5-hydroxytryptamine receptor 7

BE0000650ProteinHumansHTR7

G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:8226867). It is acted on by 52 drugs in DrugBank.

Gene name
HTR7
UniProtKB entry
P34969Swiss-Prot
Cellular location
Cell membrane
Residues / weight
479 residues · 53,554 Da
Also known as
5-HT-7 · 5-HT-X · 5-HT7 · Serotonin receptor 7

Resolves to

Protein
UniProtP34969UniProt name5HT7R_HUMAN
Gene
HGNCHGNC:5302NCBI Gene3363GenBank1857143GeneCardsHTR7
Pharmacology
IUPHAR/GtoPdb12KEGGhsa:3363
Structure
PDB7XTC
Drugs

What you can answer from here — as of September 07, 2019

52DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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127+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5-hydroxytryptamine receptor 7, how selective are they, and which programs against it are still in active trials?

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