Gamma-aminobutyric acid receptor subunit alpha-2

BE0000381ProteinHumansGABRA2

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:29961870, PubMed:31032849). It is acted on by 32 drugs in DrugBank.

Gene name
GABRA2
UniProtKB entry
P47869Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
451 residues · 51,326 Da
Also known as
GABA(A) receptor subunit alpha-2 · GABAAR subunit alpha-2

Resolves to

Protein
UniProtP47869UniProt nameGBRA2_HUMAN
Gene
HGNCHGNC:4076NCBI Gene2555GenBank386422GeneCardsGABRA2
Pharmacology
IUPHAR/GtoPdb405KEGGhsa:2555
Structure
PDB9CRVPDB9CSBPDB9CT0
Drugs

What you can answer from here — as of September 07, 2019

32DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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82+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit alpha-2, how selective are they, and which programs against it are still in active trials?

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