- Acids, Acyclic
- Accession Number
Carboxylic acids that have open-chain molecular structures as opposed to ring-shaped structures.
Drug Drug Description Indium In-111 satumomab pendetide For diagnosis of extrahepatic malignant cancers Ascorbic acid A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron. Succinic acid For nutritional supplementation, also for treating dietary shortage or imbalance Proline An amino acid commonly found as a component of total parenteral nutrition. Succinylcholine A depolarizing skeletal muscle relaxant used adjunctly to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures. Gadodiamide A gadolinium-based contrast agent used for the visualization of lesions with vascularity during magnetic resonance imaging (MRI) scans. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Calcium acetate A phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Calcium glucoheptonate A calcium supplement combined with calcium gluconate to treat hypocalcemia and maintain calcium levels. Meprobamate An anxiolytic drug used for the short-term management of anxiety symptoms. Methocarbamol A CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions. Montelukast A leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis. Fosinopril An ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics. Ritonavir An HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. Aminocaproic acid An antifibrinolytic agent used to induce clotting postoperatively. Albendazole A benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. Tolnaftate An antifungal agent used to treat various skin infections caused by fungi. Foscarnet An antiviral used to treat CMV, HIV, and HSV infections. Azelaic acid A saturated dicarboxylic acid used to treat mild to moderate acne vulgaris. Zanamivir A neuraminidase inhibitor used to treat influenza A and B. Succimer A mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning. Linezolid An oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. Candoxatril Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor. Clofibrate A fibric acid derivative used to treat hypertriglyceridemia and high cholesterol. Mebendazole A benzimidazole anthelmintic used to treat helminth infections. Dextropropoxyphene An opioid analgesic used to treat mild to moderate pain. Amprenavir A protease inhibitor used to treat HIV infection. Diethylcarbamazine An anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa. Flurbiprofen An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Gadopentetic acid A gadolinium compound used as a contrast agent in MRIs. Disulfiram A carbamate derivative used to treat alcohol addiction. Progabide Indicated for the treatment of epilepsy. Eprosartan An ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. Benzylpenicilloyl polylysine A penicillin derivative used to determine penicillin allergies. Etacrynic acid A diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease. Repaglinide A antihyperglycemic used to improve glycemic control in diabetes. Felbamate An anticonvulsant used to treat severe epilepsy. Zaleplon A sedative used for short term treatment of insomnia in adults. Edetic acid A chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias. Physostigmine A cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. Rivastigmine A cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's. Oxaprozin An NSAID used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Mycophenolic acid An immunosuppressant used to prevent organ transplant rejections. Ethinamate Used for the short-term treatment of insomnia, however, it generally has been replaced by other sedative-hypnotic agents. Fenofibrate A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia. Vigabatrin An irreversible GABA transaminase inhibitor used as an adjunct therapy to treat refractory complex partial seizures in patients ≥2 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years. Phenacemide Used to control certain seizures in the treatment of epilepsy. Rabeprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Trimetrexate A folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. Captopril An ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. Ridogrel Used as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction. Gemfibrozil A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. Fosamprenavir An antiretroviral agent used for the treatment and postexposure prophylaxis of human immunodeficiency virus (HIV-1) infection. Bezafibrate A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. gamma-Hydroxybutyric acid Used as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance. Tiaprofenic acid A nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis. Propyl acetate Not Available Fumaric Acid Not Available Isocitric Acid Not Available N,N-dimethylformamide Not Available Formic acid Formic acid (systematically called methanoic acid) is the simplest carboxylic