- Accession Number
A family of hexahydropyridines.
Drug Drug Description Argatroban A synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. Terfenadine An antihistamine for the treatment of allergy symptoms. Minoxidil An antihypertensive vasodilating agent used for resistant hypertension that is symptomatic or has caused end organ damage. Aminoglutethimide An adrenocortical steroid synthesis inhibitor used in the treatment of Cushing's syndrome. Trihexyphenidyl An antispasmodic drug used as an adjunct drug in the management of parkinsonism and as a treatment for extrapyramidal symptoms caused by drugs affecting the central nervous system (CNS). Methylphenidate A stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Cyproheptadine A combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome. Loratadine A second generation antihistamine used to manage the symptoms of allergic rhinitis. Lenalidomide A thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome. Sufentanil An opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Azatadine An H1 receptor antagonist used to treat perennial and allergic rhinitis as well as eustachian tube congestion. Biperiden A muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs. Fentanyl An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. Loperamide A long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis. Ketotifen A histamine H1 receptor blocker and mast cell stabilizer used to treat mild atopic asthma and allergic conjunctivitis. Fexofenadine A selective H1-antagonist for the symptomatic treatment of seasonal allergic rhinitis and chronic idiopathic urticaria. Mepivacaine A local anesthetic used for local or regional analgesia or anesthesia. Desloratadine A second generation tricyclic antihistamine used to treat seasonal and non seasonal allergic rhinitis, pruritus, and urticaria. Perhexiline For the management of severe angina pectoris. Domperidone A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. Flecainide A class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT). Phencyclidine A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like... Lobeline Investigated for use/treatment in addictions. Dexmethylphenidate A norepinephrine-dopamine reuptake inhibitor used in the treatment of ADHD in conjunction with other therapies. Pomalidomide A thalidomide analogue used in combination with dexamethasone to treat patients with multiple myeloma. Indoramin Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Alphaprodine Not Annotated Penfluridol Not Annotated Icaridin Icaridin is indicated for use to repel insects, such as mosquitoes, biting flies, ticks, chiggers, and fleas, via topical use or over clothing . Donepezil An acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia. Rimonabant For use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m2, or patients wih a BMI greater than 27 kg/m2 with associated... Butyrfentanyl A methylated fentanyl analog with no clinical indications but is commonly used as a recreational drug. Avacopan An orally bioavailable complement 5a receptor (C5aR) antagonist for the treatment of severe anti-neutrophil cytoplasmic (auto)antibody (ANCA)-associated vasculitis. Serdexmethylphenidate A prodrug of the CNS stimulant dexmethylphenidate used as a first-line treatment for Attention Deficit Hyperactivity Disorder (ADHD). CC-220 CC-220 has been used in trials studying the treatment of Systemic Lupus Erythematosus. Cisapride A medication used to treat heartburn associated with GERD. Remifentanil An opioid analgesic used in anesthesia. Methyprylon For the treatment of insomnia. Glutethimide For the treatment of insomnia. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Crizotinib A receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. HT-0712 BLX-028914 has been used in trials studying the treatment and basic science of Allergic Rhinitis and Age-Associated Memory Impairment (AAMI). Antineoplaston A10 Antineoplaston A10 has been used in trials studying the treatment of Sarcoma, Lymphoma, Lung Cancer, Liver Cancer, and Kidney Cancer, among others. Gemigliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. Ketanserin Ketanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer. Phenglutarimide Not Annotated Clopamide Clopamide is an oral diuretic agent with antihypertensive activity. Like thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure. Avadomide Avadomide is under investigation in clinical trial NCT02031419 (Novel Combinations of CC-122, CC-223, CC-292, and Rituximab in Diffuse Large B-cell Lymphoma and Follicular