(R)-Rolipram

DB04149InvestigationalSmall molecule

The (R)-enantiomer of rolipram, it is a phosphodiesterase inhibitor with antidepressant properties.

Chemical structure of (R)-Rolipram
Mechanism
Curator reviewed
Formula / weight
C16H21NO3 · 275.3428 g/mol (avg)
Also known as
R-rolipram

Resolves to

Compound
UNIIDPX51KUP08CAS85416-75-7ChEMBLCHEMBL430893ChEBI40133PubChem448055
Clinical / RWD
PharmGKBPA153906323
Structure
InChIKeyHJORMJIFDVBMOB-LBPRGKRZSA-NSMILES[H][C@]1(CNC(=O)C1)C1=CC(OC2CCCC2)=C(OC)C=C1
Targets
Q07343PDE4BP27815PDE4AQ08499PDE4D

What you can answer from here — as of September 13, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
2Clinical trialsPhase, status and sponsor resolved per trial
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16+ReferencesStructured and connected to the statements they support
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Which drugs share a target with (R)-Rolipram, and which of those have an active Phase 3 trial?

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