Solute carrier family 12 member 3

BE0000419ProteinHumansSLC12A3

Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:18270262, PubMed:21613606, PubMed:22009145, PubMed:36351028, PubMed:36792826). It is acted on by 15 drugs in DrugBank.

Gene name
SLC12A3
UniProtKB entry
P55017Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,021 residues · 113,138 Da
Also known as
Na-Cl cotransporter · Na-Cl symporter · NCC · Thiazide-sensitive sodium-chloride cotransporter · TSC

Resolves to

Protein
UniProtP55017UniProt nameS12A3_HUMAN
Gene
HGNCHGNC:10912NCBI Gene6559GenBank1172161GeneCardsSLC12A3
Pharmacology
KEGGhsa:6559
Structure
PDB7Y6IPDB7YG0PDB7YG1
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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72+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 12 member 3, how selective are they, and which programs against it are still in active trials?

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