Solute carrier family 22 member 1

BE0003648ProteinHumansSLC22A1

Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:11388889, PubMed:11408531, PubMed:12439218, PubMed:12719534, PubMed:15389554, PubMed:16263091, PubMed:16272756, PubMed:16581093, PubMed:19536068, PubMed:21128598, PubMed:23680637, PubMed:24961373, PubMed:34040533,... It is acted on by 129 drugs in DrugBank.

Gene name
SLC22A1
UniProtKB entry
O15245Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
554 residues · 61,153 Da
Also known as
hOCT1 · OCT1 · Organic cation transporter 1

Resolves to

Protein
UniProtO15245UniProt nameS22A1_HUMAN
Gene
HGNCHGNC:10963NCBI Gene6580GenBank2511670GeneCardsSLC22A1
Pharmacology
IUPHAR/GtoPdb1019KEGGhsa:6580
Structure
PDB8ET6PDB8ET7PDB8ET8
Drugs

What you can answer from here — as of September 07, 2019

129DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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35GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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326+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 22 member 1, how selective are they, and which programs against it are still in active trials?

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