3',5'-cyclic-AMP phosphodiesterase 4B

BE0000487ProteinHumansPDE4B

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). It is acted on by 40 drugs in DrugBank.

Gene name
PDE4B
UniProtKB entry
Q07343Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
736 residues · 83,343 Da
Also known as
3.1.4.53 · cAMP-specific phosphodiesterase 4B · DPDE4 · PDE32

Resolves to

Protein
UniProtQ07343UniProt namePDE4B_HUMAN
Gene
HGNCHGNC:8781NCBI Gene5142GenBank347122GeneCardsPDE4B
Pharmacology
IUPHAR/GtoPdb1301KEGGhsa:5142
Structure
PDB1F0JPDB1RO6PDB1RO9
Drugs

What you can answer from here — as of September 03, 2024

40DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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112+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3',5'-cyclic-AMP phosphodiesterase 4B, how selective are they, and which programs against it are still in active trials?

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