3',5'-cyclic-AMP phosphodiesterase 4D

BE0001287ProteinHumansPDE4D

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. It is acted on by 41 drugs in DrugBank.

Gene name
PDE4D
UniProtKB entry
Q08499Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
809 residues · 91,114 Da
Also known as
3.1.4.53 · cAMP-specific phosphodiesterase 4D · DPDE3 · PDE43

Resolves to

Protein
UniProtQ08499UniProt namePDE4D_HUMAN
Gene
HGNCHGNC:8783NCBI Gene5144GenBank347130GeneCardsPDE4D
Pharmacology
IUPHAR/GtoPdb1303KEGGhsa:5144
Structure
PDB1E9KPDB1MKDPDB1OYN
Drugs

What you can answer from here — as of September 03, 2024

41DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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126+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3',5'-cyclic-AMP phosphodiesterase 4D, how selective are they, and which programs against it are still in active trials?

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