Thioredoxin reductase 1, cytoplasmic

BE0001979ProteinHumansTXNRD1

Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). It is acted on by 23 drugs in DrugBank.

Gene name
TXNRD1
UniProtKB entry
Q16881Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
649 residues · 70,906 Da
Also known as
1.8.1.9 · Gene associated with retinoic and IFN-induced mortality 12 protein · Gene associated with retinoic and interferon-induced mortality 12 protein · GRIM-12 · GRIM12

Resolves to

Protein
UniProtQ16881UniProt nameTRXR1_HUMAN
Gene
HGNCHGNC:12437NCBI Gene7296GenBank1237038GeneCardsTXNRD1
Pharmacology
IUPHAR/GtoPdb3302KEGGhsa:7296
Structure
PDB2CFYPDB2J3NPDB2ZZ0
Drugs

What you can answer from here — as of September 07, 2019

23DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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65+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thioredoxin reductase 1, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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