Solute carrier family 22 member 1

Details

Name
Solute carrier family 22 member 1
Kind
protein
Synonyms
  • hOCT1
  • OCT1
  • Organic cation transporter 1
Gene Name
SLC22A1
UniProtKB Entry
O15245Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0037862|Solute carrier family 22 member 1
MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ
RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP
CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL
GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY
QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK
IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL
YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVM
IFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIIT
PFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKEN
TIYLKVQTSEPSGT
Number of residues
554
Molecular Weight
61153.345
Theoretical pI
6.81
GO Classification
Functions
(R)-carnitine transmembrane transporter activity / dopamine / identical protein binding / monoamine transmembrane transporter activity / neurotransmitter transmembrane transporter activity / norepinephrine / organic anion transmembrane transporter activity / prostaglandin transmembrane transporter activity / putrescine transmembrane transporter activity / pyrimidine nucleoside transmembrane transporter activity / spermidine transmembrane transporter activity / thiamine transmembrane transporter activity / toxin transmembrane transporter activity / xenobiotic transmembrane transporter activity
Processes
acetylcholine transport / acyl carnitine transmembrane transport / cellular detoxification / dopamine uptake / metanephric proximal tubule development / monoamine transport / prostaglandin transport / purine-containing compound transmembrane transport / putrescine transport / serotonin transport / serotonin uptake / spermidine transport / thiamine transmembrane transport / thiamine transport / transport across blood-brain barrier / xenobiotic metabolic process / xenobiotic transport / xenobiotic transport across blood-brain barrier
Components
apical plasma membrane / basal plasma membrane / lateral plasma membrane / presynapse
General Function
Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:11388889, PubMed:11408531, PubMed:12439218, PubMed:12719534, PubMed:15389554, PubMed:16263091, PubMed:16272756, PubMed:16581093, PubMed:19536068, PubMed:21128598, PubMed:23680637, PubMed:24961373, PubMed:34040533, PubMed:9187257, PubMed:9260930, PubMed:9655880). Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (By similarity). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity). Primarily expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (By similarity). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation (PubMed:16263091). Transports endogenous monoamines such as N-1-methylnicotinamide (NMN), guanidine, histamine, neurotransmitters dopamine, serotonin and adrenaline (PubMed:12439218, PubMed:24961373, PubMed:35469921, PubMed:9260930). Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover (PubMed:21128598). Involved in the hepatic uptake of vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism (PubMed:24961373). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with lower efficency (PubMed:17460754). Also capable of transporting non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (PubMed:11907186). May contribute to the transport of cationic compounds in testes across the blood-testis-barrier (Probable). Also involved in the uptake of xenobiotics tributylmethylammonium (TBuMA), quinidine, N-methyl-quinine (NMQ), N-methyl-quinidine (NMQD) N-(4,4-azo-n-pentyl)-quinuclidine (APQ), azidoprocainamide methoiodide (AMP), N-(4,4-azo-n-pentyl)-21-deoxyajmalinium (APDA) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (PubMed:11408531, PubMed:15389554, PubMed:35469921, PubMed:9260930)