acid. It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and... trans-urocanic acid Not Available 6-phospho-D-gluconic acid Not Available Aminooxyacetic acid A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem] Malonic acid Not Available 4-(2-Thienyl)Butyric Acid Not Available N-Benzylformamide Not Available Ditiocarb A chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM. Isobutyric acid Not Available Pyrrole-2-Carboxylate Not Available PD150606 Not Available Acrylic Acid A α,β-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group. Adenosine Phosphonoacetic Acid Not Available Acetamide Not Available N-(2-Acetamido)Iminodiacetic Acid Not Available Canaline Not Available Phosphonoacetic Acid A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent. [PubChem] 2-aminoisobutyric acid Not Available Nitrilotriacetic acid Nitrilotriacetic acid is a derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.) Glycolic acid Not Available Pidolic acid There is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in... Acetic acid An antimicrobial agent used to treat susceptible infections of the external auditory canal. N-Acetylproline Not Available N(4)-Adenosyl-N(4)-methyl-2,4-diaminobutanoic acid N(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. Sparfosic acid Sparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen... 2-Keto-3-Deoxygluconate Not Available Glutaric Acid Not Available Butyric Acid A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester. Mesoxalic acid Not Available Dibenzofuran-4,6-Dicarboxylic Acid Not Available Xylarohydroxamate Not Available 2-Methylbutanoic Acid Not Available Isovaleric Acid Not Available L-2,4-diaminobutyric acid Not Available Oxalic Acid A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted... Coelenteramide Not Available 5-phenylpentanoic acid Not Available Valpromide Not Available Mdl-29951 Not Available Methylmalonic Acid A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed... L-2-amino-3-butynoic acid Not Available Carbamic Acid Not Available Citric acid An anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products. L-proline betaine Not Available Maleic acid Not Available Alpha-Aminobutyric Acid Not Available Guanidinoethylmercaptosuccinic acid Not Available Caprylic acid Caprylic acid is an eight-carbon chain fatty acid, also known systematically as octanoic acid. It is found naturally in coconuts and breast milk. It is an oily liquid with a... Tricarballylic acid Not Available Gluconolactone A polyhydroxy acid used in the dissolution of calculi and used as an additive in various drug products to maintain consistency and other characteristics. 3-hydroxyglutaric acid Not Available Citraconic acid Citraconic acid is one of the isomeric dicarboxylic acids produced by the distillation of citric acid, or as metabolites by microorganisms, cis-CH3-C(CO2H)=CHCO2H; the trans-isomer is mesaconic acid. Myxothiazol Not Available 5-hydroxyvaleric acid Not Available Tagetitoxin Tagetitoxin is a bacterial phytotoxin. It preferentially inhibits eukaryotic RNA polymerase. Benoxaprofen The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets... Urethane Urethane, formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963. Tienilic acid For the treatment of hypertension. Dexloxiglumide For the treatment of Irritable Bowel Syndrome (IBS) and Gastroesophageal Reflux Disease (GERD). Merimepodib For the treatment of hepatitis C virus (HCV) infection. Brecanavir For the treatment of HIV-1 infection in combination with other antiretroviral agents. Phenserine For the treatment of Alzheimer's disease (AD). Ezogabine An antiepileptic agent used as an adjuvant treatment of partial-onset seizures. Erdosteine Fro the treatment of chronic bronchitis in adults. AN-9 Investigated for use/treatment in liver cancer, lung cancer, melanoma, and leukemia (lymphoid). Asimadoline Investigated for use/treatment in irritable bowel syndrome (IBS). AP5280 Investigated for use/treatment in solid tumors. Rilapladib Investigated for use/treatment in atherosclerosis and cardiovascular disorders. Gemcabene Investigated for use/treatment in atherosclerosis, cardiovascular disorders, and hyperlipidemia. Elafibranor Investigated for use/treatment in atherosclerosis and diabetes mellitus type 2. AM103 For the treatment of asthma and cardiovascular disease. Fenoxaprop-ethyl Chronic angina and Coronary Artery Disease Caprospinol Alzheimer's Disease Tarenflurbil Investigated for use/treatment in alzheimer's disease and prostate cancer. Arundic acid Investigated for use/treatment in cerebral ischemia. Emricasan Investigated for use/treatment in hepatitis (viral, C), liver disease, and transplantation (organ or tissue). Canertinib Investigated for use/treatment in breast cancer and lung cancer. OSI-7904L Investigated for use/treatment in gastric cancer. NOX-700 Investigated for use/treatment in diabetes mellitus (type 2). AVN-944 Investigated for use/treatment in cancer/tumors (unspecified), leukemia (unspecified), lymphoma (unspecified), multiple myeloma, and pancreatic cancer. Bedoradrine Investigated for use/treatment in asthma and labor and delivery. Sodium stibogluconate For the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment... BL-1020 Investigated for use/treatment in schizophrenia and schizoaffective disorders. Varespladib methyl Investigated for use/treatment in atherosclerosis and coronary artery disease. DP-b99 Investigated for use/treatment in strokes and traumatic brain injuries. DP-VPA Investigated for use/treatment in bipolar disorders, epilepsy, and migraine and cluster headaches. AGI-1096 Investigated for use/treatment in transplant (rejection). Ciluprevir Investigated for use/treatment in hepatitis (viral, C). Edonerpic Investigated for use/treatment in alzheimer's disease. Tirbanibulin A tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp. Indibulin Investigated for use/treatment in solid tumors. Lacosamide An antiepileptic drug used to treat partial onset seizures in adults. Amelubant Investigated for use/treatment in asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and rheumatoid arthritis. Senicapoc Investigated for use/treatment in anemia (sickle cell) and asthma. Fiboflapon Investigated for use/treatment in inflammatory disorders (unspecified). Avasimibe Investigated for use/treatment in peripheral vascular disease. Remacemide Investigated for use/treatment in epilepsy, huntington's disease, and parkinson's disease. Ganstigmine Investigated for use/treatment in alzheimer's disease. Bevirimat Investigated for use/treatment in HIV infection. Agomelatine Agomelatine is indicated to treat major depressive episodes in adults. Priralfinamide Investigated for use/treatment in pain (acute or chronic). Almorexant Investigated for use/treatment in sleep disorders and insomnia. Zaltoprofen A non-steroidal anti-inflammatory drug approved for use in Japan in 1993. Bendamustine An antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy. Levopropoxyphene Levopropoxyphene was used as an antitussive. An antitussive is a medication often recommended for the treatment of cough and associated respiratory tract disorders. Its enantiomer, dextropropoxyphene, presents an analgesic effect. Mangafodipir An organ-specific paramagnetic contrast agent indicated for the imaging of the hepatobiliary system and detecting lesions in the liver and pancreas. Monoctanoin Monoctanoin is used to dissolve cholesterol gallstones. Nepafenac An ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Sobetirome Not Available Sebacic acid Not Available IDD594 Not Available Efaproxiral Not Available Trimesic acid Not Available Dichloroacetic acid Dichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms.... Dehydroascorbic acid There is no approved indication for dehydroascorbic acid, but it has potential therapeutic use in patients with certain viruses and ischemic stroke. Oxogluric acid α-α-Ketoglutarate is not approved for any indication in the world but is an investigational drug in the United States. The potential indications for α-Ketoglutarate are in patients with the metabolic... Hydroxyproline Used in France as a combination product for the treatment of small, superficial wounds. Gabapentin enacarbil A gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN). Boceprevir A hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy. Teriflunomide A pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. Gadoxetic acid A gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to help characterize lesions in the liver. Arbaclofen Placarbil Investigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD. Dimethyl fumarate A medication used to treat patients with the relapsing-remitting form of multiple sclerosis. Ibuproxam Ibuproxam is a non steroidal anti-inflammatory drug (NSAID). Flubendazole Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe. Etofibrate Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations. Clinofibrate Clinofibrate is a fibrate drug sold and marketed in Japan. Beclamide Has been used in the management of epilepsy and epilepsy related behavioural disorders. It was used for generalised tonic-clonic seizures, and was not effective for absence seizures. More recently focus... Aliskiren A direct renin inhibitor used to manage hypertension. Ciprofibrate Not Annotated Cobicistat A CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection. Sodium oxybate A central nervous system depressant used to treat cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy. Potassium citrate An agent used to manage renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones. Technetium Tc-99m mebrofenin A diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests. Uridine triacetate A pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine. Iron sucrose An compound used as a source of iron in patients with iron deficiency anemia associated with chronic kidney disease (CKD). Sodium citrate An ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures. Piracetam Indicated in adult patients suffering from myoclonus of cortical origin, irrespective of aetiology, and should be used in combination with other anti-myoclonic therapies . Azelnidipine For the treatment of hypertension. Iproclozide For the treatment of depression. Pivhydrazine For the treatment of depression. Caroxazone For the treatment of depression. Picosulfuric acid A stimulant laxative used for cleansing of the colon as a preparation for colonoscopy in adults. Artesunate Artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. Sodium aurothiomalate A disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis. Sacubitril A neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. Ombitasvir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Osimertinib A tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma. Sodium acetate A compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy. L-tartaric acid Tartaric Acid is primarily indicated in conditions like Antiscorbutic, Antiseptic. Octocrylene A sunscreen agent found in sunscreens that absorbs UV rays. Calcium citrate An ingredient found in a variety of supplements and vitamins. Magnesium citrate A laxative used in bowel preparation for colonoscopy or as a magnesium supplement. Calcium gluconate An ingredient found in a variety of supplements and vitamins, and is used to lower potassium in the blood or treat magnesium poisoning. Manganese gluconate An ingredient found in a variety of supplements and vitamins. Trichloroacetate Trichloroacetate, or trichloroacetic acid, is a strong acid prepared by the reaction of chlorine with acetic acid in the presence of a suitable catalyst. In clinical chemistry and biochemistry, it... Calcium threonate No approved therapeutic indications. L-threonic acid Not Annotated Iron protein succinylate Not Annotated Zinc gluconate An ingredient found in a variety of supplements and vitamins. Ascorbyl glucoside Not Annotated Selexipag A non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension. Pidotimod A synthetic agent with immunomodulatory properties used in patients with documented cell-mediated immunosuppression to stimulate their immunity during lung and urinary tract infections. Dirlotapide Dirlotapide is a drug employed in the treatment of obesity in dogs. It is marketed by Pfizer and Zoetis under the brand name, Slentrol, and is not intended for human... Fenbendazole Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,... Gleptoferron Colloid solution of ferric hydroxide, dextran & glucoheptonic acid. Monensin Monensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds. Lesinurad A uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy. Velpatasvir A NS5A inhibitor used to treat chronic hepatitis C infections in patients without cirrhosis or with compensated cirrhosis. PF-06282999 Pf 06282999 is under investigation in clinical trial NCT01626976 (A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects). Antineoplaston A10 Antineoplaston A10 has been used in trials studying the treatment of Sarcoma, Lymphoma, Lung Cancer, Liver Cancer, and Kidney Cancer, among others. Raxatrigine Raxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression. Encorafenib A kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations. Spebrutinib Spebrutinib has been used in trials studying the treatment of Rheumatoid Arthritis, Lymphoma, Large B-Cell, Diffuse, and Leukemia Lymphocytic Chronic B-Cell. AZD-1305 AZD1305 has been used in trials studying the treatment and basic science of Atrial Flutter, Atrial Fibrillation, and Left Ventricle Function. AZD-5672 Azd5672 has been used in trials studying the basic science and treatment of Pharmacokinetics, Renal Impairment, and Rheumatoid Arthritis. Arhalofenate Arhalofenate has been investigated for the treatment of Gout and Hyperuricemia. Danegaptide Danegaptide has been investigated for the treatment of Focus of Study is STEMI. Ruboxistaurin Ruboxistaurin has been investigated for the basic science of Type 2 Diabetes Mellitus and Type 1 Diabetes Mellitus. Etiracetam Etiracetam is under investigation in clinical trial NCT01137110 (Comparison of Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After Subarachnoid Hemorrhage (SAH)). PF-00610355 PF-00610355 has been used in trials studying the treatment of Lung Disease, Moxifloxacin, Pulmonary Disease, Asthma, Bronchial, and Bronchial Diseases, among others. Laninamivir octanoate Laninamivir octanoate has been used in trials studying the treatment of Asthma. Sutezolid Sutezolid has been used in trials studying the treatment of Tuberculosis. Rociletinib Rociletinib has been used in trials studying the treatment and prevention of Nonsmall Cell Lung Cancer, Non-small Cell Lung Cancer, and Locally Advanced or Metastatic Non-small Cell Lung Cancer. Varespladib Varespladib has been investigated for the treatment and prevention of Sickle Cell Disease, Vaso-occlusive Crisis, and Acute Coronary Syndrome. LY-2090314 Ly2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer. Bempedoic acid A drug used in conjunction with lifestyle modification and/or other agents for the treatment of refractory hypercholesterolemia. Ingavirin Ingavirin has been used in trials studying the treatment of Influenza and Common Cold. Ozagrel Ozagrel has been used in trials studying the treatment of Dry Eye Syndromes. Atagabalin Atagabalin has been used in trials studying the treatment of Insomnia, Primary Insomnia, and Nonrestorative Sleep. 