3',5'-cyclic-AMP phosphodiesterase 4A

BE0001133ProteinHumansPDE4A

Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. It is acted on by 36 drugs in DrugBank.

Gene name
PDE4A
UniProtKB entry
P27815Swiss-Prot
Cellular location
Cytoplasm, perinuclear region
Residues / weight
886 residues · 98,142 Da
Also known as
3.1.4.53 · cAMP-specific phosphodiesterase 4A · DPDE2 · PDE46

Resolves to

Protein
UniProtP27815UniProt namePDE4A_HUMAN
Gene
HGNCHGNC:8780NCBI Gene5141GenBank347120GeneCardsPDE4A
Pharmacology
IUPHAR/GtoPdb1300KEGGhsa:5141
Structure
PDB2QYKPDB3I8VPDB3TVX
Drugs

What you can answer from here — as of September 03, 2024

36DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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100+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3',5'-cyclic-AMP phosphodiesterase 4A, how selective are they, and which programs against it are still in active trials?

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