Specific Function
(r)-carnitine transmembrane transporter activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
22-42 150-170 177-197 207-229 236-256 263-283 348-368 377-397 403-423 432-452 465-485 493-513
Cellular Location
Basolateral cell membrane
Gene sequence
>lcl|BSEQ0017170|Solute carrier family 22 member 1 (SLC22A1)
ATGCCCACCGTGGATGACATTCTGGAGCAGGTTGGGGAGTCTGGCTGGTTCCAGAAGCAA
GCCTTCCTCATCTTATGCCTGCTGTCGGCTGCCTTTGCGCCCATCTGTGTGGGCATCGTC
TTCCTGGGTTTCACACCTGACCACCACTGCCAGAGTCCTGGGGTGGCTGAGCTGAGCCAG
CGCTGTGGCTGGAGCCCTGCGGAGGAGCTGAACTATACAGTGCCAGGCCTGGGGCCCGCG
GGCGAGGCCTTCCTTGGCCAGTGCAGGCGCTATGAAGTGGACTGGAACCAGAGCGCCCTC
AGCTGTGTAGACCCCCTGGCTAGCCTGGCCACCAACAGGAGCCACCTGCCGCTGGGTCCC
TGCCAGGATGGCTGGGTGTATGACACGCCCGGCTCTTCCATCGTCACTGAGTTCAACCTG
GTGTGTGCTGACTCCTGGAAGCTGGACCTCTTTCAGTCCTGTTTGAATGCGGGCTTCTTG
TTTGGCTCTCTCGGTGTTGGCTACTTTGCAGACAGGTTTGGCCGTAAGCTGTGTCTCCTG
GGAACTGTGCTGGTCAACGCGGTGTCGGGCGTGCTCATGGCCTTCTCGCCCAACTACATG
TCCATGCTGCTCTTCCGCCTGCTGCAGGGCCTGGTCAGCAAGGGCAACTGGATGGCTGGC
TACACCCTAATCACAGAATTTGTTGGCTCGGGCTCCAGAAGAACGGTGGCGATCATGTAC
CAGATGGCCTTCACGGTGGGGCTGGTGGCGCTTACCGGGCTGGCCTACGCCCTGCCTCAC
TGGCGCTGGCTGCAGCTGGCAGTCTCCCTGCCCACCTTCCTCTTCCTGCTCTACTACTGG
TGTGTGCCGGAGTCCCCTCGGTGGCTGTTATCACAAAAAAGAAACACTGAAGCAATAAAG
ATAATGGACCACATCGCTCAAAAGAATGGGAAGTTGCCTCCTGCTGATTTAAAGATGCTT
TCCCTCGAAGAGGATGTCACCGAAAAGCTGAGCCCTTCATTTGCAGACCTGTTCCGCACG
CCGCGCCTGAGGAAGCGCACCTTCATCCTGATGTACCTGTGGTTCACGGACTCTGTGCTC
TATCAGGGGCTCATCCTGCACATGGGCGCCACCAGCGGGAACCTCTACCTGGATTTCCTT
TACTCCGCTCTGGTCGAAATCCCGGGGGCCTTCATAGCCCTCATCACCATTGACCGCGTG
GGCCGCATCTACCCCATGGCCATGTCAAATTTGTTGGCGGGGGCAGCCTGCCTCGTCATG
ATTTTTATCTCACCTGACCTGCACTGGTTAAACATCATAATCATGTGTGTTGGCCGAATG
GGAATCACCATTGCAATACAAATGATCTGCCTGGTGAATGCTGAGCTGTACCCCACATTC
GTCAGGAACCTCGGAGTGATGGTGTGTTCCTCCCTGTGTGACATAGGTGGGATAATCACC
CCCTTCATAGTCTTCAGGCTGAGGGAGGTCTGGCAAGCCTTGCCCCTCATTTTGTTTGCG
GTGTTGGGCCTGCTTGCCGCGGGAGTGACGCTACTTCTTCCAGAGACCAAGGGGGTCGCT
TTGCCAGAGACCATGAAGGACGCCGAGAACCTTGGGAGAAAAGCAAAGCCCAAAGAAAAC
ACGATTTACCTTAAGGTCCAAACCTCAGAACCCTCGGGCACCTGA
Chromosome Location
6
Locus
6q25.3
External Identifiers
ResourceLink
UniProtKB IDO15245
UniProtKB Entry NameS22A1_HUMAN
GenBank Protein ID2511670
GenBank Gene IDX98332
GeneCard IDSLC22A1
HGNC IDHGNC:10963
PDB ID(s)8ET6, 8ET7, 8ET8, 8JTS, 8JTT, 8JTV, 8JTW, 8JTX, 8JTY, 8JTZ, 8JU0, 8SC1, 8SC2, 8SC3, 8SC4, 8SC6
KEGG IDhsa:6580
IUPHAR/Guide To Pharmacology ID1019
NCBI Gene ID6580
General References
  1. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H: Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. [Article]
  2. Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. [Article]
  3. Hayer M, Bonisch H, Bruss M: Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1). Ann Hum Genet. 1999 Nov;63(Pt 6):473-82. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  5. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. [Article]
  8. van Montfoort JE, Muller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ: Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5. [Article]
  9. Ciarimboli G, Struwe K, Arndt P, Gorboulev V, Koepsell H, Schlatter E, Hirsch JR: Regulation of the human organic cation transporter hOCT1. J Cell Physiol. 2004 Dec;201(3):420-8. [Article]
  10. Muller J, Lips KS, Metzner L, Neubert RH, Koepsell H, Brandsch M: Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol. 2005 Dec 5;70(12):1851-60. Epub 2005 Nov 2. [Article]
  11. Kimura N, Masuda S, Tanihara Y, Ueo H, Okuda M, Katsura T, Inui K: Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005 Oct;20(5):379-86. [Article]