2-octyl cyanoacrylate Dermabond has been investigated for the basic science of Wound Healing. Letermovir An antiviral medication used to treat CMV infections and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT). Orantinib Orantinib has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Kidney Cancer, Gastric Cancer, and Prostate Cancer, among others. Ritobegron Ritobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin... CPI-613 CPI-613 has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors, Advanced Cancer, and Pancreatic Cancer, among others. Figopitant Figopitant is under investigation in clinical trial NCT02209714 (Safety, Tolerability and Pharmacodynamics After Oral Administration of BIIF 1149 BS in Healthy Male Volunteers). Sarpogrelate Sarpogrelate has been investigated for the treatment of Diabetes Mellitus, Diabetic Nephropathy, Coronary Artery Disease, and Renal Insufficiency, Chronic. Tricaprylin Tricaprilin has been used in trials studying the supportive care and treatment of Alzheimer's Disease. Verdinexor Kpt 335 is under investigation in clinical trial NCT02431364 (Trial of Safety and Tolerability of Oral Verdinexor (Verdinexor) in Healthy Adults). GSK-424887 Gsk424887 has been used in trials studying the basic science and treatment of Depressive Disorder and Anxiety Disorder. Oxothiazolidinecarboxylic acid Procysteine has been used in trials studying the treatment of HIV Infections. AZD-5423 AZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD). BMS-599626 BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies. Carisbamate Carisbamate has been investigated in Alcohol Abuse, Substance Abuse, and Alcohol Dependence. Enbucrilate Enbucrilate is under investigation in clinical trial NCT02468206 (Secondary Prophylaxis of Gastric Variceal Bleed). MBX-8025 MBX-8025 has been used in trials studying the treatment of Hyperlipidemia. VTP-27999 VTP-27999 has been used in trials studying the basic science of Renal Function. PAC-14028 PAC-14028 has been used in trials studying the treatment of Skin Pruritus, Papulopustular Rosacea, and Erythematotelangiectatic Rosacea. Ioforminol Ioforminol has been used in trials studying the diagnostic of Cardio Renal Safety in High-risk Elderly Subjects Undergoing a Coronary CATH With or Without PCI. PD-217014 PD-217,014 has been used in trials studying the treatment of Pain and Irritable Bowel Syndrome. Clascoterone An androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older. Imiglitazar Imiglitazar has been used in trials studying the treatment of Diabetes Mellitus. MK-0686 MK0686 has been used in trials studying the treatment of Osteoarthritis, Pain, Postoperative, and Neuralgia, Postherpetic. LY-2452473 Ly2452473 is under investigation for the supportive care of Prostate Cancer. Ly2452473 has been investigated for the treatment of Erectile Dysfunction. Pentetreotide Pentetreotide has been used in trials studying the diagnostic of cushing syndrome. Taprenepag Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle. 3,5-diiodothyropropionic acid DITPA has been investigated in Congestive Heart Failure. Givinostat Givinostat has been used in trials studying the treatment of Polycythemia Vera, Juvenile Idiopathic Arthritis, Duchenne Muscular Dystrophy (DMD), Chronic Myeloproliferative Neoplasms, and Polyarticular Course Juvenile Idiopathic Arthritis. Samatasvir Samatasvir has been used in trials studying the treatment of Hepatitis C, Chronic, Chronic Hepatitis C Virus, and Chronic Hepatitis C Infection. Daporinad Daporinad has been used in trials studying the treatment of Melanoma, Cutaneous T-cell Lymphoma, and B-cell Chronic Lymphocytic Leukemia. Bindarit Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy. Malic acid Malic acid has been used in trials studying the treatment of Xerostomia, Depression, and Hypertension. Lafutidine Lafutidine has been investigated in Peptic Ulcer, Community-acquired Pneumonia, and Gastroesophageal Reflux Disease (GERD). Laninamivir Laninamivir has been used in trials studying the treatment of Influenza. Relenopride Relenopride has been used in trials studying the treatment of Chronic Idiopathic Constipation. MK-0752 Mk 0752 is under investigation in clinical trial NCT00572182 (MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer). Pradigastat Pradigastat has been used in trials studying the treatment of Non-alcoholic Fatty Liver Disease (NAFLD). Granotapide Granotapide has