Gamma-aminobutyric acid receptor subunit alpha-3

BE0000523ProteinHumansGABRA3

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:29053855). It is acted on by 31 drugs in DrugBank.

Gene name
GABRA3
UniProtKB entry
P34903Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
492 residues · 55,164 Da
Also known as
GABA(A) receptor subunit alpha-3 · GABAAR subunit alpha-3

Resolves to

Protein
UniProtP34903UniProt nameGBRA3_HUMAN
Gene
HGNCHGNC:4077NCBI Gene2556GenBank386424GeneCardsGABRA3
Pharmacology
IUPHAR/GtoPdb406KEGGhsa:2556
Structure
PDB9CTP
Drugs

What you can answer from here — as of September 07, 2019

31DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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76+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit alpha-3, how selective are they, and which programs against it are still in active trials?

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