Carbonic anhydrase 4

BE0000535ProteinHumansCA4

Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH (PubMed:15563508, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17652713, PubMed:17705204, PubMed:19186056, PubMed:19206230, PubMed:7625839, PubMed:9054574). It is acted on by 36 drugs in DrugBank.

Gene name
CA4
UniProtKB entry
P22748Swiss-Prot
Cellular location
Cell membrane
Residues / weight
312 residues · 35,032 Da
Also known as
4.2.1.1 · CA-IV · Carbonate dehydratase IV · Carbonic anhydrase IV

Resolves to

Protein
UniProtP22748UniProt nameCAH4_HUMAN
Gene
HGNCHGNC:1375NCBI Gene762GenBank179791GeneCardsCA4
Pharmacology
IUPHAR/GtoPdb2599KEGGhsa:762
Structure
PDB1ZNCPDB3F7BPDB3F7U
Drugs

What you can answer from here — as of September 07, 2019

36DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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118+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carbonic anhydrase 4, how selective are they, and which programs against it are still in active trials?

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