Accession Number

Substituted derivatives of hydrazine (formula H2N-NH2).

DrugDrug Description
CarbidopaA dopa decarboxylase inhibitor used in combination with levodopa for the symptomatic treatment of idiopathic Parkinson disease and other conditions associated with parkinsonian symptoms.
PhenelzineA monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression.
IsoniazidAn antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis.
IproniazidFor the treatment of depression (originally intended to treat tuberculosis).
BenserazideA medication used to treat Parkinson's disease, parkinsonism, and restless leg syndrome.
LevosimendanA calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure.
BalsalazideAn aminosalicylate used to treat ulcerative colitis.
ApilimodInvestigated for use/treatment in crohn's disease and psoriasis and psoriatic disorders.
SivifeneInvestigated for use/treatment in cervical dysplasia/cancer, genital warts, and skin cancer.
AldoxorubicinInvestigated for use/treatment in solid tumors.
SemapimodSemapimod has been used in trials studying the treatment of Crohn Disease.
VP-14637MDT-637 has been investigated for the treatment of Drug Safety.
SimendanSimendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).
MeldoniumNot Annotated
DynasoreNot Annotated
HetrombopagHetrombopag is under investigation in clinical trial NCT03976882 (Hetrombopag for the Treatment of Chemotherapy-induced Thrombocytopenia in Subjects With Malignancy.).
PIK-75PIK-75 is a preferential p110 alpha/gamma PI3K inhibitor.
AconiazideNot Annotated
Drugs & Drug Targets
CarbidopaAromatic-L-amino-acid decarboxylasetarget
PhenelzineMembrane primary amine oxidasetarget
PhenelzineAmine oxidase [flavin-containing] Btarget
PhenelzineAmine oxidase [flavin-containing] Atarget
PhenelzineAmine oxidase [flavin-containing] Aenzyme
PhenelzineAmine oxidase [flavin-containing] Benzyme
PhenelzineCytochrome P450 2E1enzyme
Phenelzine4-aminobutyrate aminotransferase, mitochondrialtarget
PhenelzineGlutamic acid decarboxylasetarget
PhenelzineAlanine aminotransferase 1target
PhenelzineAlanine aminotransferase 2target
PhenelzineCytochrome P450 2C19enzyme
PhenelzineCytochrome P450 2C8enzyme
PhenelzineCytochrome P450 3A4enzyme
PhenelzineCytochrome P450 3A5enzyme
PhenelzineCytochrome P450 3A7enzyme
PhenelzineCytochrome P450 2D6enzyme
PhenelzineCytochrome P450 3A Subfamilyenzyme
IsoniazidEnoyl-[acyl-carrier-protein] reductase [NADH]target
IsoniazidCytochrome P450 2E1enzyme
IsoniazidCytochrome P450 1A2enzyme
IsoniazidCytochrome P450 2C9enzyme
IsoniazidCytochrome P450 2D6enzyme
IsoniazidCytochrome P450 2C19enzyme
IsoniazidArylamine N-acetyltransferase 2enzyme
IsoniazidArylamine N-acetyltransferaseenzyme
IsoniazidCytochrome P450 2A6enzyme
IsoniazidCytochrome P450 2C8enzyme
IsoniazidCytochrome P450 2C8target
IsoniazidCytochrome P450 1A2target
IsoniazidCytochrome P450 3A4target
IsoniazidCytochrome P450 2C19target
IsoniazidDihydrofolate reductasetarget
IsoniazidSerum albumincarrier
IsoniazidCytochrome P450 3A4enzyme
IproniazidAmine oxidase [flavin-containing] Benzyme
IproniazidCytochrome P450 2D6enzyme
IproniazidCytochrome P450 2C9enzyme
IproniazidAmine oxidase [flavin-containing] Aenzyme
BenserazideAromatic-L-amino-acid decarboxylasetarget
LevosimendanTroponin C, slow skeletal and cardiac musclestarget
LevosimendanATP-sensitive inward rectifier potassium channel 11target
LevosimendanATP-sensitive inward rectifier potassium channel 8target
LevosimendancGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
BalsalazideProstaglandin G/H synthase 1target
BalsalazideProstaglandin G/H synthase 2target
BalsalazideArachidonate 5-lipoxygenasetarget
BalsalazidePeroxisome proliferator-activated receptor gammatarget
BalsalazideNADPH azoreductaseenzyme
AldoxorubicinDNA topoisomerase 2-alphatarget