  12. Saborowski M, Kullak-Ublick GA, Eloranta JJ: The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha. J Pharmacol Exp Ther. 2006 May;317(2):778-85. Epub 2006 Jan 25. [Article]
  13. Amphoux A, Vialou V, Drescher E, Bruss M, Mannoury La Cour C, Rochat C, Millan MJ, Giros B, Bonisch H, Gautron S: Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. Epub 2006 Mar 31. [Article]
  14. Dias V, Ribeiro V: The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells. Fundam Clin Pharmacol. 2007 Aug;21(4):445-50. [Article]
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  16. Kerb R, Brinkmann U, Chatskaia N, Gorbunov D, Gorboulev V, Mornhinweg E, Keil A, Eichelbaum M, Koepsell H: Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. Pharmacogenetics. 2002 Nov;12(8):591-5. [Article]
  17. Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM: Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5902-7. Epub 2003 Apr 28. [Article]
  18. Sakata T, Anzai N, Shin HJ, Noshiro R, Hirata T, Yokoyama H, Kanai Y, Endou H: Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions. Biochem Biophys Res Commun. 2004 Jan 16;313(3):789-93. [Article]
  19. Itoda M, Saito Y, Maekawa K, Hichiya H, Komamura K, Kamakura S, Kitakaze M, Tomoike H, Ueno K, Ozawa S, Sawada J: Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1). Drug Metab Pharmacokinet. 2004 Aug;19(4):308-12. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
RocuroniumapprovedunknowntransportersubstrateDetails
Quinidineapproved, investigationalunknowntransporterinhibitorDetails
Ganciclovirapproved, investigationalunknowntransportersubstrateinhibitorDetails
AcyclovirapprovedunknowntransportersubstrateinhibitorDetails
Progesteroneapproved, vet_approvedunknowntransporterinhibitorDetails
PrazosinapprovedunknowntransportersubstrateinhibitorDetails
PhenoxybenzamineapprovedunknowntransporterinhibitorDetails
Phenforminapproved, investigational, withdrawnunknowntransportersubstrateDetails
MetforminapprovedunknowntransportersubstrateDetails
Thiamineapproved, investigational, nutraceutical, vet_approvedunknowntransportersubstrateDetails
Ranitidineapproved, withdrawnunknowntransportersubstrateinhibitorDetails
ProcainamideapprovedunknowntransporterinhibitorDetails
NicotineapprovedunknowntransporterinhibitorDetails
Histamineapproved, investigationalunknowntransporterDetails
DopamineapprovedunknowntransportersubstrateDetails
Gentian violet cationapprovedunknowntransporterDetails
Cholineapproved, nutraceuticalunknowntransportersubstrateinhibitorDetails
AmantadineapprovedunknowntransportersubstrateinhibitorDetails
VerapamilapprovedunknowntransporterinhibitorDetails
QuinineapprovedunknowntransportersubstrateinhibitorDetails
PancuroniumapprovedunknowntransportersubstrateDetails
Cimetidineapproved, investigationalunknowntransportersubstrateinhibitorDetails
DisopyramideapprovedunknowntransporterinhibitorDetails
Desipramineapproved, investigationalunknowntransporterinhibitorDetails
CaspofunginapprovedunknowntransporterDetails
GuanidineapprovedunknowntransporterinhibitorDetails
Probenecidapproved, investigationalunknowntransporterinhibitorDetails
Saquinavirapproved, investigationalunknowntransporterinhibitorDetails
NelfinavirapprovednotransporterinhibitorDetails
ChlorpheniramineapprovedunknowntransporterinhibitorDetails
Epinephrineapproved, vet_approvedunknowntransportersubstrateDetails
IndinavirapprovedunknowntransporterinhibitorDetails
Reserpineapproved, investigational, withdrawnunknowntransporterinhibitorDetails
ImatinibapprovednotransportersubstrateDetails
NorepinephrineapprovedunknowntransportersubstrateDetails
Acetylcholineapproved, investigationalunknowntransportersubstrateDetails
Spermineexperimental, nutraceuticalunknowntransportersubstrateDetails