Lymphoma). Navtemadlin Navtemadlin (AMG-232) is under investigation in clinical trial NCT03041688 (MDM2 Inhibitor AMG-232 and Decitabine in Treating Patients With Relapsed, Refractory, or Newly-Diagnosed Acute Myeloid Leukemia). Miglustat A glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement. Meperidine An opioid agonist with analgesic and sedative properties used to manage severe pain. Miglitol An oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates. Alfentanil An opioid agonist used to induce and maintain anesthesia, as well as an analgesic. Tiagabine An antiepileptic used to treat partial seizures. Anileridine An opioid analgesic used to treat moderate to severe pain. Thalidomide A medication used to treat cancers, particularly newly diagnosed multiple myeloma, and erythema nodosum leprosum. Diphenoxylate An antidiarrheal medication used with atropine to manage diarrhea. Beta-hydroxyfentanyl Not Available Desmethylprodine Desmethylprodine, a derivative of meperidine, is an opioid analgesic with the potency of morphine. It has been listed as a Schedule I controlled drug in the United States, and thus... Difenoxin An antidiarrheal agent used as an adjunct for the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea. Tenocyclidine Because of its high affinity for the phencyclidine binding site on the NMDA receptor, the 3H radiolabelled form of tenocyclidine is widely used in research into NMDA receptors. Carfentanil Carfentanil is similar (but more potent) to the opioid analgesic fentanyl. It is used as a tranquilizer for large animals. 1-Piperidinocyclohexanecarbonitrile Not Available Rolicyclidine Rolicyclidine has anesthetic properties and can induce a sedative effect. α-Methylfentanyl α-Methylfentanyl is an analog of fentanyl with opioid analgesic properties. Ohmefentanyl Ohmefentanyl is an extremely potent opioid analgesic drug which selectively binds to the µ-opioid receptor. The Chinese have recorded ohmefentanyl as having a potency that is 6,300 times morphine. Ohmefentanyl... 3-Methylfentanyl 3-Methylfentanyl is an opioid analgesic and is an analog of the potent opioid, fentanyl. 3-Methylfentanyl is one of the most powerful opioid drugs sold illegally and is estimated to be... Duvoglustat An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. 1-deoxymannojirimycin An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. [PubChem] Afegostat Not Available Migalastat An alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant. Ticalopride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. Ketobemidone For the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures. Nipecotic acid Not Annotated Dexetimide A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide. 3-Allylfentanyl 3-allyfentanyl is a fentanyl derivative opioid that can cause itching, nausea and serious respiratory depression. Fentanyl and its analogs have killed thousands of people around the world as drugs of... Brifentanil Brifentanil (also known as A-3331) is an analog of fentanyl, a potent opioid. This drug is classified as an opioid analgesic and was developed in the early 1990s. The effects... Lofentanil Lofentanil is an analog of fentanyl and is one of the most potent opioids available today. It displays most similarity to carfentanil (4-carbomethoxyfentanyl) and is considered to be slightly more... Mirfentanil Mirfentanil is a derivative of fentanyl that presents high selectivity for the mu opioid receptor. At lower doses, it antagonizes the analgesic effects of alfentanil and substitutes for naloxone in... R-30490 R-30490 is an opioid related to carfentanil used as an animal tranquilizer. It was first synthesized by Janssen Pharmaceutica as part of a structure-activity relationship study of fentanly and its... Benzylfentanyl Benzylfentanyl (R-4129) is a fentanyl analog opioid that was on the list of Schedule I drugs in America in 1985 due to its structural similarity to fentanyl. In 2010 it... Rupatadine A selective histamine H1 receptor antagonist and platelet activating factor (PAF) antagonist used to treat allergic rhinitis. Piritramide A synthetic opioid used in the treatment of severe pain. Metopimazine Not Annotated Phenoperidine Not Annotated Loperamide oxide Not Annotated Lucerastat Lucerastat is under investigation in clinical trial NCT03425539 (Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease). Carfentanil, C-11 Carfentanil, C-11 is under investigation in clinical trial NCT01899170 (Towards Individualized Deep Brain Stimulation Treatment of Chronic Neuropathic Pain).
- Drugs & Drug Targets