been used in trials studying the treatment of Type II Diabetes Mellitus. Pivagabine Pivagabine has been used in trials studying the treatment of Stress and Anxiety. Carbendazim Carbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific. MK-8245 MK-8245 has been used in trials studying the treatment of Type 2 Diabetes Mellitus. Yttrium Y-90 Yttrium 90 has been investigated for the treatment of Colon Cancer and Colorectal Cancer. Glycovir Glycovir has been used in trials studying the treatment of HIV Infections. Zofenopril Zofenopril is employed as both a cardioprotective and anti-hypertensive agent. It is an angiotensin-converting enzyme (ACE) inhibitor. Gluconic Acid An electrolyte supplement used in total parenteral nutrition. Fentiazac Not Annotated Thiram Thiram may be used in dermatology as a scabicide . Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for... Etofamide Etofamide is used as an antiamoebic agent. Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued . Bumadizone Bumadizone has been approved for use in Germany and Austria, it is a drug with anti-inflammatory, antipyretic, and analgesic properties, and was marketed for the treatment of both rheumatoid arthritis... Alminoprofen Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances. Bufexamac An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. Phenprobamate Not Annotated Tolciclate Not Annotated Oxaceprol Not Annotated Difenpiramide Not Annotated Sodium feredetate Not Annotated Simfibrate Not Annotated Prethcamide Not Annotated Mazaticol Not Annotated Phenibut Not Annotated Cyclobutyrol Not Annotated Clefamide Not Annotated Pranoprofen Not Annotated Alginic acid Indicated for the management of gastric reflux, reflux oesophagitis, hiatus hernia, heartburn (including heartburn of pregnancy) and similar gastric distress . Emylcamate Not Annotated Calcium pangamate Not Annotated Mifamurtide A muramyl dipeptide derivative used to treat high grade, resectable, non-metastatic osteosarcoma after surgical resection. Lorcainide Not Annotated Hexapropymate Not Annotated Sodium tartrate It acts as an emulsifier and pH control agent in food products , . In the laboratory, it is used while performing the Karl Fischer equation, which is used to... Magnesium gluconate A mineral supplement used to treat or prevent hypomagnesemia. Epanolol Epanolol is an beta blocker. Meclofenoxate Not Annotated Clofibride Not Annotated Albendazole oxide Not Annotated Fenofibric acid A fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia. Pentetic acid DTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It... Hopantenic acid Hopantenic acid (Pantogam) is a central nervous system depressant. Hopantenic acid has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal... Sacubitrilat A metabolite of LCZ696 with neprilysin inhibitory activity. Tetramethylthiuram monosulfide Not Annotated Zinc dibutyldithiocarbamate Zinc dibutyldithiocarbamate is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6... Fosinoprilat Fosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group. Monomethyl fumarate Not Annotated Threonic acid Not Annotated Calcium ascorbate Not Available Zinc acetate A medication used to treat zinc deficiency. Potassium acetate A medication used to treat hypokalemia. Lithium citrate Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment. Lithium succinate Not Available Aluminum acetate A medication used for temporary relief of skin irritation. Peracetic acid A liquid that functions as a strong oxidizing agent. It has an acrid odor and is used as a disinfectant. Acetyl chloride Not Annotated Zofenoprilat Not Available AB192 Investigated for use/treatment in diabetes mellitus type 2. gamma-Aminobutyric acid The most common inhibitory neurotransmitter in the central nervous system. Oseltamivir acid Not Available 4-phospho-D-erythronic acid Not Available 3-deoxy-D-arabino-hexonic acid Not Available Glucaric acid Not Available Propanoic acid An antimicrobial food additive. Meglutol An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as... 3-phospho-D-glyceric acid Not Available LY-518674 LY518674 has been used in trials studying the treatment of Metabolic Syndrome X. Deleobuvir Deleobuvir is under investigation in clinical trial NCT01983566 (Effect of Food and Increased Gastric pH Value on Bioavailability of a Single Dose of BI 207127 in Healthy Caucasian and Japanese... Coleneuramide Coleneuramide is under investigation in clinical trial NCT00307749 (Safety and Efficacy of MCC-257 in the Treatment of Diabetic Polyneuropathy). Flurbiprofen axetil Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients). AZD-7687 AZD-7687 is under investigation in clinical trial NCT01119352 (AZD7687 Multiple Ascending Dose Study). Venglustat Venglustat is under investigation in clinical trial NCT01674036 (Safety, Tolerability and Pharmacokinetics of Genz-682452 in Healthy Men). Albuvirtide Albuvirtide is under investigation in clinical trial NCT03719664 (Albuvirtide