Carbonic anhydrase 12

BE0001653ProteinHumansCA12

Reversible hydration of carbon dioxide. It is acted on by 26 drugs in DrugBank.

Gene name
CA12
UniProtKB entry
O43570Swiss-Prot
Cellular location
Membrane
Residues / weight
354 residues · 39,451 Da
Also known as
4.2.1.1 · CA-XII · Carbonate dehydratase XII · Carbonic anhydrase XII · Tumor antigen HOM-RCC-3.1.3

Resolves to

Protein
UniProtO43570UniProt nameCAH12_HUMAN
Gene
HGNCHGNC:1371NCBI Gene771GenBank2984693GeneCardsCA12
Pharmacology
IUPHAR/GtoPdb2747KEGGhsa:771
Structure
PDB1JCZPDB1JD0PDB4HT2
Drugs

What you can answer from here — as of September 07, 2019

26DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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91+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carbonic anhydrase 12, how selective are they, and which programs against it are still in active trials?

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