILESCN1CCN(CC1)C(=O)OC1N(C(=O)C2=NC=CN=C12)C1=NC=C(Cl)C=C1What you can answer from here — as of September 20, 2026
Which drugs share a target with Zopiclone, and which of those have an active Phase 3 trial?
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