and 3BNC117 as Long-Acting Maintenance Therapy in Virologically Suppressed Subjects). Telaglenastat Telaglenastat is under investigation in clinical trial NCT02071862 (Study of the Glutaminase Inhibitor CB-839 in Solid Tumors). Posiphen Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease). beta-Hydroxyisovaleric acid beta-Hydroxyisovaleric acid is under investigation in clinical trial NCT03018496 (Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men.). GLPG-0974 GLPG-0974 is under investigation in clinical trial NCT01721980 (Multiple Ascending Dose Study of GLPG0974 in Healthy Subjects). Thioglycolic acid Thioglycolic acid is under investigation in clinical trial NCT03238105 (Treatment of Periorbicular Hyperchromia Comparing 10% Thioglycolic Acid Peeling Versus Pulsed Intense Light). Vidofludimus Vidofludimus is under investigation in clinical trial NCT03722576 (Vidofludimus Calcium for Primary Sclerosing Cholangitis). Norleucine Norleucine is under investigation in clinical trial NCT00081952 (Amino Acid Therapy for Hot Flashes in Postmenopausal Women). Remifentanil An opioid analgesic used in anesthesia. Bethanechol A muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention. L-2-aminopimelic acid Not Available p-Coumaric acid Not Available Glesatinib Investigated for use/treatment in cancer/tumors (unspecified). Verinurad Verinurad has been used in trials studying the basic science and treatment of Gout, Gout and Hyperuricemia, and Gout and Asymptomatic Hyperuricemia. Radiprodil Radiprodil has been used in trials studying the treatment of Infantile Spasms (IS) and Diabetic Peripheral Neuropathic Pain. Ralinepag Ralinepag has been used in trials studying the treatment of Pulmonary Arterial Hypertension. Batefenterol Batefenterol has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive. Icosabutate Icosabutate is under investigation in clinical trial NCT02373176 ([14C] Icosabutate -A Phase I Absorption, Metabolism and Excretion Study). Odalasvir Odalasvir has been used in trials studying the treatment of Hepatitis C, Chronic and Chronic Hepatitis C Infection. ACT-451840 ACT-451840 has been used in trials studying Malaria. Triethylhexanoin Not Annotated Solriamfetol Solriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744]. Linrodostat Linrodostat is under investigation in clinical trial NCT03247283 (Pharmacokinetics and Metabolism Study in Healthy Male Participants). Pyrotinib Pyrotinib is under investigation in clinical trial NCT03756064 (Neoadjuvant Study of Pyrotinib in Patients With HER2 Positive Breast Cancer). Ocrylate Ocrylate is under investigation in clinical trial NCT01918059 (Cosmetic Outcome Study of Lid Laceration Repair With Suture Versus Tissue Adhesive). Pemafibrate Pemafibrate is under investigation in clinical trial NCT03350165 (A Study of Pemafibrate in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)). Olorofim Olorofim is under investigation in clinical trial NCT03340597 (Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects). 2-deoxy-2,3-dehydro-N-acetylneuraminic acid Not Available 5-Oxoprolinal Not Available KH064 Not Available GW-590735 Not Available Andarine Andarine is a non-steroidal selective androgen receptor modulator. Bisindolylmaleimide VIII Not Available Bisindolylmaleimide I Not Available Azoxystrobin Azoxystrobin is a methoxyacrylate analog and a strobilurin fungicide. 1-Naphthoxyacetic acid Not Available Bis(N-maleimidomethyl)ether Not Available R-95845 R-95845 is an inhibitor of HIV-1 reverse transcriptase. Allysine Not Available Indolepropionic acid Not Available Ethyl N-methylcarbamate Not Available 6-hydroxynorleucine Not Available Cyclohexylformamide Not Available Isocaproic acid Not Available Benzyl formate Not Available Iodopropynyl butylcarbamate Not Annotated Calcium monoethylfumarate Not Annotated Zinc monoethylfumarate Not Annotated Citrulline Used for nutritional supplementation, also for treating dietary shortage or imbalance. Carbaryl Not Annotated Gamma-amino-beta-hydroxybutyric acid An anticonvulsant indicated to treat convulsions in children and epilepsy. Gallium Ga-68 gozetotide A radiopharmaceutical agent used in the diagnosis of prostate-specific membrane antigen (PSMA) positive lesions in male patients during positron emission tomography. Adelmidrol Adelmidrol is under investigation in clinical trial NCT01420510 (Saginil in vs. Placebo for Gynecologic Oncology Patients Affected by Vaginitis). Iron (III) oxide adipate Not Annotated Fasoracetam Fasoracetam is under investigation in clinical trial NCT03609619 (PART B: Efficacy and Safety of AEVI-001 in Children and Adolescents With ADHD and Without Mglur Mutations). Firsocostat Firsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)). Metadoxine A medication used to increase the clearance of alcohol in patients with chronic alcohol dependancy. Succinylated gelatin A plasma volume expander indicated alone or in combination with blood transfusions.
- Drugs & Drug Targets