SpermidineexperimentalunknowntransportersubstrateDetails
TubocurarineapprovedunknowntransportersubstrateDetails
Buformininvestigational, withdrawnunknowntransportersubstrateDetails
Pramipexoleapproved, investigationalunknowntransportersubstrateDetails
Pipotiazineapproved, investigationalunknowntransporterDetails
ThiothixeneapprovedunknowntransporterDetails
Tetraethylammoniumexperimental, investigationalunknowntransporterDetails
AgmatineexperimentalunknowntransportersubstrateDetails
Codeineapproved, illicitunknowntransportersubstrateinhibitorDetails
Lamivudineapproved, investigationalunknowntransportersubstrateDetails
Dexchlorpheniramine maleateapprovedunknowncarriersubstrateinhibitorDetails
NafamostatinvestigationalunknowntransportersubstrateDetails
Brigatinibapproved, investigationalnotransporterDetails
Rucaparibapproved, investigationalnotransporterinhibitorDetails
Estradiol acetateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Estradiol benzoateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Estradiol cypionateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Estradiol dienanthateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Estradiol valerateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Pitolisantapproved, investigationalunknowntransporterinhibitorDetails
Choline salicylateapproved, nutraceuticalunknowntransportersubstrateinhibitorDetails
ClopidogrelapprovednotransporterinhibitorDetails
DoxazosinapprovednotransporterinhibitorDetails
Efavirenzapproved, investigationalunknowntransporterinhibitorDetails
NevirapineapprovedunknowntransporterinhibitorDetails
Dacomitinibapproved, investigationalnotransporterinhibitorDetails
Gilteritinibapproved, investigationalnotransporterinhibitorDetails
Palbociclibapproved, investigationalnotransporterinhibitorDetails
LinagliptinapprovedunknowntransporterinhibitorDetails
Lansoprazoleapproved, investigationalunknowntransporterDetails
NintedanibapprovedunknowntransportersubstrateinhibitorDetails
DronedaroneapprovednotransporterinhibitorDetails
Lasmiditanapproved, investigationalnotransporterinhibitorDetails
Formoterolapproved, investigationalunknowntransportersubstrateinhibitorDetails
Guanfacineapproved, investigationalunknowntransportersubstrateinhibitorDetails
SalmeterolapprovedunknowntransportersubstrateinhibitorDetails
Levofloxacinapproved, investigationalunknowntransporterinhibitorDetails
Lamotrigineapproved, investigationalunknowntransportersubstrateDetails
Osilodrostatapproved, investigationalunknowntransporterinhibitorDetails
Lurbinectedinapproved, investigationalunknowntransporterinhibitorDetails
Tirbanibulinapproved, investigationalnotransporterinhibitorDetails
Sulpirideapproved, investigationalunknowntransportersubstrateDetails
CyproheptadineapprovedunknowntransporterinhibitorDetails
Amisulprideapproved, investigationalnotransportersubstrateDetails
MirabegronapprovednotransportersubstrateDetails
Infigratinibapproved, investigationalnotransporterinhibitorDetails
Atogepantapproved, investigationalnotransporterinhibitorDetails
Asciminibapproved, investigationalnotransporterinhibitorDetails
Abrocitinibapproved, investigationalunknowntransporterinhibitorDetails
Pacritinibapproved, investigationalnotransporterinhibitorDetails
Tepotinibapproved, investigationalnotransporterinhibitorDetails
Deucravacitinibapproved, investigationalunknowntransportersubstrateDetails
ClozapineapprovednotransportersubstrateDetails
UmeclidiniumapprovednotransportersubstrateDetails
Palovaroteneapproved, investigationalnotransporterinhibitorDetails
Sofpironiumapproved, investigationalnotransporterinhibitorDetails
Lazertinibapproved, investigationalunknowntransporterinhibitorDetails