Propofol

DB00818ApprovedInvestigationalVet approvedSmall moleculeAnesthetics, General

Propofol is a medication used in general anesthesia and for sedation. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications.

Chemical structure of Propofol
Mechanism
Curator reviewed
Primary indication
Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.Curator reviewed · 5 structured indications
Formula / weight
C12H18O · 178.2707 g/mol (avg)
First approval
Canada, 2000 · United States, 1996
Code names
ICI 35-868
Brand names
  • Diprivan

Resolves to

Compound
UNIIYI7VU623SFCAS2078-54-8ChEMBLCHEMBL526ChEBI44915PubChem4943KEGGD00549
Clinical / RWD
RxNorm8782ATCN01AX10PharmGKBPA451141
Structure
InChIKeyOLBCVFGFOZPWHH-UHFFFAOYSA-NSMILESCC(C)C1=CC=CC(C(C)C)=C1O
Targets
P47870GABRB2P28472GABRB3P35499SCN4AQ99250SCN2A
Transporters
P08183ABCB1

What you can answer from here — as of September 23, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1TransporterSubstrate / inhibitor direction, not just membership
Listed above
1,921Drug interactionsStructured to mechanism, not free text
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1,511Clinical trialsPhase, status and sponsor resolved per trial
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5Structured indicationsCondition, population, route and combination as fields, not prose
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2ContraindicationsEach with its own population and attribute set
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301Marketed productsAcross 10 countries and 96 labellers
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1ATC codeIncluding every combination product, plus 37 drug categories
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43+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Propofol, and which of those have an active Phase 3 trial?

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